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| 1 | National trend of gastric cancer mortality in China(2003-2015):a population-based study显示文摘Background:Gastric cancer mortality decreased substantially over the last decades in most countries worldwide.This study aimed to assess the most recent national trend of gastric cancer mortality and examine the disparity of gastric cancer mortality between rural and urban areas in China.Methods:The crude mortality data of gastric cancer by sex,age group,and area were obtained from China Health Statistical Yearbooks(2003-2015)covering 10%of Chinese population.The age-standardized rates of mortality(ASRM)of gastric cancer in rural and urban areas were estimated using the 2010 Chinese Census population stratified by age,sex,and area.The trend of mortality of gastric cancer was assessed by using Joinpoint analysis.Results:During the 13-year period,the ASRM was reduced from 31.5/100,000 in 2003 to 20.9/100,000 in 2015 in rural areas and from 18.9/100,000 in 2003 to 14.5/100,000 in 2015 in urban areas.In the male population,the annual percent changes of mortality were−2.2%in urban areas(95%confidence interval[CI]−3.8%to−0.6%;P<0.001)and−3.4%in rural areas(95%CI−5.1%to−1.8%;P<0.001).In the female population,the annual percent changes of mortality were−2.7%in urban areas(95%CI−4.2%to−1.2%;P<0.001)and−4.6%in rural areas(95%CI−5.5%to−3.7%;P<0.001).Conclusions:The declining trend of mortality of gastric cancer was presented from 2003 to 2015 in both rural and urban areas in China.The decrease in gastric cancer mortality is greater in rural areas than in urban areas in China. | Kun Gao Jun Wu | 2019 | Cancer Communications2019，39，1： | 78 |
| 2 | Multiple genetic alterations and behavior of cellular biology in gastric cancer and other gastric mucosal lesions:H.pylori infection,histological types and staging显示文摘AIM To investigate the expression of multiplegenes and the behavior of cellular biology ingastric cancer(GC)and other gastric mucosallesions and their relations to Helicobacter pylori(H.pylori)infection,tumor staging andhistological subtypes.METHODS Three hundred and twenty-sevenspecimens of gastric mucosa obtained viaendoscopy or surgical resection,and ABCimmunohistochemical staining were used todetect the expression of p53,p16,Bcl-2 andCOX-2 proteins.H.pylori was determined byrapid urea test combined with pathologicalstaining or14C urea breath test.Cellular image analysis was performed in 66 patients withintestinal metaplasia(IM)and/or dysplasia(Dys).In 30 of them,both cancer and theparacancerous tissues were obtained at the timeof surgery.Histological pattern,tumor staging,lymph node metastasis,grading ofdifferentiation and other clinical data werestudied in the medical records.RESULTS p16 expression of IM or Dys wassignificantly lower in positive H.pylori chronicatrophic gastritis(CAG)than those withnegative H.pylori(CAG:54.8% vs 88.0%,IM:34.4% vs 69.6%,Dys:23.8% vs 53.6%,allP<0.05),Bcl-2 or COX-2 expression of IM orDys in positive H.pylori cases was significantlyhigher than that without H.pylori(Bcl-2:68.8%vs23.9%,90.5% vs 60.7%;COX-2:50.0% vs10.8%,61.8% vs 17.8%;all P<0.05).Themean number of most parameters of cellularimage analysis in positive H.pylori group wassignificantly higher than that in negative H.pylori group(Ellipser:53±14,40±12μm,Area1:748±572,302±202 μm2,Area2:3050±1661,1681±1990 μm2,all P<0.05;Ellipseb:79±23,58±15 μm,Ratio1:22%±5%,13%±4%,Ratio2:79%±17%,53%±20%,all P<0.01).There was significant correlation between Bcl-2and histologic pattern of gastric carcinoma,andbetween COX-2 and tumor staging or lymph nodemetastasis(Bcl-2:75.0% vs 16.7%;COX-2:76.0% vs 20.0%,79.2% vs 16.7%;allP<0.05).CONCLUSION p1l6, Bcl-2, and