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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | 玻璃体切割术联合人工晶状体巩膜固定术治疗眼外伤的疗效(英文)显示文摘目的:探讨玻璃体切割术(pars plana vitrectomy,PPV)联合人工晶状体(intraocular lens,IOL)巩膜固定术治疗眼外伤的疗效。方法:系列病例回顾性分析。将马来西亚大学医学中心接受PPV联合IOL巩膜固定术的8例连续性病例纳入研究,其中1例患者双眼均受伤,共有9眼。对现阶段视力,手术技巧,并发症及术后疗效进行分析。结果:9眼中有8眼(89%)视力提高。术后主要并发症是眼压升高,无缝线破裂。结论:PPV联合IOL巩膜固定术对有眼外伤病史的患者有非常好的疗效。 | Angela V PLoo Sujaya Singh Mohammadreza Peyman Visvaraja Subrayan | 2012 | 国际眼科杂志2012，12，6： | 2 |
| 3 | Personalising pancreas cancer treatment:When tissue is the issue显示文摘The treatment of advanced pancreatic cancer has not moved much beyond single agent gemcitabine until recently when protocols such as FOLFIRINOX(fluorouracil,leucovorin,irinotecan and oxaliplatin)and nab-paclitaxelgemcitabine have demonstrated some improved outcomes.Advances in technology especially in massively parallel genome sequencing has progressed our understanding of the biology of pancreatic cancer especially the candidate signalling pathways that are involved in tumourogenesis and disease course.This has allowed identification of potentially actionable mutations that may be targeted by new biological agents.The heterogeneity of pancreatic cancer makes tumour tissue collection important with the aim of being able to personalise therapies for the individual as opposed to a one size fits all approach to treatment of the condition.This paper reviews the developments in this area of translational research and the ongoing clinical studies that will attempt to move this into the everyday oncology practice. | Katrin M Sjoquist Venessa T Chin Lorraine A Chantrill Chelsie O'Connor Chris Hemmings David K Chang Angela Chou Marina Pajic Amber L Johns Adnan M Nagrial Andrew V Biankin Desmond Yip | 2014 | World Journal of Gastroenterology2014，20，24： | 2 |
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| 5 | Ellagic compounds from Diplopanax stachyanthus 显示文摘 | Duc D K Sung T V Angela M C | 1990 | Phytochemistry1990，29，1： | 1 |
| 6 | Small ruminant lentivirus Tat protein induces apoptosis in caprine cells in vitro by the intrinsic pathway显示文摘 | Angela R Stphanie V Tim G | 2009 | Virology2009，383，： | 1 |
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| 11 | Retinol Binding Protein 4 Expression in Humans: Relationship to Insulin Resistance, Inflammation, and Response to Pioglitazone 显示文摘 | AIWEO Y B VLIAYALAKSHMI V ANGELA M B | 2007 | J Clinical Endocrinology & Metabolism2007，92，7： | 1 |
| 12 | Fenton's pre-treatment of mature landfill leachate显示文摘 | Antonio L Michele P Angela V | 2004 | Chemosphere2004，54，： | 1 |
| 13 | Detection of Mycobacterium tuberculosis complex in milk using polymerase chain reaction (PCR) 显示文摘 | Angela D P Ciccarese G Forte V T | 2006 | Food Control2006，17，： | 1 |
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| 15 | From balsamic to healthy: Traditional balsamic vinegar melanoidins inhibit lipid peroxidation during simulated gastric digestion of meat显示文摘 | Elena V Davide T Angela C | 2010 | Food and Chemical Toxicology2010，，48： | 1 |
| 16 | Silage preparation from tuna fish wastes and its nutritional evaluation in broilers显示文摘 | Luis A V Ernesto A Angela A | 1999 | Journal of the science of food and agriculture1999，79，： | 1 |
| 17 | Restoring by dendritic cell vaccines and manipulation of the tumor microenviromol/Lent 显示文摘 | Angela V Mattijn V Jolanda D V | 2015 | Inmaunobilogy2015，220，2： | 1 |
| 18 | Antioxidant enzymes responses to cadmium in radish tissues显示文摘 | Angela P V Peter J L | 2001 | Phytochemistry2001，57，： | 1 |
| 19 | The T790M muta-tion in EGFR kinase causes drug resistance by increasing the af-finity for ATP显示文摘 | Cai-Hong Yun Kristen E Angela V | 2008 | Proc Natl Acad Sci2008，105，： | 1 |
| 20 | Direct infarction artery stenting without predialation and no reflow in patients with acute infarction 显示文摘 | David A Renato V Angela M | 2001 | Am Heart J2001，1429，4： | 1 |
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