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| 1 | The Chinese Society of Clinical Oncology(CSCO)clinical guidelines for the diagnosis and treatment of nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is a malignant epithelial tumor originating in the nasopharynx and has a high incidence in Southeast Asia and North Africa.To develop these comprehensive guidelines for the diagnosis and management of NPC,the Chinese Society of Clinical Oncology(CSCO)arranged a multi-disciplinary team comprising of experts from all sub-specialties of NPC to write,discuss,and revise the guidelines.Based on the findings of evidencebased medicine in China and abroad,domestic experts have iteratively developed these guidelines to provide proper management of NPC.Overall,the guidelines describe the screening,clinical and pathological diagnosis,staging and risk assessment,therapies,and follow-up of NPC,which aim to improve the management of NPC. | Ling-Long Tang Yu-Pei Chen Chuan-Ben Chen Ming-Yuan Chen Nian-Yong Chen Xiao-Zhong Chen Xiao-Jing Du Wen-Feng Fang Mei Feng Jin Gao Fei Han Xia He Chao-Su Hu De-sheng Hu Guang-Yuan Hu Hao Jiang Wei Jiang Feng Jin Jin-Yi Lang Jin-Gao Li Shao-Jun Lin Xu Liu Qiu-Fang Liu Lin Ma Hai-Qiang Mai Ji-Yong Qin Liang-Fang Shen Ying Sun Pei-Guo Wang Ren-Sheng Wang Ruo-Zheng Wang Xiao-Shen Wang Ying Wang Hui Wu Yun-Fei Xia Shao-Wen Xiao Kun-Yu Yang Jun-Lin Yi Xiao-Dong Zhu Jun Ma | 2021 | Cancer Communications2021，41，11： | 22 |
| 2 | Incidence and predictors of radial artery spasm during transradial coronary angiography and intervention显示文摘背景光线的动脉痉挛(地岬) 是在 transradial 的最普通的复杂并发症冠的 angiography 和干预。在这研究,我们设计了用汉语在 transradial 过程期间调查地岬的发生,通过多重回归发现独立预言者,并且分析在后续期间的地岬的临床的效果。方法病人安排了收到 transradial 冠的 angiography 和干预连续地被注册。地岬的发生被记录。Univariate 分析被执行发现地岬的影响因素,并且逻辑回归分析被执行发现地岬的独立预言者。病人被要求 1 个月以后为对地岬的发生是的光线的 access.Results 的评价回来(112/1427 )7.8% 在所有病人收到了 transradial 过程。 Univariate 分析显示那幼仔( P=0.038 ),女性( P=0.026 ),光线的动脉的小直径( P < 0.001 ),糖尿病( P=0.026 ),吸烟( P=0.019 ),中等或严重的疼痛在光线的动脉管子期间( P < 0.001 ),失败起初存取尝试( P=0.002 ),大鞘( P=0.004 ),导管的数字(> 3 )( P=0.048 ),快速的基线心率( P=0.032 )和长操作时间( P=0.021 )与地岬被联系。逻辑回归给那女性看了(OR=1.745, 95% CI:1.148-3.846, P=0.024 ) ,小光线的动脉直径(OR=4.028, 95%CI:1.264-12.196, P=0.008 ) ,糖尿病(OR= 2.148, 95%CI:1.579-7.458, P=0.019 ) 并且失败的存取起初尝试(OR=1.468, 95%CI:1.212-2.591, P=0.032 ) 是地岬的独立预言者。后续在(28 慥?? | JIA De-an ZHOU Yu-jie SHI Dong-mei LIU Yu-yang WANG Jian-long LIU Xiao-li WANG Zhi-jian YANG Shi-wei GE Hai-long HU Bin YAN Zhen-xian CHEN Yi GAO Fei | 2010 | Chinese Medical Journal2010，，7： | 21 |
| 3 | Higher CO_2-insufflation pressure inhibits the expression of adhesion molecules and the invasion potential of colon cancer cells显示文摘AIM:To investigate the influence of CO2-insufflation pressure on adhesion,invasion and metastatic potential of colon cancer cells based on adhesion molecules expression.METHODS:With an in vitro artificial pneumoperitoneum model,SW1116 human colon carcinoma cells were exposed to CO2-insufflation in 5 different pressure groups:6 mmHg,9 mmHg,12 mmHg,15 mmHg and control group,respectively for 1 h.Expression of E-cadherin,ICAM-1,CD44 and E-selectin was measured at 0,12,24,48 and 72 h after CO2-insufflation using flow cytometry.The adhesion and invasion capacity of SW1116 cells before and after exposure to CO2-insufflation was detected by cell adhesion/invasion assay in vitro.Each group of cells was injected intraperitoneally into 16 BALB/C mice.The number of visible abdominal cavity tumor nodules,visceral metastases and survival of the mice were recorded in each group.RESULTS:The expression of E-cadherin,ICAM-1,CD44 and E-selectin in SW1116 cells were changed significantly following exposure to CO2 insufflation at different pressures(P<0.05).The expression of E-cadherin,CD44 and ICAM-1 decreased with increasing CO2-insufflation