COX-2 but not p53 gene may play a role in the early genesis/ progression of gastric carcinoma and are associated with H. pylori infection. p53 gene is relatively late event in gastric tumorigenesis and mainly relates to its progression. There is more cellular-biological behavior of malignant tumor in gastric mucosal lesions with H. pylori infection. Aberrant Bcl-2 protein expression appears to be preferentially associated with the intestinal type cancer. COX-2 seems to be related to tumor staging and lymph node metastasis. | Heng Jun Gao Lian Zhen Yu Jian Feng Bai Yan Shen Peng Gu Sun Han Lin Zhao Kun Miu Xiu Zhen Lü Xiao Yong Zhang Zhi Quan Zhao | 2000 | World Journal of Gastroenterology2000，6，6： | 52 |
| 3 | Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study显示文摘 | Hui-Jia Lin Li-Zhong Du Xiao-Lu Ma Li-Ping Shi Jia-Hua Pan Xiao-Mei Tong Qiu-Ping Li Jian-Guo Zhou Bing Yi Ling Liu Yun-Bing Chen Qiu-Fen Wei Hui-Qing Wu Mei Li Cui-Qing Li Xi-Rong Gao Shi-Wen Xia Wen-Bin Li Chao-Ying Ya Ling He Kun Liang Xiao-Yu Zhou Shu-Ping Han Qin Lyu Yin-Ping Qiu Wen Li Dong-Mei Chen Hong-Ru Lu Xiao-Hong Liu Hong Liu Zhen-Lang Lin Li Liu Jia-Jun Zhu Hong Xiong Shao-Jie Yue Si-Qi Zhuang | 2015 | Chinese Medical Journal2015，，20： | 49 |
| 4 | Treatment efficacy of radiof requency ablation of 338 patients with hepatic malignant tumor and the relevant complications显示文摘AIM: To investigate the treatment efficacy of radiofrequency ablation (RFA) of hepatic malignant tumor and the relevant complications.METHODS: A total of 338 patients with 763 hepatic tumors underwent ultrasound-guided RFA (565 procedures).There were 204 cases of hepatic cellular carcinoma (HCC)with 430 tumors, the mean largest diameter was 4.0 cm.Of them, 48 patients (23.5%) were in stages Ⅰ-Ⅱ (UICC Systems) and 156 (76.5%) in stages Ⅲ-Ⅳ There were 134 cases of metastatic liver carcinoma (MLC), with 333metastases in the liver, the mean diameter was 4.1 cm,the liver metastases of 96 patients (71.6%) came from gastrointestinal tract. Ninety-three percent of the 338patients were treated using the relatively standard protocol. Crucial attention must be paid to monitor the abnormal changes in ultrasound images as well as the vital signs of the patients to find the possible hemorrhage and peripheral structures injury in time. The tumors were considered as ablated completely, if no viability was found on enhanced CT within 24 h or at 1 mo after RFA. These patients were followed up for 3-57 mo.RESULTS: The ablation success rate was 93.3% (401/430tumors) for HCC and was 96.7% (322/333 tumors) for MLC. The local recurrence rate for HCC and MLC was 7.9% (34/430 tumors) and 10.5% (35/333 tumors),respectively. A total of 137 patients (40.5%) underwent 2-11times of repeated ablations because of tumor recurrence or metastasis. The 1st, 2nd, and 3rd year survival rate was84.6%, 66.6%, and 63.1%, respectively;the survival rate from 48 patients of Ⅰ-Ⅱ stage HCC was 93.7%, 80.4%,and 80.4%, respectively. The major complication rate in this study was 2.5% (14 of 565 procedures), which consisted of 5 hemorrhages, 1 colon perforation, 5 injuries of adjacent structures, 2 bile leakages, and 1 skin burn.CONCLUSION: RFA, as a minimally invasive local treatment,has become an effective and relatively safe alternative for the patients of hepatic malignant tumor, even of advanced liver tumor, tumor recurrence, and liver metastases. Knowledge about possible complications and their control may increase the treatment efficacy and help to promote the use of RFA technique. | Min-Hua Chen Wei Yang Kun Yan Wen Gao Ying Dai Yan-Bin Wang Xiao-Peng Zhang Shan-Shan Yin | 2005 | World Journal of Gastroenterology2005，11，40： | 25 |
