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| 1 | Management of entecavir-resistant chronic hepatitis B with adefovir-based combination therapies显示文摘AIM: To evaluate the long-term efficacy adefovir(ADV)-based combination therapies in entecavir(ETV)-resistant chronic hepatitis B(CHB) patients. METHODS: F i fty CHB pat ient s wi t h genotypic resistance to ETV at 13 medical centers in South Korea were included for the analysis. All the patients received rescue therapy with the combination of ADV plus ETV(ADV/ETV,n = 23) or ADV plus lamivudine(LMV)(ADV/LMV,n = 27) for more than 12 mo. Patients were monitored at least every 3-4 mo during ADV-based combination therapy by clinical examination as well as biochemical and virological assessments. Hepatitis B virus(HBV) DNA levels were measured by realtime PCR and logarithmically transformed for analysis. Cumulative rates of virologic response(VR; HBV DNA < 20 IU/m L) were calculated using the Kaplan-Meier method,and the difference was determined by a logrank test. Multivariate logistic regression and Cox proportional hazards models were used to identify independent risk factors significantly associated with short-term and long-term VR,respectively.RESULTS: Baseline median HBV DNA levels were 5.53(2.81-7.63) log10 IU/m L. The most commonly observed ETV genotypic mutation sites were rt184 and rt202. Patients were treated for a median of 27(12-45) mo. Overall,cumulative VR rates at 6,12,24,and 36 mo were 26%,36%,45%,and 68%,respectively. Patients treated with the ADV/ETV combination showed higher cumulative VR rates(35%,43%,65%,and 76%,respectively) than those with the ADV/LAM combination(18%,30%,30%,and 62%,respectively; P = 0.048). In the multivariate analysis,low baseline HBV DNA levels(< 5.2 log10 IU/m L) and initial virologic response at 3 mo(IVR-3; HBV DNA < 3.3 log10 IU/m L after 3 mo) were independent predictive factors for VR. Patients with favorable predictors achieved cumulative VR rates up to 90% at 36 mo. During the same period,the cumulative incidence of virologic breakthrough was as low as 6% in patients with the both favorable predictors.CONCLUSION: If tenofovir is not available,ADV/ETV combination could be considered in ETV-resistant patients with low HBV DNA titers,and may becontinued if IVR-3 is achieved. | Hyoung Su Kim Hyung Joon Yim Myoung Kuk Jang Ji Won Park Sang Jun Suh Yeon Seok Seo Ji Hoon Kim Bo Hyun Kim Sang Jong Park Sae Hwan Lee Sang Gyune Kim Young Seok Kim Jung Il Lee Jin-Woo Lee In Hee Kim Tae Yeob Kim Jin-Wook Kim Sook-Hyang Jeong Young Kul Jung Hana Park Seong Gyu Hwang | 2015 | World Journal of Gastroenterology2015，21，38： | 13 |
| 2 | 可逆热致变色油墨的色度学特性研究显示文摘本文研究了活化温度为31℃的3种含隐色染料基的热致变色油墨的色度学特性。这3种油墨具有相似的颜料粒径分布和同等厚度且对氧等离子体腐蚀相对稳定的微胶囊壳。油墨颜色与温度、引起颜色滞后的样品热史两个因素有关。比较脱色和着色过程,在CIELAB色空间中所观测的滞后环面积决定了样品上色差的大小。同一样品所能达到的最大色差是由样品不同的热史和温度决定。4个特征温度描述了引起颜色滞后的2个化学反应。当冷却到低于活化温度时,脱色状态的稳定性超过10h。热致变色效应的可逆性随着最高加热温度约呈线性降低。 | Rahela Kular Moja Frikovec Nina Hauptman Alenka Vesel Marta Klanjek Gunde 柳玲 | 2010 | 中国印刷与包装研究2010，2，3： | 6 |
| 3 | Impact of admission blood glucose levels on prognosis of elderly patients with ST elevation myocardial infarction treated by primary percutaneous coronary intervention显示文摘OBJECTIVE:Admission hyperglycemia in acute myocardial infarction (MI) is related with increased in-hospital and long term mortality and major cardiac adverse events。 We aimed to investigate how admission hyperglycemia affects the short and long term outcomes in elderly patients >65 years) after primary percutaneous coronary intervention for ST elevation myocardial infarction。 METHODS:We retrospectively analyzed 677 consecutive elderly patients (mean age 72.2 ±5.4)。 Patients were divided into two groups according to admission blood glucose levels。 Group : low glucose group (LLG), glucose < 168 mg/dL; and Group 2: high glucose group (HGG), glucose >168 mg/dL。 