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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | Monochromatic green light stimulation during incubation shortened the hatching time via pineal function in White Leghorn eggs显示文摘Background:Effect of monochromatic green light illumination on embryo development has been reported in chickens.The avian pineal gland is an important photo-endocrine organ formed by a mediodorsal protrusion during embryonic development.However,the involvement of pineal gland in the light transduction process remains to be elucidated.In the present study,we investigated the influence of monochromatic green light on hatching time and explored the possible mechanism via pineal function.Results:A total of 600 eggs of White Leghorn(Shaver strain)were incubated under photoperiods of either 12 h of light and 12 h of darkness using monochromatic green light(12L:12D group)or 24 h of darkness(0L:24D group)for 18 d.Compared to 0L:24D group,the green light stimulation shortened the hatching time without extending the hatch window or impairing hatchability.The liver of embryos incubated in the 12L:12D light condition was heavier than those of the 0L:24D group on d 21 post incubation which may be linked to the observed increase in the serum concentration of insulin-like growth factor 1(IGF-1);primary secretion of the liver.Histological structure analysis of pineal gland demonstrated that the light stimulation increased follicle area,wall thickness and lumen area on d 10 and d 12 post incubation.Rhythmic function analysis demonstrated that three clock related genes(brain and muscle ARNT-like-1,BMAL1;circadian locomotor output cycles kaput,CLOCK;and cryptochrome-1,CRY1)and a melatonin rate-limiting enzyme related gene(arylalkylamine N-acetyltransferase,AANAT)were rhythmically expressed in the pineal gland of the 12L:12D group,but not in the 0L:24D group.Simultaneously,the light stimulation also increased the concentration of melatonin(MT),which was linked to hepatocyte proliferation and IGF-1 secretion in previous studies.Conclusions:The 12L:12D monochromatic green light stimulation during incubation shortened hatching time without impairing hatching performance.Pineal gland’s early histological development and maturation of its rhythmic function were accelerated by the light stimulation.It may be the key organ in the photo-endocrine axis that regulates embryo development,and the potential mechanism could be through enhanced secretion of MT in the 12L:12D group which promotes the secretion of IGF-1. | Panlin Wang Yanyan Sun Yunlei Li Jing Fan Yunhe Zong Adamu Mani Isa Lei Shi Yuanmei Wang Aixin Ni Pingzhuang Ge Linlin Jiang Shixiong Bian Hui Ma Zhengdong Yuan Xiaolin Liu Jilan Chen | 2021 | Journal of Animal Science and Biotechnology2021，12，3： | 3 |
| 3 | Enrichment factors of movable hydrocarbons in lacustrine shale oil and exploration potential of shale oil in Gulong Sag,Songliao Basin,NE China显示文摘The geological characteristics and production practices of the major middle-and high-maturity shale oil exploration areas in China are analyzed.Combined with laboratory results,it is clear that three essential conditions,i.e.economic initial production,commercial cumulative oil production of single well,and large-scale recoverable reserves confirmed by the testing production,determine whether the continental shale oil can be put into large-scale commercial development.The quantity and quality of movable hydrocarbons are confirmed to be crucial to economic development of shale oil,and focuses in evaluation of shale oil enrichment area/interval.The evaluation indexes of movable hydrocarbon enrichment include:(1)the material basis for forming retained hydrocarbon,including TOC>2%(preferentially 3%-4%),and typeⅠ-Ⅱkerogens;(2)the mobility of retained hydrocarbon,which is closely related to the hydrocarbon composition and flow behaviors of light/heavy components,and can be evaluated from the perspectives of thermal maturity(Ro),gas-oil ratio(GOR),crude oil density,quality of hydrocarbon components,preservation conditions;and(3)the reservoir characteristics associated with the engineering reconstruction,including the main pore throat distribution zone,reservoir physical properties(including fractures),lamellation feature and diagenetic stage,etc.Accordingly,13 evaluation indexes in three categories and their reference values are established.The evaluation indicates that the light shale oil zones in the Gulong Sag of Songliao Basin have the most favorable enrichment conditions of movable hydrocarbons,followed by light oil and black oil zones,containing 20.8×10^(8) t light oil resources in reservoirs with R_(0)>1.2%,pressure coefficient greater than 1.4,effective porosity greater than 6%,crude oil density less than 0.82 g/cm^(3),and GOR>100 m/m^(3).The shale oil in the Gulong Sag can be explored and developed separately by the categories(resource sweet spot,engineering sweet spot,and tight oil sweet spot)depending on shale oil flowability.The Gulong Sag is the most promising area to achieve large-scale breakthrough and production of continental shale oil in China. | ZHAO Wenzhi BIAN Congsheng LI Yongxin ZHANG Jinyou HE Kun LIU Wei ZHANG Bin LEI Zhengdong LIU Chang ZHANG Jingya GUAN Ming LIU Shijul | 2023 | Petroleum Exploration and Development2023，50，3： | 2 |
