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| 1 | Does immunohistochemical staining have a clinical impact in early gastric cancer conducted endoscopic submucosal dissection?显示文摘AIM: To evaluate clinicopathologic parameters and the clinical significance related lymphovascular invasion (LVI) by immunohistochemical staining (IHCS) in endoscopic submucosal dissection (ESD). METHODS: Between May 2005 and May 2010, a total of 348 lesions from 321 patients (mean age 63 ± 10 years, men 74.6%) with early gastric cancer (EGC) who met indication criteria after ESD were analyzed retrospectively. The 348 lesions were divided into the absolute (n = 100, differentiated mucosal cancer without ulcer ≤ 20 mm) and expanded (n = 248) indica-tion groups after ESD. The 248 lesions were divided into four subgroups according to the expanded ESD indication. The presence of LVI was determined by factor Ⅷ-related antigen and D2-40 assessment. We compared LVI IHCS-negative group with LVI IHCSpositive in each group. RESULTS: LVI by hematoxylin-eosin staining (HES) and IHCS were all negative in the absolute group, while was observed in only the expanded groups. The positive rate of LVI by IHCS was higher than that of LVI by HES (n = 1, 0.4% vs n = 11, 4.4%, P = 0.044). LVI IHCS-positivity was observed when the cancer invaded to the mucosa 3 (M3) or submucosa 1 (SM1) levels, with a predominance of 63.6% in the subgroup that included only SM1 cancer (P < 0.01). In a univariate analysis, M3 or SM1 invasion by the tumor was significantly associated with a higher rate of LVI by IHCS, but no factor was significant in a multivariate analysis. There were no cases of tumor recurrence or metastasis during the median 26 mo follow-up. CONCLUSION: EGCs of the absolute group are immunohistochemically stable. The presence of LVI may be carefully examined by IHCS in an ESD expanded indication group with an invasion depth of M3 or greater. | Seong Ran Jeon Joo Young Cho Gene Hyun Bok Tae Hee Lee Hyun Gun Kim Won Young Cho So Young Jin Yeon Soo Kim | 2012 | World Journal of Gastroenterology2012，18，33： | 6 |
| 2 | Chondrogenesis of periodontal ligament stem cells by transforming growth factor-β3 and bone morphogenetic protein-6 in a normal healthy impacted third molar显示文摘The periodontal ligament-derived mesenchymal stem cell is regarded as a source of adult stem cells due to its multipotency. However, the proof of chondrogenic potential of the cells is scarce. Therefore, we investigated the chondrogenic differentiation capacity of periodontal ligament derived mesenchymal stem cells induced by transforming growth factor (TGF)-β3 and bone morphogenetic protein (BMP)-6. After isolation of periodontal ligament stem cells (PDLSCs) from human periodontal ligament, the cells were cultured in Dulbecco's modified Eagle's medium (DMEM) with 20% fetal bovine serum (FBS). A mechanical force initiated chondrogenic differentiation of the cells. For chondrogenic differentiation, 10 μg ·L-1 TGF-β3 or 100 μg ·L-1 BMP-6 and the combination treating group for synergistic effect of the growth factors. We analyzed the PDLSCs by fluorescence-activated cell sorting and chondrogenesis were evaluated by glycosaminoglycans assay, histology, immunohistochemistry and genetic analysis. PDLSCs showed mesenchymal stem cell properties proved by FACS analysis. Glycosaminoglycans contents were increased 217% by TGF-β3 and 220% by BMP-6. The synergetic effect of TGF-β3 and BMP-6 were shown up to 281% compared to control. The combination treatment increased Sox9, aggrecan and collagen II expression compared with not only controls, but also TGF-β3 or BMP-6 single treatment dramatically. The histological analysis also indicated the chondrogenic differentiation of PDLSCs in our conditions. The results of the present study demonstrate the potential of the dental stem cell as a valuable cell source for chondrogenesis, which may be applicable for regeneration of cartilage and bone fracture in the field of cell therapy. | Sunyoung Choi Tae-Jun Cho Soon-Keun Kwon Gene Lee Jaejin Cho | 2013 | International Journal of Oral Science2013，5，1： | 5 |
| 3 | A novel device for endoscopic submucosal dissection,the Fork knife显示文摘瞄准:用一台新奇设备介绍并且评估功效和内视镜的粘膜下层解剖(ESD ) 的技术方面,叉刀。方法:从 2004 年 3 月到 2008 年 4 月, ESD 在一个单个第三级的工作分派中心用 Flexknife (组 B ) 在使用一把叉刀(Endo FSregister )( 组 A ) 的 265 胃的损害上并且在 72 胃的损害上被执行。我们回顾地比较了 resected 标本的肿瘤,病理检查所见,和尺寸的内视镜的特征。我们也比较了在二个组之间的整块切除术率,完全的切除术率,复杂并发症,和过程时间。结果:resected 标本的吝啬的尺寸是 4.27 +/- 在组 A 和 4.29 +/- 的 1.26 厘米在组 B 的 1.48 厘米。整块切除术率是 95.8%(254/265 损害) 在组 A 并且 93.1%(67/72 ) 在组 B。没有 resected 边缘的肿瘤房间侵略的完全的 ESD 在 81.1% 被获得(215/265 ) 组 A 并且在 73.6%(53/72 ) 组 B。穿孔率是 0.8%(2/265 ) 在组 A 并且 1.4%(1/72 ) 在组 B。吝啬的过程时间是 59.63 +/- 在组 A 和 76.65 +/- 的 56.12 min 在组 B 的 70.75 min (P <
