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| 1 | Clinical analysis of surgical treatment of portal hypertension显示文摘AIM: To review the experience in surgery for 508 patients with portal hypertension and to explore the selection of reasonable operation under different conditions.METHODS: The data of 508 patients with portal hypertension treated surgically in 1991-2001 in our centers were analyzed. Of the 508 patients, 256 were treated with portaazygous devascularization (PAD),167 with portasystemic shunt (PSS), 62 with selective shunt (SS), 11 with combined portasystemic shunt and portaazygous devascularization (PSS+PAD), 9 with liver transplantation (LT), 3 with union operation for hepatic carcinoma and portal hypertension (HCC+PH).RESULTS: In the 167 patients treated with PSS, free portal pressure (FPP) was significantly higher in the patients with a longer diameter of the anastomotic stoma than in those with a shorter diameter before the operation (P<0.01). After the operation, FPP in the former patients markedly decreased compared to the latter ones (P<0.01).The incidence rate of hemorrhage in patients treated with PAD, PSS, SS, PSS+PAD, and HCC+PH was 21.09% (54/256), 13.77 (23/167), 11.29 (7/62), 36.36% (4/11),and 100% (3/3), respectively. The incidence rate of hepatic encephalopathy was 3.91% (10/256), 9.58% (16/167),4.84% (3/62), 9.09% (1/11), and 100% (3/3), respectively while the operative mortality was 5.49% (15/256), 4.22% (7/167), 4.84% (3/62), 9.09% (1/11), and 66.67% (2/3) respectively. The operative mortality of liver transplantation was 22.22% (2/9).CONCLUSION: Five kinds of operation in surgical treatment of portal hypertension have their advantages and disadvantages. Therefore, the selection of operation should be based on the actual needs of the patients. | Xin-Bao Xu Jing-Xiu Cai Xi-Sheng Leng Jia-Hong Dong Ji-Ye Zhu Zhen-Ping He Fu-Shun Wang Ji-Run Peng Ben-Li Han Ru-Yu Du | 2005 | World Journal of Gastroenterology2005，11，29： | 15 |
| 2 | Total polysaccharides of the Sijunzi decoction attenuate tumor necrosis factor-α-induced damage to the barrier function of a Caco-2 cell monolayer via the nuclear factor-κB-myosin light chain kinase-myosin light chain pathway显示文摘AIM To explore the protective effects and underlying mechanisms of total polysaccharides of the Sijunzi decoction(TPSJ) on the epithelial barriers in vitro. METHODS Caco-2 cell monolayers were treated with or without TPSJ in the presence or absence of TNF-α, and paracellular permeability and transepithelial electrical resistance(TEER) were measured to evaluate the epithelial barrier function. Immunofluorescence and western blotting were respecti-vely used to evaluate the distribution and expression of the tight junction proteins claudin 1, claudin 2, zo3, and occludin in Caco-2 cells. western blotting was also used to evaluate the cellular expression of myosin light chain(MLC), phosphorylated MLC(pM LC), MLC kinase(MLCK), and nuclear factor(NF)-κB p65. RESULTS TPSJ promoted the proliferation of Caco-2 cells and inhibited TNF-α-induced secretion of pro-inflammatory cyto-kines. Furthermore, TPSJ significantly ameliorated both the reduction of TEER and the increased paracellular permeability observed in tumor necrosis factor(TNF)-α-damaged Caco-2 monolayers. Furthermore, TPSJ remarkably attenuated TNF-α-induced morphological changes, downregulated the expression of claudin 1, claudin 2, zo3, and occludin, and markedly suppressed TNF-α-mediated upregulation of p-MLC and MLCK expression. Finally, TPSJ inhibited the activation and expression of NF-κB p65. CONCLUSION Our results demonstrate that TPSJ alleviates the TNF-α-induced impairment of the intestinal epithelial cell barrier function by suppressing NF-κB p65-mediated phosphorylation of MLCK and MLC. | Yue Lu Leng Li Jin-wei Zhang Xiao-qin Zhong Jian-An wei Ling Han | 2018 | World Journal of Gastroenterology2018，24，26： | 10 |