| 4 | Diagnosis of coronary artery disease using targeted post-mortem computed tomography coronary angiography:a case report显示文摘Targeted post-mortem computed tomography(PMCT)combined with coronary angiography has the potential to play a significant role in the investigation of sudden cardiac death.The authors utilized a targeted PMCT coronary angiography in a case involving a 53-year-old man who died from acute myocardial ischemia and cardiac decompensation which may result from coronary artery disease(CAD).The victim collapsed suddenly at work and died soon after arrival to hospital.The body was examined using PMCT and targeted PMCT coronary angiography.The left anterior descending coronary artery exhibited 75%-100%stenosis in the middle segment;however,the distal segment could not be clearly visualized.In addition,the left circumflex and right coronary artery exhibited calcification,atherosclerosis and an area of 50% stenosis.Signs of cardiogenic pulmonary oedema were also identified.The imaging results suggested that this individual had coronary atherosclerosis and probably died from CAD.The autopsy and histological examination revealed acute myocardial ischemia and myocardial scarring,confirming the cause of death while excluding other probabilities.In summary,targeted post-mortem computed tomography angiography(PMCTA)can visualize the arteries and estimate the degree of principal pathological changes.This method is a simple,reliable and sensitive technique for identifying the presence of coronary atherosclerosis.It is a valuable post-mortem forensic imaging method and should be recommended in the investigation of suspicious cardiac deaths. | Lei Wan Yu Shao Donghua Zou Ping Huang Zhengdong Li Maowen Wang Yijiu Chen | 2017 | Forensic Sciences Research2017，2，2： | 2 |
| 5 | A Mathematical Model for Emulsion Mobilization and its Effect on EOR During ASP Flooding显示文摘 | Lei Zhengdong and Yuan Shiyi | | SPE1131450，，： | 1 |
| 6 | Key theoretical and technical issues and countermeasures for effective development of Gulong shale oil, Daqing Oilfield, NE China显示文摘Aiming at the four issues of underground storage state,exploitation mechanism,crude oil flow and efficient recovery,the key theoretical and technical issues and countermeasures for effective development of Gulong shale oil are put forward.Through key exploration and research on fluid occurrence,fluid phase change,exploitation mechanism,oil start-up mechanism,flow regime/pattern,exploitation mode and enhanced oil recovery(EOR)of shale reservoirs with different storage spaces,multi-scale occurrence states of shale oil and phase behavior of fluid in nano confined space were provided,the multi-phase,multi-scale flow mode and production mechanism with hydraulic fracture-shale bedding fracture-matrix infiltration as the core was clarified,and a multi-scale flow mathematical model and recoverable reserves evaluation method were preliminarily established.The feasibility of development mode with early energy replenishment and recovery factor of 3o%was discussed.Based on these,the researches of key theories and technologies for effective development of Gulong shale oil are proposed to focus on:(1)in-situ sampling and non-destructive testing of core and fluid;(2)high-temperature,high-pressure,nano-scale laboratory simulation experiment;(3)fusion of multi-scale multi-flow regime numerical simulation technology and large-scale application software;(4)waterless(CO_(2))fracturing technique and the fracturing technique for increasing the vertical fracture height;(5)early energy replenishment to enhance oil recovery;(6)lifecycle technical and economic evaluation.Moreover,a series of exploitation tests should be performed on site as soon as possible to verify the theoretical understanding,optimize the exploitation mode,form supporting technologies,and provide a generalizable development model,thereby supporting and guiding the effective development and production of Gulong shale oil. | YUAN Shiyi LEI Zhengdong LI Junshi YAO Zhongwen LI Binhui WANG Rui LIU Yishan WANG Qingzhen | 2023 | Petroleum Exploration and Development2023，50，3： | 1 |
