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	题名	作者	年代	出处	被引量
1	脑缺血后N-myc下游调控基因2保护血脑屏障完整性显示文摘脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAO)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAO后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAO后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。	Takarada-Iemata M Yoshikawa A Ta HM Okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M Hori O 聂昊	2018	神经损伤与功能重建2018，13，4：	4
2	Cancer risks in patients with chronic lymphocytic thyroiditis 显示文摘	Holm LE Blomgren H Lwhagen T	1985	N Engl J Med1985，312，10：	1
3	Cancer risks in patients with chronic lymphocytic thyroiditis显示文摘	Holm LE Blomgren H Lowhagen T	1985	N Engl J Med1985，312，10：	1
4	Is there a difference in range of motion, neck pain, and outcomes in patients with ossification of posterior longitudinal ligament versus those with cervical spondylosis, treated with plated laminoplasty 显示文摘	Fujimori T Le H Ziewacz JE	2013	Neurosurg Focus2013，35，1：	1
5	Characterization of Ba- cillus pmbiotics available for human use显示文摘	Due le H Hong H A Barbosa T M	2004	Appl Environ Micro- biol2004，70，4：	1
6	Analog-to-digital con-verters显示文摘	Le B Rondeau T W Reed J H	2005	IEEE Signal Processing Magazine2005，，：	1
7	High diversity and abundance of putative polyphosphate-aeeumulating Testrasphaera-related bacteria in activated sludge sys- tems显示文摘	Nguyen H T Le V Q Hansen A A	2011	FEMS Mierobiol Eeol2011，76，2：	1
8	Transpelvic anasto-motic stenting: a good option for diversion after pyelo-plasty in children显示文摘	LE T S LE C T LE T H	2011	J Pediatr Urol2011，7，：	1
9	Biological control of the rice root-knot nero atode Meloidosyne graminicola on rice, us- ing endophytic and rhizosphere fungi 显示文摘	Le H T T Padgham J L Sikora R A	2009	International Journal of Pest Management2009，55，1：	1
10	Advanced hip os- teoarthritis:magneticresonance imaging aspects and histopathology cor- relations 显示文摘	Leydet - Quilici H Le Corroller T Bouvier C	2010	Osteoarthritis and Cartilage2010，18，11：	1
11	Cytokine milieu modulates re- lease of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA 显示文摘	Kinoshita H Takai T Le TA	2009	J Allergy Clin Immu- nol2009，123，17：	1
12	Identification of phosphorylated residues that affect the activity of the mitotic kinase Aurora-A 显示文摘	Littlepag LE Wu H Andresson T	2002	Proc Natl Acad Sci USA2002，99，15：	1
13	The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘	International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M	2010	Science2010，330，6010：	1
14	Expression of the major core antigen VP7 of African horse sickness virus by a recombinant baculovirus and its use as a group-specific diagnostic reagent显示文摘	CHUMA T LE BLOIS H SANCHEZ-VIZCAiNO J M	1992	J Gen Virol1992，73，4：	1
15	Fine-sediment dynamics in the Mekong River Estuary,Vietnam显示文摘	Wolanski E Nguyen N H Le T D		0，，05：	1
16	No-reference image quality assessment using structural Activity显示文摘	Zhang J Le T M Ong S H		0，，11：	1
17	Analog-to-digital converters显示文摘	Le B Rondeau T W Reed J H	2005	Signal Processing Magazine2005，22，6：	1
18	Evaluation of acyl Coenzyme A oxidase(Aox) isozyme function in the n-alkane-assimilating yeast Yarrowia lipolytica 显示文摘	Wang H J Le Clainche A Le Dall M T	1999	J Bacteriol1999，181，：	1
19	Abdominoperineal resection and anterior resection in the treatment of rectal cancer:results in relation to adjuvant preoperative radiotherapy显示文摘	Holm T Rutqvist LE Johansson H	1995	Br J Surg1995，82，9：	1
20	Effect of dietary lysine supplement on the performance of Mong Cai sows and their piglets显示文摘	PHAM K T LE DUC N HENDRIKS W H	2010	Journal of Animal Science2010，23，3：	1

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