|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Heritability of growth traits in the Asian seabass (Lates calcarifer)显示文摘Growth is an economically important trait in aquaculture.To improve growth trait of the Asian seabass(Lates calcarifer)we have been carrying out,since 2004,a selective breeding program.This study focuses on growth traits in the F2 fish generation,comprised of offspring from 23 mass crosses from 383 F_(1) brooders.Using genotyping analysis for 10 microsatellites from both brood stock and progeny we have reconstructed the pedigree of each mass-cross.For F_(2) generation at 90 days post hatch(dph),we have recorded body weight(BW)for 12,117 individuals and total length(TL),standard length(SL)and condition factor(K_(tl) and K_(sl))for 3530 individuals;and all five traits for 2136 individuals at 270 dph.At 90 dph the average BW was 46.88±20.95 g.Combining pedigree information,recorded growth traits and Restricted Maximum Likelihood method,we have estimated that the narrow sense heritability(h^(2))in F_(1) fish for BW,TL,SL,K_(tl) and K_(sl) was at,90 dph,0.12±0.03,0.11±0.03,0.10±0.03,0.20±0.04 and 0.11±0.03,respectively and,at 270 dph,0.34±0.07,0.32±0.07,0.30±0.06,0.13±0.04 and 0.11±0.04,respectively.At 90 dph the realised heritability for BW was 0.13.Comparing with F_(1) generation,the growth performance of F_(2) fish was increased by 14.4%.Heritability of growth traits will be useful for future genetic improvement programmes of the Asian seabass. | Baoqing Ye Ziyi Wan Le Wang Hongyan Pang Yanfei Wen Huiming Liu Bing Liang Huan Sein Lim Junhui Jiang Genhua Yue | 2017 | Aquaculture and Fisheries2017，2，3： | 4 |
| 2 | A Pattern-Based Method for the Identification of MicroRNA Binding Sites and Their Corresponding Heteroduplexes显示文摘 | Kevin C. Miranda Tien Huynh Yvonne Tay Yen-Sin Ang Wai-Leong Tam Andrew M. Thomson Bing Lim Isidore Rigoutsos | 2006 | Cell2006，，6： | 3 |
| 3 | A novel strategy to derive iPS cells from porcine fibroblasts显示文摘Induced pluripotent stem (iPS) cell technology demonstrates that somatic cells can be reprogrammed to a pluripotent state by over-expressing four reprogramming factors.This technology has created an interest in deriving iPS cells from domesticated animals such as pigs,sheep and cattle.Moloney murine leukemia retrovirus vectors have been widely used to generate and study mouse iPS cells.However,this retrovirus system infects only mouse and rat cells,which limits its use in establishing iPS cells from other mammals.In our study,we demonstrate a novel retrovirus strategy to efficiently generate porcine iPS cells from embryonic fibroblasts.We transfected four human reprogramming factors (Oct4,Sox2,Klf4 and Myc) into fibroblasts in one step by using a VSV-G envelope-coated pantropic retrovirus that was easily packaged by GP2-293 cells.We established six embryonic stem (ES)-like cell lines in human ES cell medium supplemented with bFGF.Colonies showed a similar morphology to human ES cells with a high nuclei-cytoplasm ratio and phase-bright flat colonies.Porcine iPS cells could form embryoid bodies in vitro and differentiate into the three germ layers in vivo by forming teratomas in immunodeficient mice. | RUAN WeiMin HAN JianYong LI Pin CAO SuYing AN Yang LIM Bing LI Ning | 2011 | Science China(Life Sciences)2011，54，6： | 2 |
| 4 | Rheological study of interaction in the poly (acrylic acid) - cetyltrimethyl-ammonium bromide system 显示文摘 | PERRY F C LIM SHING BOR CHEN BING - HUNG CHEN | 2001 | Bulletin of the College of Engineering NTU2001，83，10： | 1 |
| 5 | Isolation of Nipah virus from Malaysian Island flying-foxes显示文摘 | Kaw Bing Chua Chong Lek Koh Poh Sim Hooi Kong Fatt Wee Jenn Hui Khong Beng Hooi Chua Yee Peng Chan Mou Eng Lim Sai Kit Lam | 2002 | Microbes and Infection2002，，： | 1 |
| 6 | Conserved long noncoding RNAs transcriptionally regulated by Oct4 and Nanog modulate pluripotency in mouse embryonic stem cells显示文摘 | Jameelah Shelk Mohamed Philip Michael Gaughwin Bing Lim | | 0，，： | 1 |
| 7 | The Nuclear Receptor Nr5a2 Can Replace Oct4 in the Reprogramming of Murine Somatic Cells to Pluripotent Cells显示文摘 | Jian-Chien Dominic Heng Bo Feng Jianyong Han Jianming Jiang Petra Kraus Jia-Hui Ng Yuriy L. Orlov Mikael Huss Lin Yang Thomas Lufkin Bing Lim Huck-Hui Ng | 2010 | Cell Stem Cell2010，，2： | 1 |