| 5 | Using the curve moment and the PSO-SVM method to diagnose downhole conditions of a sucker rod pumping unit显示文摘Downhole working conditions of sucker rod pumping wells are automatically identified on a computer from the analysis of dynamometer cards. In this process, extraction of feature parameters and pattern classification are two key steps. The dynamometer card is firstly divided into four parts which include different production information according to the 'four point method' used in actual oilfield production, and then the moment invariants for pattern recognition are extracted. An improved support vector machine (SVM) method is used for pattern classification whose error penalty parameter C and kernel function parameter g are optimally chosen by the particle swarm optimization (PSO) algorithm. The simulation results show the method proposed in this paper has good classification results. | Li Kun Gao Xianwen Tian Zhongda Qiu Zhixue | 2013 | Petroleum Science2013，10，1： | 23 |
| 6 | Radiofrequency ablation of hepatocellular carcinoma sized> 3 and ≤ 5 cm: Is ablative margin of more than 1 cm justified?显示文摘AIM:To investigate whether an ablative margin(AM)>1.0 cm might reduce chance of recurrence for patients with hepatocellular carcinoma(HCC)tumors 3.1to 5.0 cm in size,compared with an AM of 0.5-1.0 cm.METHODS:From October 2005 to December 2012,936 consecutive patients with HCC who received radiofrequency ablation were screened.Of these,281 patients,each with a single primary HCC tumor of 3.1 to5.0 cm in size on its greatest diameter,were included in the study.Based on the AM width,we categorized patients into the 0.5-1.0 cm group and the>1.0 cm group.Local tumor progression(LTP)-free survival,intrahepatic distant recurrence(IDR)-free survival and overall survival(OS)rates were obtained using the Kaplan-Meier method.RESULTS:The 1-,2-,3-,4-,and 5-year LTP-free survival rates and IDR-free survival rates were significantly higher in the>1.0 cm group compared with the 0.5-1.0cm group(97.5%,86.3%,73.6%,49.5%and 26.4%vs 91.3%,78.4%,49.5%,27.8%,and 12.8%;95.1%,90.3%,77.0%,61.0%and 48.3%vs 95.2%,85.9%,62.6%,47.2%and 28.5%;P<0.05).The 1-,2-,3-,4-,and 5-year OS rates were 98.6%,91.5%,69.2%,56.0%and 42.2%,respectively,in the 0.5-1.0 cm group and 100%,98.9%,90.1%,68.7%and 57.4%,respectively,in the>1.0 cm group(P=0.010).There were no significant differences in complication rates between the two groups.Both univariate and multivariate analyses identified AM as an independent prognostic factor linked to LTP,IDR,and OS.CONCLUSION:For HCC tumors>3.0 cm and≤5.0cm,AM>1.0 cm could reduce chances of recurrence compared with AM of 0.5-1.0 cm,emphasizing the need for a more defensive strategy using AMs>1.0 cm for ablating HCC tumors of 3.1 to 5.0 cm. | Shan Ke Xue-Mei Ding Xiao-Jun Qian Yi-Ming Zhou Bao-Xin Cao Kun Gao Wen-Bing Sun | 2013 | World Journal of Gastroenterology2013，19，42： | 21 |
| 7 | Preparation of Artificial Antigen and Egg Yolk-derived Immunoglobulin(IgY) of Citrinin for Enzyme-Linked Immunosorbent Assay显示文摘To prepare artificial antigens and anti-citrinin egg yolk-derived immunoglobulin(IgY) to build an enzyme-linked immunosorbent assay(ELISA) for citrinin(CTN).Methods CTN was conjugated with bovine serum albumin(BSA),ovalbumin(OVA) with formaldehyde condensation method to prepare artificial antigens and identified by ultraviolet(UV) spectrometry and Infrared(IR) spectrometry.Artificial antigens for CTN and anti-CTN IgY were purified with polyethylene glycol two-step precipitation method and identified by sodium dodecyl sulfate-polyacrylamide gel electrophoresis(SDS-PAGE).ELISA with IgY was established.Cross-reactivity of IgY with various structural similarities to CTN and possible