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| 1 | Cell–cell contact with proinflammatory macrophages enhances the immunotherapeutic effect of mesenchymal stem cells in two abortion models显示文摘Mesenchymal stem cells(MSCs),which are pluripotent cells with immunomodulatory properties,have been considered good candidates for the therapy of several immune disorders,such as inflammatory bowel diseases,concanavalin A-induced liver injury,and graft-versus-host disease.The embryo is a natural allograft to the maternal immune system.A successful pregnancy depends on the timely extinction of the inflammatory response induced by embryo implantation,followed by the switch to a tolerant immune microenvironment in both the uterus and the system.Excessive infiltration of immune cells and serious inflammatory responses are triggers for embryo rejection,which results in miscarriage.Here,we demonstrated that adoptive transfer of MSCs could prevent fetal loss in a lipopolysaccharide(LPS)-induced abortion model and immune response-mediated spontaneous abortion model.The immunosuppressive MSCs alleviated excessive inflammation by inhibiting CD4+T cell proliferation and promoting the decidual macrophage switch to M2 in a tumor necrosis factor-stimulated gene-6(TSG-6)-dependent manner.Cell-tocell contact with proinflammatory macrophages increased the TSG-6 production by the MSCs,thereby enhancing the suppressive regulation of T cells and macrophages.Moreover,proinflammatory macrophages in contact with the MSCs upregulated the expression of CD200 on the stem cells and facilitated the reprogramming of macrophages towards an anti-inflammatory skew through the interaction of CD200 with CD200R on proinflammatory macrophages.Therefore,the results demonstrate that a TSG-6-mediated paracrine effect,reinforced by cell-to-cell contact between MSCs and proinflammatory macrophages,is involved in the mechanism of MSC-mediated abortion relief through the induction of immune tolerance.Our study also indicates the potential application of MSCs in clinical recurrent miscarriages. | Yanhong Li Di Zhang Ling Xu Lin Dong Ji Zheng Yikong Lin Jiefang Huang Yanyun Zhang Yu Tao Xingxing Zang Dajin Li Meirong Du | 2019 | Cellular & Molecular Immunology2019，16，12： | 23 |
| 2 | Excessive UBE3A dosage impairs retinoic acid signaling and synaptic plasticity in autism spectrum disorders显示文摘孤独性光谱混乱(ASD ) 是有异构的病原学的许多人的神经病学的混乱。E3 ubiquitin (Ub ) 的活动过度 ligase UBE3A,不完全地源自 15q11-q13 拷贝数字变化,为世界范围的 ASD 盒子的 1%-3% 的报道,而是内在的机制遗体描绘了。这里,我们报导 ALDH1A2 的功能, retinoic 酸(RA ) 的限制率的酶合成,被 UBE3A 否定地以一种 ubiquitylation 依赖的方式调整。过多的 UBE3A 剂量被发现损害调停 RA 的 neuronal homeostatic synaptic 粘性。象 ASD 一样症状被 overexpressing UBE3A 在前额的外皮或由一个 ALDH1A 对手的管理在老鼠概括,而 RA 补充显著地减轻了过多的 UBE3A 导致剂量的象 ASD 一样显型。由识别在 ASD 作为内在的机制发信号的减少的 RA,显型连接了到 UBE3A 活动过度,我们的调查结果介绍 ASD 病原学的新远景并且对这逐渐地流行的疾病便于治疗学的开发的一个模式。 | Xingxing Xu Chuanyin Li Xiaobo Gao Kun Xia Hui Guo Yali Li ZijianHao Lei Zhang Daming Gao Chenfan Xu Huatai Xu Zhi-Qi Xiong Zilong Qiu Ling Mei Xiaoduo Xie Kangcheng Ruan Ronggui Hu | 2018 | Cell Research2018，28，1： | 13 |
| 3 | Rapid reconstitution of NK1 cells after allogeneic transplantation is associated with a reduced incidence of graft-versus-host disease显示文摘The balance between immunostimulation and immunoregulation in T cell immunity is achieved by maintaining specific ratios of Th1, Th2, Th3 and Tr1 cells. Here, we investigate levels of type 1(IFN-gamma; NK1), type 2(IL-13; NK2), type 3(TGF-beta;NK3) and regulatory(IL-10; NKr) cytokines in peripheral blood to assess the cytokine profiles of natural killer(NK) cells following human allogeneic hematopoietic stem cell transplantation(allo-HSCT). NK2 and NK3 cell expansion was observed after allo-HSCT; levels of NKr cells reached donor levels at day 15, though levels of NK1 cells were consistently lower than donor levels until day 60 after allo-HSCT. Multivariate analysis showed that a higher level of NK1 cells by day 15 was associated with a lower overall risk of acute graft-versus-host disease(GVHD)(HR 0.157, P=0.010) as well as II-IV acute GVHD(HR0.260, P=0.059). Furthermore, higher levels of NK1 cells by day 15 were correlated with lower rates of cytomegalovirus(CMV)reactivation(HR 0.040, 0.005–0.348, P=0.003). These results indicate that rapid reconstitution of NK cells, especially NK1 cells,can help prevent the development of GVHD as well as CMV reactivation after allogeneic transplantation. | Xingxing Yu Lingling Xu Yingjun Chang Xiaojun Huang Xiangyu Zhao | 2018 | Science China(Life Sciences)2018，61，8： | 9 |
