维普期刊资源整合服务平台（V6.5）

37篇 您的检索式：作者名="LAWRENCE David J"

选中清除导出查看参考文献查看引证文献引用追踪共2页首页上一页第1页下一页末页 /2 跳转

	题名	作者	年代	出处	被引量
1	Involvement of eicosanoids in the pathogenesis of pancreatic cancer: the roles of cyclooxygenase-2 and 5-lipoxygenase显示文摘The interplay between inflammation and cancer progression is a growing area of research. A combination of clinical, epidemiological, and basic science investigations indicate that there is a relationship between inflammatory changes in the pancreas and neoplastic progression. Diets high in ω-6 polyunsaturated fatty acids provide increased substrate for arachidonic acid metabolism by cyclooxygenase-2(COX-2) and 5-lipoxygenase(5-LOX) to form eicosanoids. These eicosanoids directly contribute to pancreatic cancer cell proliferation. Both COX-2 and 5-LOX are upregulated in multiple cancer types, including pancreatic cancer. In vitro studies using pancreatic cancer cell lines have demonstrated upregulation of COX-2 and 5-LOX at both the mRNA and protein levels. When COX-2 and 5-LOX are blocked via a variety of mechanisms, cancer cell proliferation is abrogated both in vitro and in vivo.The mechanism of COX-2 has been shown to include effects on apoptosis as well as angiogenesis. 5-LOX has been implicated in apoptosis. The use of COX-2 and 5-LOX inhibitors in clinical studies in patients with pancreatic cancer has been limited. Patient enrollment has been restricted to those with advanced disease which makes evaluation of these drugs as chemopreventive agents difficult. COX-2 and 5-LOX expression have been shown to be present during the early neoplastic changes of pancreatic cancer, well before progression to invasive disease. This indicates that the ideal role for these interventions is early in the disease process as preventive agents, perhaps in patients with chronic pancreatitis or hereditary pancreatitis.	Lawrence M Knab Paul J Grippo David J Bentrem	2014	World Journal of Gastroenterology2014，20，31：	9
2	Management of the Open Abdomen: From Initial Operation to Definitive Closure显示文摘	Vargo Daniel Richardson J David Campbell Andre Chang Michael Fabian Timothy Franz Michael Kaplan Mark Moore Frederick Reed R Lawrence Scott Bradford Silverman Ronald	2009	The American Surgeon2009，，11：	2
3	Evaluation of downsteam effects of speciality chemicals in the Bayer process显示文摘	David O O Lawrence J C	1991	Light Metals1991，，：	1
4	Empathy and enduring depersonalization: The role of self-related processes显示文摘	Lawrence E J Shaw P Baker D Patel M Sierra-Siegert M Medford N David A S	2007	Social Neuroscience2007，，2：	1
5	The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial显示文摘	Colin Baigent Martin J Landray Christina Reith Jonathan Emberson David C Wheeler Charles Tomson Christoph Wanner Vera Krane Alan Cass Jonathan Craig Bruce Neal Lixin Jiang Lai Seong Hooi Adeera Levin Lawrence Agodoa Mike Gaziano Bertram Kasiske Robert Wal	2011	The Lancet2011，，9784：	1
6	Chromium:friend or foe显示文摘	David J Porter Lawrence W Raymond Geraldine D Anastasio	1999	Archives of Family Medicine1999，8，5：	1
7	Evaluation of downstream effects of specialty chemicals in the Bayer process显示文摘	David O O Lawrence J C Peter A D Anthony E G Nancy L P	1991	Light Metals1991，，：	1
8	Global health 2035: a world converging within a generation显示文摘	Dean T Jamison Lawrence H Summers George Alleyne Kenneth J Arrow Seth Berkley Agnes Binagwaho Flavia Bustreo David Evans Richard G A Feachem Julio Frenk Gargee Ghosh Sue J Goldie Yan Guo Sanjeev Gupta Richard Horton Margaret E Kruk Adel Mahmoud Linah K Mo	2013	2013 (9908)2013，，9908：	1
9	Inhibitors of hepatitis C virus NS3·4A protease. Part 3: P 2 proline variants显示文摘	Robert B Perni Luc J Farmer Kevin M Cottrell John J Court Lawrence F Courtney David D Deininger Cynthia A Gates Scott L Harbeson Joseph L Kim Chao Lin Kai Lin Yu-Ping Luong John P Maxwell Mark A Murcko Janos Pitlik B.Govinda Rao Wayne C Schairer Roger D T	2004	Bioorganic & Medicinal Chemistry Letters2004，，8：	1
10	Low-dose compared with standard-dose m-BACOD chemotherapy for non-Hodgkin's lymphoma associated with human immunodeficiency virus infection显示文摘	Kaplan MD Lawrence D David J	1997	N Engl J Med1997，336，23：	1
11	MLH1 ‐silenced and non‐silenced subgroups of hypermutated colorectal carcinomas have distinct mutational landscapes显示文摘	Lawrence A Donehower Chad J Creighton Nikolaus Schultz Eve Shinbrot Kyle Chang Preethi H Gunaratne Donna Muzny Chris Sander Stanley R Hamilton Richard A Gibbs David Wheeler	2012	J Pathol2012，，1：	1
12	Stress and strain 显示文摘	NEEBEL Danial J BLAND INO Joseph R LAWRENCE David J	2002	College of Integrated Science and Technology Jam esM adison University2002，，：	1
13	Evaluation of downsteam effects of specialty chemicals in the bayer process显示文摘	David O O Lawrence J C	1991	Light Metals1991，，：	1
14	Varia tion of shoot morphology and bifurcation ratio in sugar maple ( Acer sac charum ) saplings显示文摘	DAVID A STEINGRAEBER LAWRENCE J	1979	American Journal of Botany1979，66，4：	1
15	Electric stimula-tion as an adjunct to heal diabetic foot ulcers i A Ran-domized Clinical Trial 显示文摘	Edgar J Lawrence A David G	2001	Arch Phys Med Rehabil2001，82，：	1
16	Stress and strain显示文摘	NEEBEL Danial J BLANDINO Joseph R LAWRENCE David J	2002	College of Integrated Science and Technology James Madison University2002，20，2：	1
17	Adaptive anomaly detection in transaction-oriented network显示文摘	David J Cacuto Symeon Papavassiliou Anthony G Zawdzki	2001	Journal of Network and Systems Management2001，9，1：	1
18	The gold deposit in metamorphic rocks in Alska显示文摘	Goldfarb R J Lance D Miller David L L Lawrence W S	1997	Economic Geology1997，，9：	1
19	Anomaly deteclion from hyperspeetral Imagery显示文摘	David W J Stein Scott G Beaven Lawrence E Hoff	2002	IEEE Signal Processing Magazine2002，，：	1
20	Articular fractures of the distal part of the humerus 显示文摘	DAVID R JESSE B J LAWRENCE G	2003	J Bone Joint Sury(AM)2003，85，1：	1

返回顶部每页显示：

共2页首页上一页第1页下一页末页 /2 跳转

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

用户提示