co-occurrence with CTN in agricultural commodities were studied.Results UV and IR absorption spectra suggested that CTN was correlated with the carrier protein of BSA or OVA.SDS-PAGE patterns showed that the anti-CTN IgY was almost pure with a molecular weight of approximate 100 KD.The indirect competitive ELISA showed that the detection limit of CTN was 10 ng·mL-1,with a good linearity ranging 20-640 ng·mL-1.Conclusion Artificial antigens of CTN can be successfully synthesized.The established ELISA can be used to determine CTN-contaminated samples. | ZHAO-HUI DUAN ZHUANG-SEN LIN HE-RUI YAO YAN-HONG GAO KUN ZHANG Su-QING ZHAO ZHEN-YU ZHU | 2009 | Biomedical and Environmental Sciences2009，22，3： | 21 |
| 8 | Evaluation of the Effects of Standard Rescue Procedure on Severe Trauma Treatment in China显示文摘 | Xiao-Feng Yin Tian-Bing Wang Pei-Xun Zhang Yu-Hui Kou Dian-Ying Zhang Kai Yu De-Cheng Lyu Mao-Zheng Liu Dong-Sheng Zhou Peng Zhang Jue-Hua Jing Wei-Wei Ge Li-Ying Cao Guo-Sheng Wang Shao-Jie Deng Weng-Hua Liu Mao Zhang Yong-An Xu Kun Zhang Bing Li Wei Wang Zhong-Li Gao Cheng-La Yi Bao-Guo Jiang | 2015 | Chinese Medical Journal2015，，10： | 18 |
| 9 | Complete chloroplast genome sequence of Magnolia grandiflora and comparative analysis with related species显示文摘Magnolia grandiflora is an important medicinal,ornamental and horticultural plant species.The chloroplast(cp) genome of M.grandiflora was sequenced using a 454 sequencing platform and the genome structure was compared with other related species.The complete cp genome of M.grandiflora was 159623 bp in length and contained a pair of inverted repeats(IR) of 26563 bp separated by large and small single copy(LSC,SSC) regions of 87757 and 18740 bp,respectively.A total of 129 genes were successfully annotated,18 of which included introns.The identity,number and GC content of M.grandiflora cp genes were similar to those of other Magnoliaceae species genomes.Analysis revealed 218 simple sequence repeat(SSR) loci,most composed of A or T,contributing to a bias in base composition.The types and abundances of repeat units in Magnoliaceae species were relatively conserved and these loci will be useful for developing M.grandiflora cp genome vectors.In addition,results indicated that the cp genome size in Magnoliaceae species and the position of the IR border were closely related to the length of the ycf1 gene.Phylogenetic analyses based on 66 shared genes from 30 species using maximum parsimony(MP) and maximum likelihood(ML) methods provided strong support for the phylogenetic position of Magnolia.The availability of the complete cp genome sequence of M.grandiflora provides valuable information for breeding of desirable varieties,cp genetic engineering,developing useful molecular markers and phylogenetic analyses in Magnoliaceae. | LI XiWen GAO HuanHuan WANG YiTao SONG JingYuan HENRY Robert WU HeZhen HU ZhiGang YAO Hui LUO HongMei LUO Kun PAN HongLin CHEN ShiLin | 2013 | Science China(Life Sciences)2013，56，2： | 17 |
| 10 | 中国胃癌死亡率趋势(2003–2015):一项基于人群的研究显示文摘背景与目的在过去几十年里,世界上多数国家的胃癌死亡率大幅下降。本研究旨在评估中国胃癌死亡率的最新趋势,并分析中国农村和城市地区胃癌死亡率的差异。方法胃癌按性别、年龄组和地域划分的粗死亡率数据来源于覆盖中国10%人口的《中国卫生统计年鉴(2003–2015)》。采用2010年中国人口普查按年龄、性别和地区划分的人群,估算城乡胃癌的年龄标准化死亡率(age-standardized rates of mortality,ASRM)。采用Joinpoint分析法评估胃癌死亡率趋势。结果在13年间,农村地区的ASRM从2003年的31.5/100,000降至2015年的20.9/100,000,城市地区从2003年的18.9/100,000降至2015年的14.5/100,000。在男性中,城市地区的死亡率年度百分比变化为-2.2%[95%置信区间(CI):-3.8%–-0.6%;P<0.001],农村地区的死亡率年度百分比变化为-3.4%(95%CI:-5.1%–-1.8%;P<0.001)。在女性中,城市地区的死亡率年度百分比变化为-2.7%(95%CI:-4.2%–-1.2%;P<0.001),农村地区的死亡率年度百分比变化为-4.6%(95%CI:-5.5%–-3.7%;P<0.001)。结论2003年至2015年,我国农村和城市的胃癌死亡率均呈下降趋势。中国农村地区胃癌死亡率的下降幅度大于城市地区。 | Kun Gao Jun Wu | 2019 | 癌症2019，38，9： | 15 |
