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| 1 | Photochemical pollution in Lanzhou, China - A case study显示文摘The photochemical air pollution in Xigu district of Lanshou city, Gansu Province was studied during a period of 1981-1984. The extremely high NMHC/NOx ratio and ozone level elevation after rain have been noticed. A series of outdoor and indoor reaction chamber simulation experiments conducted in order to understand the specific conditions. The ozone formation under NMHC/NOx condition and the possible reason for high ozone concentration after rain are discussed. | Tang Xiaoyan , Li Jinglong, Dong ZhenXing, Wang Yuying,Wang Wenxing , Qi Liwen, Liu Xiling, Zhang Yutian, Zhang Xuejin,Tian Bingshen, Jin Suwen , Yang Lingqing and Zhang Yixin Department of Technical Physics,Peking University, Beijing, China. Chinese Reaearch Academy of Eavironmental Sciences, Beijing,China. Gansu Provincial Environmental Research Institute, Lanshou, China. Lanshou Petrochemical Engineering Institute, Lanshou, China. | 1989 | Journal of Environmental Sciences1989，1，1： | 15 |
| 2 | Expression of a Buckwheat Trypsin Inhibitor Gene in Escherichia coil and its Effect on Multiple Myeloma IM-9 Cell Proliferation显示文摘荞麦胰蛋白酶抑制剂(BTI ) 的基因在 Escherichia 被克隆并且表示这个 recombinant 禁止者的产量在由在 Ni^(2+)-NTA Sepharose 列上使用 one-steppurification 的 12 mg/L 上的 coli.The。它的分子的重量是 9322.1 Da,由集体光谱分析决定了。MTT 和 cytometry 分析证明 recombinant BTI 能明确地禁止 IM-9 人的 B lymphoblastoid 房间的增长(从有多重骨髓瘤的病人) 以一种剂量依赖者方式。recombinant 的测试在 IM-9 房间的导致 BTI 的 apoptosis 暗示禁止者可能在癌症的治疗有潜在的申请。 | Zheng ZHANG Yuying LI Chen LI Jingming YUAN Zhuanhua WANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，9： | 14 |
| 3 | Advances in fabrication of ceramic corundum abrasives based on sol–gel process显示文摘Corundum abrasives with good chemical stability can be fabricated into various free abrasives and bonded abrasive tools that are widely used in the precision machining of various parts.However,these abrasives cannot satisfy the machining requirements of difficult-to-machine materials with high hardness,high strength,and strong wearing resistance.Although superhard abrasives can machine the above-mentioned materials,their dressing and manufacturing costs are high.By contrast,ceramic corundum abrasives fabricated by sol–gel method is a costeffective product between conventional and superhard abrasives.Ceramic corundum abrasives exhibit self-sharpening and high toughness.In this review,the optimization methods of ceramic corundum abrasive properties are introduced from three aspects:precursor synthesis,particle shaping,and sintering.Firstly,the functional mechanism of seeds and additives on the microstructural and mechanical properties of abrasives is analyzed.Specifically,seeds can reduce the phase transition temperature and improve fracture toughness.The grain size and uniformly dense structure can be controlled by applying an appropriate amount of multicomponent additives.Then,the urgent need of engineering application and machinability of special shape ceramic corundum abrasives is reviewed,and three methods of abrasive shaping are summarized.The micromold replication technique is highly advanced and can be used to prepare functional abrasives.Additionally,the influence of a new sintering method,namely,two-step sintering technique,on the microstructural and mechanical performance of ceramic corundum abrasives is summarized.Finally,the challenge and developmental trend of the optimization of ceramic corundum abrasives are prospected. | Baoteng HUANG Changhe LI Yanbin ZHANG Wenfeng DING Min YANG Yuying YANG Han ZHAI Xuefeng XU Dazhong WANG Sujan DEBNATH Muhammad JAMIL Hao Nan Li Hafiz Muhammad ALI Munish Kumar GUPTA Zafar SAID | 2021 | Chinese Journal of Aeronautics2021，34，6： | 11 |
