|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinical Features of Adult/Adolescent Atopic Dermatitis and Chinese Criteria for Atopic Dermatitis显示文摘 | Ping Liu Yan Zhao Zhang-Lei Mu Qian-Jin Lu Qian-Jin L U Li Zhang Xu Yao Min Zheng Yi-Wen Tang Xin-Xiano Lu Xiu-Juan xia You-Kun Lin Yu-Zhen Li Cai-Xia Tu Zhi-Rong Yao Jin-Hua Xu Wei Li Wei Lai Hui-Min Yang Hong-Fu Xie Xiu-Ping Han Zhi-Qiang Xie Xiang Nong Zai-Pei Guo Dan-Qi Deng Tong-Xin Shi Jian-Zhong Zhang | 2016 | Chinese Medical Journal2016，，7： | 64 |
| 2 | Experimental study of“Tong Xia”purgative method in ameliorating lung injury in acute necrotizing pancreatitis显示文摘AIM To investigate the role of tumor necrosisfactor(TNF)in lung injury during acutenecrotizing pancreatitis(ANP),and thetherapeutic effect of'Tong Xia'purgativemethod in minimizing the severity of lung injury.METHODS Fourteen canines were randomlydivided into 3 groups:the'Tong Xia'treatmentgroup(n = 5)using Dachengqitang;salinecontrol group(n = 5),and the sham operationgroup(n = 4).TNF activity in serum and inbronchoalveolar lavage fluid(BALF),the serumendotoxin levels were measured,and theseverity of lung injury evaluated.RESULTS Elevation of TNF activity was moreprominent in BALF than in serum.TNF activity inserum at 6 and 12 hours and in BALI:wassignificantly decreased in the'Tong Xia'treatment group than in the saline control one(q=21.11,q=12.07,q=9.03,respectively,P<0.01)and the lung injury was significantlyalleviated at 12 hours as compared with that inthe saline group,manifested as amelioration otthe lung wet/ dry weight ratio,decrease inprotein concentration and neutrophils count inBALF,and improvement of pulmonaryinflammatory changes.A positive correlationwas demonstrated between serum TNF activity and endotoxin level.CONCLUSION Hypersecretion of TNF is shownto be one of the major causes of lung injuryduring ANP;'Tong Xia'purgative method couldalleviate the degree of lung injury mediated byTNF. | Xia Q Jiang JM Gong X Chen GY Li L Huang ZW | 2000 | World Journal of Gastroenterology2000，6，1： | 31 |
| 3 | Recent developments and future prospects of Vitreoscilla hemoglobin application in metabolic engineering显示文摘 | Zhang, L Li, YJ Wang, ZN Xia, Y Chen, WS Tang, KX | 2007 | 中国生物学文摘2007，21，10： | 25 |
| 4 | Human mesenchymal stem cells overexpressing pigment epitheliumderived factor inhibit hepatocellular carcinoma in nude mice(摘要)显示文摘 | Gao, Y Yao, A Zhang, W Lu, S Yu, Y Deng, L Yin, A Xia, Y Sun, B Wang, X | 2010 | 南京医科大学学报(自然科学版)2010，30，8： | 25 |
| 5 | A huge oceanic-type UHP metamorphic belt in southwestern Tianshan, China: Peak metamorphic age and P-T path显示文摘Recent progress in the study of the UHP metamorphic belt in southwestern Tianshan,China,is summarized in this paper.This about 80-km-long and over 10-km-wide UHP belt has been recognized by the discovery of coesite,coesite pseudomorphs and other UHP minerals.It is the largest oceanic-type UHP metamorphic belt reported so far.It has formed due to northward subduction of the Tianshan Paleo-Ocean.U-Pb dating of metamorphic rims of zircons from a coesite-bearing garnet-phengite schist yields a peak UHP metamorphic ages of 320±3.7 Ma.Combined with ages of 233–226 Ma obtained from rims of zircons from retrograded eclogites,a long retrograde metamorphic evolution(>70 Ma)has been revealed.According to phase equilibria modeling,the P-T paths of both coesite-bearing eclogites and garnet-phengite schists are characterized by thermal relaxation,i.e.,the metamorphic temperature peak lags behind the pressure peak,indicating that the UHP rocks experienced slow and long heating and decompression during exhumation in the subduction channel.On the basis of the field observation that a small amount of eclogite lenses is wrapped in large volumes of metapelites,and the similar P-T paths of both rock types,we propose that the exhumation of the UHP eclogites from southwestern Tianshan,China,may have resulted from the exhumation of large volumes of low-density metapelites,which carried the denser eclogites to the Earth’s surface. | ZHANG LiFei DU JinXue Lü Zeng YANG Xin GOU LongLong XIA Bin CHEN ZhenYu WEI ChunJing SONG ShuGuang | 2013 | Chinese Science Bulletin2013，58，35： | 19 |
