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| 1 | Risk factors for intracranial aneurysm in a Chinese ethnic population显示文摘背景 Intracranial 动脉瘤( IAN )在一根大脑动脉上是一个耸出的水泡或囊汽球外面随着时间的过去,它可以导致自发的 subarachnoid 出血( SAH ),最终,残疾和 mortality.Current 研究显示疾病由于多重原因,包括环境因素和血容器的各种各样的先天的畸形。除了先天的倾向,象性别,年龄,高血压,和动脉粥样硬化那样的各种各样的高风险的因素涉及 intracranial 动脉瘤的形成。这研究的目的是调查在中国汉种族 patients.Methods 与分散的 intracranial 动脉瘤的形成联系的风险因素有 intracranial 动脉瘤的 251 个病人和有另外的服的疾病(控制组) 的 338 个病人的一个总数在这研究被注册。单个因素和逻辑回归模型被用来与年龄分析 intracranial 动脉瘤的协会;性别;香烟吸烟;酒精或可卡因消费;高血压,冠的动脉疾病,糖尿病 mellitus 和继承结缔组织疾病的历史;并且 fasting 血的层次葡萄糖和血脂肪。数据表示了同样吝啬的敤摡攠摮吗? | GU Yu-xiang CHEN Xian-cheng SONG Dong-lei LENG Bing ZHAO Fan | 2006 | Chinese Medical Journal2006，，16： | 28 |
| 2 | LncRNAs-directed PTEN enzymatic switch governs epithelial–mesenchymal transition显示文摘Despite the structural conservation of PTEN with dual-specificity phosphatases,there have been no reports regarding the regulatory mechanisms that underlie this potential dual-phosphatase activity.Here,we report that K27-linked polyubiquitination of PTEN at lysines 66 and 80 switches its phosphoinositide/protein tyrosine phosphatase activity to protein serine/threonine phosphatase activity.Mechanistically,high glucose,TGF-β,CTGF,SHH,and IL-6 induce the expression of a long non-coding RNA,GAEA(Glucose Aroused for EMT Activation),which associates with an RNA-binding E3 ligase,MEX3C,and enhances its enzymatic activity,leading to the K27-linked polyubiquitination of PTEN.The MEX3C-catalyzed PTEN^K27-polyUb activates its protein serine/threonine phosphatase activity and inhibits its phosphatidylinositol/protein tyrosine phosphatase activity.With this altered enzymatic activity,PTEN^K27-polyUb dephosphorylates the phosphoserine/threonine residues of TWIST1,SNAI1,and YAP1,leading to accumulation of these master regulators of EMT.Animals with genetic inhibition of PTEN^K27-polyUb,by a single nucleotide mutation generated using CRISPR/Cas9(Pten^K80R/K80R),exhibit inhibition of EMT markers during mammary gland morphogenesis in pregnancy/lactation and during cutaneous wound healing processes.Our findings illustrate an unexpected paradigm in which the lncRNA-dependent switch in PTEN protein serine/threonine phosphatase activity is important for physiological homeostasis and disease development. | Qingsong Hu Chunlai Li Shouyu Wang Yajuan Li Bo Wen Yanyan Zhang Ke Liang Jun Yao Youqiong Ye Heidi Hsiao Tina K.Nguyen Peter K.Park Sergey D.Egranov David H.Hawke Jeffrey R.Marks Leng Han Mien-Chie Hung Bing Zhang Chunru Lin Liuqing Yang | 2019 | Cell Research2019，29，4： | 8 |
| 3 | Percutaneous extraction of leads from coronary sinus vein and branch by modified techniques显示文摘 | CHU Xian-ming LI Xue-bin ZHANG Ping, WANG Long LI Ding LI Bing AN Yi LENG Min DUAN Jiang-bo GUO Ji-hong | 2012 | Chinese Medical Journal2012，，20： | 6 |
| 4 | MATRIEX imaging:multiarea two-photon real-time in vivo explorer显示文摘Two-photon laser scanning microscopy has been extensively applied to study in vivo neuronal activity at cellular and subcellular resolutions in mammalian brains.However,the extent of such studies is typically confined to a single functional region of the brain.Here,we demonstrate a novel technique,termed the multiarea two-photon real-time in vivo explorer(MATRIEX),that allows the user to target multiple functional brain regions distributed within a zone of up to 12mm in diameter,each with a field of view(FOV)of ~200μm in diameter,thus performing two-photon Ca2+imaging with single-cell resolution in all of the regions simultaneously.For example,we demonstrate real-time functional imaging of single-neuron activities in the primary visual cortex,primary motor cortex and hippocampal CA1 region of mice in both anesthetized and awake states.A unique advantage of the MATRIEX technique is the configuration of multiple microscopic FOVs that are distributed in three-dimensional space over macroscopic distances(>1 mm)both laterally and axially but that are imaged by a single conventional laser scanning device.In particular,the MATRIEX technique can be effectively implemented as an add-on optical module for an existing conventional single-beam-scanning two-photon microscope without requiring any modification to the microscope itself.Thus,the MATRIEX technique can be readily applied to substantially facilitate the exploration of multiarea neuronal activity in vivo for studies of brain-wide neural circuit function with single-cell resolution. | Mengke Yang Zhenqiao Zhou Jianxiong Zhang Shanshan Jia Tong Li Jiangheng Guan Xiang Liao Bing Leng Jing Lyu Kuan Zhang Min Li Yan Gong Zhiming Zhu Junan Yan Yi Zhou Jian K Liu Zsuzsanna Varga Arthur Konnerth Yuguo Tang Jinsong Gao Xiaowei Chen Hongbo Jia | 2019 | Light(Science & Applications)2019，8，1： | 4 |