| 8 | Rapid Repair of Earthquake Damaged RC Interior Beam-wide Column Joints and Beam-wall Joints Using FRP Composites显示文摘This paper studies the seismic performance of FRP-strengthened RC interior non-seismically detailed beam-wide columns and beam-wall joints after limited seismic damage.Four eccentric and concentric beam-wide column joints and two beam-wall joints,initially damaged in a previous study,were repaired and tested under constant axial loads(0.1fc′Ag and 0.35fc′Ag) and lateral cyclic loading.The rapid repair technique developed,aimed to restore the original strength and to provide minimum drift capacity.The repair schemes were characterized by the use of:(a) epoxy injections and polymer modified cementitious mortar to seal the cracks and replace spalled concrete;and(b) glass(GFRP) and carbon(CFRP) sheets to enhance the joint performance.The FRP sheets were effectively prevented against possible debonding through the use of fiber anchors.Comparison between responses of specimens before and after repair clearly indicated reasonable restoration in strength,drift capacity,stiffness and cumulative energy dissipation capacity.All specimens failed with delamination of FRP sheets at beam-column joint interfaces.The rapid repair technique developed in this study is recommended for mass upgrading or repair of earthquake damaged beam-column joints. | LI Bing LIM Chee Leong | 2009 | 四川大学学报(工程科学版)2009，41，3： | 1 |
| 9 | Controlled biominerali~ation of electrospun poly (~-ea- prolaetone) fibers to enhance their mechanical properties 显示文摘 | Xie Jingwei Zhong Shaoping Ma Bing Shuler FD Lim CT | 2013 | Acta Biomaterialia2013，9，56： | 1 |
| 10 | Sall4 Regulates Distinct Transcription Circuitries in Different Blastocyst-Derived Stem Cell Lineages显示文摘 | Chin Yan Lim Wai-Leong Tam Jinqiu Zhang Haw Siang Ang Hui Jia Leonard Lipovich Huck-Hui Ng Chia-Lin Wei Wing Kin Sung Paul Robson Henry Yang Bing Lim | 2008 | Cell Stem Cell2008，，5： | 1 |
| 11 | Solubilization of selected free fatty acids in palm oil by biodegradable ethoxylated surfactants 显示文摘 | TAU - YEE LIM JING - LIANG LI BING - HUNG CHEN | 2005 | Food Chem2005，53，1： | 1 |
| 12 | Pluripotent stem cells secrete Activin A to improve their epiblast competency after injection into recipient embryos显示文摘 | Jinzhu Xiang Suying Cao Liang Zhong Hanning Wang Yangli Pei Qingqing Wei Bingqiang Wen Haiyuan Mu Shaopeng Zhang Liang Yue Genhua Yue Bing Lim Jianyong Han | 2018 | Protein & Cell2018，9，8： | 0 |
| 13 | Comparison of direct and indirect determinations of dynamic ventilation rate in a modern dairy free stall barn显示文摘Reliable estimation of the ventilation rate(VR)in intensive livestock buildings is necessary for studying building environmental control strategies and predicting indoor air quality and air emissions.As direct air exchange measurements are time-consuming and expensive,it is environmentally inefficient to measure livestock building VR continuously in practice.Hence,indirect VR estimation methods have been widely used in modelling environmental control and air emissions,and also to measure airflow in the field.The accuracy of indirect measurement methods needs to be evaluated by comparing with direct measurements.In this study,the direct and indirect methods of determining hourly and daily mean VRs were applied to a mechanically-ventilated dairy free stall barn monitored by the 24-month National Air Emissions Monitoring Study.The direct method was used to continuously monitor fan rotational speeds,and differential static pressures,coupled with periodic in-situ fan performance assessments,to calculate the VR.The indirect method consisted of estimating the VR using CO2 concentration measurements and the CO2 mass balance method.The average daily and hourly means(mean±SD)of directly measured barn ventilation rates for two years were(246±73)m3/s and(245±77)m3/s,respectively.The average daily and hourly means(mean±SD)of barn ventilation rates estimated by the CO2 mass balance method were(287±93.4)m3/s and(287±118)m3/s,respectively.Correlation analyses showed a strong correlation between the indirect CO2 mass balance method and direct measurement methods(r=0.93 for daily means and r=0.85 for hourly means). | Bing Zou Albert J.Heber Zhengxiang Shi Songhuai Du Yaomin Jin Teng Teeh Lim | 2020 | International Journal of Agricultural and Biological Engineering2020，13，6： | 0 |
| 14 | Frontier of digitalization in Biomass-to-X supply chain:opportunity or threats?显示文摘The escalating climate crisis necessitates an urgent shift towards a sustainable business model.Un-der the context of bioeconomy,it has offered a promising alternative through its“Biomass-to-X”strategy for converting biological resources into value-added products or chemicals.However,the adoption of this approach remains scarce,which highlights the need to leverage digital technolo-gies to enhance its feasibility.Thus,this paper provides a comprehensive overview of the potential role of digital technologies in the Biomass-to-X supply chain,encompassing the entire value chain from upstream to downstream activities,specifically in the areas of 1)lab-to-fabrication transla-tion,2)biomanufacturing stage,and lastly,3)supply chain management stage.Furthermore,this study identifies and discusses research gaps in each niche area,along with potential future re-search prospects to facilitate the transition towards a sustainable bioeconomy,making it a crucial reference for stakeholders involved in decision-making processes. | Adrian Chun Minh Loy Karen Gah Hie Kong Juin Yau Lim Bing Shen How | 2023 | Journal of Bioresources and Bioproducts2023，8，2： | 0 |