| 6 | Characterization and Genetic Analysis of a Novel Rice Spotted-leaf Mutant HM47 with Broad-spectrum Resistance to Xanthomonas oryzae pv. oryzae显示文摘A stable inherited rice spotted-leaf mutant HM47 derived from an EMS-induced IR64 mutant bank was identified. The mutant expressed hypersensitive response (HR)-like symptoms throughout its whole life from the first leaf to the flag leaf, without pathogen invasion. Initiation of the lesions was induced by light under natural summer field conditions. Expression of pathogenesis-related genes including PAL, PO-C1, POX22.3 and PBZ1 was enhanced significantly in association with cell death and accumulation of H2O2 at and around the site of lesions in the mutant in contrast to that in the wild-type (WT). Disease reaction to Xanthomonas oryzae pv. oryzae from the Philippines and China showed that HM47 is a broad-spectrum disease-resistant mutant with enhanced resistance to multiple races of bacterial blight pathogens tested. An F2 progeny test showed that bacterial blight resistance to race HB-17 was cosegregated with the expression of lesions. Genetic analysis indicated that the spotted-leaf trait was controlled by a single recessive gene, tentatively named spl HM47 , flanked by two insertion/deletion markers in a region of approximately 74 kb on the long arm of chromosome 4. Ten open reading frames are predicted, and all of them are expressed proteins. Isolation and validation of the putative genes are currently underway. | Bao-Hua Feng Yang Yang Yong-Feng Shi Hai-Chao Shen Hui-Mei Wang Qi-Na Huang Xia Xu Xiang-Guang Lü Jian-Li Wu | 2013 | Journal of Integrative Plant Biology2013，55，5： | 17 |
| 7 | Establishment of hepatocellular carcinoma multidrug resistant monoclone cell line HepG2/mdr1显示文摘multidrug 抵抗(MDR ) 与 mdr1 基因和它的产品 P-glycoprotein 的表示联系了的背景是在癌房间(HCC ) 病人与化疗对待的 hepatocellular 的预后的一个主要因素。我们的学习是建立明确地,与转基因的 mdr1.Methods 的 overexpression 有关, 4.5-kb mdr1 cDNA 从 plasmid pHaMDR1-1 获得了的 multidrug 抵抗的 de novo 获得被克隆进 PCI-neo 哺乳动物的表示向量的一根稳定的 HCC MDR 房间线,后来被 liposome 转移到人的 hepatocarcinoma 房间线 HepG2 。然后,抵抗 G418 的 transfected HepG2 房间被聚类并且有教养并且在这些 HepG2 房间的 mdr1 cDNA, mRNA 和 P-glycoprotein (Pgp ) 的特定的碎片被 PCR, RT-PCR 和流动 cytometry 分别地检测。daunorubicin 的累积同时是由流动 cytometry 的 determinated。grafting 瘤的裸体老鼠模特儿被皮下地在正确腋下注射 HepG2/mdr1 房间建立。当瘤直径到达了 5 公里时, adriamycin 被注入腹洞。瘤的尺寸和生长抑制是 evaluated.Results mdr1 表示向量成功地被构造, MDR HCC 线 HepG2/mdr1 developed.The PCR 分析证明 mdr1 的特定的碎片在 HepG2/mdr1 的 cDNA 房间,然而并非在控制组 HepG2 房间。而且,在 HepG2/mdr1 房间的 mdr1 mRNA 和 Pgp 表示的特定的碎片的内容是(59. | CHEN Yong-bing YAN Mao-lin GONG Jian-ping XIA Ren-pin LIU Li-xin LI Ning LU Shi-chun ZHANG Jing-guang ZENG Dao-bing XIE Jian-guo YANG Jia-yin YAN Lü-nan | 2007 | Chinese Medical Journal2007，，8： | 16 |
| 8 | Association of farnesyl diphosphate synthase polymorphisms and response to alendronate treatment in Chinese postmenopausal women with osteoporosis显示文摘 | Liu Y Li M Zhou PR Xing XP Xia WB Xu L Liu H J Zhang ZL LiaoEY Chen DC Liu J Tao TZ Wu W | 2014 | Chinese Medical Journal2014，，4： | 16 |
| 9 | Chinese herbal medicine for subacute thyroiditis:a systematic review of randomized controlled trials显示文摘OBJECTIVE:To evaluate the effectiveness and safety of Chinese herbal medicine(CHM) in the treatmentofsubacutethyroiditis.METHODS: Randomized controlled trials found in PubMed, Cochrane Library, and three Chinese databases were selected. RevMan 5.2 software was used to analyze the data with relative risk or mean difference, expressed with 95% of confidence interval. The quality of trials was assessed and gradedthe quality of evidence with GRADE profiler software.RESULTS: Twenty one studies were included. CHM was superior to Western Medicine(include prednisone and NSAIDs) in abating fever, relieving thyroid pain, recovering