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| 1 | Analysis of the Global Burden of Disease study highlights the trends in death and disability-adjusted life years of leukemia from 1990 to 2017显示文摘Background:The patterns of leukemia burden have dramatically changed in recent years.This study aimed to estimate the global trends of leukemiarelated death and disability-adjusted life-years(DALYs)from 1990 to 2017.Methods:The data was acquired from the latest version of the Global Burden of Disease(GBD)study.Estimated annual percentage changes(EAPCs)were calculated to estimate the trend of age-standardized rate(ASR)of death and DALYs due to leukemia and its main subtypes from 1990 to 2017.Results:Globally,the numbers of death and DALYs due to leukemia were 347.58×10^(3)(95%uncertainty interval[UI]=317.26×10^(3)-364.88×10^(3))and 11975.35×10^(3)(95%UI=10749.15×10^(3)-12793.58×10^(3))in 2017,with a 31.22% and 0.03% increase in absolute numbers from 1990 to 2017,respectively.Both of their ASR showed decreasing trends from 1990 to 2017 with the EAPCs being−1.04(95%confidence interval[CI]=(−1.10-−0.99)and−1.52(95%CI=−1.59-−1.44),respectively.Globally,the most pronounced decreasing trend of death and DALYs occurred in chronic myeloid leukemia with EAPCs of−2.76(95%CI=−2.88-−2.64)and−2.84(95%CI=−2.97-−2.70),respectively,while the trend increased in acute myeloid leukemia.The death and DALYs of leukemia decreased in most areas and countries with high socio-demographic index(SDI)including Bahrain,Finland,and Australia.Conclusions:The disease burden of death and DALYs due to leukemia decreased globally,and for most regions and countries from 1990 to 2017.However,the leukemia burden is still a substantial challenge globally and required adequate and affordable medical resources to improve the survival and quality of life of leukemia patients. | Zejin Ou Danfeng Yu Yuanhao Liang Wenqiao He Yongzhi Li Minyi Zhang Fangfei You Huan He Qing Chen | 2020 | Cancer Communications2020，40，11： | 4 |
| 2 | siRNA沉默STAT5对食管癌EC9706细胞增殖、凋亡和侵袭的影响(英文)显示文摘Objective:The aim of the study was to explore the effect of STAT5 silenced by siRNA on proliferation,apoptosis and invasion of esophageal carcinoma cell line EC9706.Methods:The siRNA vectors aiming to STAT5 gene were constructed.STAT5 siRNA was transfected into EC9706 cells by Lipofectamine TM 2000.Changes of STAT5,Bcl-2 and Cyclin D1 were analyzed by Western blot and RT-PCR.Effect of STAT5 siRNA on EC9706 cells proliferation was determined by MTT.Effects of STAT5 siRNA on EC9706 cells cycle and apoptosis were detected by the flow cytometry.Boyden chamber was used to evaluate the invasion and metastasis capabilities of EC9706 cells.Results:The double strands oligonucleotide of siRNA aiming to STAT5 was successfully cloned into the pRNAT-U6.1 vector,and the target sequence was coincide with the design.RT-PCR and Western blotting detection demonstrated that the expression levels of STAT5,Bcl-2 and Cyclin D1 genes were obviously decreased in EC9706 cells transfected with STAT5 targeting siRNA expression vectors.STAT5 siRNA could suppress the proliferation of EC9706 cells.The proportions of S and G2/M periods frequency were significantly decreased (P < 0.05),and the proportion of G0/G1 period frequency was significantly increased (P < 0.05).The average amount of cells penetrating Matrigel was significantly decreased (P < 0.05).Silencing the STAT5 induced the apoptosis of esophageal carcinoma cell line EC9706 (P < 0.01).Conclusion:STAT5 silenced by siRNA of esophageal carcinoma cell line EC9706 could induce the apoptosis.And it could suppress the proliferation,invasion and metastasis of tumor cells. | Daoxin Jin Wenqiao Zang Tao Wang Min Li Jieru Wan Guoqiang Zhao | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，12： | 2 |
| 3 | A Preliminary Study on the Datong Fault Belt显示文摘The Datong fault belt is a NE trending fault in the northern Qinghai-Xizang (Tibet) Plateau and controls the boundary of the Xining Basin and Datong Basin. It consists of the Maziying-Miaogou (F_1) fault and the Laoye Mountain-Nanmenxia fault (F_2). There is obvious displacement in vertical direction along the belt. The field investigation results show that this belt has long-term activity. There are several meters long crushed zones and veins along the fault side in the basement rock. On the fault section,the Cambria system thrusts over the red-brick-colored Quaternary Period gravel,and there is a fault gouge of several centimeters thick developed on the fault plane. The fault gouge date (ESR) on the fault plane is 610±61ka. The covering deluvial loess is not dislocated,and the OSL result is 14.6±1.5ka. So it can be concluded that the fault belt was active in the middle Pleistocene,but inactive in the late Pleistocene according to the age data and geomorphologic features. Interior formations of the Datong basin features fold with the major axis orienting northwest. According to the relation of fault and fold deformation,Datong fault is a transversal tear,which is due to uneven compression of the folds in different parts and NNE trending regional compressive stress. It is common among the NE trending faults in the northeast of Qinghai-Xizang (Tibet) Plateau. These NE trending faults aren't large,and most are located in the active plate. They are all nearly vertical to the axis of the folds and compressive basins. | Li Zhimin Tian Qinjian Yao Shenghai Li Wenqiao Chen Youshun Zou Haining Gao Zhanwu | 2008 | Earthquake Research in China2008，22，3： | 2 |
