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| 1 | Bias-drift-free Mach–Zehnder modulators based on a heterogeneous silicon and lithium niobate platform显示文摘Optical modulators have been and will continue to be essential devices for energy-and cost-efficient optical communication networks.Heterogeneous silicon and lithium niobate modulators have demonstrated promising performances of low optical loss,low drive voltage,and large modulation bandwidth.However,DC bias drift is a major drawback of optical modulators using lithium niobate as the active electro-optic material.Here,we demonstrate high-speed and bias-drift-free Mach–Zehnder modulators based on the heterogeneous silicon and lithium niobate platform.The devices combine stable thermo-optic DC biases in silicon and ultra-fast electro-optic modulation in lithium niobate,and exhibit a low insertion loss of 1.8 d B,a low half-wave voltage of 3 V,an electro-optic modulation bandwidth of at least 70 GHz,and modulation data rates up to 128 Gb/s. | SHIHAO SUN MINGBO HE MENGYUE XU SHENGQIAN GAO ZIYAN CHEN XIAN ZHANG ZILIANG RUAN XIONG WU LIDAN ZHOU LIN LIU CHAO LU CHANGJIAN GUO LIU LIU SIYUAN YU XINLUN CAI | 2020 | Photonics Research2020，8，12： | 5 |
| 2 | Severity of early allograft dysfunction following donation after circulatory death liver transplantation:a multicentre study显示文摘Background:Early allograft dysfunction(EAD)is associated with decreased graft and patient survival rates.This study aimed to identify the severity of EAD and develop a predictive model for EAD after donation after circulatory death(DCD)liver transplantation(LT).Furthermore,the influence of operative time on EAD incidence was also evaluated.Methods:In this retrospective,multicentre cohort study,nomograms were established based on a single-centre training cohort(n=321)and validated in a 3-center validation cohort(n=501).Results:The incidence rate of EAD was 46.4%(149/321)in the training cohort and 40.5%(203/501)in the validation cohort.Of the 149 EAD patients in the training cohort,77 patients with either elevated alanine aminotransferase(ALT)or aspartate aminotransferase(AST)were classified as having EAD type A,and the rest of the EAD patients were classified as having EAD type B.Recipients with EAD type B had lower graft and patient survival rates than recipients with EAD type A(P=0.043 and 0.044,respectively).We further developed a nomogram to predict EAD(graft weight,cold ischemia time,donor age,model for end-stage liver disease(MELD)score)and another nomogram to predict EAD type B(graft weight,cold ischemia time,MELD score).The nomograms for the prediction of EAD and EAD type B had good discrimination[concordance index(C-index)=0.712(0.666-0.758),0.707(0.641-0.773)]and calibration[Hosmer-Lemeshow(HL)P=0.384,P=0.425]in the validation cohort.An increased operative time(>6 h)was associated with increased EAD and EAD type B incidence in the high-risk group(P=0.005,P=0.020,respectively).Conclusions:EAD type B was associated with decreased graft and patient survival rates.The novel nomograms effectively predicted the incidence of EAD and EAD type B in DCD LT patients. | Kun Wang Di Lu Yuhui Liu Wangyao Li Li Zhuang Zhenyu Ma Qinfen Xie Binhua Pan Yichao Wu Junli Chen Lidan Lin Xiaowen Feng Qiang Wei Xuyong Wei Haiyang Xie Zhengxin Wang Shusen Zheng Xiao Xu | 2021 | Hepatobiliary Surgery and Nutrition2021，10，1： | 4 |
| 3 | Hellebrigenin induces apoptosis in colorectal cancer Cells through induction of excessive reactive oxygen species显示文摘Traditional Chinese medicine(TCM)has been increasingly applied in both preventing and treating a variety of cancers in the last decades,attributing to its fewer side effects as compared with chemotherapy drugs.Hellebrigenin,a component of Chanpi from the skin of Bufo bufogargarizans Cantor or Duttaphrynus melanostictus has been reported to have an obvious anti-cancer activity on various cancers.However,the effect and mechanism of hellebrigenin on colorectal cancers were still unknown.Herein,the present study demonstrated hellebrigenin significantly reduced viability and triggered apoptosis via the intrinsic pathway in colorectal cancer cell lines HCT116 and HT29 in vitro and in vivo.Moreover,hellebrigenin led to a reduction of mitochondrial membrane potential.In addition,treatment with hellebrigenin could result in the induction of excessive reactive oxygen species,which led to cell apoptosis.These results indicated that hellebrigenin had anti-cancer potential in the treatment of colorectal cancers. | CHUNJIAO LIU QINHONG KONG FENG PAN SHAN JIANG LINGJIE MENG GAI HUANG LIDAN LU SANHUA LI YUN LIU | 2021 | BIOCELL2021，45，4： | 2 |