blood sedimentation, improving thyroid function, and preventing hypothyroidism(P<0.05), while no statistical differences were found in eliminating goiter and reducing relapse rate.CHM plusWestern Medicine were superior toWestern Medicine in abating fever, relieving thyroid pain, eliminating goiter, and reducing relapse rate,while no statistical differences(P>0.05) were found in recovering blood sedimentation and improving thyroid function. The incidence of adverse reactions in treatment group was lower than that in control group(relative risk was 0.12 and 95% confidence interval was 0.03-0.51). The methodological quality of trials is generally poor with a high risk of bias.CONCLUSION: CHM(particularly CHM combined withWestern Medicine) used to treat subacute thyroiditis may improve clinical symptoms and signs,reduce relapse rate, and alleviate the side effects of hormones. Due to poor methodological quality of included trials, further more high-quality studies are warranted to confirm the effectiveness and safety of CHM. | Hui Luo Meng Lü Xiaohua Pei Zhongyuan Xia | 2014 | Journal of Traditional Chinese Medicine2014，34，3： | 16 |
| 10 | High expression levels of IKK alpha and IKK beta are necessary for the malignant properties of liver cancer显示文摘IKK-NF-kappa B signaling is regarded as an important factor in hepatocarcinogenesis and a potential target for liver cancer therapy.Therefore,in this study,we analyzed the expression of mRNAs encoding components and targets of NF-kappa B signaling including IKK alpha,IKK beta,RANK,RANKL,OPG,CyclinD3,mammary serine protease inhibitor(Maspin),CyclinD1,c-FLIP,Bcl-x1,Stat3,Cip1 and Cip2 by real-time PCR in 40 patients with liver cancer.After statistical analysis,7 indices including IKK alpha,IKK beta,RANK,Maspin,c-FLIP,Cip2 and cyclinD1 were found to show significant differences between tumor tissue and its corresponding adjacent tissue.When IKK alpha and IKK beta were downregulated in the hepatocellular carcinoma(HCC) cell lines of MHCC-97L and MHCC-97H in vitro,the numbers of BrdU positive cells were decreased in both IKK alpha and IKK beta knockdown cells.Levels of apoptosis were also investigated in IKK alpha and IKK beta knockdown cells.The growth of HCC was inhibited in the subcutaneous implantation model,and lung metastatogenesis was also significantly inhibited in the kidney capsule transplantation model.Downregulation of IKK alpha and IKK beta in HCC cultured in vitro revealed that increased Maspin,OPG and RANKL expression was associated with metastasis of HCC.These findings were associated with downregulation of Bcl-XL and c-FLIP,which may be the reason for increased apoptosis.The therapeutic effect of IKK alpha and IKK beta downregulation depends on extent of NF-kappa B inhibition and the malignant nature of the HCC.We anticipate that IKK-targeted gene therapy can be used in the treatment of HCC,a cancer that is notoriously resistant to radiation and chemotherapy. | Jiang,RQ Xia,YX Li,J Deng,L Zhao,L Shi,J Wang,XH Sun,BC Nanjing Med Univ,Liver Transplantat Ctr,Affiliated Hosp 1,Nanjing,Jiangsu Prov,Peoples R China Nanjing Med Univ,Ctr Canc,Nanjing,Jiangsu Prov,Peoples R China | 2010 | 南京医科大学学报(自然科学版)2010，30，5： | 13 |
| 11 | Comparison of tamsulosin with extracorporeal shock wave lithotripsy in treating distal ureteral stones显示文摘背景 Tamsulosin ,一个 alpha-1 受体对手,被表明了在支持远侧的 ureteral 石头经过并且在减少与学习试图在我们把 314 个病人分到三个范畴的不同 sizes.Methods 在远侧的 ureteral 石头的逐出率上与 nifedipine 和 extracerporeal 冲击波 lithotripsy ( ESWL )比较评估 tamsulosin 的效果的石头 expulsion.This 联系的疼痛有效:,有 4.0-5.9 公里的最大的直径的石头;, 6.0-7.9mm ,并且, 8.0-9.9 mm. | ZHANG Meng-yuan DING Sen-tai Lü Jia-ju LUE Yan-he ZHANG Hui XIA Qing-hua | 2009 | Chinese Medical Journal2009，，7： | 10 |