| 7 | Effect of selenium on increasing free radical scavenging activities of polysaccharide extracts from a Se-enriched mushroom species of the genus Ganoderma显示文摘 | Lei Zhao Guanghua Zhao Ming Du Zhengdong Zhao Lixia Xiao Xiaosong Hu | 2008 | European Food Research and Technology2008，，3： | 1 |
| 8 | Selenium distribution in a Se-enriched mushroom species of the genus Ganoderma显示文摘 | ZHAO Lei ZHAO Guanghua ZHAO Zhengdong | 2004 | Journal of Agricultural and Food Chemistry2004，52，12： | 1 |
| 9 | Selenium distribution in a Se-enriched mushroom species of the genus Ganoderma 显示文摘 | ZHAO Lei ZHAO Guanghaa ZHAO Zhengdong | 2004 | Journal of Agricultural and Food Chemistry2004，52，12： | 1 |
| 10 | Why Can China Realize the Continental“Shale Oil Revolution”?显示文摘0 INTRODUCTION Continental shale oil is a strategic alternative resource to ensure the safety of national oil supply and improve the level of industrial innovation.China is a large country of continental oil resources,accounting for 90%of the total onshore oil resources;and China is also a major producer of continental oil,accounting for about 93%of the total oil production(Yang et al.,2019;Jia et al.,2018). | Caineng Zou Zhi Yang Guoxin Li Jianzhong Li Xianyang Liu Yong Tang Tao Jiang Yu Yang Xuefeng Bai Songqi Pan Minghui Lu Zhengdong Lei Bo Cai | 2022 | Journal of Earth Science2022，33，5： | 0 |
| 11 | Characteristics and mechanism of smart fluid for sweep-controlling during CO_(2) flooding显示文摘A smart response fluid was designed and developed to overcome the challenges of gas channeling during CO_(2)flooding in low-permeability,tight oil reservoirs.The fluid is based on Gemini surfactant with self-assembly capabilities,and the tertiary amine group serves as the response component.The responsive characteristics and corresponding mechanism of the smart fluid during the interaction with CO_(2)/oil were studied,followed by the shear characteristics of the thickened aggregates obtained by the smart fluid responding to CO_(2).The temperature and salt resistance of the smart fluid and the aggregates were evaluated,and their feasibility and effectiveness in sweep-controlling during the CO_(2)flooding were confirmed.This research reveals:(1)Thickened aggregates could be assembled since the smart fluid interacted with CO_(2).When the mass fraction of the smart fluid ranged from 0.05%to 2.50%,the thickening ratio changed from 9 to 246,with viscosity reaching 13 to 3100 mPas.As a result,the sweep efficiency in low-permeability core models could be increased in our experiments.(2)When the smart fluid(0.5%to 1.0%)was exposed to simulated oil,the oil/fluid interfacial tension decreased to the level of 1×10^(-2)mN/m.Furthermore,the vesicle-like micelles in the smart fluid completely transformed into spherical micelles when the fluid was exposed to simulated oil with the saturation greater than 10%.As a result,the smart fluid could maintain low oil/fluid interfacial tension,and would not be thickened after oil exposure.(3)When the smart fluid interacted with CO_(2),the aggregates showed self-healing properties in terms of shear-thinning,static-thickening,and structural integrity after several shear-static cycles.Therefore,this fluid is safe to be placed in deep reservoirs.(4)The long-term temperature and salt resistance of the smart fluid and thickened aggregates have been confirmed. | XIONG Chunming WEI Falin YANG Haiyang ZHANG Song DING Bin LEI Zhengdong ZHANG Deping ZHOU Qiang | 2023 | Petroleum Exploration and Development2023，50，3： | 0 |
| 12 | A technique for enhancing tight oil recovery by multi-field reconstruction and combined displacement and imbibition显示文摘A seepage-geomechanical coupled embedded fracture flow model has been established for multi-field coupled simulation in tight oil reservoirs,revealing the patterns of change in pressure field,seepage field,and stress field after long-term water injection in tight oil reservoirs.Based on this,a technique for enhanced oil recovery(EOR)combining multi-field reconstruction and combination of displacement and imbibition in tight oil reservoirs has been proposed.The study shows that after long-term water flooding for tight oil development,the pressure diffusion range is limited,making it difficult to establish an effective displacement system.The variation in geostress exhibits diversity,with the change in horizontal minimum principal stress being greater than that in horizontal maximum principal stress,and the variation around the injection wells being more significant than that around the production wells.The deflection of geostress direction around injection wells is also large.The technology for EOR through multi-field reconstruction and combination of displacement and imbibition employs water injection wells