| 4 | Flavonoids from tartary buckwheat induce G2/M cell cycle arrest and apoptosis in human hepatoma HepG2 cells显示文摘 | Yuying Li Shizhao Duan Haiyan Jia Chongzhi Bai Liwei Zhang Zhuanhua Wang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，6： | 10 |
| 5 | Rescued virus from infectious cDNA clone of rabbit hemorrhagic disease virus is adapted to RK13 cells line显示文摘Based on the infectious full-length cDNA clone of rabbit hemorrhagic disease virus (RHDV), the in vitro transcripts are introduced into RK13 cells. 12 h later, CPE could be observed clearly, and virual antigen could also be detected by IFA. The titre of the recovered virus is 104.6/mL. Immune electron micro-scopic observation of the virus particles revealed that the particles were rotund with a diameter of about 30 nm. Besides, virus titre quantification obtained by qRT-PCR showed a correlation between time from infection and virus titre. All these results showed that we have recovered RHDV from RK13 cells by re-verse genetics technology successfully, and this would be very useful in studies of the antigenicity, virulence, pathogenesis, maturation and new type vaccines of RHDV. | LIU Guangqing NI Zheng YUN Tao ZHANG Yuying DU Qingyun SHENG Zutian LIANG Huali HUA Jionggang LI Shuangmao Chen Jianping | 2006 | Chinese Science Bulletin2006，51，14： | 9 |
| 6 | ^11C-PIBPET和^18F-FDGPET显像诊断阿尔茨海默病与遗忘型轻度认知损害的临床价值显示文摘目的应用11C-PIB PET和18F-FDG PET显像研究阿尔茨海默病和遗忘型轻度认知损害患者β-淀粉样蛋白(Aβ)沉积与葡萄糖代谢之间的关系,联合载脂蛋白E(ApoE)基因型进一步探讨遗忘型轻度认知损害与阿尔茨海默病的相关性。方法利用PET显像对阿尔茨海默病(14例)、遗忘型轻度认知损害(10例)和正常对照者(5例)脑组织Aβ沉积和葡萄糖代谢变化进行分析,采用聚合酶链反应-限制性片段长度多态性方法对ApoE基因型进行分析。结果阿尔茨海默病组患者11C-PIB标准化摄取比值在下顶叶、颞叶外侧、额叶、后扣带回皮质和楔前叶、枕叶和纹状体均高于正常对照组(P<0.05);遗忘型轻度认知损害组患者脑组织11C-PIB结合水平呈双峰形。11C-PIB+aMCI亚组与阿尔茨海默病组、11C-PIB-aMCI亚组与正常对照组之间11C-PIB标准化摄取比值差异均无统计学意义(P>0.05)。18F-FDG PET显像显示,3/5例11C-PIB+aMCI亚组患者双侧顶叶、颞叶和楔前叶代谢减低,其中2例ApoEε4等位基因携带者随访期间进展至阿尔茨海默病;3/5例11C-PIB-aMCI亚组患者双侧额叶和前扣带回代谢减低。结论11C-PIB PET显像是筛查具有阿尔茨海默病病理特点的遗忘型轻度认知损害患者的有效工具。具有阿尔茨海默病病理特征的遗忘型轻度认知损害患者可伴有顶叶、颞叶外侧皮质和楔前叶代谢减低,其中ApoEε4等位基因携带者更易进展至阿尔茨海默病痴呆。 | Shi Zhihong Wang Ying Liu Shuai Liu Shuling Z hou Yuying Wang Jinhuan Cai Li Gao Shuo Ji Yong | 2014 | 中国现代神经疾病杂志2014，14，3： | 8 |
| 7 | Expert Consensus on the Care and Management of Patients with Cognitive Impairment in China显示文摘The cognitive disease consensus was prepared by panels of health and public representatives based on actual clinical practice in Geriatric Departments in Chinese hospitals and a systematic literature review. This consensus reflects the medical knowledge accumulated by those experts and provides information about professional medical care and advice.A multidisciplinary panel of specialists(neurologists,psychiatrists, and nursing specialists) reports an expert consensus on the medical knowledge accumulated from those experts and provides information about professional medical care and advice. The recommendations focus on the care and management of older adults with mild cognitive impairment,the objectives and methods of maintaining cognition and training, the assessments and measures of daily care for patients at different stages of dementia, the assessments and coping strategies for the behavioral and psychological symptoms of dementia, principles and suggestions for an appropriate living environment, arrangements for recreational activities, the care and management of patients with endstage dementia, and suggestions for addressing stress in caregivers. | 无 Yuliang Han Jianjun Jia Xia Li Yang Lv Xuan Sun Shanshan Wang Yongjun Wang Zhiwen Wang Jintao Zhang Jiong Zhou Yuying Zhou | 2020 | Neuroscience Bulletin2020，36，3： | 7 |
