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| 1 | TLR3 activation induces S100A7 to regulate keratinocyte differentiation after skin injury显示文摘Human S100A7 (psoriasin) is highly expressed in psoriasis and other inflammatory diseases; however, the function of S100A7 in wound repair remains largely unknown. Here we demonstrated that skin injury increased the expression of S100A7. Damaged cells from wounded skin induced the expression of S100A7 via the activation of Toll-like receptor 3 (TLR3) followed by the activation of p38 MAPK. S100A7, in turn, acted on keratinocytes to induce the expression of terminal differentiation marker gene loricrin through the activation of p38 MAPK and caspase-1. The differentiation of keratinocytes induced by S100A7 resulted in skin stratification, thus efficiently promoting wound closure. Taken together, our results demonstrate that the activation of TLR3 accelerates wound closure via the induction of S100A7 to induce keratinocyte differentiation. These findings also provide new insights into the development of different forms of treatment with skin wounds. | Hu Lei Yue Wang Tian Zhang Leilei Chang Yelin Wu Yuping Lai | 2017 | Science China(Life Sciences)2017，60，2： | 3 |
| 2 | Variational Bayesian Inference for Finite Inverted Dirichlet Mixture Model and Its Application to Object Detection显示文摘As a variant of Finite mixture model(FMM), finite Inverted Dirichlet mixture model(IDMM)can not avoid the conventional challenges, such as how to select the appropriate number of mixture components based on the observed data. Towards easing these issues,we propose a variational inference framework for learning IDMM which has been proved to be an efficient tool for modeling vectors with positive elements. Compared with the conventional Expectation maximization(EM) algorithm commonly used for learning FMM, the proposed approach prevents over-fitting well. Furthermore, it is able to do automatic determination of the number of mixture components and parameters estimation, simultaneously.Experimental results on both synthetic and real data of object detection confirm significant improvements on flexibility and efficiency being achieved. | LAI Yuping PING Yuan HE Wenda WANG Baocheng WANG Jingzhong ZHANG Xiufeng | 2018 | Chinese Journal of Electronics2018，27，3： | 2 |
| 3 | AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense显示文摘 | Yuping Lai Richard L. Gallo | 2009 | Trends in Immunology2009，，： | 1 |
| 4 | Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury显示文摘 | Yuping Lai Anna Di Nardo Teruaki Nakatsuji | 2009 | Nature Medicine2009，15，12： | 1 |
| 5 | AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense显示文摘 | Yuping Lai Richard L. Gallo | 2009 | Trends in Immunology2009，，3： | 1 |
| 6 | The Antimicrobial Protein REG3A Regulates Keratinocyte Proliferation and Differentiation after Skin Injury显示文摘 | Yuping Lai Dongqing Li Changwei Li Beda Muehleisen Katherine A. Radek Hyun Jeong Park Ziwei Jiang Zhiheng Li Hu Lei Yanchun Quan Tian Zhang Yelin Wu Paul Kotol Shin Morizane Tissa R. Hata Keiji Iwatsuki Ce Tang Richard L. Gallo | 2012 | Immunity2012，，1： | 1 |
| 7 | Sparse signal reconstruction via generalized two-stage thresholding显示文摘Dear editor,The sparse representation model has received a great amount of attention in various signal and image processing applications.Compressed sensing(CS)[1]has consistently focused on devising sparse representation methods that seek to efficiently reconstruct a k-sparse(only k nonzero entries,k< | Heping SONG Zehong AI Yuping LAI Hongying MENG Qirong MAO | 2022 | Science China(Information Sciences)2022，65，3： | 0 |
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