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| 1 | Assessment of vascular invasion in gastric cancer: A comparative study显示文摘AIM: To evaluate and compare detection of lymphatic and blood vessel invasion (LVI and BVI) by hematox-ylin-eosin (HE) and immunohistochemistry (IHC) in gastric cancer specimens, and to correlate with lymph node status. METHODS: IHC using D2-40 (a lymphatic endothelial marker) and CD34 (a pan-endothelial marker) was performed to study LVI and BVI in surgical specimens froma consecutive series of 95 primary gastric cancer cases. The results of the IHC study were compared with the detection by HE using McNemar test and kappa index. The morphologic features of the tumors and the presence of LVI and BVI were related to the presence of lymph node metastasis. A χ2 test was performed to obtain associations between LVI and BVI and other prognostic factors for gastric cancer. RESULTS: The detection rate of LVI was considerably higher than that of BVI. The IHC study identified eight false-positive cases and 13 false-negative cases for LVI, and 24 false-positive cases and 10 false-negative cases for BVI. The average Kappa value determined was moderate for LVI (k=0.50) and low for BVI (k=0.20). Both LVI and BVI were statistically associated with the presence of lymph node metastasis (HE: P=0.001, P=0.013, and IHC: P=0.001, P=0.019). The mor-phologic features associated with LVI were location of the tumor in the distal third of the stomach (P=0.039), Borrmann's macroscopic type (P=0.001), organ inva-sion (P=0.03) and the depth of tumor invasion (P=0.001). The presence of BVI was related only to the depth of tumor invasion (P=0.003). CONCLUSION: The immunohistochemical identification of lymphatic and blood vessels is useful for increasing the accuracy of the diagnosis of vessel invasion and for predicting lymph node metastasis. | Letícia Trivellato Gresta Ismael Alves Rodrigues-Júnior Lúcia Porto Fonseca de Castro Geovanni Dantas Cassali Mnica Maria Demas lva-res Cabral | 2013 | World Journal of Gastroenterology2013，19，24： | 8 |
| 2 | Antioxi- dant strategies for preventing oxidative flavor deterioration of foods enriched with n-3 polyunsaturated lipids: A comparative evaluation 显示文摘 | JACOBSEN C LET M B NIELSEN N S | 2008 | Trends Food Sci Technol2008，19，： | 1 |
| 3 | Affican swine fever virus structural protein p54 is essential for the recruitment of envelope precursors to assembly sites显示文摘 | Rodriguez J M Garcia-Escudero R Salas M Let d | 2004 | J Virol2004，78，8： | 1 |
| 4 | Orexin A stimulates glucose uptake,lipid accumulation and adiponectin secretion from 3T3-L1 adipocytes and isolated primary rat adipocytes显示文摘 | SKRZYPSKI M LET T KACEMAREK P | 2011 | Diabetologia2011，54，7： | 1 |
| 5 | Localization of the ethylene receptor ETR1 to the endoplasmic reticulum of Arabidopsis显示文摘 | Chen Y F Randlett M D Findell J Let aI | 2002 | Journal of Biological Chemistry2002，277，19： | 1 |
| 6 | Sustained release of bupivacaine from devices based on chitosan显示文摘 | Bernardo M V Blanco M D Sastre R Let aI | 2003 | Farmaco2003，58，11： | 1 |
| 7 | The role of defective clearance of apoptotic cells in systemic autoimmunity显示文摘 | Munoz LEt Lauber K Schiller M | 2010 | Nat Rev Rheumatol2010，6，5： | 1 |
| 8 | Ascorbyl palmitate,y- tocopherol, and EDTA affect lipid oxidation in fish oil enriched salad dressing differently显示文摘 | Let M B Jacobsen C Meyer A S | 2007 | Journal of Agricuhural and Food Chemistry2007，55，6： | 1 |
| 9 | Proeoagulants and osteonecrosis显示文摘 | JONES L C MONT M A LET B | 2003 | J Rheumatol2003，30，4： | 1 |
| 10 | Image decomposition using total variation and div (BMO) * 显示文摘 | LET M VESE L A | 2005 | Multiscale Modeling and Simulation2005，4，2： | 1 |
| 11 | Development of biode- gradable films from whey proteins by cross-linking and entrapment in cellulose显示文摘 | LET C LETENDRE M ISPAS S P | 2000 | J Agric Food Chem2000，48，11： | 1 |
| 12 | Image decompo- sition using total variation and homogeneous besov spaces显示文摘 | GARNETF J B LET M MEYER Y VESE L A | 2007 | Ap-plied and Computational Harmonic Analysis2007，23，1： | 1 |
| 13 | Surgical treatment of no- narticular distal tibia fractures 显示文摘 | BEDI A LET T KARUNAKAR M A | 2006 | J Am Acad Orthop Surg2006，14，7： | 1 |
| 14 | Use of upflow sludge blanket resterconcept for biological wastewater treatment 显示文摘 | Lettings G Ve-lsen A F M Zeeu W J | 1980 | Biotechnology and Bioengineering1980，22，4： | 1 |
| 15 | Diagnostic Accuracy of Cone Beam Computed Tomography and Conventional Radiography on Apical Periodontitis: A Systematic Review and Meta-Analysis显示文摘 | Kamile Leonardi Dutra Letícia Haas André Luís Porporatti Carlos Flores-Mir Juliana Nascimento Santos Luis André Mezzomo Márcio Corrêa Graziela De Luca Canto | 2015 | Journal of Endodontics2015，，： | 1 |
| 16 | Thermal characterization of polymer matrix composites containing microencapsulated paraffin in solid or liquid state显示文摘 | Sari Bey S Fois M Krupa Let a/ | 2014 | Energy Conversion and Management2014，78，： | 1 |
| 17 | Effects of cold stratification, temperature, light and salinity on seed germination and radi- cle growth of the desert halophyte shrub Kalidiurn caspicum (Chenopodiaceae)显示文摘 | Qu X X Jerry M B Let W | 2008 | Plant Growth Regulation2008，54，： | 1 |
| 18 | A study on the thermal conductivity of compact-ed bentonites显示文摘 | TANG A M C UI Y J LET T | 2008 | Applied Clay Science2008，41，3： | 1 |
| 19 | Lung transthoracic ultrasound elastograp hy imaging and guided biopsies of subpleural cancer:a preliminary report显示文摘 | Sperandeo M Trovato FM Dimitri Let a/ | 2015 | Acta Radiol2015，56，7： | 1 |
| 20 | Use of enzymetic transesterified palm stearin- sunflower oil blends in the preparation of table margarine 显示文摘 | MING L O GHAZALI M LET C C | 1999 | Food Chemistry1999，64，1： | 1 |
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