| 4 | Diclofop-methyl affects microbial rhizosphere community and induces systemic acquired resistance in rice显示文摘Diclofop-methyl(DM),a widely used herbicide in food crops,may partly contaminate the soil surface of natural ecosystems in agricultural area and exert toxic effects at low dose to nontarget plants.Even though rhizosphere microorganisms strongly interact with root cells,little is known regarding their potential modulating effect on herbicide toxicity in plants.Here we exposed rice seedlings(Xiushui 63) to 100 μg/L DM for 2 to 8 days and studied the effects of DM on rice rhizosphere microorganisms,rice systemic acquired resistance(SAR) and rice-microorganisms interactions.The results of metagenomic 16 S rDNA Illumina tags show that DM increases bacterial biomass and affects their community structure in the rice rhizosphere.After DM treatment,the relative abundance of the bacterium genera Massilia and Anderseniella increased the most relative to the control.In parallel,malate and oxalate exudation by rice roots increased,potentially acting as a carbon source for several rhizosphere bacteria.Transcriptomic analyses suggest that DM induced SAR in rice seedlings through the salicylic acid(but not the jasmonic acid) signal pathway.This response to DM stress conferred resistance to infection by a pathogenic bacterium,but was not influenced by the presence of bacteria in the rhizosphere since SAR transcripts did not change significantly in xenic and axenic plant roots exposed to DM.The present study provides new insights on the response of rice and its associated microorganisms to DM stress. | Si Chen Xingxing Li Michel Lavoie Yujian Jin Jiahui Xu Zhengwei Fu Haifeng Qian | 2017 | Journal of Environmental Sciences2017，29，1： | 8 |
| 5 | Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis显示文摘Curcumenol,an effective ingredient of Wenyujin,has been reported that exerted its antitumor potential in a few cancer types.However,the effect and molecular mechanism of curcumenol in lung cancer are largely unknown.Here,we found that curcumenol induced cell death and suppressed cell proliferation in lung cancer cells.Next,we demonstrated that ferroptosis was the predominant method that contributed to curcumenol-induced cell death of lung cancer in vitro and vivo for the first time.Subsequently,using RNA sequencing,we found that the long non-coding RNA H19(lncRNA H19)was significantly downregulated in lung cancer cells treated with curcumenol,when compared to untreated controls.Overexpression of lncRNA H19 eliminated the anticancer effect of curcumenol,while lncRNA H19 knockdown promoted ferroptosis induced by curcumenol treatment.Mechanistically,we showed that lncRNA H19 functioned as a competing endogenous RNA to bind to miR-19b-3p,thereby enhanced the transcription activity of its endogenous target,ferritin heavy chain 1(FTH1),a marker of ferroptosis.In conclusion,our data show that the natural product curcumenol exerted its antitumor effects on lung cancer by triggering ferroptosis,and the lncRNA H19/miR-19b-3p/FTH1 axis plays an essential role in curcumenol-induced ferroptotic cell death.Therefore,our findings will hopefully provide a valuable drug for treating lung cancer patients. | Ruonan Zhang Ting Pan Yu Xiang Mingming Zhang Han Xie Zimao Liang Bi Chen Cong Xu Jing Wang Xingxing Huang Qianru Zhu Ziming Zhao Quan Gao Chengyong Wen Wencheng Liu Weirui Ma Jiao Feng Xueni Sun Ting Duan Elaine Lai-Han Leung Tian Xie Qibiao Wu Xinbing Sui | 2022 | Bioactive Materials2022，7，7： | 8 |