| 5 | QTL Mapping for Rice RVA Properties Using High-Throughput Re-sequenced Chromosome Segment Substitution Lines显示文摘The rapid visco analyser(RVA) profile is an important factor for evaluation of the cooking and eating quality of rice. To improve rice quality, the identification of new quantitative trait loci(QTLs) for RVA profiling is of great significance. We used a japonica rice cultivar Nipponbare as the recipient and indica rice 9311 as the donor to develop a population containing 38 chromosome segment substitution lines(CSSLs) genotyped by a high-throughput re-sequencing strategy. In this study, the population and the parent lines, which contained similar apparent amylose contents, were used to map the QTLs of RVA properties including peak paste viscosity(PKV), hot paste viscosity(HPV), cool paste viscosity(CPV), breakdown viscosity(BKV), setback viscosity(SBV), consistency viscosity(CSV), peak time(PeT) and pasting temperature(PaT). QTL analysis was carried out using one-way analysis of variance and Dunnett's test, and stable QTLs were identified over two years and under two environments. We identified 10 stable QTLs: qPKV2-1, qSBV2-1; qPKV5-1, qHPV5-1, qCPV5-1; qPKV7-1, qHPV7-1, qCPV7-1, qSBV7-1; and qPKV8-1 on chromosomes 2, 5, 7 and 8, respectively, with contributions ranging from-95.6% to 47.1%. Besides, there was pleiotropy in the QTLs on chromosomes 2, 5 and 7. | ZHANG Chang-quan HU Bing ZHU Kong-zhi ZHANG Hua LENG Ya-lin TANG Shu-zhu GU Ming-hong LIU Qiao-quan | 2013 | Rice science2013，20，6： | 2 |
| 6 | Stability of superconducting Nd_(0.8)Sr_(0.2)NiO_(2) thin films显示文摘The discovery of superconducting states in the nickelate thin film with infinite-layer structure has paved a new way for studying unconventional superconductivity.So far,research in this field is still very limited due to difficulties in sample preparation.Here we report the successful preparation of the superconducting state of Nd_(0.8)Sr_(0.2)NiO_(2)thin film(T_(c)=8.0-11.1 K)and study the stability of such films in the ambient environment,water,and under electrochemical conditions.Our work demonstrates that the superconducting state of Nd_(0.8)Sr_(0.2)NiO_(2)is remarkably stable,which can last for at least 47-day continuous exposure to air at 20°C and 35%relative humidity.We also show that the superconductivity disappears after being immersed in de-ionized water at room temperature for 5 h.Surprisingly,it can also survive under ionic liquid gating conditions with an applied voltage of about 4 V,which is even more stable than conventional perovskite complex oxides. | Xiang Ding Shengchun Shen Huaqian Leng Minghui Xu Yan Zhao Junrui Zhao Xuelei Sui Xiaoqiang Wu Haiyan Xiao Xiaotao Zu Bing Huang Huiqian Luo Pu Yu Liang Qiao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，6： | 2 |
| 7 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 8 | Power scaling on tellurite glass Raman fibre lasers for mid-infrared applications显示文摘The power scaling on mid-infrared Raman fibre lasers(RFLs) is in demand for applications in health, environment and security. In this paper, we present the simulated laser behaviours of the tellurite glass RFLs pumped by 300-W Tm-doped fibre lasers(TDFLs) at 2 μm for the first time. By combining the advantages of the TDFLs and tellurite fibre, the output power at 2.35 μm has reached over hundreds of watts by first-order Raman shift. Moreover, the cascaded RFLs have been demonstrated with a wavelength extension greater than 3 μm and output power of tens of watts. To maximize the output power and the slope efficiency of the RFLs, we further analyse the interaction between the Raman gain and cavity loss, which are determined by fibre length and output reflectance of the laser cavity. | Tianfu Yao Liangjin Huang Pu Zhou Bing Lei Jinyong Leng Jinbao Chen | 2018 | High Power Laser Science and Engineering2018，6，2： | 2 |
| 9 | Clear Cell Sarcoma: A Case Report with Radiological and Pathological Features of an Atypi- cal Case显示文摘 | Bing Leng Xinmin Zhang Sayed Ali | 2012 | Case Rep Oncol2012，8，： | 1 |