| 4 | Effect of nitric oxide treatment on storage quality and disease resistance of satsuma mandarin fruits显示文摘 | LI Shunmin LIU Lidan ZHANG Lu | 2012 | Advanced Materials Research2012，524，： | 1 |
| 5 | Highly hydroxylated carbon fibres as electrode materials of all-vanadium redox flow battery显示文摘 | Lu Yue Weishan Li Fengqiang Sun Lingzhi Zhao Lidan Xing | 2010 | Carbon2010，，11： | 1 |
| 6 | Investigations for vibration and friction torque behaviors of thrust ball bearing with self-driven textured guiding surface显示文摘In order to improve the starved lubrication condition of rolling bearings,three kinds of textures,namely dimple,groove texture,and gradient groove texture,were developed on the guiding surface of thrust ball bearings in this study.The results show that gradient groove texture has the one-way self-driving function of liquid droplets.The root mean square(RMS)value of vibration acceleration of gradient groove textured bearing(GGB)decreased by 49.1% and the kurtosis decreased by 24.6% compared with non-textured bearing(NB)due to the directional spreading effect of gradient groove textures on oil.The frequency domain analysis showed that the textures mainly suppressed the medium and high-frequency energy of bearing vibration,and the GGB was reduced the most with 65.3% and 48%,respectively.In addition,whether the grease is sufficiently sheared has a large impact on the oil guiding effect,and the friction torque of GGB could decrease by 10.5% compared with NB in the sufficiently sheared condition.Therefore,the gradient groove texture with oil self-driven effect on the guiding surface of rolling bearing can effectively improve the lubrication condition of the bearing and thus reduce the bearing vibration and friction torque,which has a promising application prospect. | Can WU Kai YANG Jing NI Shuigen LU Lidan YAO Xinglin LI | 2023 | Friction2023，11，6： | 1 |
| 7 | Identification of a cytochrome P450 from Tripterygium hypoglaucum(Levl.)Hutch that catalyzes polpunonic acid formation in celastrol biosynthesis显示文摘Tripterygium hypoglaucum(Levl.)Hutch,a traditional Chinese medicinal herb with a long history of use,is widely distributed in China.One of its main active components,celastrol,has great potential to be developed into anti-cancer and anti-obesity drugs.Although it exhibits strong pharmacological activities,there is a lack of sustainable sources of celastrol and its derivatives,making it crucial to develop novel sources of these drugs through synthetic biology.The key step in the biosynthesis of celastrol is considered to be the cyclization of 2,3-oxidosqualene into friedelin under the catalysis of 2,3-oxidosqualene cyclases.Friedelin was speculated to be oxidized into celastrol by cytochrome P450 oxidases(CYP450s).Here,we reported a cytochrome P450 ThCYP712K1 from Tripterygium hypoglaucum(Levl.)Hutch that catalyzed the oxidation of friedelin into polpuonic acid when heterologously expressed in yeast.Through substrate supplementation and in vitro enzyme analysis,ThCYP712K1 was further proven to catalyze the oxidation of friedelin at the C-29 position to produce polpunonic acid,which is considered a vital step in the biosynthesis of celastrol,and will lay a foundation for further analysis of its biosynthetic pathway. | CHEN Xiao-Chao LU Yun LIU Yuan ZHOU Jia-Wei ZHANG Yi-Feng GAO Hai-Yun LIDan GAO Wei | 2022 | Chinese Journal of Natural Medicines2022，20，9： | 1 |