| 6 | A review:Photonics devices,architectures,and algorithms for optical neural computing显示文摘The explosive growth of data and information has motivated various emerging non-von Neumann computational approaches in the More-than-Moore era.Photonics neuromorphic computing has attracted lots of attention due to the fascinating advantages such as high speed,wide bandwidth,and massive parallelism.Here,we offer a review on the optical neural computing in our research groups at the device and system levels.The photonics neuron and photonics synapse plasticity are presented.In addition,we introduce several optical neural computing architectures and algorithms including photonic spiking neural network,photonic convolutional neural network,photonic matrix computation,photonic reservoir computing,and photonic reinforcement learning.Finally,we summarize the major challenges faced by photonic neuromorphic computing,and propose promising solutions and perspectives. | Shuiying Xiang Yanan Han Ziwei Song Xingxing Guo Yahui Zhang Zhenxing Ren Suhong Wang Yuanting Ma Weiwen Zou Bowen Ma Shaofu Xu Jianji Dong Hailong Zhou Quansheng Ren Tao Deng Yan Liu Genquan Han Yue Hao | 2021 | Journal of Semiconductors2021，42，2： | 7 |
| 7 | A Scenario-Based Evaluation of COVID-19-Related Essential Clinical Resource Demands in China显示文摘The coronavirus disease 2019(COVID-19)pandemic is a global crisis,and medical systems in many countries are overwhelmed with supply shortages and increasing demands to treat patients due to the surge in cases and severe illnesses.This study aimed to assess COVID-19-related essential clinical resource demands in China,based on different scenarios involving COVID-19 spreads and interventions.We used a susceptible–exposed–infectious–hospitalized/isolated–removed(SEIHR)transmission dynamics model to estimate the number of COVID-19 infections and hospitalizations with corresponding essential healthcare resources needed.We found that,under strict non-pharmaceutical interventions(NPIs)or mass vaccination of the population,China would be able to contain community transmission and local outbreaks rapidly.However,under scenarios involving a low intensity of implemented NPIs and a small proportion of the population vaccinated,the use of a peacetime–wartime transition model would be needed for medical source stockpiles and preparations to ensure a normal functioning healthcare system.The implementation of COVID-19 vaccines and NPIs in different periods can influence the transmission of COVID-19 and subsequently affect the demand for clinical diagnosis and treatment.An increased proportion of asymptomatic infections in simulations will not reduce the demand for medical resources;however,attention must be paid to the increasing difficulty in containing COVID-19 transmission due to asymptomatic cases.This study provides evidence for emergency preparations and the adjustment of prevention and control strategies during the COVID-19 pandemic.It also provides guidance for essential healthcare investment and resource allocation. | Ting Zhang Qing Wang Zhiwei Leng Yuan Yang Jin Yang Fangyuan Chen Mengmeng Jia Xingxing Zhang Weiran Qi Yunshao Xu Siya Chen Peixi Dai Libing Ma Luzhao Feng Weizhong Yang | 2021 | Engineering2021，7，7： | 7 |
| 8 | Recent progress of integrated circuits and optoelectronic chips显示文摘Integrated circuits(ICs)and optoelectronic chips are the foundation stones of the modern information society.The IC industry has been driven by the so-called'Moore's law'in the past 60 years,and now has entered the post Moore's law era.In this paper,we review the recent progress of ICs and optoelectronic chips.The research status,technical challenges and development trend of devices,chips and integrated technologies of typical IC and optoelectronic chips are focused on.The main contents include the development law of IC and optoelectronic chip technology,the IC design and processing technology,emerging memory and chip architecture,brain-like chip structure and its mechanism,heterogeneous integration,quantum chip technology,silicon photonics chip technology,integrated microwave photonic chip,and optoelectronic hybrid integrated chip. | Yue HAO Shuiying XIANG Genquan HAN Jincheng ZHANG Xiaohua MA Zhangming ZHU Xingxing GUO Yahui ZHANG Yanan HAN Ziwei SONG Yan LIU Ling YANG Hong ZHOU Jiangyi SHI Wei ZHANG Min XU Weisheng ZHAO Biao PAN Yangqi HUANG Qi LIU Yimao CAI Jian ZHU Xin OU Tiangui YOU Huaqiang WU Bin GAO Zhiyong ZHANG Guoping GUO Yonghua CHEN Yong LIU Xiangfei CHEN Chunlai XUE Xingjun WANG Lixia ZHAO Xihua ZOU Lianshan YAN Ming LI | 2021 | Science China(Information Sciences)2021，64，10： | 7 |