RESULTS:In-hospital, long term mortality and in-hospital major adverse cardiac events were higher in the high admission blood glucose group (P <0.001)。 Multivariate regression analysis showed: Killip > 1, post-thrombolysis in MI <3 and admission blood glucose levels were independent predictors of in-hospital adverse cardiac events (P <0.001)。 CONCLUSIONS:Admission hyperglycemia in elderly patients presented with ST elevation myocardial infarction is an independent predictor of in-hospital major adverse cardiac events and is associated with in-hospital and long term mortality。 | Ahmet Ekmekci Mahmut Uluganyan Fatif Tufan Huseyin Uyarel Gurkan Karaca Seref Kul Barl(s) Gungor | 2013 | Journal of Geriatric Cardiology2013，10，4： | 6 |
| 4 | Assessment of scoring systems for acute-on-chronic liver failure at predicting short-term mortality in patients with alcoholic hepatitis显示文摘AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting shortterm mortality among patients with alcoholic hepatitis.METHODS We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-term mortality was calculated for Chronic Liver FailureSequential Organ Failure Assessment(CLIF-SOFA), CLIF Consortium Organ Failure score(CLIF-C OFs), Maddrey'sdiscriminant function(DF), age, bilirubin, international normalized ratio and creatinine score(ABIC), Glasgow Alcoholic Hepatitis Score(GAHS), model for end-stage liver disease(MELD), and MELD-Na.RESULTS Of 264 patients, 32(12%) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86(0.81-0.90), 0.89(0.84-0.92), 0.79(0.74-0.84), 0.78(0.72-0.83), 0.81(0.76-0.86), 0.83(0.78-0.88), and 0.83(0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1% sensitivity and 79.7% specificity, and CLIF-C OFs of 10 had 68.8% sensitivity and 91.4% specificity for predicting 28-d mortality.CONCLUSION CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis. | Hee Yeon Kim Chang Wook Kim Tae Yeob Kim Do Seon Song Dong Hyun Sinn Eileen L Yoon Young Kul Jung Ki Tae Suk Sang Soo Lee Chang Hyeong Lee Tae Hun Kim Jeong Han Kim Hyung Joon Yim Sung Eun Kim Soon Koo Baik Byung Seok Lee Jae Young Jang Young Seok Kim Sang Gyune Kim Jin Mo Yang Joo Hyun Sohn Heon Ju Lee Seung Ha Park Eun Hee Choi Dong Joon Kim Korean Acute-on-Chronic Liver Failure Study Group | 2016 | World Journal of Gastroenterology2016，22，41： | 5 |
| 5 | 响应面法优化电炉炼钢粉尘中Zn的选择性浸出显示文摘研究浸出参数对电炉炼钢粉尘灰中选择浸出性Zn的影响,以Zn和Fe的浸出率为响应变量,以硫酸浓度、浸出温度、浸出时间和液固比为独立变量,采用基于三水平Box-Behnken的响应面法对浸出参数进行优化。对试验结果进行ANOVA分析和验证。在硫酸浓度为2.35 mol/L,浸出温度为25℃,浸出时间为56.42 min,液固比为5的条件下,可得到Zn的最大浸出率为79.09%,Fe的最小浸出率为4.08%。通过ANOVA分析表明,对Zn和Fe浸出率影响最大的因素为硫酸浓度和浸出温度。基于响应面法的模型与试验数据具有很好的一致性,Zn和Fe浸出率的相关系数分别为0.98和0.97。 | Mehmet KUL Kürsad Oguz OSKAY Mehmet SIMSIR Halit SüBüTAY Habip KIRGEZEN | 2015 | Transactions of Nonferrous Metals Society of China2015，25，8： | 5 |
| 6 | Diagnostic delay in inflammatory bowel disease increases the risk of intestinal surgery显示文摘AIM To investigate the factors affecting diagnostic delay and outcomes of diagnostic delay in inflammatory bowel disease(IBD) METHODS We retrospectively studied 165 patients with Crohn's disease(CD) and 130 patients with ulcerative colitis(UC) who were diagnosed and had follow up durations > 6 mo at Korea University Ansan Hospital from January 2000 to December 2015. A diagnostic delay was defined as the time interval between the first symptom onset and IBD diagnosis in which the 76^(th) to 100^(th) percentiles of patients were diagnosed.RESULTS The median diagnostic time interval was 6.2 and 2.4 mo in the patients with CD and UC, respectively. Among the initial symptoms, perianal discomfort before diagnosis(OR = 10.2, 95%CI: 1.93-54.3, P = 0.006) was associated with diagnostic delays in patients with CD; however, no clinical factor was associated with diagnostic delays in