| 12 | Tidally induced upwelling off Yangtze River estuary and in Zhejiang coastal waters in summer显示文摘MASNUM wave-tide-circulation coupled numerical model (MASNUM coupled model, hereinafter) is de-veloped based on the Princeton Ocean Model (POM). Both POM and MASNUM coupled model are ap-plied in the numerical simulation of the upwelling off Yangtze River estuary and in Zhejiang coastal waters in summer. The upwelling mechanisms are analyzed from the viewpoint of tide, and a new mechanism is proposed. The study suggests that the tidally inducing mechanism of the upwelling in-cludes two dynamic aspects: the barotropic and the baroclinic process. On the one hand, the residual currents induced by barotropic tides converge near the seabed, and upwelling is generated to maintain mass conservation. The climbing of the residual currents along the sea bottom slope also contributes to the upwelling. On the other hand, tidal mixing plays a very important role in inducing the upwelling in the baroclinic sea circumstances. Strong tidal mixing leads to conspicuous front in the coastal waters. The considerable horizontal density gradient across the front elicits a secondary circulation clinging to the tidal front, and the upwelling branch appears near the frontal zone. Numerical experiments are de-signed to determine the importance of tide in inducing the upwelling. The results indicate that tide is a key and dominant inducement of the upwelling. Experiments also show that coupling calculation of the four main tidal constituents (M2, S2, K1, and O1), rather than dealing with the single M2 constituent, im-proves the modeling precision of the barotropic tide-induced upwelling. | L XinGang1,2,3,4, QIAO FangLi1,2, XIA ChangShui1,2 & YUAN YeLi1,2 1 The First Institute of Oceanography, State Oceanic Administration, Qingdao 266061, China 2 Key Laboratory of Marine Science and Numerical Modeling (MASNUM), State Oceanic Administration, Qingdao 266061, China 3 Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China 4 Graduate University of the Chinese Academy of Sciences, Beijing 100039, China | 2007 | Science China Earth Sciences2007，50，3： | 9 |
| 13 | Effect of electroacupuncture on chemotherapy-induced peripheral neuropathy in patients with malignant tumor:a single-blinded,randomized controlled trial显示文摘OBJECTIVE:To evaluate the effect of electroacupuncture on chemotherapy-induced peripheral neuropathy(CIPN), quality of life and immune status of patients with malignant tumors.METHODS:From Jan, 2013 to May, 2014, 37 patients with malignant tumors were included in this prospective single-blinded study, and randomized to receive either electroacupuncture or acupuncture treatment on basis of chemotherapy.The chemotherapy was continued for 2 courses as previous before the treatments, with 21 days as a course of treatment.Patients received acupuncture and electroacupuncture once per day starting at the day before chemotherapy for consecutive 7 days followed by 14 days off, with 21 days as a course of treatment, and continued for two courses of treatment.Then CIPN, traditional Chinese clinical symptoms,quality of life and immune status were all evaluated for each patient prior treatment and after two courses of treatment.RESULTS:The gender, age, cancer species as well as incidence(83.3% vs 84.2%) and grades of CIPN before treatments were all similar in patients receiving acupuncture or electroacupuncture(all P >0.05).After treatments, most patients with peripheral neuropathy were cured by two courses of electroacupuncture(84.2% vs 21.1%), whereas the other group of patients had similar incidences of peripheral neuropathy compared with prior-acupuncture(83.3% vs 72.2%).Besides, patients receiving electroacupuncture had lower incidence of peripheral neuropathy than those receiving acupuncture treatment(χ~2= 9.745, P = 0.002).The grades of peripheral neuropathy were significantly different in the two groups post-treatment(χ~2= 13.983, P =0.007).The total effective rates for traditional Chinese clinical symptoms were 16.7% and 84.2% in acupuncture and electroacupuncture groups, respectively(Z =-4.239, P < 0.001).The electroacupuncture treatment provided a more satisfactory life for patients compared with acupuncture(Z =-4.76, P < 0.001).Both electroacupuncture and acupuncture had no effects on immune function.CONCLUSION:Electroacupuncture could alleviate CIPN, and improve traditional Chinese clinical symptoms and quality of life, but did not affect immune function. | Zhang Shiqiang Wu Tingting Zhang Haisheng Yang Yun Jiang Haiyan Cao Shengcheng Xie Fang Xia Xiaoting Lü Junqiang Zhong Yi | 2017 | Journal of Traditional Chinese Medicine2017，37，2： | 7 |