| 10 | Performance evaluation of BPM sys- tem in SSRF using PCA method显示文摘 | CHEN Zhichu LENG Yongbin YAN Ying- bing | 2014 | Chinese Physics C2014，38，08： | 1 |
| 11 | The role of ABA in triggering ethylene biosynthesis and ripening of tomato fruit显示文摘 | Zhang Mei Yuan Bing Leng Ping | | 0，，06： | 1 |
| 12 | A metapattern Based Automated Discovery Loop for Integrated Data Mining-Unsupervised Learning of Relational Patterns显示文摘 | Wei-Min Shen Bing Leng | 1996 | IEEE Transaction on Knowledge and Data Engineering1996，8，6： | 1 |
| 13 | A Metapattern- Based Automated Discovery Loop for Integrated Data Ming-Unsupervised Learning of Relational显示文摘 | Shen Weimin Leng Bing | 1996 | IEEE Transactions on knowledge and Data Engineering1996，8，6： | 1 |
| 14 | Analysis of shrinkage-induced stresses in concrete pavements显示文摘 | ZHANG Jun LENG Bing | 2004 | Magazine of Concrete Research2004，56，10： | 1 |
| 15 | Evidence for solar forcing of climate variation from δ18O of peat cellulose显示文摘 | Liu Tongsheng Jiang Hongbo Zhou Liping Hong Bing Zhu Yongxuan Li Handing Leng Xuetian Qin Xiaoquang Wang Yu Lin Qinghua Zeng Yiqiang | 2000 | Science in China (Series D)2000，43，2： | 1 |
| 16 | Highly efficient visible-light photocatalytic degradation and antibacterial activity by GaN:ZnO solid solution nanoparticles显示文摘The development of high-efficiency photocatalysts is the primary goal in the field of photocatalytic antibacterial research.In this work,the Ga N:Zn O solid solution nanoparticles(NPs)photocatalyst with strong visible absorption and large specific surface area was synthesized via the sol-gel and nitridation reaction process.Also,we systematically investigated the removal efficiency of the organic pollutant and antibacterial activity on E.coli and S.aureus.Notably,methylene blue solution could be completely degraded after 100 min of visible light illumination using 2 mg/m L Ga N:Zn O catalyst.Moreover,~94%of the E.coli were inactivated within 120 min,whereas 100%antibacterial activity against S.aureus was achieved after 90 min of visible light illumination mediated by Ga N:Zn O NPs.We further explore the potential mechanism of visible light photocatalytic antibacterial activity enhanced by Ga N:Zn O NPs photocatalyst.The current work not only provides a new and efficient photocatalytic antibacterial nanomaterial but also demonstrates its promising applications in environmental and biological fields. | Bing Leng Xinglai Zhang Shanshan Chen Jing Li Ziqing Sun Zongyi Ma Wenjin Yang Bingchun Zhang Ke Yang Shu Guo | 2021 | Journal of Materials Science & Technology2021，，35： | 1 |
| 17 | Transition from multiple macro- cracking to multiple micro-cracking in eementitious compos- ites显示文摘 | ZHANG Jun LENG Bing | 2008 | Tsinghua Science and Technology2008，13，66： | 1 |
| 18 | Experimental Study and Theoretical Analysis of Resistance of Steel-Concrete-Steel Sandwich Beams显示文摘 | LENG Yu Bing SONG Xiao Bing CHU Meng GE Hong Hui | 2014 | Journal of Structural Engineering2014，141，04： | 1 |
| 19 | Beta-delayed Proton Decay of Proton Drip-line Nucleus ^(142)Ho显示文摘Unknown beta-delayed proton precursor^(142)Ho was synthesized in the reaction^(106)Cd(^(40)Ca,p3n)and identified for the first time by using a proton-gamma coincidence measurements in combination with a helium-jet fast tape transport system^([1~3]).Its beta-delayed proton spectrum was observed.The hal-life of^(142)Ho | Xu Shuwei, Li Zhankui, Xie Yuanxiang, Wang Xudong, Guo Bing, Leng Changgeng Yu Yong, Wang Chunfang, Xing Jianping, Chen Hongyan and Zhang Tianmei | 2001 | IMP & HIRFL Annual Report2001，，1： | 1 |
| 20 | Biosynthesis and functions of metabolites显示文摘Metabolism is the basic activity of life.Two international conferences,including the 4th International Conference on Plant Metabolism(ICPM2017,http://gffzzcb1b8d6db44943e3hp6vcqv0fpqfb6knq.ffgz.tsg.suse.edu.cn/2017/icpm.asp),and the 13th International Meeting on Biosynthesis,Function and Synthetic Biology of Isoprenoids(TERPNET2017,http://gffzzcb1b8d6db44943e3hp6vcqv0fpqfb6knq.ffgz.tsg.suse.edu.cn/2017/terpnet.asp)were concurrently convened side by side in Dalian from July 16 to 20,2017.The two conferences were scheduled with independent programs to keep their traditional style,but also arranged | juncong sun bing leng guoan sheng xin fang laigeng li jirong huang xiaoquan qi xiaoya chen | 2017 | Science China(Life Sciences)2017，60，11： | 1 |
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