| 4 | Effects of Octreotide on Activated Pancreatic Stellate Cell-Induced Pancreas Graft Fibrosis in Rats显示文摘 | Dan Long Jun Lu Lei Luo Yingjia Guo Chengwen Li Wenqiao Wu Juan Shan LuLu Li Shengfu Li YouPing Li Tao Lin Li Feng | 2012 | Journal of Surgical Research2012，，1： | 1 |
| 5 | Interpretation of the Spatial Distribution Characteristics of the Co-seismic Landslides Induced by the 1920 Haiyuan M81/2 Earthquake Using Remote Sensing Images显示文摘Analyzing the spatial distribution characteristics of earthquake-induced secondary disasters based on advanced techniques is significantly important,especially in understanding the process of strong earthquakes in the Loess Pateau.Using ArcGIS,this study interprets multi-temporal high-resolution satellite images,field investigation data,and historical seismic records.Major conclusions are obtained as follows:①Landslides induced by the Haiyuan earthquake are mainly distributed in the intersection area of the end of the Haiyuan fault and Liupanshan fault,as indicated by multiple dense distribution centers;②The landslide distribution of the Haiyuan Earthquake is determined by the distance to the fault,topographic relief,slope,lithology,and other factors.In detail,the closer the distance to the fault,the greater the density of the landslide.The greater the slope and relief of the terrain,the greater the density and the smaller the average area of a landslide.Compared with tertiary strata,Quaternary strata has a larger average area,and the density of the landslides is smaller;③The density curve of the death toll in the Haiyuan earthquake can be used as a reference for the distribution of co-seismic landslides.Several Haiyuan co-seismic landslides are distributed in the Tongwei landslide area;however,the major landslides here are induced by the 1718 Tongwei earthquake rather than the 1920 Haiyuan earthquake;④The co-seismic landslides of the Haiyuan earthquake exhibits the“slope effect”in the south-west plate of Haiyuan fault,presenting the dominant sliding direction towards the fault and epicenter;however,the“slope effect”is not evident in the northeast plate of the fault. | ZHANG Weiheng XU Yueren DU Peng LI Wenqiao TIAN Qinjian CHEN Lize | 2020 | Earthquake Research in China2020，34，4： | 1 |
| 6 | Relationship between the Landslides Triggered by the Tongwei M71/2 Earthquake in 1718 AD and the Disappearance of Yongning Ancient Town显示文摘Although China’s historical earthquake documentation is relatively rich,it is not all based on scientific records.Therefore,the verification of the seismic information in historical records can effectively avoid exaggerating or underestimating the damage they produced.In this paper,we analyze the detailed information of the 1718 AD Tongwei M7⅟��earthquake through field surveys,document sorting,and manual visual interpretation of UAV images.Major conclusions are listed as follows:①The low-level terraces of Weihe River between Gangu and Wushan are fully developed with flatted surface,and the residents here are mostly killed by house collapses.In addition,the disappearance of Yongning Ancient Town is not directly related to the earthquakeinduced landslides;②In fact,“Yongning Town is entirely buried by the earthquake”in the historical records describes the phenomenon that loess dust has pervaded the entire Weihe Valley.These dust grains are produced by the sliding of earthquakeinduced landslides.Thus,there is no possibility that large-scale landslides have slipped over Weihe bedrock and buried Yongning Town;③After the earthquake,survivors abandoned the ruins and selected a new site to live.They built a new town named“Pan’an(means always peaceful in the future)”.earthquake-induced landslides may be the reason of burying the residential areas on valley-side slopes,while those locations inside the valley are associated with the amplification effect of ground vibration.On the basis of compiling historical seismic data,scientific methods are used to explore the real meaning of these documents,for the purpose of providing basic data for the risk evaluation of strong historical earthquakes. | XU Yueren DU Peng LI Wenqiao TIAN Qinjian CHEN Lize | 2020 | Earthquake Research in China2020，34，4： | 1 |