| 15 | MDMX phosphorylation-dependent p53 downregulation contributes to an immunosuppressive tumor microenvironment显示文摘A role of tumor-suppressive activity of p53 in the tumor microenvironment(TME)has been implicated but remains fairly understudied.To address this knowledge gap,we leveraged our MdmxS314A mice as recipients to investigate how implanted tumor cells incapacitate host p53 creating a conducive TME for tumor progression.We found that tumor cell-associated stress induced p53 downregulation in peritumor cells via an MDMX-Ser314 phosphorylation-dependent manner.As a result,an immunosuppressive TME was developed,as reflected by diminished immune cell infiltration into tumors and compromised macrophage M1 polarization.Remarkably,ablation of MDMX-Ser314 phosphorylation attenuated p53 decline in peritumor cells,which was associated with mitigation of immunosuppression and significant tumor growth delay.Our data collectively uncover a novel role of p53 in regulating the tumor immune microenvironment,suggesting that p53 restoration in the TME can be exploited as a potential strategy of anticancer therapy. | Bing Wang Chuan-Bian Lim Jiawei Yan Lizhen Li Jufang Wang John B.Little Zhi-Min Yuan | 2020 | Journal of Molecular Cell Biology2020，12，9： | 0 |
| 16 | Genome-wide identification of histone H2A and histone variant H2A.Z-interacting proteins by bPPI-seq显示文摘H2A 是涉及把 DNA 组织成对规章的酶经常无法接近的染色质结构的一个 nucleosome 核心子单元。由它的变体 H2A.Z 的 H2A 的代替在 enhancers 和倡导者使染色质变为可存取。然而, H2A.Z 怎么从正规 H2A 那么不同地工作,仍然保持不清楚。这里,我们报导直接用新奇策略在 vivo 与 H2A 和 H2A.Z 交往的蛋白质的染色体宽的鉴定, bPPI-seq。我们证明 bPPI-seq 是一种敏感、柔韧的技术在 vivo 识别蛋白质蛋白质相互作用。我们的数据显示交往 H2A.Z 蛋白质和交往 H2A 蛋白质参予不同生物过程。与交往 H2A 蛋白质相对照,交往 H2A.Z 蛋白质涉及 transcriptional 规定。我们发现抄写因素 Osr1 在 vitro 并且在 vivo 与 H2A.Z 交往。它也调停 H2A.Z 加入到很多目标地点并且调整基因表示。我们的数据显示 bPPI-seq 能广泛地被使用在生理的条件下面识别染色体宽的交往的蛋白质。 | Yi Zhang Wai Lim Ku Shuai Liu Kairong Cui Wenfei Jin Qingsong Tarlg William Lu Bing Ni Keji Zhao | 2017 | Cell Research2017，27，10： | 0 |
| 17 | Credit Card Fraud Detection on Original European Credit Card Holder Dataset Using Ensemble Machine Learning Technique显示文摘The proliferation of digital payment methods facilitated by various online platforms and applications has led to a surge in financial fraud,particularly in credit card transactions.Advanced technologies such as machine learning have been widely employed to enhance the early detection and prevention of losses arising frompotentially fraudulent activities.However,a prevalent approach in existing literature involves the use of extensive data sampling and feature selection algorithms as a precursor to subsequent investigations.While sampling techniques can significantly reduce computational time,the resulting dataset relies on generated data and the accuracy of the pre-processing machine learning models employed.Such datasets often lack true representativeness of realworld data,potentially introducing secondary issues that affect the precision of the results.For instance,undersampling may result in the loss of critical information,while over-sampling can lead to overfitting machine learning models.In this paper,we proposed a classification study of credit card fraud using fundamental machine learning models without the application of any sampling techniques on all the features present in the original dataset.The results indicate that Support Vector Machine(SVM)consistently achieves classification performance exceeding 90%across various evaluation metrics.This discovery serves as a valuable reference for future research,encouraging comparative studies on original dataset without the reliance on sampling techniques.Furthermore,we explore hybrid machine learning techniques,such as ensemble learning constructed based on SVM,K-Nearest Neighbor(KNN)and decision tree,highlighting their potential advancements in the field.The study demonstrates that the proposed machine learning models yield promising results,suggesting that pre-processing the dataset with sampling algorithm or additional machine learning technique may not always be necessary.This research contributes to the field of credit card fraud detection by emphasizing the potential of employing machine learning models directly on original datasets,thereby simplifying the workflow and potentially improving the accuracy and efficiency of fraud detection systems. | Yih Bing Chu Zhi Min Lim Bryan Keane Ping Hao Kong Ahmed Rafat Elkilany Osama Hisham Abusetta | 2023 | Journal of Cyber Security2023，5，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员