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| 1 | Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts' consensus statement显示文摘Since the outbreak of 2019 novel coronavirus infection (2019-nCoV) in Wuhan City,China,by January 30,2020,a total of 9692 confirmed cases and 15,238 suspected cases have been reported around 31 provinces or cities in China.Among the confirmed cases,1527 were severe cases,171 had recovered and been discharged at home,and 213 died.And among these cases,a total of 28 children aged from 1 month to 17 years have been reported in China.For standardizing prevention and management of 2019-nCoV infections in children,we called up an experts' committee to formulate this experts' consensus statement.This statement is based on the Novel Coronavirus Infection Pneumonia Diagnosis and Treatment Standards (the fourth edition) (National Health Committee) and other previous diagnosis and treatment strategies for pediatric virus infections.The present consensus statement summarizes current strategies on diagnosis,treatment,and prevention of 2019-nCoV infection in children. | Kunling Shen Yonghong Yang Tianyou Wang Dongchi Zhao Yi Jiang Runming Jin Yuejie Zheng Baoping Xu Zhengde Xie Likai Lin Yunxiao Shang Xiaoxia Lu Sainan Shu Yan Bai Jikui Deng Min Lu Leping Ye Xuefeng Wang Yongyan Wang Liwei Gao | 2020 | World Journal of Pediatrics2020，16，3： | 56 |
| 2 | Characteristics of paleoflood deposits archived in unit T0403 of Yuxi Site in the Three Gorges reservoir areas,China显示文摘Based on the detailed analyses,multi-proxies such as AMS 14 C dating,grain size,component and morphology of heavy minerals,micromorphology of zircon,magnetic susceptibility,Rb/Sr and Hg content are used to research the paleoflood sediments archived in the Yuxi Site.The research indicates that, since 7.6 kaBP,at least 16 times of paleoflood with water level above Wusong Elevation 147.024 m(a.s.l.) left deposits in the Neolithic layers of unit T0403 from the Yuxi Site.The results are induced from the following aspects:(1)The plaeoflood sediments take on great similarities with modern flood sediments in the Yuxi Site and Zhongba Site in probability cumulative curves which mainly show a pattern of 3 segments in fluvial pattern.(2)There is some resemblance between the heavy mineral components and the zircon shape characteristics of paleoflood deposits and those of modern flood deposits.(3) Magnetic susceptibility values(40.44―70.10SI)are lower than those of sediments from cultural layers (59.59―188.68SI).(4)Hg values(290.71―742.51 ng/g)are lower than those of sediments from cultural layers(344.16―10518.17 ng/g).(5)Rb/Sr values are higher than those of sediments from cultural layers, while those of the 4th,5th,6th,7th,8th cultural layers are high,which shows that they are inundated by paleoflood.The reason for many flood deposits existing is related to the site situated on the first terrace where the Yuxi River joins with the Yangtze River.As there are some similarities between the plaeoflood sediments and those of the Zhongba Site,it is feasible to confirm the existence of paleoflood sediments based on the above points. | ZHU Cheng MA ChunMei XU WeiFeng BAI JiuJiang ZHENG ChaoGui ZHU GuangYao WANG HuiLin CHEN Ye LU XueFeng | 2008 | Chinese Science Bulletin2008，53，S1： | 16 |
| 3 | Milling surface roughness for 7050 aluminum alloy cavity influenced by nozzle position of nanofluid minimum quantity lubrication显示文摘In nanofluid minimum quantity lubrication(NMQL)milling of aviation aluminum alloy,it is the bottleneck problem to adjust the position parameters(target distance,incidence angle,and elevation angle)of the nozzle to improve the surface roughness of milling,which has large and uncontrollable errors.In this paper,the influence law of milling cutter speed,helical angle,and cavity shape on the flow field around the milling cutter was studied,and the optimal nozzle profile parameters were obtained.Using 7050 aluminum alloy as the workpiece material,the milling experiment of the NMQL cavity was conducted by utilizing cottonseed oil-based Al2 O3 nanofluid.Results