| 8 | Visualization of perforin/gasdermin/complement-formed pores in real cell membranes using atomic force microscopy显示文摘Different types of pores ubiquitously form in cell membranes,leading to various types of cell death that profoundly influence the fate of inflammation and the disease status.However,these pores have never truly been visualized to date.Atomic force microscopy(AFM),which is emerging as a powerful tool to analyze the mechanical properties of biomolecules and cells,is actually an excellent imaging platform that allows biological samples to be visualized by probing surface roughness at the level of atomic resolution.Here,membrane pore structures were clearly visualized using AFM.This visualization not only describes the aperture and depth of the pore complexes but also highlights differences among the pores formed by perforin and gasdermins in tumor cell membranes and by complement in immune cell membranes.Additionally,this type of visualization also reveals the dynamic process of pore formation,fusion,and repair. | Yuying Liu Tianzhen Zhang Yabo Zhou Jiping Li Xiaoyu Liang Nannan Zhou Jiadi Lv Jing Xie Feiran Cheng Yiliang Fang Yunfeng Gao Ning Wang Bo Huang | 2019 | Cellular & Molecular Immunology2019，16，6： | 6 |
| 9 | Biomechanical analysis of optic nerve injury treated by compound light granules and ciliary neurotrophic factor显示文摘In this study, rabbit models of optic nerve injury were reproduced by the clamp method. After modeling, rabbit models were given one injection of 50 ng recombinant human ciliary neurotrophic factor into the vitreous body and/or intragastric injection of 4 g/kg compound light granules containing Radix Angelicae Sinensis and Raidix Paeoniae Alba at 4 days after modeling, once per day for 30 consecutive days. After administration, the animals were sacrificed and the intraorbital optic nerve was harvested. Hematoxylin-eosin staining revealed that the injured optic nerve was thinner and optic nerve fibers were irregular. After treatment with recombinant human ciliary neurotrophic factor, the arrangement of optic nerve fibers was disordered but they were not markedly thinner. After treatment with compound light granules, the arrangement of optic nerve fibers was slightly disordered and their structure was intact. After combined treatment with recombinant human ciliary neurotrophic factor and compound light granules, the arrangement of optic nerve fibers was slightly disordered and the degree of injury was less than after either treatment alone. Results of tensile mechanical testing of the optic nerve showed that the tensile elastic limit strain, elastic limit stress, maximum stress and maximum strain of the injured optic nerve were significantly lower than the normal optic nerve. After treatment with recombinant human ciliary neurotrophic factor and/or compound light granules, the tensile elastic limit strain, elastic limit stress, maximum stress and maximum strain of the injured optic nerve were significantly increased, especially after the combined treatment. These experimental findings indicate that compound light granules and ciliary neurotrophic factor can alleviate optic nerve injury at the histological and biochemical levels, and the combined treatment is more effective than either treatment alone. | Yuying Jiang Haitao Xu Jingxiang Liu Peng Li Yazhen Wu | 2012 | Neural Regeneration Research2012，7，36： | 6 |
