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您的检索式：作者名="Kunqiang Li"
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| 1 | Enhanced physicochemical and biological properties of C/Cu dual ions implanted medical titanium显示文摘It is increasingly popular for titanium and its alloys to be utilized as the medical implants.However,their bioinert nature and lack of antibacterial ability limit their applications.In this work,by utilizing plasma immersion ion implantation and deposition(PIII&D)technology,the titanium surface was modified by C/Cu co-implantation.The mechanical property,corrosion resistance,antibacterial ability and cytocompatibility of modified samples were studied.Results indicate that after C/Cu co-implantation,copper nanoparticles were observed on the surface of titanium,and titanium carbide existed on the near surface region of titanium.The modified surface displayed good mechanical property and corrosion resistance.The Cu/C galvanic corrosion existed on the titanium surface implanted by C/Cu dual ions,and release of copper ions can be effectively controlled by the galvanic corrosion effect.Moreover,improved antibacterial performance of titanium surface can be achieved without cytotoxicity. | Chao Xia Xiaohan Ma Xianming Zhang Kunqiang Li Ji Tan Yuqin Qiao Xuanyong Liu | 2020 | Bioactive Materials2020，5，2： | 5 |
| 2 | Impact of twice-a-day transcranial direct current stimulation intervention on cognitive function and motor cortex plasticity in patients with Alzheimer's disease显示文摘Background Non-invasive brain stimulation has improved cognitive functions in patients with Alzheimer's disease(AD),and some studies suggest a close relationship between cognition and plasticity.However,the clinical benefits of transcranial direct current stimulation(tDCS)in patients still need to be evaluated.Aims This study examined the role of tDCS in improving cognition and whether the improved cognition is related to altered cortical plasticity.Methods 124 patients with AD were randomly assigned to active tDCS(n=63)or sham tDCS(n=61).The tDCS was applied at the dorsolateral prefrontal cortex for 30 treatment sessions across 6 weeks(5 days per week,2 days off).The Mini-Mental State Examination and the Alzheimer's Disease Assessment Scale-Cognitive(ADAS-Cog)were used for cognition evaluation at baseline,week 2 and week 6.The cortical plasticity was represented by motor-evoked potential(MEP)measured with an electromyogram.Results The results showed thatmultiplecourses of active tDcS can improve the cognitive functions of patients with AD,especially in the memory domain(word recall,recall of test instructions and word recognition).In addition,the damaged MEP level was enhanced following active treatment.In the active tDCS group,the improvements in ADAS-Cog total and subitem(word recall and word recognition)scores were negatively correlated with the enhancement of MEP.Conclusions Our research indicates for the first time that twice-a-day tDS may improve the cognitive function of patients with AD.This study also suggests that cognitive dysfunction may be related to impaired cortical plasticity,which warrants mechanistic investigations of the relationship between cognition and plasticity in the future. | Xingxing Li Lei Chen Kunqiang Yu Wenhao Zhuang Hui Zhu Wenqiang Xu Hui Yan Gangqiao Qi Dongsheng Zhou Shaochang Wu | 2023 | General Psychiatry2023，36，6： | 0 |
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