show that the high velocity of the surrounding air flow field and the strong gas barrier could be attributed to high rotating velocities of the milling cutter.The incidence angle of the nozzle was consistent with the helical angle of the milling cutter,the target distance was appropriate at 25–30 mm,and the elevation angle was suitable at 60°–65°.The range and variance analyses of the signal-to-noise ratio of milling force and roughness were performed,and the chip morphology was observed and analyzed.The results show that the optimal combination of nozzle position parameters was the target distance of 30 mm,the incidence angle of 35°,and the elevation angle of 60°.Among these parameters,target distance had the largest impact on cutting performance with a contribution rate of more than 55%,followed by incidence angle and elevation contribution rate.Analysis by orthogonal experiment revealed that the nozzle position parameters were appropriate,and Ra(0.087 lm)was reduced by 30.4%from the maximum value(0.125 lm).Moreover,Rsm(0.05 mm)was minimum,which was 36%lower than that of the seventh group(Rsm=0.078 mm). | Zhenjing DUAN Changhe LI Yanbin ZHANG Lan DONG Xiufang BAI Min YANG Dongzhou JIA Runze LI Huajun CAO Xuefeng XU | 2021 | Chinese Journal of Aeronautics2021，34，6： | 10 |
| 4 | Cold hardiness estimation of Pinus densiflora var. zhangwuensis based on changes in ionic leakage, chlorophyll fluorescence and other physiological activities under cold stress显示文摘Pinus densiflora var. zhangwuensis grows fast,and its drought and salinity resistance are better than Pinus sylvestris var. mongolica. We compared cold hardiness and mechanisms of cold hardiness between the two species, to provide a theoretical basis for promoting and applying P.densiflora var. zhangwuensis in cold regions. A cold stress experiment was carried out on 3-year-old plantlets of P.densiflora var. zhangwuensis and P. sylvestris var. mongolica after hardening at five temperature regimes, 5,-10,-20,-40, and-60℃, respectively. Some indices of needle samples for both species were measured, such as relative conductivity(REL), maximum photochemical efficiency(F_v/F_m), malondialdehyde(MDA), catalase(CAT), proline(Pro), soluble sugar(SS), and stomata density. REL and MDA values of both species after hardening had the same trend of increasing, but the trend was opposite in F_v/F_mvalue with increasing cold stress. Compared with P. sylvestris var. mongolica, the P. densiflora var. zhangwuensis had smaller increases in REL and MDA,and a smaller decline in F_v/F_mduring cold stress. Compared to the control, REL growth of P. densiflora var.zhangwuensis and P. sylvestris var. mongolica at-60℃ were 0.41 and 0.60, and MDA growth was 29.94 mol g^-1FW and 47.80 mol g^-1FW, and F_v/F_mdeclines were 0.08 and 0.27. Half-lethal temperatures(LT_50) calculated by logistic equation for P. densiflora var. zhangwuensis and P.sylvestris var. mongolica were-58.23 and-50.34℃,respectively. These data suggest that cold resistance of P.densiflora var. zhangwuensis is stronger than that of P.sylvestris var. mongolica. Cold-resistance mechanisms of the two species differed. In response to cold stress, P.sylvestris var. mongolica had strong osmotic adjustment ability because of higher Pro and SS content, while P.densiflora var. zhangwuensis had strong antioxidant ability due to stronger CAT activity. Stomata density and diameter of P. densiflora var. zhangwuensis were smaller, as were single leaf area and number of leaves per plant, both characteristics promoting survival in a cold environment.Greater shoot height and total biomass of seedlings of P.densiflora var. zhangwuensis might be another reason for its stronger cold tolerance. | Peng Meng Xuefeng Bai Hongdan Li Xiaodong Song Xueli Zhang | 2015 | Journal of Forestry Research2015，26，3： | 8 |