| 10 | The transcription factor SlHY5 regulates the ripening of tomato fruit at both the transcriptional and translational levels显示文摘Light plays a critical role in plant growth and development,but the mechanisms through which light regulates fruit ripening and nutritional quality in horticultural crops remain largely unknown.Here,we found that ELONGATED HYPOCOTYL 5(HY5),a master regulator in the light signaling pathway,is required for normal fruit ripening in tomato(Solanum lycopersicum).Loss of function of tomato HY5(SlHY5)impairs pigment accumulation and ethylene biosynthesis.Transcriptome profiling identified 2948 differentially expressed genes,which included 1424 downregulated and 1524 upregulated genes,in the Slhy5 mutants.In addition,genes involved in carotenoid and anthocyanin biosynthesis and ethylene signaling were revealed as direct targets of SlHY5 by chromatin immunoprecipitation.Surprisingly,the expression of a large proportion of genes encoding ribosomal proteins was downregulated in the Slhy5 mutants,and this downregulation pattern was accompanied by a decrease in the abundance of ribosomal proteins.Further analysis demonstrated that SlHY5 affected the translation efficiency of numerous ripening-related genes.These data indicate that SlHY5 regulates fruit ripening both at the transcriptional level by targeting specific molecular pathways and at the translational level by affecting the protein translation machinery.Our findings unravel the regulatory mechanisms of SlHY5 in controlling fruit ripening and nutritional quality and uncover the multifaceted regulation of gene expression by transcription factors. | Weihao Wang Peiwen Wang Xiaojing Li Yuying Wang Shiping Tian Guozheng Qin | 2021 | Horticulture Research2021，8，1： | 6 |
| 11 | Hydrothermal Self-assembly Synthesis of Mn3O4Reduced Graphene Oxide Hydrogel and Its High Electrochemical Performance for Supercapacitors显示文摘在现在的工作 Mn3O4/reduced graphene 氧化物 hydrogel (Mn3O4-rGOH ) 与三维(3D ) 网络被制作由一热水自己组装线路。同样获得的样品的形态学,作文,和微观结构用粉末X光检查衍射( XRD )被描绘,X光检查光电子光谱学( XPS ), thermogravimetry 分析( TG ),原子吸收 spectrometry ( AAS ),回答扫描电子显微镜学( FESEM )和传播电子显微镜( TEM )的排放。而且,电气化学的行为被周期的 voltammogram (CV ) 评估, galvanostatic 费用分泌物和电气化学的阻抗光谱学(EIS ) 。测试结果显示有 6.9% Mn3O4 的 hydrogel 完成了 148 F | Li Li Zhongai Hu Yuying Yang Pengju Liang Ailian Lu Huan Xu Yingying Hu Hongying Wu | 2013 | Chinese Journal of Chemistry2013，31，10： | 6 |
| 12 | Mucus production stimulated by IFN-AhR signaling triggers hypoxia of COVID-19显示文摘Silent hypoxia has emerged as a unique feature of coronavirus disease 2019(COVID-19).In this study,we show that mucins are accumulated in the bronchoalveolar lavage fluid(BALF)of COVID-19 patients and are upregulated in the lungs of severe respiratory syndrome coronavirus 2(SARS-CoV-2)-infected mice and macaques.We find that induction of either interferon(IFN)-P or IFN-y upon SARS-CoV-2 infection results in activation of aryl hydrocarbon receptor(AhR)signaling through an IDO-Kyn-dependent pathway,leading to transcriptional upregulation of the expression of mucins,both the secreted and membrane-bound,in alveolar epithelial cells.Consequently,accumulated alveolar mucus affects the blood-gas barrier,thus inducing hypoxia and diminishing lung capacity,which can be reversed by blocking AhR activity.These findings potentially explain the silent hypoxia formation in COVID-19 patients,and suggest a possible intervention strategy by targeting the AhR pathway. | Yuying Liu Jiadi Lv Jiangning Liu Man Li Jing Xie Qi Lv Wei Deng Nannan Zhou Yabo Zhou Jiangping Song Peng Wang Chuan Qin Wei-Min Tong Bo Huang | 2020 | Cell Research2020，30，12： | 5 |