| 14 | Osteopontin gene polymorphism in association with systemic lupus erythematosus in Chinese patients显示文摘背景 Osteopontin ( OPN )是能在支持 T 淋巴细胞的激活起很多个作用的一个种 cytokine ,调整在 Th1 和 Th2 之间的平衡,参予导致房间的 immunologic 反应并且刺激 B 淋巴细胞表示多克隆 antibodies.Some 研究证明了 OPN 可以涉及这研究的 .The 目的是在位置 9250 点调查单个核苷酸多型性( SNP )的可能的协会在里面的全身的豺狼座 erythematosus ( SLE ) | XU An-ping BAI Jie Lü Jun LIANG Yan-yi LI Jin-gao LAI De-yuan WAN Xia HUANG Hu-hui | 2007 | Chinese Medical Journal2007，，23： | 6 |
| 15 | 二甲双胍通过沉默MATE1表达富集在细胞内选择性抑制KRAS突变转移性结肠癌显示文摘结肠癌(CRC)是常见癌症之一,转移是导致死亡的主要原因。近期研究发现一线化疗药物伊立替康或奥沙利铂联合表皮生长因子受体(EGFR)靶向药物可将转移性结直肠癌(mCRC)患者中位总体生存期提高2年以上。然而,KRAS突变的结肠癌患者(约30%~50%)表现对EGFR靶向药物的耐药性。因此,EGFR靶向药物不能用于KRAS突变的mCRC患者治疗。前期多项研究指出二甲双胍具有抗肿瘤作用,且服用二甲双胍与患者良好预后密切相关。然而,多项回顾性研究发现二甲双胍与癌症患者预后不相关,关于二甲双胍对肿瘤的治疗作用及分子机制尚存在诸多问题和分歧。 | 安华英(编译) Xie J Xia L Xiang W | 2020 | 中华医学杂志2020，100，32： | 5 |
| 16 | Multi-length scale bioprinting towards simulating microenvironmental cues显示文摘 | Elisabeth L Gill Xia Li Mark A. Birch Yan Yan Shery Huang | 2018 | Bio-Design and Manufacturing2018，1，2： | 4 |
| 17 | QTL effects and epistatic interaction for flowering time and branch number in a soybean mapping population of Japanese×Chinese cultivars显示文摘Flowering time and branching type are important agronomic traits related to the adaptability and yield of soybean. Molecular bases for major flowering time or maturity loci, E1 to E4, have been identified. However, more flowering time genes in cultivars with different genetic backgrounds are needed to be mapped and cloned for a better understanding of flowering time regulation in soybean. In this study, we developed a population of Japanese cultivar(Toyomusume)×Chinese cultivar(Suinong 10) to map novel quantitative trait locus(QTL) for flowering time and branch number. A genetic linkage map of a F_2 population was constructed using 1 306 polymorphic single nucleotide polymorphism(SNP) markers using Illumina Soy SNP8 ki Select Bead Chip containing 7 189(SNPs). Two major QTLs at E1 and E9, and two minor QTLs at a novel locus, qFT2_1 and at E3 region were mapped. Using other sets of F_2 populations and their derived progenies, the existence of a novel QTL of qFT2_1 was verified. qBR6_1, the major QTL for branch number was mapped to the proximate to the E1 gene, inferring that E1 gene or neighboring genetic factor is significantly contributing to the branch number. | YANG Guang ZHAI Hong WU Hong-yan ZHANG Xing-zheng LüShi-xiang WANG Ya-ying LI Yu-qiu HU Bo WANG Lu WEN Zi-xiang WANG De-chun WANG Shao-dong Kyuya Harada XIA Zheng-jun XIE Fu-ti | 2017 | Journal of Integrative Agriculture2017，16，9： | 3 |
| 18 | Identification and Genetic Analysis of a Novel Rice Spotted-Leaf Mutant with Broad-Spectrum Resistance to Xanthomonas oryzae pv. oryzae显示文摘A spotted-leaf mutant of rice HM143 was isolated from an EMS-induced IR64 mutant bank. Brown lesions randomly distributed on leaf blades were observed about 3 wk after sowing. The symptom lasted for the whole plant growth duration. Histochemical analysis indicated that cell death occurred in and around the site of necrotic lesions accompanied with accumulation of hydrogen hyperoxide. Agronomic traits were largely similar to the wild type IR64 except seed setting rate and 1 000-grain weight which were significantly decreased in the mutant. Disease resistance of the mutant to multiple races of Xanthomonas oryzae pv. oryzae was significantly enhanced. Genetic analysis showed that the mutation was controlled by a single recessive gene, tentatively termed splHM143. In addition, using molecular markers and 1 023 mutant type individuals from an F2 segregating population derived from the cross HM143/R9308, the spotted-leaf gene was finally delimited to an interval of 149 kb between markers XX25 and ID40 on the long arm of chromosome 4. splHM143 is likely a novel rice spotted-leaf gene since no other similar genes have been identified near the chromosomal region. | SHEN Hai-chao SHI Yong-feng FENG Bao-hua WANG Hui-mei XU Xia HUANG Qi-na Lü Xiang-guang WU Jian-li | 2014 | Journal of Integrative Agriculture2014，13，4： | 3 |