| 9 | Genome-wide identification of OSCA gene family and their potential function in the regulation of dehydration and salt stress in Gossypium hirsutum显示文摘Background:Cotton(Gossypium hirsutum) provides the largest natural fiber for the textile manufacturing industries,but its production is on the decline due to the effects of salinity.Soil salt-alkalization leads to damage in cotton growth and a decrease in yields.Hyperosmolality-gated calcium-permeable channels(OSCA) have been found to be involved in the detection of extracellular changes which trigger an increase in cytosolic free calcium concentration.Hyperosmolality-induced calcium ion increases have been widely speculated to be playing a role in osmosensing in plants.However,the molecular nature of the corresponding calcium ion channels remains unclearly.In this research work,we describe the OSCA genes and their putative function in osmosensing in plants by carrying out genomewide identification,characterization and functional analysis of the significantly up-regulated OSCA gene,GhOSCA1.1 through reverse genetics.Result:A total of 35,21 and 22 OSCA genes were identified in G.hirsutum,G.arboreum,and G.raimondii genomes,respectively,and were classified into four different clades according to their gene structure and phylogenetic relationship.Gene and protein structure analysis indicated that 35 GhOSCA genes contained a conserved RSN17 TM(PF02714) domain.Moreover,the cis-regulatory element analysis indicated that the OSCA genes were involved in response to abiotic stress.Furthermore,the knockdown of one of the highly up-regulated genes,GhOSCA1.1 showed that the virus-induced gene silenced(VIGS) plants were highly sensitive to dehydration and salinity stresses compared with the none VIGS plants as evident with higher concentration levels of oxidant enzymes compared with the antioxidant enzymes on the leaves of the stressed plants.Conclusion:This study provides the first systematic analysis of the OSCA gene family and will be important for understanding the putative functions of the proteins encoded by the OSCA genes in cotton.These results provide a new insight of defense responses in general and lay the foundation for further investigation of the molecular role played by the OSCA genes,thereby providing suitable approaches to improve crop performance under salinity and drought stress conditions. | YANG Xiu XU Yanchao YANG Fangfang MAGWANGA Richard Odongo CAI Xiaoyan WANG Xingxing WANG Yuhong HOU Yuqing WANG Kunbo LIU Fang ZHOU Zhongli | 2019 | Journal of Cotton Research2019，2，2： | 7 |
| 10 | Effects of deformation processes on morphology,microstructure and corrosion resistance of LDHs films on magnesium alloy AZ31显示文摘Highly oriented Mg-Al layered double hydroxide(LDHs)films were deposited on magnesium alloy AZ31 with different deformation processes by an easy in-situ growth method.The characteristics of the films were investigated by optical microscopy(OM),X-ray diffraction(XRD),scanning electron microscopy(SEM),and electrochemical,immersion and hydrogen evolution tests.The corrosion protection performance ranked the LDHs films as the increasing series:CS-LDHs(as-cast sample with LDHs) | Jing Chen Liang Wu Xingxing Ding Qiang Liu Xu Dai Jiangfeng Song Bin Jiang Andrej Atrens Fusheng Pan | 2021 | Journal of Materials Science & Technology2021，，5： | 6 |
| 11 | Sensitive and selective molecularly imprinted electrochemical sensor based on multi-walled carbon nanotubes for doxycycline hyclate determination显示文摘An electrochemical sensor for doxycycline hyclate(DC)detection with high sensitivity and good selectivity is reported.The sensor was fabricated by electro-polymerization of molecularly imprinted polymers(MIPs)in the presence of DC onto multi-walled carbon nanotubes modified glassy carbon electrode(MWCNTs/GCE).The MWCNTs can significantly increase the current response of the sensor,leading to enhanced sensitivity.The MIPs provide selective recognition sites for DC detection.The experimental parameters,such as the polymer monomer concentration,supporting electrolyte pH,the time for electro-polymerization and the incubation time of the sensor with DC were optimized.Under optimized experimental conditions,the sensor displayed a linear range of 0.05μmol/L-0.5μmol/L towards DC detection,with the detection limit of 1.3×10^-2μmol/L.The sensor was successfully applied for recovery test of DC in human serum samples. | Zeyu Xu Xingxing Jiang Shuping Liu Minghui Yang | 2020 | Chinese Chemical Letters2020，31，1： | 6 |
