| 1 | Osteogenesis and angiogenesis of a bulk metallic glass for biomedical implants显示文摘Implantation is an essential issue in orthopedic surgery.Bulk metallic glasses(BMGs),as a kind of novel materials,attract lots of attentions in biological field owing to their comprehensive excellent properties.Here,we show that a Zr_(61)Ti_(2)Cu_(25)Al_(12)(at.%)BMG(Zr-based BMG)displays the best cytocompatibility,pronounced positive effects on cellular migration,and tube formation from in-vitro tests as compared to those of commercial-pure titanium and poly-ether-ether-ketone.The in-vivo micro-CT and histological evaluation demonstrate the Zr-based BMG can significantly promote a bone formation.Immunofluorescence tests and digital reconstructed radiographs manifest a stimulated effect on early blood vessel formation from the Zr-based BMG.Accordingly,the intimate connection and coupling effect between angiogenesis and osteogenesis must be effective during bone regeneration after implanting Zr-based BMG.Dynamic gait analysis in rats after implanting Zr-based BMG demonstrates a tendency to decrease the pain level during recovery,simultaneously,without abnormal ionic accumulation and inflammatory reactions.Considering suitable mechanical properties,we provide a realistic candidate of the Zr61Ti2Cu25Al12 BMG for biomedical applications. | K.Sun R.Fu X.W.Liu L.M.Xu G.Wang S.Y.Chen Q.J.Zhai S.Pauly | 2022 | Bioactive Materials2022，7，2： | 1 |
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