patients with UC. Diagnostic delays, stricturing type, and penetrating type were associated with increased intestinal surgery risks in CD(OR = 2.54, 95%CI: 1.06-6.09; OR = 4.44, 95%CI: 1.67-11.8; OR = 3.79, 95%CI: 1.14-12.6, respectively). In UC, a diagnostic delay was the only factor associated increased intestinal surgery risks(OR = 6.81, 95%CI: 1.12-41.4).CONCLUSION A diagnostic delay was associated with poor outcomes, such as increased intestinal surgery risks in patients with CD and UC. | Dong-won Lee Ja Seol Koo Jung Wan Choe Sang Jun Suh Seung Young Kim Jong Jin Hyun Sung Woo Jung Young Kul Jung Hyung Joon Yim Sang Woo Lee | 2017 | World Journal of Gastroenterology2017，23，35： | 3 |
| 7 | Helicobacter pylori eradication lowers serum homocysteine level in patients without gastric atrophy显示文摘AIM: To determine whether Helicobacter pylori ( H pylori)infection caused hyperhomocysteinemia by altering serum vitamin B12, serum folate and erythrocyte folate levels and whether eradication of this organism decreased serum homocysteine level.METHODS: The study involved 73 dyspeptic H pylori-positive patients, none of them had gastric mucosal atrophy based on rapid urease test and histology. Out of 73 patients, 41 (56.2%) showed a successful eradication of Hpylori4 wk after the end of treatment. In these 41 patients, fasting serum vitamin B12, folate and homocysteine levels, and erythrocyte folate levels before and 4 wk after Hpylorieradication therapy were compared.RESULTS: The group with a successful eradication of Hpylori had significantly higher serum vitamin B12 and erythrocyte folate levels in the post-treatment period compared to those in pre-treatment period (210±97 pg/mL vs237±94pg/mL, P<0.O01 and 442±212 ng/mL vs 539±304 ng/mL,P = 0.024, respectively), but showed no significant change in serum folate levels (5.6±2.6 ng/mL vs 6.0±2.4 ng/mL,P= 0.341). Also, the serum homocysteine levels in this group were significantly lower after therapy (13.1±5.2 μmol/L vs 11.9±6.2 μmol/L, P = 0.002). Regression analysis showed that serum homocysteine level was positively correlated with age (P = 0.01) and negatively with serum folate level before therapy (P = 0.003).CONCLUSION: Eradication of H pylori decreases serum homocysteine even in patients who do not exhibit gastric mucosal atrophy. It appears that the level of homocysteine in serum is related to a complex interaction among serum vitamin B12, serum folate and erythrocyte folate levels. | Birol Ozer Ender Serin Yuksel Gumurdulu Fazilet Kayaselcuk Ruksan Anarat Gurden Gur Kemal Kul Mustafa Guclu Sedat Boyacioglu | 2005 | World Journal of Gastroenterology2005，11，18： | 3 |
| 8 | Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein improves diagnostic accuracy for hepatocellular carcinoma显示文摘BACKGROUND Diagnostic accuracy of various tumor markers and their combinations for hepatocellular carcinoma(HCC)was not fully investigated.AIM To evaluate the diagnostic accuracy of alpha-fetoprotein(AFP),the Lens culinaris agglutinin-reactive fraction of AFP(AFP-L3),and protein induced by vitamin K absence or antagonist-II(PIVKA-II)and their combination for HCC diagnosis.METHODS Patients with newly detected liver mass or elevated serum AFP levels were considered eligible.Serum AFP level,AFP-L3 fraction,and PIVKA-II level were measured at the first visit.RESULTS In total,622 patients were included;355 patients(57.1%)had chronic liver disease,and 208(33.4%)had liver cirrhosis.HCC was diagnosed in 160 patients(25.7%).The area under the receiver operating characteristics curves(AUROCs)of the serum AFP,AFP-L3 fraction,AFP-L3,and PIVKA-II levels for the diagnosis of HCC were 0.775,0.792,0.814,and 0.834,respectively.A novel diagnostic model was developed by classifying patients in a 1:1 ratio into training and validation sets.Using the binary