| 3 | LncRNAs-directed PTEN enzymatic switch governs epithelial–mesenchymal transition显示文摘Despite the structural conservation of PTEN with dual-specificity phosphatases,there have been no reports regarding the regulatory mechanisms that underlie this potential dual-phosphatase activity.Here,we report that K27-linked polyubiquitination of PTEN at lysines 66 and 80 switches its phosphoinositide/protein tyrosine phosphatase activity to protein serine/threonine phosphatase activity.Mechanistically,high glucose,TGF-β,CTGF,SHH,and IL-6 induce the expression of a long non-coding RNA,GAEA(Glucose Aroused for EMT Activation),which associates with an RNA-binding E3 ligase,MEX3C,and enhances its enzymatic activity,leading to the K27-linked polyubiquitination of PTEN.The MEX3C-catalyzed PTEN^K27-polyUb activates its protein serine/threonine phosphatase activity and inhibits its phosphatidylinositol/protein tyrosine phosphatase activity.With this altered enzymatic activity,PTEN^K27-polyUb dephosphorylates the phosphoserine/threonine residues of TWIST1,SNAI1,and YAP1,leading to accumulation of these master regulators of EMT.Animals with genetic inhibition of PTEN^K27-polyUb,by a single nucleotide mutation generated using CRISPR/Cas9(Pten^K80R/K80R),exhibit inhibition of EMT markers during mammary gland morphogenesis in pregnancy/lactation and during cutaneous wound healing processes.Our findings illustrate an unexpected paradigm in which the lncRNA-dependent switch in PTEN protein serine/threonine phosphatase activity is important for physiological homeostasis and disease development. | Qingsong Hu Chunlai Li Shouyu Wang Yajuan Li Bo Wen Yanyan Zhang Ke Liang Jun Yao Youqiong Ye Heidi Hsiao Tina K.Nguyen Peter K.Park Sergey D.Egranov David H.Hawke Jeffrey R.Marks Leng Han Mien-Chie Hung Bing Zhang Chunru Lin Liuqing Yang | 2019 | Cell Research2019，29，4： | 8 |
| 4 | LINC00511 promotes gastric cancer cell growth by acting as a ceRNA显示文摘BACKGROUND Gastric cancer(GC)is one of the most aggressive malignancies,with a high incidence and poor prognosis worldwide.Recently,accumulating evidence has illustrated that long noncoding RNAs(lnc RNAs)play pivotal roles in many cancers.It has been reported that LINC00511 contributes to tumorigenesis in various diseases.However,the role of LINC00511 in GC cell growth remains mostly unknown.AIM To determine whether the lnc RNA LINC00511 exerted its carcinogenic function in GC via the miR-124-3 p/PDK4 axis.METHODS Cell culture and transfection,RNA extraction and quantitative real-time PCR,CCK-8 assay,Colony formation assay,Luciferase reporter assay,RIP assay,RNA pull-down assay,and Western blot analysis were used to show expression and mechanisms of LINC00511 in GC progression and apoptosis.Rescue assays were performed to verify the relationships among LINC00511,miR-124-3 p and PDK4 further.RESULTS The expression of LINC00511 was remarkably upregulated in GC cells compared to that in corresponding normal cell lines.Compared to the controls,cell proliferation was inhibited,and cell apoptosis was increased upon LINC00511knockdown,demonstrating that LINC00511 influenced GC cell growth.An exploration of the molecular mechanism revealed that LINC00511 functioned as a molecular sponge of miR-124-3 p and that PDK4 was a downstream target of miR-124-3 p in GC.Rescue assays showed that the overexpression of PDK4 could partly restore the inhibitory function of si-LINC00511 in GC.CONCLUSION These data demonstrate that LINC00511 promotes gastric cancer cell growth by acting as a ce RNA to regulate the miR-124-3 p/PDK4 axis,which may be a promising therapeutic target for GC. | Chong-Bing Sun Hong-Yi Wang Xiao-Qing Han Yong-Ning Liu Meng-Chun Wang Hong-Xia Zhang You-Feng Gu Xiao-Gang Leng | 2020 | World Journal of Gastrointestinal Oncology2020，12，4： | 7 |
| 5 | Protective effects of MCI-186 on oxidative damage in a cell model of Alzheimer's disease显示文摘Oxidative stress has an important role in the development of Alzheimer's disease (AD). Beta amyloid protein 25-35 (Aβ25-35) can generate oxygen free radicals, and MCI-186 (3-methyl-1-phenyl-2-pyrazolin-5-one, edaravone) can specifically eliminate hydroxyl radicals. The present study introduced Aβ25-35 into PC12 cells to establish a cell model of AD, and investigated the neuroprotective effects of MCI-186 on AD. Results showed that MCI-186 had a positive effect on the prevention and treatment of AD by inhibiting protein oxidative products, advanced glycation end products, lipid oxidative end products and DNA oxidative damage in PC12 cells induced by Aβ25-35. | Ming Yu Shujuan Li Wenhui Leng Han Chen Yingquan Wu Lirong Yan | 2010 | Neural Regeneration Research2010，5，16： | 5 |