| 12 | Polar, catalytic, and conductive CoSe2/C frameworks for performance enhanced S cathode in Li–S batteries显示文摘Lithium-sulfur battery(Li-S)is considered as one of the new-generation rechargeable batteries with high performance because of its extremely high theoretical capacity,energy density,environmental harmony and low cost.However,low electrical and ionic conductivity of sulfur,safety concerns and parasitic reaction generated by the dissolved polysulfide species in electrolyte hinder the commercialization of Li-S battery.Herein,we report a polyhedral porous structure comprising of carbon coating metal selenide nanoparticles(CoSe2/C),which could not only host sulfur for Li-S battery owing to its porous and conductive structure,but also mitigate the shuttle phenomenon by polysulfides adsorption and catalytic acceleration of redox kinetics.As a result,a performance enhanced CoSe2/C-S electrode for Li-S battery is achieved. | Bo Yuan Di Hua Xingxing Gu Yu Shen Li-Chun Xu Xiuyan Li Bing Zheng Jiansheng Wu Weina Zhang Sheng Li Fengwei Huo | 2020 | Journal of Energy Chemistry2020，29，9： | 5 |
| 13 | Some logarithmic Minkowski inequalities for nonsymmetric convex bodies显示文摘We prove some analogs inequalities of the logarithmic Minkowski inequality for general nonsymmetric convex bodies. As applications of one of those inequalities, the p-affine isoperimetric inequality and some other inequalities are obtained. | WANG XingXing XU WenXue ZHOU JiaZu | 2017 | Science China Mathematics2017，60，10： | 3 |
| 14 | Synchronous chirp mode extraction: A promising tool for fault diagnosis of rolling element bearings under varying speed conditions显示文摘As critical components in modern aerospace productions,rolling element bearings(REBs)generally work under varying speed conditions,which brings great challenges to their operating health monitoring.Some novel time–frequency decomposition(TFD)algorithms are established recently to extract nonlinear features from the non-stationary signals effectively,which are promising for realizing fault diagnosis of REBs under varying speed conditions.However,numerous personal experiences must be incorporated and the anti-noise performance of these methods needs to be further enhanced.Given these issues,a synchronous chirp mode extraction(SCME)-based REB fault diagnosis method is proposed for the health monitoring of REBs under varying speed conditions in this study.It mainly consists of following two parts.(a)The shaft rotational frequency(SRF)is initially estimated from the low-frequency band of the vibration signal.Simultaneously,an adaptive refining strategy is incorporated to obtain a suitable bandwidth parameter.(b)A cycle-one-step estimation frame is constructed to extract synchronous modes from the envelope waveform of the vibration signal.Meanwhile,a synchronous mode spectrum(SMS)is generated using the information of the extracted synchronous modes,which is a novel REBs fault diagnosis technique with tacholess and resampling-free.In contrast to the current TFD algorithms,the proposed method needs fewer input parameters and owns a well anti-noise performance because there is no iterative optimization in the procedure of construction of SMS.As a result,the health conditions of REBs are evaluated by detecting the exhibited features in the SMS.Simulations and experiments are conducted to validate the effectiveness of the proposed method in terms of REB fault diagnosis.Analysis results demonstrate that the proposed method outperforms the current TFD algorithm and the conventional order tracking technique for fault diagnosis of REB under varying speed conditions. | Xingxing JIANG Qiang HUANG Changqing SHEN Qian WANG Kun XU Jie LIU Juanjuan SHI Zhongkui ZHU | 2022 | Chinese Journal of Aeronautics2022，35，1： | 3 |