| 13 | Genomic surveillance of coxsackievirus A10 reveals genetic features and recent appearance of genogroup D in Shanghai,China,2016–2020显示文摘Coxsackievirus A10(CVA10)is one of the major causative agents of hand,foot and mouth disease(HFMD).To investigate the epidemiological characteristics as well as genetic features of CVA10 currently circulating in Shanghai,China,we collected a total of 9,952 sporadic HFMD cases from January 2016 to December 2020.In the past five years,CVA10 was the fourth prevalent causatives associated with HFMD in Shanghai and the overall positive rate was 2.78%.The annual distribution experienced significant fluctuations over the past five years.In addition to entire VP1 sequencing,complete genome sequencing and recombination analysis of CVA10 isolates in Shanghai were further performed.A total of 64 near complete genomes and 11 entire VP1 sequences in this study combined with reference sequences publicly available were integrated into phylogenetic analysis.The CVA10sequences in this study mainly belonged to genogroup C and presented 91%-100%nucleotide identity with other Chinese isolates based on VP1 region.For the first time,our study reported the appearance of CVA10 genogroup D in Chinese mainland,which had led to large-scale outbreaks in Europe previously.The recombination analysis showed the recombination break point located between 5,100 nt and 6,700 nt,which suggesting intertypic recombination with CVA16 genogroup D.To conclusion,CVA10 genogroup C was the predominant genogroup in Shanghai during 2016-2020.CVA10 recombinant genogroup D was firstly reported in circulating in Chinese mainland.Continuous surveillance is needed to better understand the evolution relationships and transmission pathways of CVA10 to help to guide disease control and prevention. | Jiayu Wang Jiajing Liu Fanghao Fang Jiajin Wu Tianjiao Ji Yuying Yang Ling Liu Chongshan Li Wanju Zhang Xi Zhang Zheng Teng | 2022 | Virologica Sinica2022，37，2： | 5 |
| 14 | TRANSFER MATRIX METHOD FOR ANALYZING VIBRATION AND DAMPING CHARACTERISTICS OF ROTATIONAL SHELL WITH PASSIVE CONSTRAINED LAYER DAMPING TREATMENT显示文摘The first order differential matrix equations of the host shell and constrained layer for a sandwich rotational shell are derived based on the thin shell theory.Employing the layer wise principle and first order shear deformation theory, only considering the shearing deformation of the viscoelastic layer, the integrated first order differential matrix equation of a passive constrained layer damping rotational shell is established by combining with the normal equilibrium equation of the viscoelastic layer.A highly precise transfer matrix method is developed by extended homogeneous capacity precision integration technology.The numerical results show that present method is accurate and effective. | Jing Lu Yu Xiang Yuying Huang Xiaoni Li Qiao Ni | 2010 | Acta Mechanica Solida Sinica2010，23，4： | 5 |
| 15 | Occurrence of bisphenol A in surface and drinking waters and its physicochemical removal technologies显示文摘Bisphenol A (BPA ) ,内分泌的破坏混合物,在环境和有害效果由于它的宽出现引起了宽公共担心。BPA 与最大的集中在许多表面水和喝的水里被检测了直到十 | Liping LIANG Jing ZHANG Pian FENG Cong LI Yuying HUANG Bingzhi DONG Lina LI Xiaohong GUAN | 2015 | Frontiers of Environmental Science & Engineering2015，9，1： | 5 |