regression analysis of the training cohort,the AFP,AFP-L3 fraction,and PIVKA-II(ALPs)score was calculated as follows:ALPs score=3.8×[serum AFP level(ng/mL)×AFP-L3 fraction(%)×0.01]+0.2×PIVKA-II level(mAU/mL).The AUROC of the ALPs score for diagnosis of HCC was 0.878,significantly higher than that of serum AFP level(P<0.001),AFP-L3 fraction(P<0.001),PIVKA-II level(P=0.036),and AFP-L3 level(P=0.006).The optimal ALPs score cut-off was 5.3(sensitivity,85.0%,specificity 80.1%).The validation cohort showed similar results.CONCLUSION The ALPs score calculated using serum AFP level,AFP-L3 fraction,and PIVKA-II level showed improved accuracy in HCC diagnosis. | Han Ah Lee Yoo Ra Lee Young-Sun Lee Young Kul Jung Ji Hoon Kim Hyunggin An Hyung Joon Yim Yoon Tae Jeen Jong Eun Yeon Kwan Soo Byun Yeon Seok Seo | 2021 | World Journal of Gastroenterology2021，27，28： | 2 |
| 9 | Adsorption of Pb(II) ions from aqueous solution by native and activated bentonite: Kinetic, equilibrium and thermodynamic study显示文摘 | Ali R?za Kul Hülya Koyuncu | 2010 | Journal of Hazardous Materials2010，，1： | 2 |
| 10 | Ten‐day sequential versus triple therapy for H elicobacter pylori eradication: A prospective, open‐label, randomized trial显示文摘 | Jun‐Won Chung Young Kul Jung Yoon Jae Kim Kwang Ahn Kwon Jung Ho Kim Jong Joon Lee Sung Min Lee Ki Baik Hahm Sun Mi Lee Jin Yong Jeong Sung‐Cheol Yun | 2012 | J Gastroenterol Hepatol2012，，11： | 2 |
| 11 | 木豆CGMS杂交种生产中的传粉昆虫显示文摘木豆是世界上唯一的木本食用豆类作物,具有较强的抗旱性。木豆杂交制种需昆虫传粉,制种地传粉昆虫的种类及数量是制种产量的决定性因素。本文调查了云南省元谋县CGMS木豆[Cajanus cajan(L.) Millspaugh]杂交种ICPH2671制种田访花昆虫种类、数量、访花频次及杂交种制种产量。结果表明,在云南元谋,木豆访花昆虫共有5目15科25种,其中主要5种传粉媒介为绒切叶蜂(Megachile velutina)、切叶蜂属1种(Megachile sp5)、圆柄木蜂(Xylocopa tenuiscapa)、蜜蜂亚科1种(Apinae sp1)和切叶蜂属1种(Megachile sp2)。木豆盛花期,制种亲本不育系每个分枝昆虫访花频次为每10min 2.8次,而恢复系植株上的访花频次为每10min 5.2次,表明昆虫对恢复系花朵有明显偏好;在前述昆虫访花频次下,不育系单株干籽粒产量达383.7g,恢复系单株产量为357.0g,二者无显著差异,说明这样的昆虫访问频次已能满足杂交制种中将花粉由恢复系传至不育系的需要。 | 李正红 梁宁 马宏 Kul Bhushan SAXENA 刘秀贤 宗绪晓 | 2011 | 作物学报2011，37，12： | 2 |
| 12 | Characterization,gene cloning, and heterogeneous expression of ^-mannanasefrom thermophilic Bacillus subtilis 显示文摘 | Summpunn P Chaijan S Isarar^kul D | 2011 | The Journal ofMicrobiology2011，49，1： | 1 |
| 13 | Effect of whey composition on ultrafihration performance显示文摘 | MUSAL E D A KUL KARNI S S | 1998 | J Agic Food Chem1998，46，： | 1 |
| 14 | Adsorption of Zinc(II) on diatomite and manganese-oxide-modified diatomite: A kinetic and equilibrium study显示文摘 | Necla Caliskan Ali Riza Kul Salih Alkan Eda Gokirmak Sogut ?hsan Alacabey | 2011 | Journal of Hazardous Materials2011，，： | 1 |
| 15 | Effect of polymeric proanthoeyanidin on the contractile activity of smooth muscle cells in lymphatic vessels 显示文摘 | Luchinin Y S Kim T D Kul' zhanov Z K | 1984 | Deposited Doc1984，，193284： | 1 |
| 16 | Phenotypic correlations between some external and internal egg quality traits in the Japanese quail (Coturnix coturnix japonica)显示文摘 | Kul S Seker I | 2004 | International Journal of Poultry Science2004，3，6： | 1 |
| 17 | Overactivebladderasamaskofchronicprostatitis显示文摘 | Kul'chaveniaEV BrizhatiukEV BreusovAA | 2012 | Urologiia2012，13，6： | 1 |
| 18 | Active phase of a nickel phophide(Niz P)catalyst supported on KUSY zeolite for the hydrodesulfurization of 4,6-DMDB显示文摘 | Lee Yong Kul Shu Yuying Oyama S Ted | 2007 | Applied Catalysis2007，322，： | 1 |
| 19 | Prognostic value of epithelial growth factor receptor, vascular endothelial growth factor, E- cadherin, and p120 catenin in resected non-small cell lung carcinoma 显示文摘 | Ucvet A Kul C Gursoy S | 2011 | Arch Bronconeumol2011，47，8： | 1 |
| 20 | Contribution of diffusion-weighted imaging to dynamic contrast-enhanced MRI in the characteriza tion of breast tumors显示文摘 | Kul S Cansu A Alhan E | 2011 | Am J Roentgenology2011，196，1： | 1 |
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