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您的检索式：作者名="LIAM Grogan"
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| 1 | Emergence of MRSA in positive blood cultures from patients with febrile neutropenia—a cause for concern显示文摘 | Patrick G. Morris Tidi Hassan Mairead McNamara Astrid Hassan Rebecca Wiig Liam Grogan Oscar S. Breathnach Edmond Smyth Hilary Humphreys | 2008 | Supportive Care in Cancer2008，，9： | 1 |
| 2 | Oesophageal cancer metastases:An observational study of a more aggressive approach显示文摘BACKGROUND The prognosis for oesophageal carcinoma is poor,but once distant metastases emerge the prognosis is considered hopeless.There is no consistent protocol for the early identification and aggressive management of metastases.AIM To examine the outcome of a policy of active postoperative surveillance with aggressive treatment of confirmed metastases.METHODS A prospectively maintained database of 205 patients diagnosed with oesophageal carcinoma between 1998 and 2019 and treated with curative intent was interrogated for patients with metastases,either at diagnosis or on follow-up surveillance and treated for cure.This cohort was compared with incomplete clinical responders to neoadjuvant chemoradiotherapy(nCRT)who subsequently underwent surgery on their primary tumour.Overall survival was estimated using the Kaplan-Meier method,and the log-rank test was used to compare survival differences between groups.RESULTS Of 205 patients,11(5.4%)had metastases treated for cure(82%male;median age 60 years;9 adenocarcinoma and 2 squamous cell carcinomas).All had undergone neoadjuvant chemotherapy or chemoradiotherapy,followed by surgery in all but 1 case.Of the 11 patients,4 had metastatic disease at diagnosis,of whom 3 were successfully downstaged with nCRT before definitive surgery;2 of these 4 also developed oligometastatic recurrence and were treated with curative intent.Following definitive treatment,7 had treatment for metachronous oligometastatic disease;5 of whom underwent metastasectomy(adrenal×2;lung×2;liver×1).The median overall survival was 10.9 years[95%confidence interval(CI):0.7-21.0 years],which was statistically significantly longer than incomplete clinical responders undergoing surgery on the primary tumour without metastatic intervention[n=62;median overall survival=1.9(95%CI:1.1-2.7;P=0.012].The cumulative proportion surviving 1,3,and 5 years was 100%,91%,and 61%,respectively compared to 71%,36%,and 25%for incomplete clinical responders undergoing surgery on the primary tumour who did not undergo treatment for metastatic disease.CONCLUSION Metastatic oesophageal cancer represents a unique challenge,but aggressive treatment can be rewarded with impressive survival data.In view of recent advances in targeted therapies,intensive follow-up may yield a greater number of patients with curative potential and thus improved long-term survival. | Lianne Pickett Mary Dunne Orla Monaghan Liam Grogan Oscar Breathnach Thomas N Walsh | 2022 | World Journal of Gastrointestinal Surgery2022，14，9： | 0 |
| 3 | p53与主反应基因Egr-1物理相互作用的研究(英文)显示文摘目的:肿瘤抑制因子p53和主反应基因Egr-1是细胞核转录因子,在介导细胞增殖、分化及细胞凋亡和生长停止的信号传导通路中扮演调控的角色。我们试图证明在体内、外这两种调控蛋白间有一种物理上的联系。方法:体内实验中,用免疫沉淀法和Western blot3分析含有高水平Egr-1活性的细胞裂解物的血清和过度表达Egr-1和突变型p53的人肺癌细胞株中两种蛋白间的相互作用。结果:p53突变在154密码子时与Egr-1没有联系,而当p53蛋白突变点在156,246,247和273殖基则与此锌指转录因子有联系。p53结合全长的Egr-1和1个Egr-1缺失5'活化范围的Egr-1突变体,但不能结合1个缺少包含头两个锌指区的内部片断的Egr-1蛋白,说明结合需要完整的锌指基序存在。肺成纤维细胞系MRC-9表达不同大小的Egr-1蛋白,该蛋白也同样与p53结合。结论:两种调控蛋白之间存在联系,它们之间的相互作用可能改变了它们的多种生物学活性尤其是关于转录控制的特性。 | 刘军 LIAM Grogan MARION M Nau CARMEN J Allegra EDW ARD Chu JOHN J Wrzght | 2004 | 河南医学研究2004，13，3： | 0 |
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