| 16 | Boosted electromagnetic wave absorption performance from synergistic induced polarization of SiC_(NWs)@MnO_(2)@PPy heterostructures显示文摘In the last decade,electromagnetic pollution has caused people’s considerable attention.Developing absorbing material with low cost,lightweight,simple preparation,and high electromagnetic attenuation efficiency has become a feasible means to deal with this problem.In this work,core–shell SiC_(NWs)@MnO_(2)@PPy(NWs:nanowires,PPy:polypyrrole)heterostructures composed of SiC nanowires core,MnO_(2)nanosheets inter-layer,and PPy coating were successfully prepared through chemical vapor deposition and two-step electrodeposition process.Taking advantage of the interfacial polarization and dipole polarization,the obtained product displays excellent electromagnetic wave absorption performances with the minimum reflection loss(RLmin)of−50.59 dB when the matching thickness is 2.41 mm,and the optimal effective absorption bandwidth(EAB)value reaches to 6.64 GHz at a matching thickness of 2.46 mm,revealing that the SiC_(NWs)@MnO_(2)@PPy nanocomposite could be served as a promising electromagnetic wave absorbing material.On the basis of systematic analysis concerning the electromagnetic parameters,the dissipation process of the incident electromagnetic wave was demonstrated reasonably,which may provide a referable preparation strategy for novel heterostructures,especially nonmagnetic lightweight absorbing material. | Meng Zhang Laibin Zhao Wenxin Zhao Ting Wang Liying Yuan Yuying Guo Yuxin Xie Tingting Cheng Alan Meng Zhenjiang Li | 2023 | Nano Research2023，16，2： | 4 |
| 17 | Blastic Plasmacytoid Dendritic Cell Neoplasm:Progress in Cell Origin,Molecular Biology,Diagnostic Criteria and Therapeutic Approaches显示文摘Blastic plasmacytoid dendritic cell neoplasm(BPDCN)is a rare hematological malignancy characterized by recurrent skin nodules,an aggressive clinical course with rapid involvement of hematological organs,and a poor prognosis with poor overall survival.BPDCN is derived from plasmacytoid dendritic cells(pDCs)and its pathogenesis is unclear.The tumor cells show aberrant expression of CD4,CD56,interleukin-3 receptor alpha chain(CD 123),blood dendritic cell antigen 2(BDCA 2/CD303),blood dendritic cell antigen 4(BDCA4)and transcription factor(E protein)E2-2(TCF4).The best treatment drugs are based on experience by adopting those used for either leukemia or lymphoma.Relapse with drug resistance generally occurs quickly.Stem cell transplantation after the first complete remission is recommended and tagraxofusp is the first targeted therapy.In this review,we summarize the differentiation of BPDCN from its cell origin,its connection with normal pDCs,clinical characteristics,genetic mutations and advances in treatment of BPDCN.This review provides insights into the mechanisms of and new therapeutic approaches for BPDCN. | Wei CHENG Tian-tian YU Ai-ping TANG Ken HE YOUNG Li YUI | 2021 | Current Medical Science2021，41，3： | 4 |
| 18 | ANALYSIS ON BUCKLING AND POSTBUCKLING OF DELAMINATION IN 3D COMPOSITES显示文摘In this paper, the problem of axisymmetric buckling and postbuckling of a circular thin-film delamination bridged by through-thickness fiber tows in 3D composites is presented. An iterativeprocedure based on Taylor’s series expansion is used to generate a family of nondimensionalized post-buckling solutions of the above problem by yon Karman’s nonlinear plate theory. Attention is fo-cused, herein, on the effects of the bridge force of through-thickness fibers on the buckling and post-buckling behavior of the