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| 1 | Impact of CYP3A4*1G Polymorphism on Fentanyl Analgesia Assessed by Analgesia Nociception Index in Chinese Patients Undergoing Hysteroscopy显示文摘Background:The clinical efficacy of fentanyl for pain control differs greatly across individuals.The purpose of this study was to investigate the impact of CYP3A4*1G polymorphism including wild-type homozygote (CYP3A4*1/*1,GG),mutant heterozygote (CYP3A4*1/*1G,GA),and mutant homozygote (CYP3A4*1G/*1G,AA)on fentanyl analgesia in Chinese patients undergoing hysteroscopy by the assessment of analgesia nociception index (ANI). Methods:A total of 200 gynecologic patients scheduled for elective hysteroscopy under general anesthesia at Peking University People's Hospital from May to December in 2017 were enrolled in this study.Venous blood was withdrawn for genotyping of CYP3A4*1G before operation.Fentanyl 1μg/kg was administered preoperatively followed by target-controlled infusion of propofol for induction and maintenance.Intraoperative analgesic efficacy of fentanyl was assessed by ANI monitoring at T0(entering room),T1(cervical dilation), T2(start of cervical aspiration),and T3(end of cervical aspiration)time points.The duration of propofol infusion and total dosage of propofol were recorded as well. Results:The patients were divided into three groups according to CYP3A4*1G polymorphism,including 143 in GG group,47in GA group, and 10 in AA group.There was no significant difference in clinical demographics among three groups.The frequency of CYP3A4*1G variant alleles accounted for 16.8%and the distribution of variant alleles was consistent with Hardy-Weinberg equilibrium.Using a multilevel model,ANI values at T1(63.81±19.61),T2(63.63±17.82),and T3(65.68±17.79)were significantly lower than that at T0 (77.16±12.93)in the study population (F =23.50,P <0.001),suggesting that higher levels of pain at T 1,T2,and T3 than T0.Patients with GG genotype showed significantly lower ANI than those with GA or AA genotypes during hysteroscopy under the same dose of fentanyl. Conclusion:CYP3A4*1G polymorphism associated with the analgesic efficacy of intraoperative fentanyl in the patients undergoing hysteroscopy under general anesthesia. | Qi Yan Yi Su Lan Gao Nan Ding Hong-Ying Zhang Wen E Yue Wang Yi Feng Hai-Yan An | 2018 | Chinese Medical Journal2018，，22： | 8 |
| 2 | Enterolithiasis显示文摘Enterolithiasis or formation of gastrointestinal concretions is an uncommon medical condition that develops in the setting of intestinal stasis in the presence of the intestinal diverticula,surgical enteroanastomoses,blind pouches,afferent loops,incarcerated hernias,small intestinal tumors,intestinal kinking from intra-abdominal adhesions,and stenosing or stricturing Crohn’s disease and intestinal tuberculosis.Enterolithiasis is classified into primary and secondary types.Its prevalence ranges from 0.3%to 10%in selected populations.Proximal primary enteroliths are composed of choleic acid salts and distal enteroliths are calcified.Clinical presentation includes abdominal pains,distention,nausea,and vomiting of occasionally sudden but often fluctuating subacute nature which occurs as a result of the enterolith tumbling through the bowel lumen.Thorough history and physical exam coupled with radiologic imaging helps establish a diagnosis in a patient at risk.Complications include bowel obstruction,direct pressure injury to the intestinal mucosa,intestinal gangrene,intussusceptions,afferent loop syndrome,diverticulitis,iron deficiency anemia,gastrointestinal hemorrhage,and perforation.Mortality of primary enterolithiasis may reach 3%and secondary enterolithiasis 8%.Risk factors include poorly conditioned patients with significant obstruction and delay in diagnosis.Treatment relies on timely recognition of the disease and endoscopic or surgical intervention.With advents in new technology,improved outcome is expected for patients with enterolithiasis. | Grigoriy E Gurvits Gloria Lan | 2014 | World Journal of Gastroenterology2014，20，47： | 2 |