| 6 | Micelle or polymersome formation by PCL-PEG-PCL copolymers as drug delivery systems显示文摘Polye-caprolactone)-b-poly(ethylene glycol)-b-poly(e-caprolactone)(PCL-b-PEG-b-PCL,PCEC) triblock copolymers have been widely investigated in last several decades.Here,by altering the weight ratio of monomers in ring-opening polymerization,a series of PCEC triblock copolymers with varying hydrophobicity were synthesized,which were characterized by FTIR,1 H NMR,GPC and DSC.When PCEC copolymers with different weight ratios of PCL/PEG were dispersed in different aqueous solutions,they could self-assemble and form two distinctive nanoparticular structures:micelles or polymersomes.We then chose paclitaxel(PTX) as the model drug and encapsulate PTX into PCEC polymeric micelles and polymersomes.The physicochemical characterizations of the nanoparticles such as morphology,the size and distribution,zeta potential,drug loading content,and encapsulation efficiency were also performed.Our results showed that polymeric micelles or polymersomes from PCEC both displayed narrow size distributions and could achieve high drug loading efficiencies.In vitro cellular uptake results suggested that Nile Red loaded polymeric micelles or polymersomes displayed more internalization after 24 h incubation than those after 4 h incubation.These findings suggest that polymeric micelles and polymersomes based on PCL-b-PEG-b-PCL copolymers have great potential to effectively delivery hydrophobic drugs. | Chunyan Hu Zhuo Chen Shengjie Wu Yanfeng Han Hai Wang Hongfan Sun Deling Kong Xigang Leng Chun Wang Linhua Zhang Dunwan Zhu | 2017 | Chinese Chemical Letters2017，28，9： | 4 |
| 7 | A remote sensing monitoring method for alpine grasslands desertification in the eastern Qinghai–Tibetan Plateau显示文摘Alpine grassland is the typical vegetation in the eastern Qinghai–Tibetan Plateau,which has important ecological service functions,and also supports the development of alpine stock farming.In recent years,under both the natural and human disturbance,alpine grasslands in this area have appeared to different degrees of desertification.A diagnosis of the desertification degree serves as the basis for grassland ecological restoration.This study constructs a comprehensive index based on remote sensing called alpine grassland desertification index(AGDI)to monitor the areas and degree of desertification.The most relevant indicators of desertification,namely,vegetation fraction,aboveground biomass,soil moisture,and land surface temperature,were selected to establish AGDI.The geographical detector is used to reselect and assess these indicators.The results show that the overall verification accuracy of AGDI is 82.05%.In particular,the accuracy of identifying severe desertification is the highest.Our study confirms that the desertification of alpine grasslands in the eastern Qinghai–Tibetan Plateau is characterized by fragmentation.Thus,Landsat-8 OLI data with a spatial resolution of 30 m is more suitable than MODIS data for alpine grasslands desertification monitoring.The research results can provide a methodological reference for monitoring desertification of alpine grasslands and other grassland regions in the world. | KUANG Qian YUAN Quan-zhi HAN Ji-chong LENG Rong WANG Yu-shuang ZHU Ke-hong LIN Shuo REN Ping | 2020 | Journal of Mountain Science2020，17，6： | 4 |
| 8 | A beam position measurement system of fully digital signal processing at SSRF显示文摘This fully digital beam position measurement instrument is designed for beam position monitoring and machine research in Shanghai Synchrotron Radiation Facility. The signals received from four position-sensitive detectors are narrow pulses with a repetition rate up to 499.654 MHz and a pulse width of around 100 ps, and their dynamic range could vary over more than 40 dB in machine research. By the employment of the under-sampling technique based on high-speed high-resolution A/D conversion, all the processing procedure is performed fully by the digital signal processing algorithms integrated in one single Field Programmable Gate Array. This system functions well in the laboratory and commissioning tests, demonstrating a position resolution (at the turn by turn rate of 694 kHz) better than 7 μm over the input amplitude range of -40 dBm to 10 dBm which is well beyond the requirement. | YAN Han ZHAO Lei LIU Shubin CHEN Kat WU Weihao AN Qi LENG Yongbin YI Xing YAN Yingbing LAI Longwei | 2012 | Nuclear Science and Techniques2012，23，2： | 3 |