| 5 | Assessing the impacts of human activities and climate variations on grassland productivity by partial least squares structural equation modeling(PLS-SEM)显示文摘The cause-effect associations between geographical phenomena are an important focus in ecological research. Recent studies in structural equation modeling(SEM) demonstrated the potential for analyzing such associations. We applied the variance-based partial least squares SEM(PLS-SEM) and geographically-weighted regression(GWR) modeling to assess the human-climate impact on grassland productivity represented by above-ground biomass(AGB). The human and climate factors and their interaction were taken to explain the AGB variance by a PLS-SEM developed for the grassland ecosystem in Inner Mongolia, China. Results indicated that 65.5% of the AGB variance could be explained by the human and climate factors and their interaction. The case study showed that the human and climate factors imposed a significant and negative impact on the AGB and that their interaction alleviated to some extent the threat from the intensified human-climate pressure. The alleviation may be attributable to vegetation adaptation to high human-climate stresses, to human adaptation to climate conditions or/and to recent vegetation restoration programs in the highly degraded areas. Furthermore, the AGB response to the human and climate factors modeled by GWR exhibited significant spatial variations. This study demonstrated that the combination of PLS-SEM and GWR model is feasible to investigate the cause-effect relation in socio-ecological systems. | SHA Zongyao XIE Yichun TAN Xicheng BAI Yongfei LI Jonathan LIU Xuefeng | 2017 | Journal of Arid Land2017，9，4： | 8 |
| 6 | Aromatization over nanosized Ga-containing ZSM-5 zeolites prepared by different methods:Effect of acidity of active Ga species on the catalytic performance显示文摘Nanosized Ga-containing ZSM-5 zeolites were prepared via isomorphous substitution and impregnation followed by characterized using various techniques. The catalytic performance of the zeolites for the aromatization of 1-hexene was investigated. The results indicate that isomorphous substitution promotes the incorporation of Ga heteroatoms into the framework along with the formation of extra-framework GaO^+species([GaO^+]a) that have stronger interactions with the negative potential of the framework. In addition, based on the Py-IR results and catalytic performance, the [GaO^+]aspecies with stronger Lewis acid sites produced a better synergism with moderate Br?nsted acid sites and thus improved the selectivity to aromatic compounds. However, the impregnation results in the formation of Ga_2O_3 phase and small amounts of GaO^+species that are mainly located on the external surface([GaO^+]~b), which contribute to weaker Lewis acid sites due to weaker interactions with the zeolite framework. During 1-hexene aromatization, the nanosized Ga isomorphously substituted ZSM-5 zeolite samples(Gax-NZ5) exhibited better catalytic performance compared to the impregnated samples, and the highest aromatic yield(i.e.,65.4 wt%) was achieved over the Ga4.2-NZ5 sample, which contained with the highest Ga content. | Yujun Fang Xiaofang Su Xuefeng Bai Wei Wu Gaoliang Wang Linfei Xiao Anran Yu | 2017 | Journal of Energy Chemistry2017，26，4： | 8 |
| 7 | ZBP1(DAI/DLM-1) promotes osteogenic differentiation while inhibiting adipogenic differentiation in mesenchymal stem cells through a positive feedback loop of Wnt/β-catenin signaling显示文摘The lineage specification of mesenchymal stem/stromal cells(MSCs) is tightly regulated by a wide range of factors. Recently, the versatile functions of ZBP1(also known as DAI or DLM-1) have been reported in the blood circulation and immune systems.However, the biological function of ZBP1 during the lineage specification of MSCs is still unknown. In the present study, we found that ZBP1 was upregulated during osteogenesis but downregulated during adipogenesis in mouse bone marrow-derived MSCs(m BMSCs). ZBP1 was highly expressed in osteoblasts but expressed at a relatively low level in marrow adipocytes. Knockdown of ZBP1 inhibited alkaline phosphataseactivity, extracellular matrix mineralization, and osteogenesis-related gene expression in vitro and reduced ectopic bone formation in vivo. Knockdown of ZBP1 also promoted adipogenesis in MSCs in vitro. Conversely, the