converted to production and large-scale fracturing techniques to restructure the artificial fracture network system.Through a full lifecycle energy replenishment method of pre-fracturing energy supplementation,energy increase during fracturing,well soaking for energy storage,and combination of displacement and imbibition,it effectively addresses the issue of easy channeling of the injection medium and difficult energy replenishment after large-scale fracturing.By intensifying the imbibition effect through the coordination of multiple wells,it reconstructs the combined system of displacement and imbibition under a complex fracture network,transitioning from avoiding fractures to utilizing them,thereby improving microscopic sweep and oil displacement efficiencies.Field application in Block Yuan 284 of the Huaqing Oilfield in the Ordos Basin has demonstrated that this technology increases the recovery factor by 12 percentage points,enabling large scale and efficient development of tight oil. | LEI Zhengdong WANG Zhengmao MU Lijun PENG Huanhuan LI Xin BAI Xiaohu TAO Zhen LI Hongchang PENG Yingfeng | 2024 | Petroleum Exploration and Development2024，51，1： | 0 |
| 13 | 4D-stress evolution of tight sandstone reservoir during horizontal wells injection and production: A case study of Yuan 284 block,Ordos Basin,NW China显示文摘To investigate the 4D stress change during injection and production in tight sandstone reservoirs, a multi-physical fields modeling method is proposed considering the reservoir heterogeneity, hydraulic fracture and complex injection-production system. The 4D stress evolution of tight sandstone reservoir in Yuan 284 block of Huaqing oilfield, Ordos Basin,during injection-production in horizontal well network is investigated by modeling coupled flow and geomechanics. Results show:(1) Induced by injection and production, the 3D stress increases near the injectors but decreases near the producers, and the horizontal stresses are distributed in obvious strips along their respective stress directions.(2) The horizontal stress difference is the highest at the horizontal wellbore beside injectors during injection and production, while it is the lowest in undeveloped zone between the injectors, and the orientation of maximum horizontal principal stress changes the most near the injectors, which is distributed radially.(3) The hydraulic fracture in re-fracturing well was observed to be asymmetrical in geometry and deflected as the stress changed. The results provide theoretical guidance for horizantal well network modification and re-fracturing optimization design in tight sandstone reservoir. | ZHU Haiyan SONG Yujia LEI Zhengdong TANG Xuanhe | 2022 | Petroleum Exploration and Development2022，49，1： | 0 |
| 14 | Mathematical model of dynamic imbibition in nanoporous reservoirs显示文摘The oil-water imbibition equation in the nano-scale pores considering the dynamic contact angle effect, nanoconfinement effect, inertia effect, and inlet end effect was established, and the relation between the friction coefficient of solid-oil-water three-phase contact line and the fluid viscosity in the interface zone was derived. In combination with the capillary bundle model and the lognormal distribution theory, the imbibition model of tight core was obtained and key parameters affecting imbibition dynamics were analyzed. The study shows that in the process of nanopore imbibition, the dynamic contact angle effect has the most significant impact on the imbibition, followed by nanoconfinement effect(multilayer sticking effect and slippage effect), and the inertia effect and inlet end effect have the least impact;in the initial stage of imbibition, the effect of inertial force decreases, and the effect of contact line friction increases, so the dynamic contact angle gradually increases from the initial equilibrium contact angle to the maximum and then remains basically stable;in the later stage of imbibition,the effect of contact line friction decreases, and the contact angle gradually decreases from the maximum dynamic contact angle and approaches the initial equilibrium contact angle;as the pore radius decreases, the dynamic contact angle effect increases in the initial stage of imbibition and decreases in the later stage of imbibition;as the oil-water interfacial tension increases, the imbibition power increases, and the dynamic contact angle effect increases;there is a critical value for the influence of interfacial tension on the imbibition dynamics. In improving oil recovery by imbibition in tight oil reservoir, interfacial tension too low cannot achieve good imbibition effect, and the best interfacial tension needs to be obtained through optimization. | TIAN Weibing WU Keliu CHEN Zhangxing LEI Zhengdong GAO Yanling LI Jing | 2022 | Petroleum Exploration and Development2022，49，1： | 0 |
