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| 1 | Overexpression of HSP27 and HSP70 is associated with decreased survival among patients with esophageal adenocarcinoma显示文摘BACKGROUND Overexpression of heat shock proteins(HSPs) is associated with several malignancies and contributes to the development, progression, and metastasis of cancer, in addition to the inhibition of cellular death. In recent years, there has been active research into using HSP inhibitors in several malignancies. Due to the poor prognosis of esophageal adenocarcinoma(EAC), it would be valuable to find new biomarkers for the development of cancer treatments.AIM To evaluate the expressions of HSP27 and HSP70 and their effect on survival in EAC.METHODS Immunohistochemical analyses and evaluations of HSP27 and HSP70 expression were performed on all available samples from 93 patients diagnosed with EACbetween 1990 and 2007 at two university hospitals. Fifteen cases with Barrett's metaplasia and 5 control cases from the same patient population were included in the analysis. HSP expression was quantitatively assessed and classified as high or low. Kaplan-Meier analyses and Cox regression models adjusting for age and sex as well as tumor site, stage, and grade were used to evaluate the effect on survival.RESULTS Tumor stage and surgical treatment were the main prognostic factors. High HSP27 expression in cancer cases was a strong negative predictive factor, with a mean survival of 23 mo compared to the 49 mo in cases with a low expression(P= 0.018). The results were similar for HSP70, with a poorer survival of 17 mo in cases with high HSP70 expression, in contrast to 40 mo(P = 0.006) in cases with a low expression. A Cox regression survival analysis was performed, adjusting for possible confounding factors, and higher HSP27 and HSP70 expressions remained an independent negative prognostic factor. The HSPs' correlation with survival was not affected by cancer treatments. When the analysis was adjusted for all factors, the odds ratios for HSP27 and HSP70 were 3.3(CI: 1.6–6.6, P =0.001) and 2.2(CI: 1.2–3.9, P = 0.02), respectively.CONCLUSION HSP27 and HSP70 overexpression is associated with poor survival in EAC, which is, to the best of our knowledge, reported for the first time. | Henna K S?derstr?m Juha T Kauppi Niku Oksala Timo Paavonen Leena Krogerus Jari R?s?nen Tuomo Rantanen | 2019 | World Journal of Clinical Cases2019，7，3： | 7 |
| 2 | Ragiofrequency 天 enervation for neck an天 back pain:A systematic review within the framework of the cochrane collaboration back review group显示文摘 | Leena N Eija K Antti M | | 0，，： | 1 |
| 3 | Evaluation of Sur- face Lignin on Cellulose Fibers with XPS显示文摘 | LEENA S J CAMPBELL J M KRISTA K | 1999 | Applied Surface Science1999，14，： | 1 |
| 4 | Structure of Catalase-A from Saccharomyces cerevisiae显示文摘 | Mate M J Zamocky M Leena M | 1999 | J Mol Biol1999，286，1： | 1 |
| 5 | Structure of catalase-A from Saccharomyces cerevisiae显示文摘 | Mate M J Zamocky M Leena M | 1999 | J Mo| Biol1999，286，1： | 1 |
| 6 | Patient-controlled sedation with propofol and remifentanil for ERCP: a randomized, controlled study显示文摘 | Maxim Mazanikov Marianne Udd Leena Kyl?np?? Outi Lindstr?m Pekka Aho Jorma Halttunen Martti F?rkkil? Reino P?yhi? | 2011 | Gastrointestinal Endoscopy2011，，2： | 1 |
| 7 | Microalbuminuria is associated with insulin resistance in nondiabetic subjects: The insulin resistance atherosclerosis study显示文摘 | DANIEL J LYNNE E | 1998 | Diabetes1998，47，5： | 1 |
| 8 | Valproate - induced hyperandrogenism during pubertal maturation in girls with epilepsy显示文摘 | Johanna R Knip M | 1999 | Ann Neurol1999，45，4： | 1 |
| 9 | International collaborative study to compare reverse transcrip tase PCR assays for detection and genotyping of Noroviruses显示文摘 | JAN V HARRY V LEENA M | 2003 | J Clin Microbiol2003，41，4： | 1 |
| 10 | Joint Effects of Serum Triglyceride and LDL Cholesterol and HDL Cholesterol Concentrations on Coronary Heart Disease Risk in the Helsinki Heart Study: Implications for Treatment显示文摘 | Vesa Manninen Leena Tenkanen Pekka Koskinen Jussi K. Huttunen Matti M?ntt?ri Olli P. Heinonen M. Heikki Frick | 1992 | Circulation1992，，1： | 1 |
| 11 | EfficientCORDIC algorithms and architectures for low area and highthroughput implementation显示文摘 | Leena Vachhani Sridharan K Pramod K M | 2009 | IEEE Transactions on cir-cuits and systems-II:express briefs2009，56，1： | 1 |
| 12 | Validity of Physical activity Intensity Predic- tions by Actigraph, Actical, and RT3 Accelerometers显示文摘 | MEGAN P ROTHNEY EMILY V SCHAEFER MEGAN M LEENA | 2008 | Obesity (Silver Spring)2008，16，8： | 1 |
| 13 | Multi-detector row CT:radiation dose characteristics显示文摘 | Leena M Hamberg DS James T | 2003 | Radiology2003，226，3： | 1 |
| 14 | Degree of Damage to the Small Bowel and Serum Antibody Titers Correlate With Clinical Presentation of Patients With Celiac Disease显示文摘 | Juha Taavela Kalle Kurppa Pekka Collin Marja–Leena L?hdeaho Teea Salmi P?ivi Saavalainen Katri Haimila Heini Huhtala Kaija Laurila Harri Siev?nen Markku M?ki Katri Kaukinen | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 1 |
| 15 | Investigation of water uptake behavior and mechanical properties of superporous hydrogels显示文摘 | Bajpai S K Bajpai M Sharma Leena | | 0，，： | 1 |
| 16 | Joint Effects of Serum Triglyceride and LDL Cholesterol and HDL Cholesterol Concentrations on Coronary Heart Disease Risk in the Helsinki Heart Study: Implications for Treatment显示文摘 | Vesa Manninen Leena Tenkanen Pekka Koskinen Jussi K. Huttunen Matti M?ntt?ri Olli P. Heinonen M. Heikki Frick | 1992 | Circulation1992，，1： | 1 |
| 17 | Peptide-polymer biotherapeutic synthesis on novel cross-linked beads with 'Spatially Tunable' and 'Isolated' functional sites显示文摘 | Jacob M K Leena S Kumar K S | 2008 | Biopolymers2008，90，： | 1 |
| 18 | Ragiofrequency denervation for neck and back pain: A systematic review within the framework of the cochrane collaboration back review group显示文摘 | Leena N Eija K Antti M | 2003 | Spine2003，28，： | 1 |
| 19 | Insulin/IGF-1 signaling regulates proteasome activity through the deubiquitinating enzyme UBH-4显示文摘 | OLLI M LEENA A VILLE R | 2013 | Cell Reports2013，3，6： | 1 |
| 20 | 显示文摘 | Riku F Krister M Leena K | 2002 | J Biol Chem2002，277，： | 1 |
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