| 9 | Pheromone Model Selection in Ant Colony Optimization for the Travelling Salesman Problem显示文摘As a meta-heuristic approach,Ant colony optimization(ACO) has many applications.In the algorithm selection of pheromone models is the top priority.Selecting pheromone models that don't suffer negative biases is a natural choice.Specifically for the travelling salesman problem,the first order pheromone is widely recognized.When come across travelling salesman problem,we study the reasons for the success of ant colony optimization from the perspective of pheromone models,and unify different order pheromone models.In tests,we have introduced the concept of sample locations and the similarity coefficient to pheromone models.The first order pheromone model and the second order pheromone model are compared and are further analysed.We illustrate that the second order pheromone model has better global search ability and diversity of population than the former.With appropriate-scale travelling salesman problems,the second order model performs better than the first order pheromone model. | LIU Shufen LENG Huang HAN Lu | 2017 | Chinese Journal of Electronics2017，26，2： | 3 |
| 10 | The genome of the recretohalophyte Limonium bicolor provides insights into salt gland development and salinity adaptation during terrestrial evolution显示文摘Halophytes have evolved specialized strategies to cope with high salinity.The extreme halophyte sea lavender(Limonium bicolor)lacks trichomes but possesses salt glands on its epidermis that can excrete harmful ions,such as sodium,to avoid salt damage.Here,we report a high-quality,2.92-Gb,chromosome-scale L.bicolor genome assembly based on a combination of Illumina short reads,single-molecule,real-time long reads,chromosome conformation capture(Hi-C)data,and Bionano genome maps,greatly enriching the genomic information on recretohalophytes with multicellular salt glands.Although the L.bicolor genome contains genes that show similarity to trichome fate genes from Arabidopsis thaliana,it lacks homologs of the decision fate genes GLABRA3,ENHANCER OF GLABRA3,GLABRA2,TRANSPARENT TESTA GLABRA2,and SIAMESE,providing a molecular explanation for the absence of trichomes in this species.We identified key genes(LbHLH and LbTTG1)controlling salt gland development among classical trichome homologous genes and confirmed their roles by showing that their mutations markedly disrupted salt gland initiation,salt secretion,and salt tolerance,thus offering genetic support for the long-standing hypothesis that salt glands and trichomes may share a common origin.In addition,a whole-genome duplication event occurred in the L.bicolor genome after its divergence from Tartary buckwheat and may have contributed to its adaptation to high salinity.The L.bicolor genome resource and genetic evidence reported in this study provide profound insights into plant salt tolerance mechanisms that may facilitate the engineering of salt-tolerant crops. | Fang Yuan Xi Wang Boqing Zhao Xiaojing Xu Miao Shi Bingying Leng Xinxiu Dong Chaoxia Lu Zhongtao Feng Jianrong Guo Guoliang Han Haikuan Zhang Jianwei Huang Min Chen Bao-Shan Wang | 2022 | Molecular Plant2022，15，6： | 3 |
| 11 | dentification of DW532 as a novel anti-tumor agent targeting both kinases and tubulin显示文摘 | Ting PENG Jian-rui WU Lin-jiang TONG Meng-yuan LI Fang CHEN Yi-xin LENG Rong QU Kun HAN Yi SU Yi CHEN Wen-hu DUAN Hua XIE Jian DING | 2014 | Acta Pharmacologica Sinica2014，35，7： | 3 |
| 12 | Impact of Chronic Stress on Attention Control:Evidence from Behavioral and Event-Related Potential Analyses显示文摘Chronic stress affects brain function,so assessing its hazards is important for mental health.To overcome the limitations of behavioral data,we combined behavioral and event-related potentials(ERPs)in an attention network task.This task allowed us to differentiate between three specific aspects of attention:alerting,orienting,and execution.Forty-one participants under chronic stress and 31 non-stressed participants were enrolled.On the performance level,the chronically stressed group showed a significantly slower task response