| 15 | Blue revolution for food security under carbon neutrality: A case from the water-saving and drought-resistance rice显示文摘The increasing concentration of greenhouse gases(GHGs)in Earth's atmosphere leads to global warming,which further causes a series of climate changes and does great harm to both human society and natural ecosystems.Agricultural GHG emissions,mainly in theform of methane(CH4)and nitrous oxide(N2O),areasignificantsourceofGHGs,accountingfor~14%total global GHGs(Zhang et al.,2022).One major source of agricultural GHGs is CH4 emissions from rice paddies,which is responsiblefor~10%-12%ofhuman-inducedCH4emissions(van Groenigen et al.,2013)and contributes~2.40%to the enhanced global warming effect(Zhang et al.,2022).The global warming potential of GHGs emissions from rice systems is roughly four times higher than either wheat or maize(Linquist et al.,2012). | Hui Xia Xianxian Zhang Yi Liu Junguo Bi Xiaosong Ma Anning Zhang Hongyan Liu Liang Chen Sheng Zhou Huan Gao Kai Xu Haibin Wei Guolan Liu Feiming Wang Hongyang Zhao Xingxing Luo Danping Hou Qiaojun Lou Fangjun Feng Liguo Zhou Shoujun Chen Ming Yan Tianfei Li Mingshou Li LeiWang Zaochang Liu Xinqiao Yu HanweiMei Lijun Luo | 2022 | Molecular Plant2022，15，9： | 3 |
| 16 | Lattice constant effects of photonic crystals on the extraction of guided mode of GaN based light emitting diodes显示文摘We have fabricated a series of square-lattice hole photonic crystal (2PhC) arrays simultaneously at the un-current injection region on a special sample of GaN based light emitting diode (LED) by using focus ion beam milling (FIBM). The lattice constants of the 2PhC arrays vary from 230 to 1500 nm,while the 2PhC arrays have a constant area of about 9 μm×18 μm and a fixed depth of 150±10 nm which approaches but does not penetrate the active layer. Microscopic electroluminescence images and spectral measurements consistently confirm that the top emitting intensities from different 2PhCs are all enhanced compared with the unpatterned region. It is demonstrated that the output coupling of propagating guided modes is realized by the diffracted transmission of the 2PhCs. The enhancement factors of the guided modes compared with the unpatterned region are plotted as function of the lattice constant. It is found that the highest enhancements for the extraction of guided modes were obtained for the lattice constant of 230 and 460 nm of 2PhCs. The results are discussed by the two-dimensional rigorous coupled wave analysis (RCWA). | FU XingXing ZHANG Bei KANG XiangNing XU Jun XIONG Chang ZHANG GuoYi | 2011 | Science China(Technological Sciences)2011，54，1： | 2 |
| 17 | Compound C620-0696,a new potent inhibitor targeting BPTF,the chromatin-remodeling factor in non-small-cell lung cancer显示文摘Bromodomain PHD-finger transcription factor(BPTF)is the largest subunit of the nucleosome remodeling factor and plays an important role in chromatin remodeling for gene activation through its association with histone acetylation or methylation.BPTF is also involved in oncogene transcription in diverse progressions of cancers.Despite clinical trials for inhibitors of bromodomain and extra-terminal family proteins in human cancers,no potent and selective inhibitor targeting the BPTF bromodomain has been discovered.In this study,we identified a potential inhibitor,namely,C620-0696,by computational docking modeling to target bromodomain.Results of biolayer interferometry revealed that compound C620-0696 exhibited high binding affinity to the BPTF bromodomain.Moreover,C620-0696 was cytotoxic in BPTF with a high expression of non-small-cell lung cancer(NSCLC)cells.It suppressed the expression of the BPTF target gene c-MYC,which is known as an oncogenic transcriptional regulator in various cancers.C620-0696 also partially inhibited the migration and colony formation of NSCLC cells owing to apoptosis induction and cell cycle blockage.Thus,our study presents an effective strategy to target a bromodomain factor-mediated tumorigenesis in cancers with small molecules,supporting further exploration of the use of these inhibitors in oncology. | Jiahui Xu Qianqian Wang Elaine Lai Han Leung Ying Li Xingxing Fan Qibiao Wu Xiaojun Yao Liang Liu | 2020 | Frontiers of Medicine2020，14，1： | 2 |