delamination. It is found that fiber bridge not only increases the ability of re-sisting delamination buckling and postbuckling, but also brings on the jump of the delamination deflec-tion mode during the postbuckling phase. Consequently the behavior of the composite structure with de-lamination is greatly improved, such as increasing the residual strength and prolonging the service life. | Li Siping** Huang Yuying Hu Yuantai Zhong Weifang, Huazhong University of Science and Technology, Wuhan 430074, China Doctoral candidate from Zhengzhou University of Technology, Zhengzhou 450002, China. | 1997 | Acta Mechanica Solida Sinica1997，10，3： | 4 |
| 19 | Enhancing phytolith carbon sequestration in rice ecosystems through basalt powder amendment显示文摘由于大气的公司的快速的增加的全球温暖 < 潜水艇 class= “ a-plus-plus ” > 2 排放显著地正在影响世界经济和人的活动。在 phytoliths 的碳隐遁在陆上的生态系统被认为是高度稳定的碳水池机制减轻气候变化。然而,植物的反应到外部硅修正案的堵塞 phytolith 的碳(PhytOC ) 仍然保持不清楚。在这研究,我们调查了暗岩粉末(BP ) 的效果在米饭(Oryza sativa ) 的 phytolith 碳隐遁上的改正,一个 high-PhytOC 蓄电池。结果证明在米饭的 phytolith 和 PhytOC 的内容与 BP 改正增加了。在不同米饭植物部分的 PhytOC 生产流动更加变化了(0.0050.041 ? Mg 公司 < 潜水艇 class= “ a-plus-plus ” > 2 哈 < 啜 class= “ a-plus-plus ” > 1 一 < 啜 class= “ a-plus-plus ” > 有在鞘的最高的流动的 1 ), 。BP 改正能显著地在 150 在农田提高 phytolith 碳隐遁的流动 ?% 。如果 1.55 的全球米饭耕作 ?? 慣敲? | Fengshan Guo Zhaoliang Song Leigh Sullivan Hailong Wang Xueyan Liu Xudong Wang Zimin Li Yuying Zhao | 2015 | Science Bulletin2015，60，6： | 4 |
| 20 | Economic evaluation of cervical cancer screening strategies in urban China显示文摘Objective:This study evaluated the feasibility of different cervical cancer screening strategies in urban China.Methods:A Markov model was constructed to simulate a hypothetical cohort of 100,000 females aged 30-59 years in a 20-year period.Screening strategies included liquid-based cytology(LBC)every three years,human papillomavirus(HPV)DNA testing every three and five years,respectively,and a combination of HPV DNA testing and LBC(HPV+LBC)every three and five years,respectively.Model outcomes included cumulative incidence over 20 years,cumulative risk of cervical cancer,costs,life year saved(LYS),quality-adjusted life years(QALYs)and benefits.The cost-effectiveness ratios(CERs),incremental cost-effectiveness ratios(ICERs),costutility ratios(CURs),and benefit-cost ratios(BCRs)were used as outcomes in the health economic evaluation analysis.Univariate sensitivity analyses were performed to examine the stability of the results.Results:The cumulative incidence of the five screening strategies ranged from 833.02 to 1,158.07 cases per100,000 females.HPV DNA testing was most effective in reducing the cumulative risk of cervical cancer,saving life years and QALYs and gaining benefits.The CERs of HPV DNA testing every three and five years,and LBC every three years were considered to be very cost-effective if they were below China's GDP per capita.The CERs of HPV+LBC were considered to be cost-effective if they were below three times GDP per capita.The incremental cost-effectiveness analysis showed that HPV DNA testing every three and five years,LBC every three years and HPV+LBC every five years were dominant strategies.Conclusions:The findings of this study indicated that HPV DNA testing every five years or LBC every three years should be recommended in urban China. | Li Ma Yuying Wang Xiaohong Gao Yi Dai Yu Zhang Zhaojing Wang Xiaoxia Wang Limin Wang Jing Jiang Xinhua Jing Chunxia Yang Fanghui Zhao Jinghe Lang Youlin Qiao | 2019 | Chinese Journal of Cancer Research2019，31，6： | 4 |
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