| 7 | The Calculation Method for the Volume of Landslides and Dammed Lake Sediments Triggered by a Strong Historical Earthquake in the Loess Plateau:A Case Study of Qiuzigou, Gansu Province, Northwest China显示文摘The quantitative calculation of the volume of large earthquake-triggered landslides and related dammed lake sediments is of great significance in the study of secondary disasters and focal parameters of strong historical earthquakes.In this study,the dammed lake induced by Qishan M7 earthquake(Lingtai County,Gansu Province,Northwest China)is selected as the research object.Based on the information collected from the 4 boreholes in the dammed lake area,we further take advantage of the lowlevel Unmanned Aerial Vehicle(UAV)photogrammetry and the morphology recovery method,to calculate the volume of the dammed lake and landslides,respectively.Finally,major conclusions are obtained as follows:①the AMS-14C age at the bottom of the Qiuzigou Dammed Lake sediments is 2890±30 BP,which coincides with the 780 BC Qishan earthquake;furthermore,the Qiuzigou Landslides seem to have been triggered by the earthquake,forming an enclosed dammed lake deposition environment after the upstream sediments accumulate;②the Qiuzigou landslides are opposite-sliding landslides that have blocked the river valley;in detail,landslide volumes at the right and left banks are 235×104 m3 and 229×104 m3,respectively.The length of the dammed lake is 2.6 km,with a thickness of approximately 43 m near the landslides,and the total sedimentary volume is 573×104 m3;③the erosion rate of Qiuzigou Landslide Dammed Lake is 0.44 mm/a,the accumulation rate is 15.05 mm/a,and the soil erosion modulus is 593 t/(km2/a),characterized as slight erosion.Quantitative research on the formation of landslides and dammed lakes from strong historical earthquakes is vital for increasing our understanding of the vibrational characteristics and surface action processes of these types of earthquakes. | DU Peng XU Yueren LI Wenqiao TIAN Qinjian CHEN Lize | 2020 | Earthquake Research in China2020，34，4： | 1 |
| 8 | The Volume Calculation Method of Rock Collapses and Loess Landslides Triggered by the 1556 AD Huaxian M81/2 Earthquake in Shaanxi Province, China显示文摘Accurate volume calculation of each individual landslide triggered by strong historical earthquakes can help understand the characteristics of the typical earthquake-induced landslides,thus providing significant information for the modification of the focal parameters of historical earthquakes.In this study,we select one rock fall and three loess landslides triggered by the 1556 AD Huaxian M8⅟��earthquake,compute their volumes using the low-altitude high-precision Unmanned Aerial Vehicle(UAV)photogrammetry and landslide profile restoration methods.The results show that:①the whole influencing area of the Huangjiagou Rock Fall is approximately 3.03×105 m2 and the area of the collapsed rock accumulated at the slope foot is 3.33×104 m2,accounting for approximately 10%of the entire influencing range.However,the estimated volume of the collapsed rock is only 0.699×106 m3,indicating a rock fall with large influencing range but limited collapsed rock;②the geological form of thethree loess landslides are preserved intactly,with volumes of 0.283×108 m3,0.074×108 m3,and 0.377×108 m3.These important geological hazard relics reflect the strong vibrations and severe casualties in the meizoseismal area;③loess landslides are the key reason of the serious death toll in the hilly-gully loess area.Our new method can be used to estimate the influencing area and the actual volume of each individual landslide,and rationally evaluate the role of earthquake landslides in the disaster.In addition,quantitative research on secondary disasters triggered by strong historical earthquakes is beneficial for understanding the surface process and focal parameters of the earthquakes. | ZHANG Yanbo XU Yueren DU Peng LI Wenqiao CHEN Lize TIAN Qinjian | 2020 | Earthquake Research in China2020，34，4： | 1 |
| 9 | Do CD4 + Foxp3 + Treg cells correlate with transplant outcomes: A systematic review on recipients of solid organ transplantation显示文摘 | Juan Shan Yinjia Guo Lei Luo Jun Lu Chengwen Li Chuntao Zhang Yuchuan Huang Li Feng Wenqiao Wu Dan Long Shengfu Li Youping Li | 2011 | Cellular Immunology2011，，1： | 1 |
| 10 | Population genetic structure in wild and aquaculture populations of Hemibarbus maculates inferred from microsatellites markers显示文摘The objective of this study was to investigate 4 aquaculture populations Shanghai(SH),Hangzhou(HZ),Kaihua(KH)and Xianju(XJ)and one wild population Yingshan(YS)of spotted barbell(Hemibarbus maculates)to assess their genetic diversity level and investigate the genetic structure of the populations.The dendrogram and STRUCTURE revealed that the populations XJ,KH,and HZ jointly formed one cluster,to which the populations SH and YS were sequentially adhered.The genetic diversity of the cultured populations maintained better,possible due to favourable hatchery conditions that decreased the effect of environmental selection present in wild populations.The results of the present study will contribute to the management of spotted barbell genetic resources,but also demonstrates how the genetic diversity of freshwater species is vulnerable to human activity. | Linlin Li Hungdu Lin Wenqiao Tang Dong Liu Baolong Bao Jinquan Yang | 2017 | Aquaculture and Fisheries2017，2，2： | 1 |