| 11 | Detection of DNA methylation changes during seed germination in rapeseed (Brassica napus)显示文摘DNA methylation is known to play a crucial role in regulating plant development and or- gan or tissue differentiation. In this study, we as- sessed the extent and pattern of cytosine methylation during rapeseed (Brassica napus L.) seed germina- tion, and compared the methylation level of various tissues in seedling, using the techniques of methyla- tion-sensitive amplified polymorphism (MSAP) and HPLC separation and quantification of nucleosides. In all, 484 bands, each representing a recognition site cleaved by either or both of the isoschizomers, were amplified by 12 pairs of selective primers in DNA ob- tained from dry seeds. A total of 76 sites were found to be differentially digested by the isoschizomers, indicating that approximately 15.7% of 5′-CCGG-3′ sites in the genome were cytosine methylated. Four classes of patterns were observed in a comparative assay of cytosine methylation in the dry and germi- nating seeds; a small number of hypermethylation events occurred at 5′-CCGG-3′ sites in germinating seeds compared with dry seeds, while many more hypomethylation events were detected after seed germination. Differences in DNA methylation level in various tissues were also detected; radicel was less methylated than hypocotyl and cotyledon. These observations were further confirmed by HPLC analy- sis. In addition, sequencing of eleven differentially methylated fragments and the subsequent blast search revealed that cytosine methylated 5′-CCGG- 3′ sequences were equally distributed between cod- ing and non-coding regions. These results clearly demonstrate the power of MSAP technique for large-scale DNA methylation detection in rapeseed genome, and the complexity of DNA methylationchange during seed germination. DNA Hypomethyla- tion going with seed germination appears to be a necessary step toward transcriptional activation in gene expression, and may well contribute to the de- velopmental gene regulation. | LU Guangyuan WU Xiaoming CHEN Biyun GAO Guizhen XU Kun LI Xiangzhi | 2006 | Chinese Science Bulletin2006，51，2： | 14 |
| 12 | Evaluation of Genetic and Epigenetic Modification in Rapeseed(Brassica napus)Induced by Salt Stress显示文摘咸度是为世界范围的油菜籽生产的一个重要限制环境因素。在这研究,我们估计了盐应力在油菜籽植物引起的脱氧核糖核酸损坏的程度和模式。放大碎片长度多型性(AFLP ) 分析表明在小植物的顺序改变的剂量相关的增加暴露了 000 mmol/L 氯化钠到 10-1。另外,暴露于一样的盐集中的单个小植物证明不同 AFLP 和选择区域放大了多型性 banding 模式。这些观察建议响应盐应力的那个脱氧核糖核酸变化在染色体是随机的,效果是剂量家属。响应应力也是的盐的脱氧核糖核酸甲基化变化由甲基化评估了敏感放大多型性(MSAP ) 。MSAP 乐队的三种类型被恢复。类型我乐队们与两 isoschizomers Hpa II 和 Msp 被观察我当类型 II 和类型 III 乐队仅仅与 Hpa II 和 Msp 被观察时我分别地。在在 NaCl 处理以后的 MSAP 乐队的类型的广泛的变化被观察,包括在也之间我, II 和 III 乐队,以及交换打的类型的外观和消失我和类型 II 或类型我和类型 III 乐队。0.2-17.6% cytosine methylated CCGG 地点的增加在与控制相比暴露于 10-200 mmol/L 盐的小植物被检测,并且这些变化包括了重新甲基化和 demethylation 事件。相关碎片也是的九甲基化恢复了并且定序,并且与乙烯分享高顺序相同的应答的元素绑定因素被识别。这些结果在对盐的回答强调,并且这些变化可以在盐应力下面为植物改编建议机制的小植物表明了基因的清楚的脱氧核糖核酸和 epigenetic 改变。 | Guangyuan Lu Xiaoming Wu Biyun Chen Guizhen Gao Kun Xu | 2007 | Journal of Integrative Plant Biology2007，49，11： | 14 |
| 13 | Excessive UBE3A dosage impairs retinoic acid signaling and synaptic plasticity in autism spectrum disorders显示文摘孤独性光谱混乱(ASD ) 是有异构的病原学的许多人的神经病学的混乱。E3 ubiquitin (Ub ) 的活动过度 ligase UBE3A,不完全地源自 15q11-q13 拷贝数字变化,为世界范围的 ASD 盒子的 1%-3% 的报道,而是内在的机制遗体描绘了。这里,我们报导 ALDH1A2 的功能, retinoic 酸(RA ) 的限制率的酶合成,被 UBE3A 否定地以一种 ubiquitylation 依赖的方式调整。过多的 UBE3A 剂量被发现损害调停 RA 的 neuronal homeostatic synaptic 粘性。象 ASD 一样症状被 overexpressing UBE3A 在前额的外皮或由一个 ALDH1A 对手的管理在老鼠概括,而 RA 补充显著地减轻了过多的 UBE3A 导致剂量的象 ASD 一样显型。由识别在 ASD 作为内在的机制发信号的减少的 RA,显型连接了到 UBE3A 活动过度,我们的调查结果介绍 ASD 病原学的新远景并且对这逐渐地流行的疾病便于治疗学的开发的一个模式。 | Xingxing Xu Chuanyin Li Xiaobo Gao Kun Xia Hui Guo Yali Li ZijianHao Lei Zhang Daming Gao Chenfan Xu Huatai Xu Zhi-Qi Xiong Zilong Qiu Ling Mei Xiaoduo Xie Kangcheng Ruan Ronggui Hu | 2018 | Cell Research2018，28，1： | 13 |