pressure.The adhesive/invasive cells also decreased gradually with increasing pressure as determined by the adhesion/invasion assay.In animal experiments,the number of abdominal cavity tumor nodules in the 15 mmHg group was also signif icantly lower than that in the 6 mmHg group(29.7±9.91 vs 41.7±14.90,P=0.046).However,the survival in each group was not statistically different.CONCLUSION:CO2-insufflation induced a temporary change in the adhesion and invasion capacity of cancer cells in vitro.Higher CO2-insufflation pressure inhibited adhesion,invasion and metastatic potential in vitro and in vivo,which was associated with reduced expression of adhesion molecules. | Jun-Jun Ma Bo Feng Yi Zhang Jian-Wen Li Ai-Guo Lu Ming-Liang Wang Yuan-Fei Peng Wei-Guo Hu Fei Yue Min-Hua Zheng | 2009 | World Journal of Gastroenterology2009，15，22： | 16 |
| 4 | Effects of Environmental Factors on Tree Seedling Regeneration in a Pine-oak Mixed Forest in the Qinling Mountains, China显示文摘Natural seedling regeneration and tree establishment are affected by various environmental factors.In this study,we established eight,eight,six,and four independent forest stands(each stand was further divided into five subplots) respectively based on the altitudinal gradient,stand density,slope location,and slope aspect to investigate the effects of environmental factors on tree seedling regeneration in a pine-oak mixed forest.The results indicated that the seedling density was significantly higher at altitudes of 1,283 m to 1,665 m,whereas the sapling density did not differ with altitudes.The seedling and sapling density decreased significantly at 1,835 m.The seedling densities on the upper slopes were much higher than those on the middle and lower slopes,whereas the sapling density had no difference.The sapling density decreased gradually from the southwest(20°-75°) whereas it increased on the shady slopes to the northeast(40°).The seedling density increased from southwest(20°) to northeast(40°).The seedling and sapling densities increased with the stand density(850 trees ha-1to 1,525 trees ha-1) whereas the sapling density was significantly lower in stands(1,900 trees ha-1).Principal components analysis showed that the slope aspect and stand density had more important roles in tree regeneration in this study region compared with the other two factors.Therefore,our findings suggest that it will be beneficial to keep stands at a moderate density on shady slopes.Appropriate thinning of higher density stands is also expected to promote the natural regeneration of pine-oak mixed forest. | YU Fei WANG De-xiang SHI Xiao-xiao YI Xian-feng HUANG Qing-ping HU You-ning | 2013 | Journal of Mountain Science2013，10，5： | 13 |
| 5 | Cadmium Activates Reactive Oxygen Species-dependent AKT/mT OR and Mitochondrial Apoptotic Pathways in Neuronal Cells显示文摘Objective To examine the role of Cd-induced reactive oxygen species(ROS)generation in the apoptosis of neuronal cells.Methods Neuronal cells(primary rat cerebral cortical neurons and PC12 cells)were incubated with or without Cd post-pretreatment with rapamycin(Rap)or N-acetyl-L-cysteine(NAC).Cell viability was determined by MTT assay,apoptosis was examined using flow cytometry and fluorescence microscopy,and the activation of phosphoinositide 3'-kinase/protein kinase B(Akt)/mammalian target of rapamycin(m TOR)and mitochondrial apoptotic pathways were measured by western blotting or immunofluorescence assays.Results Cd-induced activation of Akt/m TOR signaling,including Akt,m TOR,p70 S6 kinase(p70 S6K),and eukaryotic initiation factor 4E binding protein 1(4E-BP1).Rap,an m TOR inhibitor and NAC,a ROS scavenger,blocked Cd-induced activation of Akt/m TOR signaling and apoptosis of neuronal cells.Furthermore,NAC blocked the decrease of B-cell lymphoma 2/Bcl-2 associated