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| 1 | Isolation of the mucilages from Hibiscus rosasinensis linn.and Okra(Abelmoschus esculentus linn.) and studies of the binding effects of the mucilages显示文摘Objective:To isolate and evaluate comparatively the binding efficacy of the mucilages obtained from the plants of Hibiscus rosasinensis and Okra(Abelmoschus esculentus).Methods:Extraction of mucilages from the leaves of Hibiscus and pods of Okra(Ladies finger) was carried out by a cold maceration process.The extracted mucilages were subjected to various physicochemical properties for its suitability as an excipient in the formulation of tablet dosage form.Different concentrations(10,8,5,2 and 1%w/v) of binder solutions of Hibiscus and Okra were used for the formulation of tablets and the formulated tablets were evaluated by studying the standard parameters like diameter,thickness,weight variation,hardness,friability,disintegration and in vitro dissolution.Stability studies of the formulated tablets were conducted for four weeks. Results:The formulated tablets prepared using the mucilages of both Hibiscus and Okra had good appearance.The in vitro drug release profile of the tablets prepared using Okra mucilage had an optimum of 90%at a mucilage concentration of 1%w/v concentration mucilage itself within 4 h.Conclusions:According to the observations,the lower concentration levels of Okra can be used as an alternative binder to starch.The higher concentration levels of Okra mucilage show a slow and sustained release,and can be considered as an alternative natural excipient in the modified drug delivery systems.At the same time,the above natural excipient of Hibiscus mucilage could be used as a platform for prolonged release if its binder concentrations are increased. | Ameena K Dilip C Saraswathi R Krishnan PN Sankar C Simi SP | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，7： | 8 |
| 2 | Antidepressant pharmacotherapy in the treatment of depression in the very old:a randomized placebo-controlled trial显示文摘 | ROOSE SP SACKEIM HA KRISHNAN KR | 2004 | Am J Psychiatry2004，161，11： | 1 |
| 3 | In hospital mortality fol- lowing acute exacerbations of COPD显示文摘 | Patil SP Krishnan JA Lechtzin N | 2003 | Arch Intern Med2003，163，： | 1 |
| 4 | In-hospital mortality following acute exacerbations of COPD 显示文摘 | Patil SP Krishnan JA Lechtzin N | 2003 | Arch Intern Med2003，163，： | 1 |
| 5 | The neural mechanisms of antennal positioning in flying moths显示文摘 | Krishnan A Prabhakar S Sudarsan S Sane SP | | 0，，17： | 1 |
| 6 | Antimie: a database of antimicrobial sequences 显示文摘 | Brahmachary M Krishnan SP Kohn | 2004 | Nucleic Acids Res2004，32，： | 1 |
| 7 | A review of rap-id prototyped surgical guides for patient-specific total kneereplacement显示文摘 | Krishnan SP Dawood A Richards R | 2012 | J Bone Joint Surg Br2012，94，11： | 1 |
| 8 | Antimic:a database of antimicrobial sequences显示文摘 | Krishnan SP Kohn | 2004 | Nucleic Acids Res2004，32，： | 1 |
| 9 | ANTIMIC : a database of antimicrobial sequences 显示文摘 | Brabmachary M Krishnan SP Koh JL | 2004 | Nucleic Acids Res2004，32，： | 1 |
| 10 | Antidepressant pharmacotherapy in the treatment of depression in the very old : a randomized, placebo - controlled trial 显示文摘 | Roose SP Sackheim HA Krishnan KRR | 2004 | Am J Psychiatry2004，161，11： | 1 |
| 11 | Col agen-covered versus matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee A comparison of tourniquet times显示文摘 | Bartlett W Krishnan SP Skinner JA | | 0，，： | 1 |
| 12 | Who is the ideal candidate for autologous chondrocyte implantation? 显示文摘 | Krishnan SP Skinner JA Bartlett W | 2006 | J Bone Joint Surg Br2006，88，： | 1 |
| 13 | Formulation and evaluation of Albendazole microcapsules for colon delivery using chitosan显示文摘Objective:To formulate and evaluate Albendazole microcapsules using chitosan,a natural polymer for colon-specific delivery for better treatment of helminthiasis,filariasis,colorectal cancer,avoiding the side effects.Methods:The Albendazole microcapsules were prepared by the use of different concentrations of sodium alginate,chitosan and hydroxypropyl methylcellulose(HPMC).The polysaccharides chitosan reacted with sodium alginate in the presence of calcium chloride to form microcapsules with a polyelectrolyte complex membrane by electrostatic interactions between the two oppositely charged polymers.The microcapsules were then studied for entrapment efficiency,drug-polymer compatibility and surface morphology. In vitro drug release study in presence and absence of cecal content were also studied.Further, kinetic modellings were employed to find out release mechanisms.Results:Albendazole loaded microspheres showd high entrapment efficiency(72.8%) and the microcapsules were free flowing,non aggregated and spherical,between 600 and 1 000μm in diameter.The surface of microcapsules were found to be porous and wavy.The FT-IR spectrum showed that there is no interaction between the polymer and the drug.The in vitro drug release study found to be affected by change in chitosan,sodium alginate and HPMC concentration.The microcapsules with 2.5% sodium alginate and 0.4% chitosan shown minimum release in gastrointestinal simulated condition but shows maximum drug release at the end of 24th hour in presence of cecal content.The rate of drug release follows Korsmeyer-peppas model that was the drug release is by diffusion and erosion.Conclusions:The study reveals that Albendazole loaded chitosanalginate based microsphere can be used effectively for the colon targeting. | Simi SP Saraswathi R Sankar C Krishnan PN Dilip C Ameena K | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，5： | 1 |
| 14 | Antimic:a database of antimicrobial sequences显示文摘 | Brahmachary M Krishnan SP Kohn | 2004 | Nucleic Acids Res2004，32，： | 1 |
| 15 | In-hospital mortality followingacute exacerbations of chronic obstructive pulmonary disease显示文摘 | Patil SP Krishnan JA Lechtzin N | 2003 | ArchIntern Med2003，163，10： | 1 |
| 16 | ANTIMIC: a database of antimicrobial sequences 显示文摘 | Brahmachary M Krishnan SP Koh JL | 2004 | Nucleic Acids Res2004，32，： | 1 |
| 17 | ANTIMIC:a database of antimicrobial sequences显示文摘 | Brahmachary M Krishnan SP Koh JL | 2004 | Nucleic Acids Res2004，32，： | 1 |
| 18 | Common misconceptions of normal hip joint relations on pelvic radiographs 显示文摘 | Krishnan SP Carrington RW Mohiyaddin S | 2006 | J Arthroplasty2006，21，： | 1 |
| 19 | Barriers to condum use: results from a study in Mumbai (Bombay) 显示文摘 | Roth J Krishnan SP Bunch E | 2001 | India AIDS Educ prev2001，13，1： | 1 |
| 20 | Who is the ideal candidate for autologous chondrocyte implantation 显示文摘 | Krishnan SP Skinner JA Bartlett W | 2006 | J Bone Joint Surg Br2006，88，1： | 1 |
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