0.05 ) 。结论:叉刀(Endo FSregister ) 为临床的实践是有用的并且有的优点减少过程时间。 | Hyun Gun Kim Joo Young Cho Gene Hyun Bok Won Young Cho Wan Jung Kim Bong Min Ko Jin Oh Kim Joon Seong Lee Moon Sung Lee Chan Sup Shim | 2008 | World Journal of Gastroenterology2008，14，43： | 3 |
| 4 | Electrospinning of silk fibroin nanofiber and its effect on the adhesion and spreading of normal human keratinocytes and fibroblasts in vitro显示文摘 | Byung-Moo Min Gene Lee So hyun Kim | 2004 | Polymer2004，25，： | 1 |
| 5 | Electrospinning of silk fibroin nanofibers and its effect on the adhesion and spreading of normal human keratinocytes and fibroblasts in vitro显示文摘 | Byung-Moo Min Gene Lee So Hyun Kim | 2004 | Biomaterials2004，，25： | 1 |
| 6 | Ginsenoside Rhl suppresses matrix metalloproteinase-1 expression through inhi- bition of activator protein-1 and mitogen-aetivated protein kinase signaling pathway in human hepatocellular carcinoma cells 显示文摘 | JiHae Yoon Yeo Jin Choi Seong Gene Lee | 2012 | European Journal of Pharmacology2012，697，： | 1 |
| 7 | Electrospinning of collagen nanofibers: Effects on behavior of normal human keratinocytes and early wound healing显示文摘 | Kyong So Rho Lim Jeong Gene Lee | 2006 | Biomaterials2006，27，： | 1 |
| 8 | Electrospinning of silk fibroin nanofiber and its effect on the adhesion and spreading of normal human keratinocytes and fibroblasts in vitro 显示文摘 | MIN Byung-Moo LEE Gene KIM So Hyun | 2004 | Carbohydrate Polymer2004，，57： | 1 |
| 9 | Eleetrospinning of collagen nanofibers:Effects on the behavior of normal human keratinocytes and early-stage wound healing 显示文摘 | RHO Kyong Su JEONG Lim LEE Gene | 2006 | Biomaterials2006，，27： | 1 |
| 10 | Meta-analysis of Research on Class Size and Its Relationship to Attitudes and Instruction 显示文摘 | Mary Lee Smith & Gene V Glass | 1980 | American Educational Research Journal1980，17，4： | 1 |
| 11 | Meta-analysis of Research on Class Size and Its Relationship to Attitudes and Instruction显示文摘 | Mary Lee Smith & Gene V Glass | 1980 | American Educational Research Journal1980，17，4： | 1 |
| 12 | Evaluation of Pathologists (Histopathology) and Radiologists (Cone Beam Computed Tomography) Differentiating Radicular Cysts from Granulomas显示文摘 | Paul A. Rosenberg Jared Frisbie Jaehoon Lee Kyung Lee Herbert Frommer Shailesh Kottal Joan Phelan Louis Lin Gene Fisch | 2010 | Journal of Endodontics2010，，： | 1 |
| 13 | Electrospinning of silk fibroin nanofibers and it s effect on the adhesion and spreading of normal human keratinocytes and fibroblasts in vitro显示文摘 | BYUNG-MOO MIN GENE LEE WON HO PARK | 2004 | Biomaterials2004，25，78： | 1 |
| 14 | Characterizing Alzheimer’s disease using a hypometabolic convergence index显示文摘 | Kewei Chen Napatkamon Ayutyanont Jessica B.S. Langbaum Adam S. Fleisher Cole Reschke Wendy Lee Xiaofen Liu Dan Bandy Gene E. Alexander Paul M. Thompson Leslie Shaw John Q. Trojanowski Clifford R. Jack Susan M. Landau Norman L. Foster Danielle J. Harvey Mi | 2011 | Neuroimage2011，，1： | 1 |
| 15 | Electrospining of silk fibroin nanofibers and its effect on the adhesion and spreading of normal human keratinocytes and fibroblasts in vitro显示文摘 | Min Byung Moo Lee Gene Kim So Hyun | 2004 | Biomaterials2004，，25： | 1 |
| 16 | Electrospining of silk fibroin nanofibers and its effect on the adhesion and spreading of normal human keratinocytes and fibroblasts in vitro显示文摘 | Min Byung-Moo Lee Gene Kim So Hyun | 2004 | Biomaterials2004，，25： | 1 |
| 17 | Hepatic Surgery and Hepatic Surgical Anatomy: Historical Partners in Progress显示文摘 | David A. McClusky III Lee J. Skandalakis Gene L. Colborn John E. Skandalakis | 1997 | World Journal of Surgery1997，，3： | 1 |
| 18 | Electrospinning of silk fibroin nanofiber and its effect on the adhesion and spreading of normal human keratinocytes and fibroblasts in vitro显示文摘 | Byung-Moo Min Gene Lee So Hyun Kim | 2004 | Carbohydrate Polymer2004，57，： | 1 |
| 19 | Electrospinning of silk fibroin nanofiber and its effect on the adhesion and spreading of normal human keratinocytes and fibroblasts in vitro显示文摘 | Byung-Moo Min Gene Lee So Hyun Kim | 2004 | Polymer2004，25，： | 1 |
| 20 | Electrospining of silk fibroin nanofibers and its effect on the adhesion and spreading of normal human keratinocytes and fibroblasts in vitro 显示文摘 | Byung-Moo Min Gene Lee So Hyun Kim | 2004 | Biomaterials2004，，25： | 1 |
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