X protein(Bcl-2/Bax)ratio,release of cytochrome c,cleavage of caspase-3 and poly(ADP-ribose)polymerase(PARP),and nuclear translocation of apoptosis-inducing factor(AIF)and endonuclease G(Endo G).Conclusion Cd-induced ROS generation activates Akt/m TOR and mitochondrial pathways,leading to apoptosis of neuronal cells.Our findings suggest that m TOR inhibitors or antioxidants have potential for preventing Cd-induced neurodegenerative diseases. | YUAN Yan WANG Yi HU Fei Fei JIANG Chen Yang ZHANG Ya Jing YANG Jin Long ZHAO Shi Wen GU Jian Hong LIU Xue Zhong BIAN Jian Chun LIU Zong Ping | 2016 | Biomedical and Environmental Sciences2016，29，2： | 8 |
| 6 | Nanoindentation characteristics of cement with different mineral admixtures显示文摘In order to determine the effects of different mineral admixtures including fly ash(FA),blast furnace slag(BFS) and metakaolin(MK) on hydration product phases from the nanoscale structure perspective,nanoindentation characteristics of the samples with similar 28-day strengths have been investigated.The results indicate that the volume fractions of porosity in porosity and hydration product phases of the samples with the same kind of mineral admixture are almost equal to each other,and are greater than that of the sample without mineral admixture.Mineral admixtures especially MK can decrease remarkably the volume fractions of CH in porosity and hydration product phases,and there exists a good linear relationship between the(Al+Si)/Ca molar ratio of cementitious materials chemical compositions and the volume fraction of HD C-S-H gel in C-S-H gel.Therefore,it is possible to predict the volume fraction change of HD C-S-H gel in C-S-H gel by simply calculating the(Al+Si)/Ca molar ratio of cementitious materials with similar 28-day strengths under the constant water-binder ratio. | HE ZhiHai QIAN ChunXiang ZHANG Yi ZHAO Fei HU YingBo | 2013 | Science China(Technological Sciences)2013，56，5： | 7 |
| 7 | Vascular endothelial growth factor expressing mesen-chymal stem cells improves cardiac function in chronic myocardial infarction in pigs显示文摘 | YI Fu GUO Wen-yi Lue An-lin WANG Hai-chang LI Hu LI Wei-jie LIU Bing ZHANG Dian-xin LUAN Rong-hua CHENG He-xiang LI Fei QIN Tao ZHAO Zhi-jing GAO Feng JIA Guo-liang | 2006 | Chinese Medical Journal2006，，19： | 6 |
| 8 | Eosinophil-derived CCL-6 impairs hematopoietic stem cell homeostasis显示文摘嗜曙红血球(曙光女神) 长在层次造血的系统被看作了结束阶段受动器房间。证据的众多的线建议了那个曙光女神是关于各种各样的煽动性或有免疫力的反应的开始,繁殖和规定的多功能的白血球,特别在过敏疾病。最近的研究证明了那个曙光女神也为骨头髓血浆房间的维护和 B 房间的区别被要求。然而,曙光女神是否贡献造血的干细胞(HSC ) 的规定,仍然保持不清楚动态平衡。这里,我们证明曙光女神由在野类型的老鼠损害 HSC 静止和体质能力破坏 HSC 动态平衡后面的 ovalbumin (卵) 挑战并且甚至由引起骨头髓 HSC 在 Cd3-Il-5 转基因的老鼠的失败和疲劳。HSC 的损害维护和功能与导致曙光女神的氧化还原作用不平衡(增加的氧化 phosphorylation 和减少的抗氧化剂层次) 被联系。用集体 spectrometry,更重要地,我们决定 CCL-6 在嗜曙红血球过多下面在高水平被表示。我们证明 CCL-6 为损害 HSC 动态平衡导出曙光女神、负责。有趣地,有特定的抵销抗体的 CCL-6 的阻塞,当在质问卵的老鼠加重嗜曙红血球过多航线发炎时,恢复了 HSC 的体质能力。因此,我们的学习在 HSC 动态平衡揭示 Eos/CCL-6 的意外功能。 | Chao Zhang, Fei Li, Xufei Du, Man Luo, Wen Hua, Wen Li, Zhihua Chen, Songmin Ying, Huahao Shen Weiwei Yi, Hu Wang, Zhenyu Ju Hu Wang, Zhenyu Ju Ping Wu, Chao Peng, Catherine CL Wong James J Lee Songmin Ying Songmin Ying Huahao Shen | 2018 | Cell Research2018，28，3： | 6 |
| 9 | Recent advancements in metal-organic frameworks for green applications显示文摘A series of environmental and energy issues,such as global warming,water pollution,acid rain,and energy shortage,have to be settled urgently.Metal-organic frameworks(MOFs)are compounds consisting of metal ions or clusters coordinated to organic ligands,which show great promise for alleviating or mitigating these challenges owing to their outstanding physical and chemical properties.In this review,we summarize the recent advances of MOFs in the fields of green applications,including carbon capture,harmful gas removal,sewage treatment,and green energy storage.In addition,the challenges and prospects of the large-scale commercialized use of MOFs in handling environmental issues are also discussed. | Chongxiong Duan Yi Yu Jing Xiao Yuanyuan Li Pengfei Yang Fei Hu Hongxia Xi | 2021 | Green Energy & Environment2021，6，1： | 6 |