| 14 | HBx-DNA probe preparation and its application in study of hepatocarcinogenesis显示文摘HBxDNAprobepreparationanditsapplicationinstudyofhepatocarcinogenesisGAOFengGuang,SUNWenSheng,CAOYingLin,ZHANGLiNing,SON... | GAO FengGuang, SUN WenSheng, CAO YingLin, ZHANG LiNing, SONG Jing, LI HuaFen and YAN ShiKunKeywords hepatitis B virus liver neoplasms/etiology carcinoma, hepatocellular/etiology DNA probe | 1998 | World Journal of Gastroenterology1998，4，4： | 12 |
| 15 | Diffusion-tensor imaging as an adjunct to dynamic contrastenhanced MRI for improved accuracy of differential diagnosis between breast ductal carcinoma in situ and invasive breast carcinoma显示文摘Objective:To determine the value of diffusion-tensor imaging(DTI) as an adjunct to dynamic contrastenhanced magnetic resonance imaging(DCE-MRI) for improved accuracy of differential diagnosis between breast ductal carcinoma in situ(DCIS) and invasive breast carcinoma(IBC).Methods:The MRI data of 63 patients pathologically confirmed as breast cancer were analyzed.The conventional MRI analysis metrics included enhancement style,initial enhancement characteristic,maximum slope of increase,time to peak,time signal intensity curve(TIC) pattern,and signal intensity on FST2 WI.The values of apparent diffusion coefficient(ADC),directionally-averaged mean diffusivity(D_(avg)),exponential attenuation(EA),fractional anisotropy(FA),volume ratio(VR) and relative anisotropy(RA)were calculated and compared between DCIS and IBC.Multivariate logistic regression was used to identify independent factors for distinguishing IBC and DCIS.The diagnostic performance of the diagnosis equation was evaluated using the receiver operating characteristic(ROC) curve.The diagnostic efficacies of DCEMRI,DWI and DTI were compared independendy or combined.Results:EA value,lesion enhancement style and TIC pattern were identified as independent factor for differential diagnosis of IBC and DCIS.The combination diagnosis showed higher diagnostic efficacy than a single use of DCE-MRI(P=0.02),and the area of the curve was improved from 0.84(95%CI,0.67-0.99) to0.94(95%CI,0.85-1.00).Conclusions:Quantitative DTI measurement as an adjunct to DCE-MRI could improve the diagnostic performance of differential diagnosis between DCIS and IBC compared to a single use of DCE-MRI. | Yuan Wang Xiaopeng Zhang Kun Cao Yanling Li Xiaoting Li Liping Qi Lei Tang Zhilong Wang Shunyu Gao | 2015 | Chinese Journal of Cancer Research2015，27，2： | 12 |
| 16 | A Matched Comparison Study of Uniportal Versus Triportal Thoracoscopic Lobectomy and Sublobectomy for Early-stage Nonsmall Cell Lung Cancer显示文摘 | Ju-Wei Mu Shu-Geng Gao Qi Xue Jun Zhao Ning Li Kun Yang Kai Su Zhu-Yang Yuan Jie He | 2015 | Chinese Medical Journal2015，，20： | 12 |
| 17 | Acupuncture at heterotopic acupoints enhances jejunal motility in constipated and diarrheic rats显示文摘AIM:To investigate the effect and mechanism of acupuncture at heterotopic acupoints on jejunal motility,particularly in pathological conditions.METHODS:Jejunal motility was assessed using a manometric balloon placed in the jejunum approximately18-20 cm downstream from the pylorus and filled with approximately 0.1 m L warm water in anesthetized normal rats or rats with diarrhea or constipation.The heterotopic acupoints including LI11(Quchi),ST37(Shangjuxu),BL25(Dachangshu),and the homotopic acupoint ST25(Tianshu),and were stimulated for 60 s by rotating acupuncture needles right and left at a frequency of 2 Hz.To determine the type of afferent fibers mediating the regulation of jejunal motility by manual acupuncture,the ipsilateral sciatic A