overexpression of ZBP1 increased the osteogenesis but suppressed the adipogenesis of MSCs. When the expression of ZBP1 was rescued, the osteogenic capacity of ZBP1-depleted m BMSCs was restored at both the molecular and phenotypic levels.Furthermore, we demonstrated that ZBP1, a newly identified target of Wnt/β-catenin signaling, was required for β-catenin translocation into nuclei. Collectively, our results indicate that ZBP1 is a novel regulator of bone and fat transdifferentiation via Wnt/β-catenin signaling. | Xuefeng Zhao Liang Xie Zhiyong Wang Jiongke Wang Hao Xu Xianglong Han Ding Bai Peng Deng | 2020 | Bone Research2020，8，2： | 8 |
| 8 | Aerenchyma Formed Under Phosphorus Deficiency Contributes to the Reduced Root Hydraulic Conductivity in Maize Roots显示文摘根水力的电导率被显示了在磷(P) 缺乏下面减少。这研究调查通气组织的形成与这个变化有关的独桅三角帆船。Rootanatomy,以及根水力的电导率在玉米(Zea mays L.) 被学习在不同的磷营养条件下面的根。在应力显示出的 P 下面的植物根提高了外皮的房间的降级,通气组织形成与他们的减少的根被联系水力的电导率,支持我们让在根柱体在强调 ofphosphorus 的根阻碍的外皮形成水的光线的运输的空格通风的假设。进一步的证据由于 genotyplc 差别来自变化 inaerenchyma 形成。有在他们的根外皮的不同的孔的五个玉米近交系与他们的根显示出一道重要负相关水力的电导率。当如此的处理足够被延长时,相对含水量也被发现的射击在 P 足够的比那在 P 缺乏的玉米植物降低,建议由于 P-deficlent 的水力的电导率种的降低的根的水运输的限制。 | Mingshou Fan Ruiqin Bai Xuefeng Zhao Jianhua Zhang | 2007 | Journal of Integrative Plant Biology2007，49，5： | 7 |
| 9 | The synergic effects of highly selective bimetallic Pt-Pd/SAPO-41 catalysts for the n-hexadecane hydroisomerization显示文摘The hydroisomerization of n-hexadecane over Pt-Pd bimetallic catalysts is an effective way to produce clean fuel oil.This work reports a useful preparation method of bimetallic bifunctional catalysts by a co-impregnation or sequential impregnation process.Furthermore,monometallic catalysts with loading either Pt or Pd are also prepared for comparison.The effects of the metal species and impregnation order on the characteristics and catalytic performance of the catalysts are investigated.The catalytic test results indicate that the maximum iso-hexadecane yield over different catalysts increases as follows:Pt/silicoaluminophosphate SAPO-41 | Guozhi Jia Chunmu Guo Wei Wang Xuefeng Bai Xiaomeng Wei Xiaofang Su Tong Li Linfei Xiao Wei Wu | 2021 | Frontiers of Chemical Science and Engineering2021，15，5： | 4 |
| 10 | Challenges and strategies in high-accuracy manufacturing of the world’s largest SiC aspheric mirror显示文摘In the process of manufacturing the world’s largest silicon carbide(SiC)aspheric mirror,the primary difficulties are mirror blank preparation,asphere fabrication,and testing,as well as cladding and coating.Specifically,the challenges include the homogeneity of the complicated structure casting,accuracy and efficiency of the fabrication process,print-through effect,fidelity and precision of test procedure,stress and denseness of cladding process,the dynamic range of interferometric measurement,and air turbulence error due to the long optical path.To break through such a barrier of difficulties,we proposed the water-soluble room temperature vanishing mold and gel casting technology,homogeneous microstructure reaction-formed joint technology,nano-accuracy efficient compound fabrication,gravity unloading technology,high-denseness low-defect physical vapor deposition(PVD)Si-cladding technology,test data fusion method,and time-domain averaging method,etc.Based on the proposed technologies and methods,we have accomplished the world’s largest SiC aspheric mirror with a size of φ4.03 m.The impressive performance of the SiC aspheric mirror is validated by the characteristics of the fabricated SiC aspheric mirror.The aerial density of the SiC blank is less than 120 kg/m^(2),surface shape test accuracy is better than 6 nm RMS,thickness inhomogeneity of the cladding layer is less than 5%,and the final surface figure error and roughness are 15.2 nm RMS and 0.8 nm RMS,respectively. | Xuejun Zhang Haixiang Hu Xiaokun Wang Xiao Luo Ge Zhang Wenxing Zhao Xiaoyi Wang Zhenyu Liu Ling Xiong Erhui Qi Congcong Cui Yanchao Wang Yingjie Li Xu Wang Longxiang Li Yang Bai Qiang Cheng Zhiyu Zhang Ruigang Li Wa Tang Xuefeng Zeng Weijie Deng Feng Zhang | 2022 | Light(Science & Applications)2022，11，12： | 3 |