| 18 | Experimental demonstration of coherent photonic neural computing based on a Fabry–Perot laser with a saturable absorber显示文摘As Moore’s law has reached its limits,it is becoming increasingly difficult for traditional computing architectures to meet the demands of continued growth in computing power.Photonic neural computing has become a promising approach to overcome the von Neuman bottleneck.However,while photonic neural networks are good at linear computing,it is difficult to achieve nonlinear computing.Here,we propose and experimentally demonstrate a coherent photonic spiking neural network consisting of Mach–Zehnder modulators(MZMs)as the synapse and an integrated quantum-well Fabry–Perot laser with a saturable absorber(FP-SA)as the photonic spiking neuron.Both linear computation and nonlinear computation are realized in the experiment.In such a coherent architecture,two presynaptic signals are modulated and weighted with two intensity modulation MZMs through the same optical carrier.The nonlinear neuron-like dynamics including temporal integration,threshold,and refractory period are successfully demonstrated.Besides,the effects of frequency detuning on the nonlinear neuron-like dynamics are also explored,and the frequency detuning condition is revealed.The proposed hardware architecture plays a foundational role in constructing a large-scale coherent photonic spiking neural network. | DIANZHUANG ZHENG SHUIYING XIANG XINGXING GUO YAHUI ZHANG BILING GU HONGJI WANG ZHENZHEN XU XIAOJUN ZHU YUECHUN SHI YUE HAO | 2023 | Photonics Research2023，11，1： | 2 |
| 19 | An SDP randomized approximation algorithm for max hypergraph cut with limited unbalance显示文摘We consider the design of semidefinite programming(SDP) based approximation algorithm for the problem Max Hypergraph Cut with Limited Unbalance(MHC-LU): Find a partition of the vertices of a weighted hypergraph H =(V, E) into two subsets V1, V2 with ‖V2|- |V1‖ u for some given u and maximizing the total weight of the edges meeting both V1 and V2. The problem MHC-LU generalizes several other combinatorial optimization problems including Max Cut, Max Cut with Limited Unbalance(MC-LU), Max Set Splitting,Max Ek-Set Splitting and Max Hypergraph Bisection. By generalizing several earlier ideas, we present an SDP randomized approximation algorithm for MHC-LU with guaranteed worst-case performance ratios for various unbalance parameters τ = u/|V|. We also give the worst-case performance ratio of the SDP-algorithm for approximating MHC-LU regardless of the value of τ. Our strengthened SDP relaxation and rounding method improve a result of Ageev and Sviridenko(2000) on Max Hypergraph Bisection(MHC-LU with u = 0), and results of Andersson and Engebretsen(1999), Gaur and Krishnamurti(2001) and Zhang et al.(2004) on Max Set Splitting(MHC-LU with u = |V|). Furthermore, our new formula for the performance ratio by a tighter analysis compared with that in Galbiati and Maffioli(2007) is responsible for the improvement of a result of Galbiati and Maffioli(2007) on MC-LU for some range of τ. | XU BaoGang YU XingXing ZHANG XiaoYan ZHANG Zan-Bo | 2014 | Science China Mathematics2014，57，12： | 2 |
| 20 | Sliding-Mode PID Control of UAV Based on Particle Swarm Parameter Tuning显示文摘Due to the coupled motion between the rotor unmanned aerial vehicle(UAV)and the manipulator,the underactuation characteristics of the system itself,and the influence of external uncertainties,the stability of the rotor UAV’s manipulator control system is difficult to control.Based on the dynamic model of the rotor UAV,the stability of the whole UAV manipulator control system is improved by using the piecewise cost function,the compression factor particle swarm optimization(PSO)algorithm and the sliding mode PID to establish the sliding mode PID control stability method based on the PSO.Compared with the sliding mode PID control method,this method solves the serious buffeting problem in the sliding mode control,reduces the influence of the external disturbance and realizes the attitude stabilization control of the UAV manipulator quickly and accurately,thus shortens the system adjustment time and improves the anti-interference ability. | Yunping Liu Xingxing Yan Fei Yan Ze Xu Weiyan Shang | 2020 | Computers, Materials & Continua2020，，4： | 2 |
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