| 11 | MicroRNA-124 inhibits cellular proliferation and invasion by targeting Ets-1 in breast cancer显示文摘 | Wentao Li Wenqiao Zang Pei Liu Yuanyuan Wang Yuwen Du Xiaonan Chen Meng Deng Wencong Sun Lei Wang Guoqiang Zhao Baoping Zhai | 2014 | Tumor Biology2014，，： | 1 |
| 12 | A case-based reasoning method of recognizing liquefaction pits induced by 2021 M_(W) 7.3 Madoi earthquake显示文摘Earthquake-triggered liquefaction deformation could lead to severe infrastructure damage and associated casualties and property damage.At present,there are few studies on the rapid extraction of liquefaction pits based on high-resolution satellite images.Therefore,we provide a framework for extracting liquefaction pits based on a case-based reasoning method.Furthermore,five covariates selection methods were used to filter the 11 covariates that were generated from high-resolution satellite images and digital elevation models(DEM).The proposed method was trained with 450 typical samples which were collected based on visual interpretation,then used the trained case-based reasoning method to identify the liquefaction pits in the whole study area.The performance of the proposed methods was evaluated from three aspects,the prediction accuracies of liquefaction pits based on the validation samples by kappa index,the comparison between the pre-and post-earthquake images,the rationality of spatial distribution of liquefaction pits.The final result shows the importance of covariates ranked by different methods could be different.However,the most important of covariates is consistent.When selecting five most important covariates,the value of kappa index could be about 96%.There also exist clear differences between the pre-and post-earthquake areas that were identified as liquefaction pits.The predicted spatial distribution of liquefaction is also consistent with the formation principle of liquefaction. | Peng Liang Yueren Xu Wenqiao Li Yanbo Zhang Qinjian Tian | 2023 | Earthquake Research Advances2023，3，1： | 0 |
| 13 | Calculation of reverse-fault-related parameters using topographic profiles and fault bedding显示文摘Fault-related parameters are critical for studying tectonic evolution, deformation characteristics, active tectonism, and seismic hazards. A new method of calculating reverse-faultrelated parameters has been developed, which uses systematic analysis of the geometrical characteristics of normal and reverse scarps of reverse faults together with measurements of topographic profiles and fault bedding. The results show that the most suitable method of calculating fault parameters heavily relies on the specific type of fault scarp. For a reverse scarp,the size of the vertical displacement(VD) of the fault, the vertical separation(VS) of the hanging wall and the footwall, and the fault scarp height(SH) show the relationship VD VS SH;conversely, for normal scarps, VD VS SH. The theoretical equations were used to study fault deformation in the Southwest Tianshan Mountain foreland basin. The results showed that,for every fault, VD VS SH, which is consistent with our predicted relationship. This finding demonstrates that this method is suitable to explore structural information of reverse faults. In the study area, the vertical displacement is 1.4 times the horizontal displacement, suggesting that flexural-slip faults may play an important role in transferring local deformation from horizontal shortening to vertical uplift. Therefore, one of the most important steps in correct calculation of reverse-fault-related parameters is selection of the proper equations by identifying the specific type of fault scarp and the corresponding calculation method. | Yang Xiaodong Li Wenqiao Qin Zhen | 2015 | Geodesy and Geodynamics2015，6，2： | 0 |