or C fibers of ST37 were inactivated by local application of the A-fiber selective demyelination agent cobra venom or the C fiber blocker capsaicin.Methoctramine,a selective M2 receptor antagonist,was injected intravenously to identify a specific role for M2 receptors in mediating the effect of acupuncture on jejunal motility.RESULTS:Acupuncture at heterotopic acupoints,such as LI11 and ST37,increased jejunal motility not only in normal rats,but also in rats with constipation or diarrhea.In normal rats,manual acupuncture at LI11 or ST37 enhanced jejunal pressure from 7.34±0.19 cmH2O to 7.93±0.20 cm H2O,an increase of 9.05%±0.82%(P<0.05),and from 6.95±0.14 cm H2O to 8.97±0.22cm H2O,a significant increase of 27.44%±1.96%(P<0.01),respectively.In constipated rats,manual acupuncture at LI11 or ST37 increased intrajejunal pressure from8.17±0.31 cm H2O to 9.86±0.36 cm H2O,an increase of 20.69%±2.10%(P<0.05),and from 8.82±0.28cm H2O to 10.83±0.28 cm H2O,an increase of 22.81%±1.46%(P<0.05),respectively.In rats with diarrhea,MA at LI11 or ST37 increased intrajejunal pressure from 11.95±0.35 cm H2O to 13.96±0.39 cm H2O,an increase of 16.82%±2.35%(P<0.05),and tended to increase intrajejunal pressure(from 12.42±0.38 cm H2O to 13.05±0.38 cm H2O,an increase of 5.07%±1.08%,P>0.05),respectively.In contrast,acupuncture ST25,a homotopic acupoint,decreased not only intrajejunal pressure,but also significantly decreased frequency in normal rats and rats with constipation or diarrhea.Following demyelination of Aδfibers,acupuncture at ST37again augmented intrajejunal pressure to 121.48%±3.06%of baseline.Following capsaicin application for24 h,acupuncture at ipsilateral ST37 increased intrajejunal pressure significantly to 106.63%±1.26%of basallevels when compared to measurements prior to capsaicin treatment(P<0.05).Acupuncture at LI11,ST37,or BL25 significantly rescued methoctramine-mediated inhibition of jejunal motility amplitude from 42.83%±1.65%to 53.43%±1.95%of baseline(P<0.05),from45.15%±2.22%to 70.51%±2.34%of baseline(P<0.01),and from 38.03%±2.34%to 70.12%±2.22%of baseline(P<0.01),respectively.CONCLUSION:Acupuncture at heterotopic acupoints increases the amplitude of jejunal motility in rats.C fibers and M2 receptors predominantly and partially mediate the regulation of jejunal motility by acupuncture,respectively. | Qing-Guang Qin Xin-Yan Gao Kun Liu Xiao-Chun Yu Liang Li Hai-Ping Wang Bing Zhu | 2014 | World Journal of Gastroenterology2014，20，48： | 12 |
| 18 | Multiple fault diagnosis of down-hole conditions of sucker-rod pumping wells based on Freeman chain code and DCA显示文摘It is important to achieve continuous, stable and efficient pumping well operation in actual oilfield operation. Down-hole pumping well working conditions can be monitored in real-time and a reasonable production scheme can be designed when computer diagnosis is used. However, it is difficult to make a comprehensive analysis to supply efficient technical guidance for operation of the pumping well with multiple faults of down-hole conditions, which cannot be effectively dealt with by the common methods. To solve this problem, a method based on designated component analysis (DCA) is used in this paper. Freeman chain code is used to represent the down-hole dynamometer card whose important characteristics are extracted to construct a designated mode set. A control chart is used as a basis for fault detection. The upper and lower control lines on the control chart are determined from standard samples in normal working conditions. In an incompletely orthogonal mode, the designated mode set could be divided into some subsets in which the modes are completely orthogonal. The observed data is projected into each designated mode to realize fault detection according to the upper and lower control lines. The examples show that the proposed method can effectively diagnose multiple faults of down-hole conditions. | LI Kun GAO Xian-wen YANG Wei-bing DAI Ying-long TIAN Zhong-da | 2013 | Petroleum Science2013，10，3： | 12 |