| 15 | A Q-band CMOS LNA exploiting transformer feedback and noise-cancelling显示文摘In this paper, a Q-band CMOS low noise amplifier(LNA) exploiting transformer positive-negative feedback and noise cancelling is presented. The proposed low noise amplifier consists of a positive transformer feedback to achieve noise-reduction and a negative transformer feedback to obtain high reverse isolation and stability. The noise cancellation technique is applied in this LNA to achieve a low noise figure. This LNA has been fabricated by standard commercial 90 nm CMOS. According to measurements, this proposed LNA achieves a peak gain of 11.5 d B, a noise figure of 6.5 d B and an input P1 d B of-12 d Bm. It consumes 11.5 m A from a1.2 V supply occupying the area of 0.6×0.7 mm2. | WU Jing JIANG ZhengDong YI Kai KANG Kai YU YiMing CHEN JiXin ZHANG Lei LIU Jun LI Le-Wei Joshua | 2015 | Science China(Information Sciences)2015，58，4： | 0 |
| 16 | Controlling factors for oil production in continental shales:A case study of Cretaceous Qingshankou Formation in Songliao Basin显示文摘Continental shale oil is widely distributed in the Cretaceous Qingshankou Formation of the Songliao Basin in Northeast China.In the Qijia-Gulong sag and the Changling sag in the Songliao Basin,breakthroughs of shale oil exploration and development have been made in the first and second members of the Qingshankou Formation,and several wells represented byWell GYYP1 have achieved high and stable shale oil production.However,some horizontal wells in shale oil development pilot test(Well groups A and D)were characterized by low shale oil production,high flowback rate and rapid production decline.Therefore,controlling factors of the shale oil production were investigated.The results show that shale oil enrichment area and optimal sweet spots are fundamental for high shale oil production,improving horizontal length and drilling ratio of sweet spots is a technical guarantee for enhancing shale oil production of single well,and artificial fracture network(incl.scale,complexity,and coupling with preexisting geological bodies)created by fracturing is a direct factor for controlling the shale oil production.For subsequent exploration and development of the shale oil,the heterogeneity of sweet spot distribution should be carefully considered,the shale oil enrichment areas and optimal sweet spots also need be optimized,and the wellbore trajectory control and fine geological modeling techniques should be figured out.Moreover,the fracturing techniques suitable for the shale with high clay mineral content and weak brittleness should be developed,and the personalized and differentiated staged fracturing also needs to be performed,to effectively enhance single-well shale oil production and estimated ultimate recovery. | Bo Zhou Yuxiang Xiao Zhengdong Lei Rui Wang Shuiqing Hu Xiulin Hou | 2023 | Petroleum Research2023，8，2： | 0 |
| 17 | The Geoscience Frontier of Gulong Shale Oil:Revealing the Role of Continental Shale from Oil Generation to Production显示文摘The clay mineral content of Daqing Gulong shale is in the range of about 35%–45%,with particle sizes less than 0.0039 mm.The horizontal fluidity of oil in Gulong shale is poor,with near-zero vertical flowability.As a result,Gulong shale has been considered to lack commercial value.In recent years,however,interdisciplinary research in geoscience,percolation mechanics,thermodynamics,and surface mechanics has demonstrated that Gulong shale oil has a high degree of maturity and a high residual hydrocarbon content.The expulsion efficiency of Gulong shale in the high mature stage is 32%–48%.Favorable storage spaces in Gulong shale include connecting pores and lamellar fractures developed between and within organic matter and clay mineral complexes.The shale oil mainly occurs in micro-and nano-pores,bedding fractures,and lamellar fractures,with a high gas–oil ratio and medium–high movable oil saturation.Gulong shale has the characteristics of high hardness,a high elastic modulus,and high fracture toughness.This study achieves breakthroughs in the exploration and development of Gulong shale,including the theories of hydrocarbon generation and accumulation,the technologies of mobility and fracturing,and recoverability.It confirms the major transition of Gulong shale from oil generation to oil production,which has extremely significant scientific value and application potential for China’s petroleum industry. | Wenyuan He Rukai Zhu Baowen Cui Shuichang Zhang Qian Meng Bin Bai Zihui Feng Zhengdong Lei Songtao Wu Kun He He Liu Longde Sun | 2023 | Engineering2023，，9： | 0 |
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