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| 1 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
| 2 | Monitoring microbial biomass and respiration in different soils from the Czech Republic:a summary of results显示文摘 | JAKUB H LADISLAV D JANA K | 2004 | Environment International2004，，30： | 1 |
| 3 | Can viable pollen carry Scots pine genes over long distances? 显示文摘 | Lindgren D Ladislav P Shen X H | 1995 | Grana1995，34，1： | 1 |
| 4 | Methods for Isolationof Streptoverticillia from Soils显示文摘 | LADISLAV J H RONDADS | 1988 | J Antibiot1988，41，4： | 1 |
| 5 | Development of LC-MS method for determination of ursolic acid:application to the analysis of ursolic acid in staphylea holocarpa hemsl显示文摘 | Ladislav N Mohammed E A-H Hoda H | | 0，，： | 1 |
| 6 | Methods for isolation of Streptoverticillia from Soils显示文摘 | LADISLAV F H RONDA D S | 1988 | J Antibiot1988，41，4： | 1 |
| 7 | Role of reactive oxygen spe cies-generating enzymes and hydrogen peroxide during cadmi urn,mercury and osmotic stresses in barley root tip 显示文摘 | Ladislav T Igor M Jana H | 2010 | Planta2010，231，： | 1 |
| 8 | 3D fourth order stag gered-grid finite-difference schemes: stability and grid dispersion 显示文摘 | Peter M Jozef K Ladislav H | 2000 | Bulletin of the Seismological So- ciety of America2000，90，3： | 1 |
| 9 | On elliptical model for forest fire spread modeling anti simulation 显示文摘 | JAN G LADISLAV H | 2008 | Matbematics and Cnmputers in Simulation2008，78，： | 1 |
| 10 | Structural characterization of photosystem 1] complex from red alga porphyridium cruentum retaining extrinsic subunits of the oxygen-evolving complex 显示文摘 | Ladislav B Helena H D Michal H | 2005 | European Journal of Bio- chemist2005，271，14： | 1 |
| 11 | Structural characterization of photosystem II complex from red alga porphyridium cruentum retaining extrinsic subunits of the oxygen-evolving complex显示文摘 | Ladislav B Helena H D Michal H | 2005 | European Journal of Biochemist2005，271，： | 1 |
| 12 | Interactions between soil development, vegetation and soil fauna during spontaneous succession in post mining sites显示文摘 | Jan Frouz Karel Prach Václav Pi?l Ladislav Háněl Josef Stary Karel Tajovsky Jan Materna Vladimír Balík Ji?í Kal?ík Klára ?ehounková | 2007 | European Journal of Soil Biology2007，，1： | 1 |
| 13 | Structural characterization of photosystem Ⅱ complex from red alga porphyridium cruentum retaining extrinsic subunits of the oxygen-evolving complex Eur显示文摘 | Ladislav B Helena H D Michal H | 2005 | Biochemist2005，271，： | 1 |
| 14 | Development of LC-MS method for determination of ursolic acid: application to the analysis of ursolic acid in staphylea holocarpa hemsl 显示文摘 | Ladislav N Mohammed E A-H Hoda H | 2003 | Journal of Pharmaceutical and Biomedical Analysis2003，31，： | 1 |
| 15 | Lobster All-sky Monitor显示文摘 | Libor S Rene H Ladislav P | 2004 | SPIE2004，5539，： | 1 |
| 16 | Inhibition of A1-induced root elongation and enhancement of A1-induced peroxidase activity in A1-sensitive and A1-resistant barley cultivars are positively correlated显示文摘 | Ladislav T Jana H Igor M | 2003 | Plant and Soil2003，250，： | 1 |
| 17 | Development of soil nematode communities on coal-mining dumps in two different landscapes and reclamation practices 显示文摘 | Ladislav H nel | 2002 | European Journal of Soil Biology2002，38，： | 1 |
| 18 | Preparation and crossing of basidiospore-derlved monokaryons-a useful tool for obtaining laccase and other liguinolytic enzyme higher-producing dikaryotie strains of Pleurotus ostreatus 显示文摘 | Ivana E Ladislav H | 1999 | Antonie van Leeuwenhoek1999，75，： | 1 |
| 19 | Monitoring microbial bio mass and respiration in differentsoils from the Czech Re- public: A summary of results显示文摘 | Jakub H Ladislav D Jana K | 2004 | Environment Interna- tional2004，30，1： | 1 |
| 20 | Large AreaDeposition of Boron Doped Nano-crystalline Diamond Filmsat Low Temperatures Using Microwave Plasma EnhancedChemical Vapour Deposition with Linear Antenna Delivery显示文摘 | ANDREW T LADISLAV F PAVEL H | 2014 | Diamond and Related Materials2014，47，： | 1 |
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