| 19 | Role of macrophages in peripheral nerve injury and repair显示文摘Resident and inflammatory macrophages are essential effectors of the innate immune system. These cells provide innate immune defenses and regulate tissue and organ homeostasis. In addition to their roles in diseases such as cancer, obesity and osteoarthritis, they play vital roles in tissue repair and disease rehabilitation. Macrophages and other inflammatory cells are recruited to tissue injury sites where they promote changes in the microenvironment. Among the inflammatory cell types, only macrophages have both pro-inflammatory (Ml) and anti-inflammatory (M2) actions, and M2 macrophages have four subtypes. The co-action of Ml and M2 subtypes can create a favorable microenvironment, releasing cytokines for damaged tissue repair. In this review, we discuss the activation of macrophages and their roles in severe peripheral nerve injury. We also describe the therapeutic potential of macrophages in nerve tissue engineering treatment and highlight approaches for enhancing M2 cell-mediated nerve repair and regeneration. | Ping Liu Jiang Peng Gong-Hai Han Xiao Ding Shuai Wei Gang Gao Kun Huang Feng Chang Yu Wang | 2019 | Neural Regeneration Research2019，14，8： | 11 |
| 20 | Continuous Positive Airway Pressure Effectively Alleviates Arrhythmias in Patients with Obstructive Sleep Apnea:Possible Relationship with Counteracting Oxidative Stress显示文摘This work is aimed at exploring the clinical efficacy of continuous positive airway pressuie(CPAP)in treatment of patients with arrhythmias combined with obstructive sleep apnea(OSA).Through evaluating serum native thiol,malonaldehyde(MDA)and nicotinamide adenine dinucleotide phosphate oxidase(NADPH oxidase)in these patients and describing the effects on oxidative parameters of CPAP therapy for 3 months,we confirmed the impact of oxidative stress on arrhythmias.A total of 64 patients with OSA combined with arrhythmias were collected from April 2014 to April 2017 with full clinical information.Patients were divided into two groups(paired experiment design):32 patients in group A(control group),who received unchanged anti-arrhythmia treatment and 32 patients in group B,who were subjected to unchanged pharmacological anti-arrhythmia therapy combined with CPAP.OSA related parameters were compared between the two groups after 3-month therapy.And the levels of parameters of oxidative stress in patients were measured before and after CPAP therapy.After 3 months of CPAP therapy,compared with the control group,the percentage of sage N3(NREM 3)and stage R(REM)in total sleep time was significantly increased,while apnea-hypopnea index(AHI)and the Epworth Sleepiness Scale(ESS)score were evidently decreased.Meanwhile,the lowest oxygen saturation(LSpCh)was also elevated after CPAP treatment for 3 months.The CPAP therapy significantly prevented the occurrence of arrhythmias(P<0.05).Both the MDA level and NADPH oxidase levels were significantly lower in the group B than in the group A(P<0.05).But serum native thiol was improved by CPAP treatment(P<0.05).In conclusion,proper use of CPAP therapy provides significant benefits for the treatment of arrhythmia in patients with OSA. | Xiao-ting WANG Gang ZHAO Ling TU Zhi-yong YUE Zhen-hua LIU Jie HAN Kun GAO Xuan-chen ZHOU Shuai XU Jian-feng LI | 2019 | Current Medical Science2019，39，1： | 10 |
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