| 14 | Research of the Differential Uplifting in the Palongzangbu Region Based on the Synthesis of the Watershed Index and Seismic Data显示文摘Research on the differential uplifting in the Palongzangbu region is crucial to understanding the tectonic deformation mechanism and establishing the model of the faulted blocks in the region of the east structural knot.In this paper,based on the ASTER-30m DEM,we calculate the hypsometry index(HI)of 19 watersheds in the Palongzangbu region,and study the differential uplifting in this region combining with seismic data,the ground deposition and erosion process.The result shows that the spatial distribution of the HI value can reflect the differential uplifting in the study area.Differential uplifting exists within different zones,and there are 2 relative strong uplifting centers.One center is near the east structural knot,and the other lies between the Lhari fault and Nujiang fault at their converging segment.Also,the watershed evolution,seismic activity,and ground deposition and erosion process are closely related to each other,and they constitute a chain of evidence which reveals the whole process from the tectonic movement underground to the landform evolution on the surface. | Wang Lin Zhao Yan Tian Qinjian Li Wenqiao Xu Yueren | 2018 | Earthquake Research in China2018，32，1： | 0 |
| 15 | Coseismic surface rupture characteristics and earthquake damage analysis of the eastern end of the 2021 M_(S)7.4 Madoi(Qinghai)earthquake显示文摘At 02:04 on May 22,2021,an M_(S)7.4 earthquake occurred in Madoi County in Qinghai Province,China.This earthquake is the largest seismic event in China since the 2008M_(S) 8.0 Wenchuan earthquake.Thus,it is critical to investigate surface deformation and damage in time to accurately understand the seismogenic structure of the Madoi earthquake and the seismogenic capacity of the blocks in this region.This study focuses on the Xuema Village,located at the eastern end of the coseismic surface ruptures produced by the event,and assesses the deformation and seismic damage in this area based on field surveys,UAV photogrammetry,and ground penetrating radar(GPR).The results indicate that the rupture scale is substantially smaller at the eastern end of the rupture zone compared to other segments.En echelon type shear tensile fractures are concentrated in a width range of 50–100 m,and the width of single fractures ranges from 20 to 30 cm.In contrast,the degree of seismic damage significantly increases at this site.All of the brick and timber houses are damaged or collapsed,while the steel frame structures and the color steel houses are slightly damaged.More than 80%of the bridge decks on the Changma River Bridge collapse,similar to the terraces along the Youerqu and Changma Rivers and the cut slopes of Provincial Highway S205.We infer that the seismogenic fault of the Madoi earthquake exerts a tail effect in this segment.The tension zone has led to a reduction at the eastern end of the rupture zone,causing shaking damage.Local topography and buildings without earthquake-resistant construction along the strike of the rupture zone have undergone different levels of seismic damage. | Yanbo Zhang Yueren Xu Wenqiao Li Runchao Liu Ruoyu Mu Jiayi Li Da Zhang Haofeng Li Qinjian Tian | 2022 | Earthquake Research Advances2022，2，2： | 0 |
| 16 | Blubber fatty acid compositions in different geographic populations of finless porpoise in Chinese waters:implications for thermal adaptation显示文摘The stratification of blubber fatty acids(FAs)is a widely used strategy in marine mammals and can be influenced by many factors,including their diet,environmental temperature,and physiological status.There are 3 distinct finless porpoise species/subspecies in Chinese coastal and inland waters in a wide range from 20°N to 40°N.The biochemical stratification of the blubbers of finless porpoises in different regions may provide valuable information for understanding their environmental adaptations.The FA compositions of 4 geographic populations of finless porpoise(FP)collected from the Bohai Gulf,East China Sea,South China Sea,and Yangtze River were therefore analyzed and compared.The blubber FA compositions of finless porpoises were dominated by∑MUFAs,followed by∑SFAs and∑PUFAs,and were generally consistent with those of other cetaceans.The blubber of finless porpoises was significantly stratified with increasing levels of∑MUFAs and decreasing levels of∑SFAs and∑PUFAs from the inner to the outer layers.The 3 marine populations shared more similarities in their FA compositions and stratifications compared to the freshwater porpoises,particularly regarding the PUFAs in the inner layers,which might have been mainly influenced by the diet compositions of marine and freshwater porpoises.Contrary to what was expected,in the 3 marine populations,the SFA and MUFA levels showed opposite correlations(negative and positive,respectively)with habitat temperatures,possibly indicating an adaptation mechanism in finless porpoises characterized by a trade-off between the insulation and fluidity properties of the blubber through the adjustment of the compositions and gradients of MUFAs and SFAs across the blubber depth in response to environmental temperature/latitude changes. | Bin TANG Ya ZHANG Peijun ZHANG Songhai LI Jinsong ZHENG Wenqiao TANG Kexiong WANG Ding WANG Yujiang HAO | 2022 | Integrative Zoology2022，17，4： | 0 |
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