| 11 | Gastrointestinal toxicities associated with immune checkpoint inhibitors: a disproportionality analysis leveraging VigiBase,the WHO Adverse Drug Reaction Database显示文摘With the improvement of people's living standards, gastrointestinal adverse reactions caused by various adverse factors have attracted more and more people's attention. A recent study has indicated that coronavirus disease 2019(COVID-19) could also invade the gastrointestinal tract, leading to gastrointestinal adverse reactions(Song et al., 2020). In recent years, immunotherapy has provided certain effects for some patients with advanced malignant tumors. | Sifu HUANG Xuefeng BAI Taiyong FANG Yanta GUO Kainan ZHENG Xiahong LIN | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，2： | 3 |
| 12 | Natural variations of ZmSRO1d modulate the trade-off between drought resistance and yield by affecting ZmRBOHC-mediated stomatal ROS production in maize显示文摘While crop yields have historically increased,drought resistance has become a major concern in the context of global climate change.The trade-off between crop yield and drought resistance is a common phenomenon;however,the underlying molecular modulators remain undetermined.Through genome-wide association study,we revealed that three non-synonymous variants in a drought-resistant allele of ZmSRO1d-R resulted in plasma membrane localization and enhanced mono-ADP-ribosyltransferase activity of ZmSRO1d toward ZmRBOHC,which increased reactive oxygen species(ROS)levels in guard cells and promoted stomatal closure.ZmSRO1d-R enhanced plant drought resilience and protected grain yields under drought conditions,but it led to yield drag under favorable conditions.In contrast,loss-of-function mutants of ZmRBOHC showed remarkably increased yields under well-watered conditions,whereas they showed compromised drought resistance.Interestingly,by analyzing 189 teosinte accessions,we found that the ZmSRO1d-R allele was present in teosinte but was selected against during maize domestication and modern breeding.Collectively,our work suggests that the allele frequency reduction of ZmSRO1d-R in breeding programs may have compromised maize drought resistance while increased yields.Therefore,introduction of the ZmSRO1d-R allele into modern maize cultivars would contribute to food security under drought stress caused by global climate change. | Huajian Gao Junjun Cui Shengxue Liu Shuhui Wang Yongyan Lian Yunting Bai Tengfei Zhu Haohao Wu Yijie Wang Shiping Yang Xuefeng Li Junhong Zhuang Limei Chen Zhizhong Gong Feng Qin | 2022 | Molecular Plant2022，15，10： | 2 |
| 13 | Predicting the Reflection Coefficient of a Viscoelastic Coating Containing a Cylindrical Cavity Based on an Artificial Neural Network Model显示文摘A cavity viscoelastic structure has a good sound absorption performance and is often used as a reflective baffle or sound absorption cover in underwater acoustic structures.The acoustic performance field has become a key research direction worldwide.Because of the time-consuming shortcomings of the traditional numerical analysis method and the high cost of the experimental method for measuring the reflection coefficient to evaluate the acoustic performance of coatings,this innovative study predicted the reflection coefficient of a viscoelastic coating containing a cylindrical cavity based on an artificial neural network(ANN).First,themapping relationship between the input characteristics and reflection coefficient was analysed.When the elastic modulus and loss factor value were smaller,the characteristics of the reflection coefficient curve were more complicated.These key parameters affected the acoustic performance of the viscoelastic coating.Second,a dataset of the acoustic performance of the viscoelastic coating containing a cylindrical cavity was generated based on the finite elementmethod(FEM),which avoided a large number of repeated experiments.The minmax normalization method was used to preprocess the input characteristics of the viscoelastic coating,and the reflection coefficient was used as the dataset label.The grid search