| 8 | Artificial interphases enable dendrite-free Li-metal anodes显示文摘Li-metal is an ideal anode that can provide rechargeable batteries with high energy density,but its application in large scale is restricted by its high activity that leads to the severe decomposition of electrolyte components(solvents and salts) and the growth of Li dendrites.These parasitic reactions are responsible for the cycle life deterioration and the safety accidents of rechargeable Li-metal batteries.Correspondingly,much effort has been made to regulate Li/electrolyte interface chemistry.In this review,we summarize some strategies that have been developed recently to stabilize Li/electrolyte interface by constructing protective interphases on Li-metal anodes.Firstly,the currently available understandings on the instability of Li/electrolyte interface are outlined.Then,artificial interphases recently constructed exsitu and in-situ are illustrated in detail.Finally,possible approaches to acquire more efficiently protective interphases are prospected. | Qiankui Zhang Si Liu Yitong Lu Lidan Xing Weishan Li | 2021 | Journal of Energy Chemistry2021，30，7： | 1 |
| 9 | Optimization of optical convolution kernel of optoelectronic hybrid convolution neural network显示文摘To enhance the optical computation’s utilization efficiency, we develop an optimization method for optical convolution kernel in the optoelectronic hybrid convolution neural network(OHCNN). To comply with the actual calculation process, the convolution kernel is expanded from single-channel to two-channel, containing positive and negative weights. The Fashion-MNIST dataset is used to test the network architecture’s accuracy, and the accuracy is improved by 7.5% with the optimized optical convolution kernel. The energy efficiency ratio(EER) of two-channel network is 46.7% higher than that of the single-channel network, and it is 2.53 times of that of traditional electronic products. | XU Xiaofeng ZHU Lianqing ZHUANG Wei ZHANG Dongliang LU Lidan YUAN Pei | 2022 | Optoelectronics Letters2022，18，3： | 0 |
| 10 | Mid-wavelength InAs/GaSb type-Ⅱ superlattice barrier detector with nBn design and M barrier显示文摘This study reports the performance of an InAs/GaSb type-Ⅱ superlattices(T2SLs) detector with nBn structure for mid-wavelength infrared(MWIR) detection. An electronic band structure of M barrier is calculated using 8-band k·p method, and the nBn structure is designed with the M barrier. The detector is prepared by wet etching, which is simple in manufacturing process. X-ray diffraction(XRD) and atomic force microscope(AFM) characteristics indicate that the detector material has good crystal quality and surface morphology. The saturation bias of the spectral response measurements at 77 K is 300 m V, and the device is promising to work at a temperature of 140 K. Energy gap of T2SLs versus temperature is fitted by the Varshni curve, and zero temperature bandgap Eg(0), empirical coefficients α and β are extracted. A dark current density of 3.2×10-5A/cm2and differential resistance area(RA) product of 1.0×104Ω·cm2are measured at 77 K. The dominant mechanism of dark current at different temperature ranges is analyzed. The device with a 50% cutoff wavelength of 4.68 μm exhibits a responsivity of 0.6 A/W, a topside illuminated quantum efficiency of 20% without antireflection coating(ARC), and a detectivity of 9.17×1011cm·Hz1/2/W at 77 K and 0.3 V. | LIU Zhaojun ZHU Lianqing LU Lidan DONG Mingli ZHANG Dongliang ZHENG Xiantong | 2023 | Optoelectronics Letters2023，19，10： | 0 |
| 11 | Advances and applications of machine learning and intelligent optimization algorithms in genome‑scale metabolic network models显示文摘Due to the increasing demand for microbially manufactured products in various industries,it has become important to find optimal designs for microbial cell factories by changing the direction of metabolic flow and its flux size by means of metabolic engineering such as knocking out competing pathways and introducing exogenous pathways to increase the yield of desired products.Recently,with the gradual cross-fertilization between computer science and bioinformatics fields,machine learning and intelligent optimization-based approaches have received much attention in Genome-scale metabolic network models(GSMMs)based on constrained optimization methods,and many high-quality related works have been published.Therefore,this paper focuses on the advances and applications of machine learning and intelligent optimization algorithms in metabolic engineering,with special emphasis on GSMMs.Specifically,the development history of GSMMs is first reviewed.Then,the analysis methods of GSMMs based on constraint optimization are presented.Next,this paper mainly reviews the development and application of machine learning and intelligent optimization algorithms in genome-scale metabolic models.In addition,the research gaps and future research potential in machine learning and intelligent optimization methods applied in GSMMs are discussed. | Lidan Bai Qi You Chenyang Zhang Jun Sun Long Liu Hengyang Lu Qidong Chen | 2023 | Systems Microbiology and Biomanufacturing2023，3，2： | 0 |