| 3 | Laboratory evaluation of the GreenSeeker^(TM) handheld optical sensor to variations in orientation and height above canopy显示文摘Handheld optical sensors recently have been introduced to the agricultural market.These handheld sensors are able to provide operators with Normalized Difference Vegetative Index(NDVI)data when cloud cover prevents acquisition of satellite or aerial images.This research addressed the sensitivity of the GreenSeeker handheld optical sensor to changes in orientation and height above a ryegrass canopy.Planter boxes were oriented both parallel and perpendicular to the light beam from the sensor head and heights of 30.5 cm(12”),61.0 cm(24”),91.5 cm(36”),122 cm(48”)and 152 cm(60”)were tested.Results indicated that the sensor was highly sensitive(P<0.0001)to both height above canopy and orientation of the sensor relative to the target.Operators should follow manufacturer’s recommendations on operating height range of 81-122 cm and orient the sensor head in-line with the target to obtain maximum signal response. | Daniel E Martin Juan D Lopez Jr Yubin Lan | 2012 | International Journal of Agricultural and Biological Engineering2012，5，1： | 2 |
| 4 | Use of genetic mouse models in the study of diabetic nephropathy显示文摘 | Allen T J Cooper M E Lan H Y | 2004 | Curr Diab Rep2004，4，6： | 1 |
| 5 | Predicting strangulated small bowel obstruction:An old problem revisited显示文摘 | Tim J Lan T Vu Alexandra E | 2008 | Gastrointest Surg2008，13，1： | 1 |
| 6 | In-situ test of soil-root systems显示文摘 | Wu T H Beal P E Lan C | 1988 | Journal of Geotechnical Engineering ASCE1988，114，12： | 1 |
| 7 | Entrepreneurial competencies and the performance of small and medium enterprises: an investi- gation through a framework of competitiveness 显示文摘 | Man T Lan T Snape E | 2008 | Journal of Small Business and Entrepreneurship2008，21，3： | 1 |
| 8 | Fetal growth and the physiological control of glucose tolerance in adults: a minimal model analysis显示文摘 | Daniel E Vivienne M lan F | 2000 | Am J Physiol Endocrinol Metab2000，278，： | 1 |
| 9 | Highperformance polymer heterojunction solar cells of a polysilafluorene derivative显示文摘 | Wang E G Wang L Lan L F | 2008 | Applied Physics Letters2008，92，3： | 1 |
| 10 | Translocation of XRCC1and DNA ligaseⅢαfrom centrosomes to chromosomes in response to DNA damage in mitotic human cells显示文摘 | Okano S Lan L Tomkinson A E | 2005 | Nucleic Acids Res2005，33，1： | 1 |
| 11 | Parenteral nutrition impairs gut-associated lymphoid tissue and mucosal immunity by reducing lymphotoxin Beta receptor expression 显示文摘 | KANG W GOMEZ F E LAN J | 2006 | Ann Surg2006，244，3： | 1 |
| 12 | The clinically inapparent adrenal mass : update in diagnosis and management 显示文摘 | Mansmann G Lan J Balk E | 2004 | Endocr Rev2004，25，2： | 1 |
| 13 | Intra - abdominal hypertension in medical critically ill patients:a narrative review显示文摘 | Ortiz - Diaz E Lan CK | 2014 | Shock2014，41，3： | 1 |
| 14 | Nitrogen digestion and metabolism in sheep consuming diets containing contrasting forms and levels of nitrogen显示文摘 | Siddons R E No lan J V Boever D E | 1985 | British Journal of Nutrition1985，54，： | 1 |
| 15 | High serum oestradiol concentrations in fresh IVF cycles do not impair implantation and pregnancy rates in subsequent frozen-thawed embryo transfer cycles显示文摘 | YU-NG E H YEUNG W S YEE LAN LAU E | 2000 | Hum Reprod2000，15，2： | 1 |
| 16 | Activation of the NF-κB pathway in human cytomegalovirus-infected cells is necessary for efficient transactivation of the major immediate-early promoter显示文摘 | lan B De Meritt Liesl E | 2004 | J Virol2004，78，9： | 1 |
| 17 | Driving forces enable high-titer anaerobic 1-butanol synthesis in Escherichia coli 显示文摘 | Shen C R Lan E I Dekishima Y | 2011 | Appl Environ Microbio12011，77，9： | 1 |
| 18 | International Accounting Standards and Accounting Quality显示文摘 | Barth M E Landsman W R Lan M H | 2008 | Journal of Accounting Research2008，46，3： | 1 |
| 19 | A novol assay for cobalt- albumin binding and its potential as a marker tor myocardial ischemia-a preliminary report显示文摘 | BAR-OR D LAN E WINKLER J V | 2000 | J Emtry Med2000，19，： | 1 |
| 20 | A rapid decline in serum estradiol concentrations around the mid - luteal phase had no adverse effect on outcome in 763 assisted reproduction cycles 显示文摘 | Hung Yu Ng E Shu Biu Yeung W Yee Lan Lau E | 2000 | Hum Reprod2000，15，9： | 1 |
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