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| 1 | 被激光损伤软骨释放的凋亡因子诱导软骨细胞凋亡的研究显示文摘目的探讨组织损伤后凋亡信号怎样促进细胞的死亡进程。方法在激光照射后猪软骨块置培液中,在不同时间(3、6、9、12、24 h)收集的培液,即实验条件培养液(TCM),从未经激光照射的软骨块培液取得的为对照条件培养液(CCM)。软骨块继续培养28 d,用聚焦显微镜评价其受损区的进展。分离的软骨细胞单层放于 TCM、CCM 或正常培养液(NM)培养,阳性对照组单层细胞经紫外线照射10 min 后继续用正常培养液培养,培养24 h 后,收集细胞并用荧光标记物染色,经流式细胞仪分析。结果所有经 TCM 培养的细胞显现半胱氨酸蛋白水解酶(caspase)-3阳性、CMXRos 和一氧化氮信号减少或失去;经 CCM 或 NM 培养的细胞显现 caspase-3阴性、CMXRos 和一氧化氮信号完好;阳性对照组细胞显现 Caspase-3和 CMXRos 均阳性、一氧化氮信号减少或失去,代表处于凋亡早期的细胞。不同 TCM 浓度(100%、50%、25%、12.5%)和时间(0.5、1、3、9、12 h)对细胞作用后,所有细胞均呈现 caspase-3阳性、CMXRos 和一氧化氮信号减少或失去。结论激光照射受损软骨释放凋亡因子,可诱导单层细胞死亡。 | 郑敏 Grogan SP Schaffner T Mainil-Varlet P | 2007 | 中华医学杂志2007，87，21： | 3 |
| 2 | The prognostic value of tumour regression grade following neoadjuvant chemoradiation therapy for rectal cancer显示文摘 | K. I. Abdul‐Jalil K. M. Sheehan J. Kehoe R. Cummins A. O’Grady D. A. McNamara J. Deasy O. Breathnach L. Grogan B. D. P. O’Neill C. Faul I. Parker E. W. Kay B. T. Hennessy P. Gillen | 2014 | Colorectal Dis2014，，1： | 2 |
| 3 | Combination of fludarabine and mitoxantrone in untreated stages Ⅲ and Ⅳ low-grade lymphoma:S9501显示文摘 | Velasquez WS Lew D Grogan TM | | 0，，10： | 2 |
| 4 | Is salivary histatin 5 a metallopeptide?显示文摘 | Gusman H Lendenmann U Grogan J | 2001 | Biochim Biophys Acta2001，1545，12： | 1 |
| 5 | Fire effects on ecosystem nitrogen cycling in a Californian bishop pine forest显示文摘 | Grogan P Bruns T D Chapin III F S | 2000 | Oecologia2000，122，： | 1 |
| 6 | Reduced heart rate volatility an early pre-dictor of death in trauma patients显示文摘 | Grogan EL Morris JA Jr Norris PR | 2004 | AnnSurg2004，240，3： | 1 |
| 7 | The pathophysiology of biliary obstruction and its effect on phagocytic and immune function显示文摘 | Scott-Conner CE Grogan JB | 1994 | J Surg Res1994，57，2： | 1 |
| 8 | Intrafollicular cortisol levels inversely correlate with cumulus cell lipid content as a possible energy source during ooeyte meiotic resumption in women undergoing ovarian stimulation for in vitro fertilization显示文摘 | Simerman AA Hill DL Grogan TR | 2015 | Fertil Steril2015，103，： | 1 |
| 9 | Planarizing technique for ion-beam polishing of diamond films 显示文摘 | Grogan D F Zhao T Bovard B G | 1992 | Applied Optics1992，31，10： | 1 |
| 10 | Plasma membrane fluidity gradients of human peripheral blood leukoeytes显示文摘 | Collins JM Scott RB Grogan WM | 1990 | J Cell Physical1990，144，1： | 1 |
| 11 | The pre-clinical absorption, distribution, metabolism and excretion properties of IPI-926, an orally bioavailable antagonist of the hedgehog signal transduction pathway显示文摘 | Sherri Smith Jennifer Hoyt Nigel Whitebread Joseph Manna Marisa Peluso Kerrie Faia Veronica Campbell Martin Tremblay Somarajan Nair Michael Grogan Alfredo Castro Matthew Campbell Jeanne Ferguson Brendan Arsenault Jylle Nevejans Bennett Carter John Lee Joi | 2013 | Xenobiotica2013，，10： | 1 |
| 12 | Discovery of a potent and orally active hedgehog pathway antagonist(IPI-926)显示文摘 | Tremblay M R Lescarbeau A Grogan M J | 2009 | Journal of Medicinal Chemistry2009，52，14： | 1 |