and lower accuracy.Concerning ERP measures,smaller cue-N1,cueN2,and larger cue-P3 amplitudes were found in the stressed group,indicating that this group was less able to assign attention to effective information,i.e.,they made inefficient use of cues and had difficulty in maintaining alerting.In addition,the stressed group showed larger target-N2 amplitudes,indicating that this group needed to allocate more cognitive resources to deal with the conflict targets task.Subgroup analysis revealed lower target-P3 amplitudes in the stressed than in the non-stressed group.Group differences associated with the attention networks were found at the ERP level.In the stressed group,excessive depletion of resources led to changes in attention control.In this study,we examined the effects of chronic stress on individual executive function from a neurological perspective.The results may benefit the development of interventions to improve executive function in chronically stressed individuals. | Qingjin Liu Yong Liu Xuechen Leng Jinfeng Han Feng Xia Hong Chen | 2020 | Neuroscience Bulletin2020，36，11： | 3 |
| 13 | Industrial TiO2 based nacreous pigments as functional building materials:Photocatalytic removal of NO显示文摘In this paper,the photocatalytic activity of industrial titanium dioxide(TiO2)based nacreous pigments was researched as functional building materials for photocatalytic NO remove.Three industrial TiO2 based nacreous pigments were selected to estimate the photocatalytic activity for NO remove.This study is a good proof that pearlescent pigments can eliminate NO,and its performance is positively correlated with its titanium dioxide content.And this research will widen the application of nacreous pigments in functional building materials,and provide a new way to eliminate in door nitric oxide pollution. | Jue Li Li Wang Chunqiu Han Fengyun Su Yumin Leng Liqun Ye | 2020 | Chinese Journal of Chemical Engineering2020，28，10： | 3 |
| 14 | Microbial diversity and functionally distinct groups in produced water from the Daqing Oilfield,China显示文摘The microbial community structure and functionally distinct groups in three kinds of produced water samples from the shallow,mesothermic and low-salinity Daqing oil reservoir were systematically evaluated using both culture-dependent and culture-independent methods.Sequence analysis of the 16S rRNA genes indicated that the bacterial library was dominated by Acinetobacter and Arcobacter and the archaeal community was dominated by Methanosaeta and Methanolinea.Two isolated methanogens were closely related with Methanothermobacter thermautotrophicus and Methanoculleus receptaculi.The fermentative bacteria were identified as Pseudomonas,Haloanaerobium,Alcalibacter,Arcobacter,and Pannonibacter.The predominant nitrate-reducing bacteria fell within the genus Pseudomonas.The dominant members of the cultured hydrocarbon-oxidizing bacteria were phylogenetically associated with Micrococcus,Pseudomonas,and Bacillus.Enrichments of biosurfactants and biopolymer producing groups mainly yielded Pseudomonas,Bacillus,and Acenitobacter-related members.The functional groups related to polymer degradation were also affiliated with Pseudomonas and Bacillus.Results from this study provide the fresh insight into the diversity of microbial communities in Daqing petroleum reservoirs.The vast pool of functional strains retrieved in this study was presumed to include the promising strains that could be applied in microbial-enhanced oil recovery in future. | Li Hui Ai Mingqiang Han Siqin Guo Yanling Li Nana Shi Rongjiu Zeng Xiangling Leng Shengbing Zhao Jinyi Liu Xiaobo Zhang Ying | 2012 | Petroleum Science2012，9，4： | 3 |
