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| 1 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 2 | Systematic analysis of the safety and benefits of transvaginal hybrid-NOTES cholecystectomy显示文摘AIM: To evaluate transvaginal hybrid-NOTES cholecystectomy(TVC) during its clinical establishment and compare it with the traditional laparoscopic technique(LC).METHODS: The specific problems and benefits of TVC were reviewed using a registry analysis,a comparative cohort study and a randomized clinical trial. At first,feasibility,safety and specific complications of the TVC were analyzed based on the first 488 data sets of the German NOTES Registry(GNR). Hereafter,we compared the early postoperative results of our first 50 TVC-patients with those of 50 female LCpatients matched by age,BMI and ASA classification. The same cohort was contacted an average of two years later to evaluate long-term results concerning pain and satisfaction with the aesthetic results and the overall postoperative results as well as sexual intercourse by means of two domains of the German version of the Female Sexual Function Index(FSFI-d). Consequently,we performed a randomized clinical trial comparing 20 TVC-patients with 20 needlescopic/3-trocar cholecystectomies(NC) also concerning the early postoperative results as well as pain,satisfaction and quality of life by means of the Eypasch Gastrointestinal Quality of Life Index(GIQLI) in the later course. Finally,we discussed the results in accordance with other published studies.RESULTS: The complication(3.5%) and conversion rates(4.1%) for TVC were low in the GNR and comparable to those of the LC. Access related intraoperative complications included injuries to the bladder(n = 4; 0.8%) and bowel(n = 3; 0.6%). The study cohort revealed less postoperative pain after TVC comparing to the LC-patients on the day of surgery(NRS,1.5/10 vs 3.1/10,P = 0.003),in the morning(NRS,1.9/10 vs 2.8/10,P = 0.047) and in the evening(NRS,1.1/10 vs 1.8/10,P = 0.025) of postoperative day(POD) one. The randomized clinical trial consistently found less cumulative pain until POD 2(NRS,8/40 vs 14/40,P = 0.043),as well as until POD 10(NRS,22/190 vs 41/190,P = 0.010). Furthermore,the TVC-patients had a better quality of life on POD 10 than did the LC-patients(GIQLI,124/144 vs 107/144,P = 0.028). The complication rates were comparable and no specific problems were detected in the long-term follow-up for sexual intercourse for either group. The TVC-patients were more satisfied with the aesthetic result in the long-term course in the matched cohort analysis(1.00 vs 1.88,P < 0.001) as well as in the randomized clinical trial(1.00 vs 1.70,P < 0.001) when compared with the LC-patients.CONCLUSION: TVC is a feasible procedure with a high safety profile and has advantages in regard to postoperative pain and aesthetic results when compared with LC or NC. | Dirk R Bulian Jurgen Knuth Kai S Lehmann Axel Sauerwald Markus M Heiss | 2015 | World Journal of Gastroenterology2015，21，38： | 3 |
| 3 | Nonmonotonic reasoning,preferential modelsand cumulative logics显示文摘 | KRAUS S LEHMANN D MEGIDOR M | 1990 | Artificial Intelligence1990，44，12： | 1 |
| 4 | Wing Rotation and the Aerodynamic Basis of Insect Flight显示文摘 | Dickinson M H Lehmann F O Sanjay P S | 1999 | Science1999，，284： | 1 |
| 5 | Dose dependent alteraton in gene expression and testosterone synthesis in the fetal testes of male rats exposed to di (n-butyl) phthalate 显示文摘 | Lehmann K P Phillips S Sar M | 2004 | Toxicol Sci2004，81，： | 1 |
| 6 | Durability of the resin bond strength to zirconia ceramic after using different surface conditioning methods显示文摘 | Wolfart M Lehmann F Wolfart S | 2007 | Dent Mater2007，23，1： | 1 |
| 7 | Activation of thenuclear receptor LXR by oxysterols defines a new hormoneresponse pathway显示文摘 | Lehmann J M Kliewer S A Moore L B | 1997 | J Biol Chem1997，272，： | 1 |
| 8 | Wing rotation and the aerodynamic basis of insect flight 显示文摘 | DICKINSON M H LEHMANN F-O SANE S P | 1999 | Sci1999，284，： | 1 |
| 9 | Wing rotation and the aerodynamic basis of insect flight 显示文摘 | Dickinson M H Lehmann F O Sane S | 1999 | Science1999，284，5422： | 1 |
| 10 | Preservation of organic matter and alteration of its carbon and nitrogen isotope composition during simulated and in situ early sedimentary diagenesis 显示文摘 | Lehmann M F Bernasconi S M Barbieri A | 2002 | Geochimica et Cosmochimica Acta2002，66，20： | 1 |
| 11 | Biclique communities 显示文摘 | LEHMANN S SCHWARTZ M HANSEN L K | 2008 | Physical Review E2008，78，01： | 1 |
| 12 | Left ventricular hypertrophy in patient-s with chronic renal failure treated by hemodialysis显示文摘 | Wanic-Kossowska M Lehmann P Czekalski S | 2002 | Pol Arch Med Wewn2002，107，6： | 1 |
| 13 | Durability of the resin bond strength to zirconia ceramic after using different surface conditioning methods显示文摘 | Wolfart M Lehmann F Wolfart S | 2007 | Dent Mater2007，23，1： | 1 |
| 14 | Wing rotation and the aerodynamic basis of insect flight 显示文摘 | Dickinson M H Lehmann F O Sane S P | 1999 | Science1999，，284： | 1 |
| 15 | Wing rotation and the aerodynamic basis of insect flight 显示文摘 | Dickinson M H Lehmann F O Sane S S | 1999 | Science1999，284，5422： | 1 |
| 16 | Wing rota- tion and the aerodynamic basis of insect flight显示文摘 | DICKINSON M H LEHMANN F O SANE S P | 1999 | Science1999，284，5422： | 1 |
| 17 | Reversibility of soil productivity decline with matter of differing quality along a degradation gradient 显示文摘 | Kimetu J M Lehmann J Ng~e S O | 2008 | Fx''osyst eros2008，11，5： | 1 |
| 18 | Nonmonotonic reasoning, preferential models and cumulative logics 显示文摘 | Kraus S Lehmann D Magidor M | 1990 | Artificial Intelligence1990，，44： | 1 |
| 19 | Wing rotation and the aerodynamic basis of insect flight显示文摘 | DICKINSON M H LEHMANN F O SANJAY P S | 1999 | Science1999，284，： | 1 |
| 20 | A method for the extraction of ammonium fromfreshwaters for nitrogen isotope analysis 显示文摘 | Lehmann M F Bemasconi S M McKenzie J A | 2001 | AnalyticalChemistry2001，73，： | 1 |
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