| 13 | Pediatric interfacility transport effects on mortality and length of stay显示文摘Background We aimed to evaluate the effects of interfacility pediatric critical care transport response time,physician presence during transport,and mode of transport on mortality and length of stay(LOS)among pediatric patients.We hypothesized that a shorter response time and helicopter transports,but not physician presence,are associated with lower mortality and a shorter LOS.Methods Retrospective,single-center,cohort study of 841 patients(<19 years)transported to a quaternary pediatric intensive care unit and cardiovascular intensive care unit between 2014 and 2018 utilizing patient charts and transport records.Multivariate linear and logistic regression analyses adjusted for age,diagnosis,mode of transport,response time,stabilization time,return duration,mortality risk(pediatric index of mortality-2 and pediatric risk of mortality-3),and inotrope,vasopressor,or mechanical ventilation presence on admission.Results Four hundred and twenty-eight(50.9%)patients were transported by helicopter,and 413(49.1%)were transported by ambulance.Physicians accompanied 239(28.4%)transports.The median response time was 2.0(interquartile range 1.4–2.9)hours.Although physician presence increased the median response time by 0.26 hours(P=0.020),neither physician presence nor response time significantly affected mortality,ICU length of stay(ILOS)or hospital length of stay(HLOS).Helicopter transports were not significantly associated with mortality or ILOS,but were associated with a longer HLOS(3.24 days,95%confidence interval 0.59–5.90)than ambulance transports(P=0.017).Conclusions These results suggest response time and physician presence do not significantly affect mortality or LOS.This may reflect the quality of pre-transport care and medical control communication.Helicopter transports were only associated with a longer HLOS.Our analysis provides a framework for examining transport workforce needs and associated costs. | Rod M.Shinozaki Andreas Schwingshackl Neeraj Srivastava Tristan Grogan Robert B.Kelly | 2021 | World Journal of Pediatrics2021，17，4： | 1 |
| 14 | Persistence of the fungicides thiabendazole, carbendazim and Prochloraz- Mn in mushroom casing soil显示文摘 | Helen M Grogan Andrew A Jukes | 2003 | Pest Manag Sci2003，59，： | 1 |
| 15 | Decreasing intracellular superoxide corrects defective ischemia-induced new vessel formation in diabetic mice显示文摘 | Ceradini D J Yao D Grogan R H | 2008 | J Biol Chem2008，283，10： | 1 |
| 16 | Tumours of histiocytes and accessory dendritic cells:an immunohistochemical approach to classification from the international Lymphoma Study Group based on 61 cases显示文摘 | Pileri SA Grogan TM Harris NL | 2002 | Histopathology2002，41，1： | 1 |
| 17 | Hyphal interactions and antagonismamong field isolates and single-basidiospore strains of Athelia (Sclerotium rolfsii)显示文摘 | Punja Z K Grogan R G | 1983 | Phytopathology1983，73，： | 1 |
| 18 | Geo- metallurgy of uranium deposits 显示文摘 | Bowell R J Grogan J Hutton-Ashkenny M | 2011 | Minerals Engineer- ing2011，24，12： | 1 |
| 19 | Age related changes in human articular chondrocyte yield,proliferation and post- expansion chondrogenic capacity显示文摘 | Barbero A Grogan S Schfer D | 2004 | Osteoarthritis Cartilage2004，12，6： | 1 |
| 20 | Deepened snow al- ters soil microbial nutrient limitations in arctic birch hummock tundra 显示文摘 | BUCKERIDGE K M GROGAN P | 2008 | Applied Soil Ecology2008，39，2： | 1 |
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