| 12 | Computer Simulations and Measurements of RadialSolid Flow Distribution in a Riser显示文摘Comparisons between the numerical predictions from a two-phase model and the experimental hydrodynamic data have been performed in fully developed gas-solid flows for FCC catalysts. The resultssuggested the existence of self-similar solid flux profiles at low solid fluxes. Non-uniformity in theradial solids fluxes was found with a high solid flowing mainly downward near the wall. The modelpredictions were reasonably caught up the experimental trends. | Lu Huilin Zhao Gangbo Yang Lidan Liu Wenti(Department of Power Engineering, Harbin Institute of Technology, Harbin 150001, China) | 1998 | Journal of Thermal Science1998，7，2： | 0 |
| 13 | Silicon-based Fano resonance devices based on photonic crystal nanobeams显示文摘To address the driving power and density of wavelength-division-multiplexing(WDM)computing architectures,a Fano resonator based on a photonic crystal nanobeam is proposed.The Fano resonator comprises a T-shaped waveguide,introducing an additional phase shift in the continuous propagation mode,and a photonic crystal nanobeam with a discrete mode.The device has one resonance peak within wavelength ranging from 1500 nm to 1600 nm,with a maximum extinction ratio of 8.7 dB and a transmission spectrum slope of up to 11.30 dB/nm.The device has good reusability,extinction ratio,and spectral resolution.It is expected to provide essential photonic components for low-energy consumption and high-density photonic computing to meet the requirements of future convolutional neural network(CNN)acceleration computing. | WANG Yihao LU Wenda LAI Xiaohan DONG Mingli LU Lidan ZHU Lianqing | 2023 | Optoelectronics Letters2023，19，12： | 0 |
| 14 | Highly efficient convolution computing architecture based on silicon photonic Fano resonance devices显示文摘Convolutional neural networks(CNNs)require a lot of multiplication and addition operations completed by traditional electrical multipliers,leading to high power consumption and limited speed.Here,a silicon waveguide-based wavelength division multiplexing(WDM)architecture for CNN is optimized with high energy efficiency Fano resonator.Coupling of T-waveguide and micro-ring resonator generates Fano resonance with small half-width,which can significantly reduce the modulator power consumption.Insulator dataset from state grid is used to test Fano resonance modulator-based CNNs.The results show that accuracy for insulator defect recognition reaches 99.27%with much lower power consumption.Obviously,our optimized photonic integration architecture for CNNs has broad potential for the artificial intelligence hardware platform. | NI Jiarong LU Wenda LAI Xiaohan LU Lidan OU Jianzhen ZHU Lianqing | 2023 | Optoelectronics Letters2023，19，11： | 0 |
| 15 | Silicon waveguide-based single cavity Fano resonance temperature sensor显示文摘A compact Fano resonant temperature sensor composed of a micro-ring resonator(MRR)coupled double-T-shaped waveguide is developed.The coupling gap and coefficient of the device are optimized by the finite difference time domain(FDTD)method.The maximum slope ratio(SR)of the MRR-coupled single-T-shaped waveguide is-2.13 d B/nm.The SR of the double-T-shaped waveguide is-49.69 d B/nm which is 23 times that of the single-T-shaped waveguide.The simulation results show that the temperature sensitivity of optical intensity decreases with increasing temperature in the range from 303.6 K to 343.8 K.The wavelength-temperature sensitivity of the double-T-shaped waveguide microring is 76.5 pm/K.After introducing the double-T-shaped waveguide structure,the device’s performance is greatly improved,and the double-T-shaped waveguide has a good application prospect as a temperature sensor. | WANG Shuai LU Wenda LAI Xiaohan WANG Hong ZHU Lianqing LU Lidan | 2023 | Optoelectronics Letters2023，19，3： | 0 |