| 19 | Establishment and validation of a model for brain injury state evaluation and prognosis prediction显示文摘Purpose:Traumatic brain injury(TBI)is one of the leading causes of disability and death in modern times,whose evaluation and prognosis prediction have been one of the most critical issues in TBI management.However,the existed models for the abovementioned purposes were defective to varying degrees.This study aims to establish an ideal brain injury state clinical prediction model(BISCPM).Methods:This study was a retrospective design.The six-month outcomes of patients were selected as the end point event.BISCPM was established by using the split-sample technology,and externally validated via different tests of comparison between the observed and predicted six-month mortality in validating group.TBI patients admitted from July 2006 to June 2012 were recruited and randomly divided into establishing model group and validating model group.Twenty-one scoring indicators were included in BISCPM and divided into three parts,A,B,and C.Part A included movement,pupillary reflex and diameter,CT parameters,and secondary brain insult factors,etc.Part B was age and part C was medical history of the patients.The total score of part A,B and C was final score of BISCPM.Results:Altogether 1156 TBI patients were included with 578 cases in each group.The score of BISCPM from validating group ranged from 2.75 to 31.94,averaging 13.64±5.59.There was not statistical difference between observed and predicted mortality for validating group.The discrimination validation showed that the BISCPM is superior to international mission for prognosis and analysis of clinical trials(IMPACT)lab model.Conclusion:BISCPM is an effective model for state evaluation and prognosis prediction of TBI patients.The use of BISCPM could be of great significance for decision-making in management of TBI. | Xia Li Chao Lü Jun Wang Yi Wan Shu-Hui Dai Lei Zhang Xue-An Hu Xiao-Fan Jiang Zhou Fei | 2020 | Chinese Journal of Traumatology2020，23，5： | 3 |
| 20 | Evaluation of non-typical diffuse axonal injury by magnetic resonance techniques显示文摘Because diffuse axonal injury (DAI) lacks specific clinical manifestations, it is difficult to evaluate DAI using computer tomography or conventional magnetic resonance imaging (MRI). This study investigated the value of magnetic resonance techniques using fluid-attenuated inversion recovery (FLAIR) and proton magnetic resonance spectroscopy (1HMRS) for diagnosing DAI. The corpus callosum and basal nuclei were analyzed using morphological and functional imaging. Similar to the DAI group, the non-typical DAI group exhibited similar lesion characteristics on FLAIR, as well as post-injury neurochemical and molecular changes in the corpus callosum, as detected by 1HMRS. However, there were differences in degree and severity of injury. Compared to conventional MRI, FLAIR significantly increased lesion detection. 1HMRS determined biochemical metabolism changes in midline structures following DAI, which resulted in increased diagnosis of non-typical DAI, which displayed similar lesion distribution, morphology, and function as DAI. Thus, the experiment proved the value of FLAIR and 1HMRS in non-typical DAI. | Haijian Xia Xiaochuan Sun Zongduo Guo Weidong Fang Fajin Lü Haitao Wu Tianyou Luo Wenyuan Tang | 2010 | Neural Regeneration Research2010，5，17： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员