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	题名	作者	年代	出处	被引量
1	脑缺血后N-myc下游调控基因2保护血脑屏障完整性显示文摘脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAO)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAO后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAO后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。	Takarada-Iemata M Yoshikawa A Ta HM Okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M Hori O 聂昊	2018	神经损伤与功能重建2018，13，4：	4
2	Secoviridae:a proposed family of plant viruses within the order Picornavirales that combines the families Sequiviridae and Comoviridae,the unassigned genera Cheravirus and Sadwavirus and the proposed genus Torradovirus显示文摘	SANFACON H WELLINK J LE GALL O	2009	Archives of Virol2009，，154：	1
3	Molecular variation in the nucleoprotein gene(ORF7) of the porcine reproductive and respiratory syndrome virus (PRRSV)显示文摘	Le Gall A L Legeay O Bourhy H	1998	Virus Research1998，54，1：	1
4	Modulation of liver injury by interleukin-10 显示文摘	Louis H Le Moine O Goldman M	2003	Acta Gastroenterol Belg2003，66，1：	1
5	The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘	International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M	2010	Science2010，330，6010：	1
6	Modulation of Liver Injury by Interleukin-10 显示文摘	Louis H Le Moine O Goldman M	2003	Acta Gastroenterol Belg2003，66，1：	1
7	Cold liver ischemia reperfusion injury critically depends on liver T cells and is improved by donor pretreatment with interleukin 10 in mice显示文摘	Le Moine O Louis H Demols A	2000	Hepatology2000，31，6：	1
8	Molec- ular and biological characterization of Lettuce mosaic virus (LMV) isolates reveals a distinct and widespread type of resistance-breaking isolate : LMV-Most 显示文摘	Krause-Sakate R Le Gall O Fakhfakh H	2002	Phytopatholo- gy2002，92，：	1
9	Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03) 显示文摘	Le Clerc S Limou S Coulonges C Carpentier W Dina C Taing L Delaneau O Labib T Sladek R ANRS Genomic Group Deveau C Guillemain H Ratsimandresy R Montes M Spadoni JL Therwath A Schichter F Matsuda F Gut I Leli6vre JD L6vy Y Froguel P Delfraissy JF Hercberg S Zagury JF	2009	Infect Dis2009，200，8：	1
10	Cold liver ischemia-reperfusion injury critically depends on liver T cells and is improved by donor pretreatment with interleukin 10 in miee显示文摘	Le Moine O Louis H Demols A Desalle F Demoor F Quertinmont E	2000	Hepatology2000，31，：	1
11	Cold liver ischemia/reperfusion injury critically depends on liver T cells and is improved by donor pre- treatment with interleukin 10 in mice显示文摘	Le Moine O Louis H Demols A	2000	Hepatology2000，31，6：	1
12	Voltage-gatedion channels, new targets in anti-cancer re- search 显示文摘	Le Guennec JY Ouadid-Ahidouch H Soriani O	2007	Recent Pat Anticancer Drug Discov2007，2，3：	1
13	Estimation of the flutter derivatives of an NACA airfoil by means of Navier-Stokes simulation显示文摘	Le Maitre O P Scanlan R H Knio O M	2003	Journal of Fluids and Structures2003，17，：	1
14	Shannon entropy applied to the measurement of the electroencephalographic effects of desflurane显示文摘	Bruhn J Lehmann LE R(o)pcke H	2001	Anesthesiology2001，95，1：	1
15	100-Mb/s NRZ visible light communications using a postequalized white LED 显示文摘	LE Minh H O'Brien D Faulkner G	2009	PhotonicsTechnologyLetters(S1041-1135)2009，21，15：	1
16	Acute lymphoblastic leukemia in elderly:prognosis and treatment显示文摘	THOMAS T TAVEMIER E LE O H	2004	Bull Cancer2004，91，：	1
17	Estimation of the flutter derivatives of an NACA airfoil by means of Navier - Stokes simulation 显示文摘	Le Maitre O P Scanlan R H Knioc O M	2003	Journal of Fluids and stryctures2003，17，：	1
18	Evaluation of radiology departmental hurricane season emergency planning with lessons learned from hurricane rita显示文摘	Ernst R Mun S J Le O Leonard M H Chaljub G Oto A Riascos-Castaneda R	2007	American Journal Of Roentgenology2007，188，5：	1
19	Effects of local simvas-tatin -alendronate conjugate in preventing periodontitis bone loss显示文摘	PRICE U LE H O POWELL S E	2013	J Periodontal Res2013，48，5：	1
20	Demand response from household customers:Experiences from a pilot study in Norway显示文摘	S?le H Grande O S		0，，01：	1

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