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| 1 | Efficacy and safety of liquid nitrogen cryotherapy for treatment of Barrett's esophagus显示文摘AIM To evaluate the efficacy and safety of liquid nitrogen cryotherapy as a primary or rescue treatment for BE,with and without dysplasia,or intramucosal adenocarcinoma (IMC).METHODS This was a retrospective,single-center study carried out in a tertiary care center including 45 patients with BE who was treatment-na?ve or who had persistent intestinal metaplasia(IM),dysplasia,or IMC despite prior therapy.Barrett's mucosa was resected via EMR when clinically appropriate,then patients underwent cryotherapy until eradication or until deemed to have failed treatment.Surveillance biopsies were taken at standard intervals.RESULTS From 2010 through 2014,33 patients were studied regarding the efficacy of cryotherapy.Overall,29 patients (88%) responded to cryotherapy,with 84% having complete regression of all dysplasia and cancer.Complete eradication of cancer and dysplasia was seen in 75% of subjects with IMC; the remaining two subjects did not respond to cryotherapy.Following cryotherapy,15 patients with high-grade dysplasia (HGD) had 30% complete regression,50% IM,and 7% low-grade dysplasia (LGD); one subject had persistent HGD.Complete eradication of dysplasia occurred in all 5 patients with LGD.In 5 patients with IM,complete regression occurred in 4,and IM persisted in one.In 136 cryotherapy sessions amongst 45 patients,adverse events included chest pain (1%),stricture (4%),and one gastrointestinal bleed in a patient on dual antiplatelet therapy who had previously undergone EMR.CONCLUSION Cryotherapy is an efficacious and safe treatment modality for Barrett's esophagus with and without dysplasia or intramucosal adenocarcinoma. | Kristen Suchniak-Mussari Charles E Dye Matthew T Moyer Abraham Mathew Thomas J McGarrity Eileen M Gagliardi Jennifer L Maranki John M Levenick | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，9： | 4 |
| 2 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 3 | Reaction kinetics and optimization of the copper-catalyzed oxidation of ApoA-1M 显示文摘 | Sa V H Joseph K M Kristen E T | 2009 | Chemical Engineering Science2009，64，： | 1 |
| 4 | A Handbook: A decade of advice for women and men in the best-selling self-help literature 显示文摘 | Toni Schindler Zimmerman Kristen E Holm Shelley | 2001 | Family Relations Apr 2001 502001，，： | 1 |
| 5 | Duchenne muscular dystrophy and dystrophin:pathogenesis and opportunities for treatment 显示文摘 | Kristen J N Kay E D | 2004 | EMBO Reports2004，5，9： | 1 |
| 6 | Yard stories: examining residents' conceptions of their yards as part of the urban ecosystem in Minnesota显示文摘 | MARIA E D KRISTEN C N | 2014 | Urban Ecosystem2014，，17： | 1 |
| 7 | Diseordent atrial natri- uretic peptide and brain natriuretic peptide levels in lone atrial fibrillation显示文摘 | Patrick T E Adrian F Kristen K | 2005 | J Am Coil Cardio2005，45，： | 1 |
| 8 | Post-transcriptional regulation of glucose transporter-1 by an AU-rich element in the 3 ′ UTR and by hnRNP A2显示文摘 | Mary E Griffin B.JoNell Hamilton Kristen M Roy Min Du Alicia M Willson Benjamin J Keenan Xiao Wei Wang Ralph C Nichols | 2004 | Biochemical and Biophysical Research Communications2004，，4： | 1 |
| 9 | Mitochondrial H^sub 2^O^sub 2^ emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans显示文摘 | Anderson Ethan J Lustig Mary E Boyle Kristen E Woodlief Tracey L Kane Daniel A Lin Chien-Te Rice Jesse W Kang Li Rabinovitch Peter S Szeto Hazel H Houmard Joseph A Cortright Ronald N Wasserman David H Neufer P Darrell | 2009 | Journal of Clinical Investigation2009，，3： | 1 |
| 10 | Chemical properties of x-3 fortified gels made of protein isolate recovered with isoelectrie solubilisation/precipitation from whole fish 显示文摘 | Reza T Sarah K B Kristen E | 2013 | Food Chemistry2013，139，： | 1 |
| 11 | Fish protein isolate: Development of functional foods with nutraceutical ingredients 显示文摘 | Reza T Kristen E M Jacek J | 2014 | Journal of Functional Foods2014，18，： | 1 |
| 12 | Transcription Activator Interactions with Multiple SWI/SNF Subunits显示文摘 | Kristen E N Ahmed H H Christine E B | 2002 | Molecular and Cellular Biology2002，22，6： | 1 |
| 13 | Urodynamic testing and interstitial cystitis/painful bladder syndrome 显示文摘 | Deeptha N Sastry Krystal M Hunter Kristene E Whitmore | 2010 | Int Urogynecol J2010，，21： | 1 |
| 14 | The T790M muta-tion in EGFR kinase causes drug resistance by increasing the af-finity for ATP显示文摘 | Cai-Hong Yun Kristen E Angela V | 2008 | Proc Natl Acad Sci2008，105，： | 1 |
| 15 | Assessment of potential antibiotics contaminants in water and preliminary occurrence analysis显示文摘 | CHING H H JAY E R KRISTEN L S | 2002 | Journal of Environmental Quality2002，11，： | 1 |
| 16 | Functional food productsmade from fish protein isolate recovered with isoelectricsolubilization/precipitation 显示文摘 | Tahergorabi R Sarah K Kristen E | 2012 | Food Science and Technology2012，42，6： | 1 |
| 17 | Assessment of potential anti-biotics contaminants in water and preliminary occurrence analysis显示文摘 | CHING H H JAY E R KRISTEN L S | 2002 | our-nal of Environmental Quality2002，11，： | 1 |
| 18 | Benign phyllodes tumor of thebreast recurring as a malignant phyllodes tumor and spindle cellmetaplastic carcinoma显示文摘 | Kristen E Muller DO Laura J | 2015 | Human Pathology2015，46，2： | 1 |
| 19 | An Economic-Engineering Study of Ohmic显示文摘 | VERNON E JEAN K | 1996 | Food Processing Food Technology1996，，3： | 1 |
| 20 | Transient bone marrow edema syndrome of the knee: clinical and magnetic resonance imaging resuhs at 5 years after core decompression 显示文摘 | Berger C E Kroner A H Kristen K H | 2006 | Arthroscopy2006，22，8： | 1 |
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