method was used to fine-tune the ANNparameters,and the prediction error was studied based on a 10-fold cross-validation.Finally,the error distributions were analysed.The average root means square error(RMSE)and the mean absolute percentage error(MAPE)predicted by the improved ANN model were 0.298%and 1.711%,respectively,and the Pearson correlation coefficient(PCC)was 0.995,indicating that the improved ANN model accurately predicted the acoustic performance of the viscoelastic coating containing a cylindrical cavity.In practical engineering applications,by expanding the database of the material range,cavity size and backing of the coating,the reflection coefficient of more sound-absorbing layers was evaluated,which is useful for efficiently predicting the acoustic performance of coatings in a specific frequency range and has great application value. | Yiping Sun Qiang Bai Xuefeng Zhao Meng Tao | 2022 | Computer Modeling in Engineering & Sciences2022，，2： | 2 |
| 14 | Screening and evaluation of antioxidants from lees by micro-injector systems combined with a fluorescent probe,N-borylbenzyloxycarbonyl-3,7-dihydroxyphenoxazine,in living Drosophila显示文摘Over the past few decades, the determination of antioxidant activity by chemical probe has been widely reported, but in vivo evaluation via model organisms of Drosophila melanogaster and rapid discovery system has not been studied adequately. In this study, we determined the antioxidant activity of lees and demonstrated the ability of compounds in lees to scavenge H_2O_2 in vitro and in vivo by different chemical probes. Lees increased the ability of Drosophila against oxidative stress and antioxidant enzyme activity in vivo. Five ingredients of organic acids and flavones in lees extract that rapidly scavenged H_2O_2 were revealed by a post-column-derived HPLC-UV-FLD system based on 4-hydroxyphenylacetic acid(PHPAA)chemiluminescence. Additionally, another fluorescent probe,N-borylbenzyloxycarbonyl-3,7-dihydroxyphenoxazine(NBCD), was selected to evaluate the reactive oxygen species(ROS) scavenging capacity of lees in living Drosophila melanogaster using a microfluidic injection test coupled with microscopic imaging analysis, and similar effects were observed in flies when they were treated with tartaric acid and caffeic acid. The results demonstrated that the novel integrated system was suitable for screening and evaluating antioxidant ingredients from natural products. | Guangcui Chu Dandan Cheng Wenjuan Liu Xuefeng Wang Xiaotao Hou Yuanyuan Hou Hongjun Wei Jiagang Deng Gang Bai | 2018 | Chinese Chemical Letters2018，29，10： | 2 |
| 15 | MiR-181a enhances drug sensitivity in mitoxantone-resistant breast cancer cells by targeting breast cancer resistance protein (BCRP/ABCG2)显示文摘 | Xuyang Jiao Lin Zhao Mengtao Ma Xuefeng Bai Miao He Yuanyuan Yan Yan Wang Qiuchen Chen Xinnan Zhao Mingyi Zhou Zeshi Cui Zhihong Zheng Enhua Wang Minjie Wei | 2013 | Breast Cancer Research and Treatment2013，，3： | 1 |
| 16 | A unified approach for processing unbalanced conditions in transient stability calculations显示文摘 | BAI Xuefeng JIANG Tong GUO Zhizhong | 2006 | IEEE Trans on Power Systems2006，21，1： | 1 |
| 17 | Wheel Slip Measurement in 4WD Tractor Based on LABVIEW显示文摘 | Zhixiong Lu Yang Lu Jiangxue Chang Xuefeng Bai Yiguan Liu | 2013 | International Journal of Automation and Control Engineering2013，，3： | 1 |
| 18 | Alternating Stress Dynamics Analysis of Harmonic Gear Flexible Wheel显示文摘 | Han Xuefeng Bai Yang Li Ming | 2012 | Advanced Materials Research2012，，7： | 1 |
| 19 | Clinical implications of ERβ methylation on sporadic breast cancers in Chinese women显示文摘 | Lin Zhao Zhaojin Yu Yunan Li Xiaoyan Wen Wenfeng Ma Lin Wang Jie Ren Caigang Liu Miao He Xuefeng Bai Mingli Sun Zhihong Zheng Xiaoyi Mi Enhua Wang Olufunmilayo I. Olopade Feng Jin Minjie Wei | 2012 | Medical Oncology2012，，3： | 1 |
| 20 | Clinical analysis of 42 cases of drug-induced liver disease 显示文摘 | Wang Haijun Liu Juan Bai Xuefeng | 2009 | Journal of yan an university (medical science edition)2009，12，4： | 1 |
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