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| 1 | Colorectal cancer carcinogenesis:a review of mechanisms显示文摘Colorectal cancer(CRC) is the second most common cancer in women and the third most common in men globally. CRC arises from one or a combination of chromosomal instability, Cp G island methylator phenotype, and microsatellite instability. Genetic instability is usually caused by aneuploidy and loss of heterozygosity. Mutations in the tumor suppressor or cell cycle genes may also lead to cellular transformation. Similarly, epigenetic and/or genetic alterations resulting in impaired cellular pathways, such as DNA repair mechanism, may lead to microsatellite instability and mutator phenotype. Non-coding RNAs, more importantly micro RNAs and long non-coding RNAs have also been implicated at various CRC stages. Understanding the specific mechanisms of tumorigenesis and the underlying genetic and epigenetic traits is critical in comprehending the disease phenotype. This paper reviews these mechanisms along with the roles of various non-coding RNAs in CRCs. | Kanwal Tariq Kulsoom Ghias | 2016 | Cancer Biology & Medicine2016，13，1： | 15 |
| 2 | Breast cancer pattern andchemotherapy response -- an institutional study in Pakistan 显示文摘 | Afsar NA Kulsoom B Mateen A | 2010 | Asi-an Pac J Cancer Prev2010，11，3： | 1 |
| 3 | lntraarterial thrombolysis with reteplase in acute isehaemic stroke in a Pakistani center 显示文摘 | Khatri IA Rana A Kulsoom A | 2008 | J Pak Med Assoc2008，58，7： | 1 |
| 4 | Stress, anxiety, and depression among medical students in a multiethnic setting显示文摘 | KULSOOM B AFSAR NA | 2015 | Neuropsychiatr Dis Treat2015，11，： | 1 |
| 5 | 8-Amino-adenosine induces loss of phosphorylation of p38 mitogen-activated protein kinase,extracellular signal-regulated kinase 1/2,and Akt kinase; Role in induction of apoptosis in multiple myeloma显示文摘 | Kulsoom G Chunguang M Varsha G | 2005 | Mol Cancer Ther2005，4，： | 1 |
| 6 | Clinical Features and Outcome of Sporadic Colorectal Carcinoma in Young Patients: A Cross-Sectional Analysis from a Developing Country显示文摘 | Muhammad Nauman Zahir Eisha Mahpara Azhar Sobia Rafiq Kulsoom Ghias Munira Shabbir-Moosajee W. Habano S. Holdenrieder | 2014 | ISRN Oncology2014，，： | 1 |
| 7 | Breast feeding practices and beliefs about breast among mothers of infants aged 0 - 12 mothers 显示文摘 | Kulsoom U Saeed A | | J PMA0，47，2： | 1 |
| 8 | Phytochemcal investigation and biological evaluation of Schinus terebinthifolius显示文摘 | Youssef Moustafa A M Kouam S F Kulsoom A | 2007 | Res J Phytochemistry2007，1，1： | 1 |
| 9 | Phytochemical investigation and biological evaluation of Schinus terebinthifolius显示文摘 | Moustafa A M Y Kouam S F Kulsoom A | 2007 | Res J Phytochem2007，1，1： | 1 |
| 10 | Crystal Structure Analysis of 1-Hydroxy-3,5-dimethoxy-9H-xanthen-9-one Isolated from Ajuga bracteosa Root Extract and Its Biological Studies显示文摘The structure of 1-hydroxy-3,5-dimethoxy-9 H-xanthen-9-one isolated from chloroform extract of Ajuga bracteosa root was analyzed by single-crystal X-ray diffraction. DPPH(1,1-diphenyl-2-picryl hydrazyl), ABTS(2,2?-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging activities(RSA) and Fe2+ chelating activities were carried out to determine the antioxidant potential of the compound. RSA values for the compound were 96%, 96% and 96% for all the three activities respectively at maximum concentration of the compound(100 μ gmL-1) with the IC50 values of 3.40, 4.86 and 0.10(μ gmL-1). Antidiabetic activities including antiglycation and α-glucosidase inhibition were also performed where the antiglycation activity was performed using two techniques including spectrofluorometric as well as spectrophotometric technique. Spectrofluorometric technique provided 97% antiglycation potential while 92% antiglycation potential was observed by spectrophotometric technique for the isolated compound. The compound at a concentration of 10 μ gmL-1 exhibited 31% α-glucosidase inhibitory potential with IC50 of 15.56 μ gmL-1. Antimicrobial activity data showed that the compound was active against all the studied pathogenic bacteria. | AKHTER Kulsoom AHMED Muhammed Naeem GHOUS Tahseen RASHEED Basharat TAHIR Muhammad Nawaz ARSHAD Ifzan | 2019 | Chinese Journal of Structural Chemistry2019，38，9： | 0 |
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