| 16 | Effect of growth interruption time on the quality of InAs/GaSb type-Ⅱ superlattice grown by molecular beam epitaxy显示文摘We systematically investigate the influence of growth interruption time on the properties of In As/Ga Sb type-II superlattices(T2SLs) epitaxial materials grown by molecular beam epitaxy(MBE). X-ray diffraction(XRD) and atomic force microscope(AFM) are used to characterize the material quality and morphology. The full width at half maximum(FWHM) of the XRD 0th satellite peaks ranges from 32″ to 41″, and the root mean square(RMS) roughness on a 5 μm×5 μm scan area is 0.2 nm. Photoluminescence(PL) test is used to reveal the influence of the growth interruption time on the optical property. Grazing incidence X-ray reflectivity(GIXRR) measurements are performed to analyze the roughness of the interface. The interface roughness(0.24 nm) is optimal when the interruption time is 0.5 s. The crystal quality of T2SLs can be optimized with appropriate interruption time by MBE, which is a guide for the material epitaxy of high performance T2SL infrared detector. | LIU Zhaojun ZHU Lianqing ZHENG Xiantong LU Lidan ZHANG Dongliang LIU Yuan | 2023 | Optoelectronics Letters2023，19，3： | 0 |
| 17 | Single-cell RNA sequencing reveals the dynamics of hepatic non-parenchymal cells in autoprotection against acetaminophen-induced hepatotoxicity显示文摘Gaining a better understanding of autoprotection against drug-induced liver injury(DILI)may provide new strategies for its prevention and therapy.However,little is known about the underlying mechanisms of this phenomenon.We used single-cell RNA sequencing to characterize the dynamics and functions of hepatic non-parenchymal cells(NPCs)in autoprotection against DILI,using acetaminophen(APAP)as a model drug.Autoprotection was modeled through pretreatment with a mildly hepatotoxic dose of APAP in mice,followed by a higher dose in a secondary challenge.NPC subsets and dynamic changes were identified in the APAP(hepatotoxicity-sensitive)and APAP-resistant(hepatotoxicity-resistant)groups.A chemokine(C-C motif)ligand 2^(+)endothelial cell subset almost disappeared in the APAP-resistant group,and an R-spondin 3^(+)endothelial cell subset promoted hepatocyte proliferation and played an important role in APAP autoprotection.Moreover,the dendritic cell subset DC-3 may protect the liver from APAP hepatotoxicity by inducing low reactivity and suppressing the autoimmune response and occurrence of inflammation.DC-3 cells also promoted angiogenesis through crosstalk with endothelial cells via vascular endothelial growth factor-associated ligand-receptor pairs and facilitated liver tissue repair in the APAP-resistant group.In addition,the natural killer cell subsets NK-3 and NK-4 and the Sca-1^(-)CD62L^(+)natural killer T cell subset may promote autoprotection through interferon-γ-dependent pathways.Furthermore,macrophage and neutrophil subpopulations with anti-inflammatory phenotypes promoted tolerance to APAP hepatotoxicity.Overall,this study reveals the dynamics of NPCs in the resistance to APAP hepatotoxicity and provides novel insights into the mechanism of autoprotection against DILI at a high resolution. | Lingqi Yu Jun Yan Yingqi Zhan Anyao Li Lidan Zhu Jingyang Qian Fanfan Zhou Xiaoyan Lu Xiaohui Fan | 2023 | Journal of Pharmaceutical Analysis2023，13，8： | 0 |
| 18 | Single silicon waveguide MRR based Fano resonance in the whole spectral bands显示文摘To improve the integration of Fano devices,we design a T-shaped waveguide coupling micro-ring resonator(MRR)structure to achieve a single cavity with Fano resonance in the whole spectral bands.The mathematical relationship between the phase factor,the coupling coefficient of the bus waveguide,and the Fano resonance slope extinction ratio(ER)is established.The electron beam exposure process is used to obtain a device with an insertion loss of~3 dB.The maximum ER of the Fano lineshape exceeds 15 dB,and the slope ratio(SR)is 251.3 dB/nm.This design improves the compactness of the Fano resonant device. | LU Lidan WANG Shuai ZENG Zhoumo DONG Mingli ZHU Lianqing | 2022 | Optoelectronics Letters2022，18，7： | 0 |
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