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| 1 | SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target显示文摘Cytokine storm and multi-organ failure are the main causes of SARS-CoV-2-related death.However,the origin of excessive damages caused by SARS-CoV-2 remains largely unknown.Here we show that the SARS-CoV-2 envelope(2-E)protein alone is able to cause acute respiratory distress syndrome(ARDS)-like damages in vitro and in vivo. | Bingqing Xia Xurui Shen Yang He Xiaoyan Pan Feng-Liang Liu Yi Wang Feipu Yang Sui Fang Yan Wu Zilei Duan Xiaoli Zuo Zhuqing Xie Xiangrui Jiang Ling Xu Hao Chi Shuangqu Li Qian Meng Hu Zhou Yubo Zhou Xi Cheng Xiaoming Xin Lin Jin Hai-Lin Zhang Dan-Dan Yu Ming-Hua Li Xiao-Li Feng Jiekai Chen Hualiang Jiang Gengfu Xiao Yong-Tang Zheng Lei-Ke Zhang Jingshan Shen Jia Li Zhaobing Gao | 2021 | Cell Research2021，31，8： | 7 |
| 2 | Effects of Antiretroviral Therapy and HIV Exposure in Utero on Adverse Pregnancy and Infant Outcomes:A Prospective Cohort Study in Guangzhou, China显示文摘Objective This study aimed to evaluate the effects of in-utero exposure to HIV and ART on pregnancy outcome and early growth of children.Methods This cohort study enrolled 802 HIV-infected pregnant women between October 2009 and May 2018 in Guangzhou, China. The women were assigned to receive combination ART(c ART) or mono/dual ART or no treatment. The primary outcomes were the combined endpoints of any adverse pregnancy outcome [including ectopic pregnancy, spontaneous abortion, stillbirth, preterm birth, small for gestational age(SGA)] and adverse early growth outcome(including infant death, HIV infection of mother-to-child transmission, and underweight, wasting and stunting of infants at 4 weeks of age).Results Adverse pregnancy outcomes occurred in 202(35.1%) of all enrolled HIV-infected women, and121(31.3%) of all infants exhibited adverse effects on early growth at 4 weeks of age. The rates of adverse pregnancy outcomes, spontaneous abortion, ectopic pregnancy, stillbirth, infant death and perinatal HIV infection were higher among women not receiving ART, compared to those treated with c ART or mono/dual ART(P < 0.05). However, women treated with c ART had a higher rate of SGA,compared to untreated women(P < 0.05). No differences in early infant growth were observed among the different treatment regimens.Conclusion Our findings underscore the essentiality of prioritizing HIV-positive pregnant women for ART, as even mono/dual ART available in resource-limited countries could improve pregnancy outcomes and infant survival. | HU Fang LIANG Jing Jing LU Jian Jun HU Yi Fei HU Yan YU Jia ZOU Xing Wen MA Ying Hua LIN Sui Fang | 2019 | Biomedical and Environmental Sciences2019，32，10： | 2 |
| 3 | The investigation of Chinese peopleblood uric acid and the relationship between it and blood -lipid 显示文摘 | Fang Qi You Kai Lin Qi - sui | 1983 | Chinese Journal of Internal Medicine1983，22，： | 1 |
| 4 | The heterogeneity and dynamic equilibrium of rat embryonic stem cells显示文摘 | Yan Shen Cheng Shi Wei Wei Weidong Yu Wenlin Li Yang Yang Jun Xu Wenqin Ying Xin Sui Lingling Fang Weiwei Lin Huan Yang Sheng Ding Huan Shen Yan Shi Hongkui Deng | 2011 | Cell Research2011，21，7： | 1 |
| 5 | Design and fabrication of button-style beam position monitors for the HEPS synchrotron light facility显示文摘At the High Energy Photon Source (HEPS),a high orbital stability of typically 10% of the beam size and angular divergence must be achieved.The beam size at the insertion devices is 10μm horizontally and 1μm vertically,which implies that the beam orbit must be stabilized to the sub-micrometer level.This results in stringent tolerance and quality control requirements for the series production of beam position monitor (BPM) pickups.In this study,analytical formulas were used and CST simulations were performed to analyze the effects of the mechanical tolerances of BPM pickups on beam position measurement.The results of electromagnetic?eld simulations revealed how various mechanical errors,such as button size and location accuracy,as well as the related button capacitance,exert different in?uences on the beam position measurement.The performance of an actual BPM pickup was measured,along with an assessment of the error on the beam position measurement.Additionally,a wake?eld analysis,including an investigation of trapped resonant modes and related thermal deformation,was conducted. | Jun He Yan-Feng Sui Yong Li Xu-Hui Tang Lin Wang Fang Liu Zhi Liu Ling-Da Yu Xiao-Yu Liu Tao-Guang Xu Jian-She Cao Jun-Hui Yue | 2022 | Nuclear Science and Techniques2022，33，11： | 0 |
| 6 | Milestone progress of the HEPS booster commissioning显示文摘The high-energy photon source(HEPS)is the first fourth-generation synchrotron light source facility in China.The HEPS injector consists of a linear accelerator(Linac)and a full energy booster.The booster captures the electron beam from the Linac and increases its energy to the value required for the storage ring.The full-energy beam could be injected to the storage ring directly or after“high-energy accumulation.”On November 17,2023,the key booster parameters successfully reached their corresponding target values.These milestone results were achieved based on numerous contributions,including nearly a decade of physical design,years of equipment development and installation,and months of beam commissioning.As measured at the extraction energy of 6 GeV,the averaged beam current and emittance reached 8.57 mA with 5 bunches and 30.37 nm rad with a single-bunch charge of 5.58 nC,compared with the corresponding target values of 6.6 mA and 35 nm rad,respectively.This paper presents the physical design,equipment development,installation,and commissioning process of the HEPS booster. | Yue-Mei Peng Jian-She Cao Jin-Hui Chen Hai-Yi Dong Ping He Yi Jiao Ling Kang Wen Kang Jian Li Jing-Yi Li Guo-Ping Lin Fang Liu Feng-Li Long Cai Meng Xin Qi Hua-Min Qu Yan-Feng Sui Sheng Wang Gang Xu Qiang Ye Jing Zhang Pei Zhang Wei-Min Pan | 2024 | Nuclear Science and Techniques2024，35，1： | 0 |
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