| 15 | Chlorine doped graphitic carbon nitride nanorings as an efficient photoresponsive catalyst for water oxidation and organic decomposition显示文摘Rationally engineering the microstructure and electronic structure of catalysts to induce high activity for versatile applications remains a challenge. Herein, chlorine doped graphitic carbon nitride(Cl-doped g-C3N4) nanorings have been designed as a superior photocatalyst for pollutant degradation and oxygen evolution reaction(OER). Remarkably, Cl-doped g-C3N4 nanorings display enhanced OER performance with a small overpotential of approximately 290 m V at current density of 10 m A cm^-2 and Tafel slope of 83 m V dec-1, possessing comparable OER activity to precious metal oxides RuO2 and IrO2/C. The excellent catalytic performance of Cl-doped g-C3N4 nanorings originates from the strong oxidation capability,abundant active sites exposed and efficient charge transfer. More importantly, visible light irradiation gives rise to a prominent improvement of the OER performance, reducing the OER overpotential and Tafel slope by 140 m V and 28 m V dec^-1, respectively, demonstrating the striking photo-responsive OER activity of Cl-doped g-C3N4 nanorings. The great photo-induced improvement in OER activity would be related to the efficient charge transfer and the·OH radicals arising spontaneously on CN-Cl100 catalyst upon light irradiation. This work establishes Cl-doped g-C3N4 nanorings as a highly competitive metal-free candidate for photoelectrochemical energy conversion and environmental cleaning application. | Er-Xun Han Yuan-Yuan Li Qi-Hao Wang Wei-Qing Huang Leng Luo Wangyu Hu Gui-Fang Huang | 2019 | Journal of Materials Science & Technology2019，35，10： | 2 |
| 16 | Assessment of ischemia-modified albumin levels for emergency room diagnosis of acute coronary syndrome显示文摘 | Xiao-li Shen Cai-jing Lin Li-li Han Lin Lin Leng Pan Xiao-dong Pu | 2010 | International Journal of Cardiology2010，，3： | 2 |
| 17 | Validation of Landsat land surface temperature product in the conterminous United States using in situ measurements from SURFRAD, ARM, and NDBC sites显示文摘Since 1982,Landsat series of satellite sensors continuously acquired thermal infrared images of the Earth’s land surface.In this study,Landsat 5,7,and 8 land surface temperature(LST)products in the conterminous United States from 2009 to 2019 were validated using in situ measurements collected at 6 SURFRAD(Surface Radiation Budget Network)sites,6 ARM(Atmospheric Radiation Measurement)sites,and 9 NDBC(National Data Buoy Center)sites.The results indicate that a relatively consistent performance among Landsat 5,7,and 8 LST products is obtained for most sites due to the consistent LST retrieval algorithm in conjunction with the same atmospheric compensation and land surface emissivity(LSE)correction methods for Landsat 5,7,and 8 sensors.Large bias and root mean square error(RMSE)of Landsat LST product are obtained at some vegetated sites due to incorrect LSE estimation where LSE is invariant with the increasing of normalized difference vegetation index(NDVI).Except for the sites with incorrect LSE estimation,a mean bias(RMSE)of the differences between Landsat LST and in situ LST is 1.0 K(2.1 K)over snow-free land surfaces,−1.1 K(1.6 K)over snow surfaces,and−0.3 K(1.1 K)over water surfaces. | Si-Bo Duan Zhao-Liang Li Wei Zhao Penghai Wu Cheng Huang Xiao-Jing Han Maofang Gao Pei Leng Guofei Shang | 2021 | International Journal of Digital Earth2021，14，5： | 2 |
| 18 | Similar or different: the same Spiro-core but different alkyl chains with apparently improved device performance of perovskite solar cells显示文摘By intelligently utilizing the odd-even effect existing in the melting points of alkanes as presented in the basic textbook of Organic Chemistry, different alkoxy groups were introduced to modify the structure of commercial Spiro-OMeTAD to give new Spiro derivatives of Spiro-OEtTAD, Spiro-OPrTAD, Spiro-OiPrTAD and Spiro-OBuTAD, with the aim to adjust the molecular packing status in perovskite solar cells as hole transporting compounds. Excitedly, with the introduction of ethoxy groups instead of the methoxy ones in Spiro-OMeTAD, Spiro-OEtTAD-based perovskite solar cells demonstrated the highest device performance of 20.16%, higher than that of Spiro-OMeTAD(18.64%). | Fan Liu Shiqing Bi Xiaorui Wang Xuanye Leng Mengmeng Han Baoda Xue Qianqian Li Huiqiong Zhou Zhen Li | 2019 | Science China Chemistry2019，62，6： | 2 |
| 19 | Cyclooxygenase-2 promotes hepatocelluar carcinoma cell growth throush Akt activation:evidence for Akt inhibition in celecoxib-induced apoptosis显示文摘 | Han C Demetris AJ | 2003 | Hepatology2003，38，3： | 1 |
| 20 | Cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through Akt activation:evidence for Akt inhibition in celecoxib-induced apoptosis显示文摘 | Leng J Han C Demetris AJ | 2003 | Hepatology2003，38，3： | 1 |
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