| 10 | Design of Secure Distributed Intrusion Detection Systems显示文摘Intrusion Detection System ( IDS ) have received a great deal of attention because of their excellent ability of preventing network incidents. Recently, many efficient approaches have been proposed to improve detection ability of IDS . While the self protection ability of IDS is relatively worse and easy to be exploited by attackers, this paper gives a scheme of Securely Distributed Intrusion Detection System ( SDIDS ). This system adopts special measurements to enforce the security of IDS components. A new secure mechanism combining role based access control and attribute certificate is used to resist attack to communication. | GUO Dai fei, YANG Yi xian, HU Zheng ming (Information Security Center, Beijing University of Posts and Telecommunications, Beijing 100876, P. R. China) | 2002 | The Journal of China Universities of Posts and Telecommunications2002，9，2： | 5 |
| 11 | Towards a global One Health index: a potential assessment tool for One Health performance显示文摘Background:A One Health approach has been increasingly mainstreamed by the international community, as it provides for holistic thinking in recognizing the close links and inter-dependence of the health of humans, animals and the environment. However, the dearth of real-world evidence has hampered application of a One Health approach in shaping policies and practice. This study proposes the development of a potential evaluation tool for One Health performance, in order to contribute to the scientific measurement of One Health approach and the identification of gaps where One Health capacity building is most urgently needed.Methods:We describe five steps towards a global One Health index (GOHI), including (i) framework formulation;(ii) indicator selection;(iii) database building;(iv) weight determination;and (v) GOHI scores calculation. A cell-like framework for GOHI is proposed, which comprises an external drivers index (EDI), an intrinsic drivers index (IDI) and a core drivers index (CDI). We construct the indicator scheme for GOHI based on this framework after multiple rounds of panel discussions with our expert advisory committee. A fuzzy analytical hierarchy process is adopted to determine the weights for each of the indicators.Results:The weighted indicator scheme of GOHI comprises three first-level indicators, 13 second-level indicators, and 57 third-level indicators. According to the pilot analysis based on the data from more than 200 countries/territories the GOHI scores overall are far from ideal (the highest score of 65.0 out of a maximum score of 100), and we found considerable variations among different countries/territories (31.8–65.0). The results from the pilot analysis are consistent with the results from a literature review, which suggests that a GOHI as a potential tool for the assessment of One Health performance might be feasible.Conclusions:GOHI—subject to rigorous validation—would represent the world’s first evaluation tool that constructs the conceptual framework from a holistic perspective of One Health. Future application of GOHI might promote a common understanding of a strong One Health approach and provide reference for promoting effective measures to strengthen One Health capacity building. With further adaptations under various scenarios, GOHI, along with its technical protocols and databases, will be updated regularly to address current technical limitations, and capture new knowledge. | Xiao-Xi Zhang Jing-Shu Liu Le-Fei Han Shang Xia Shi-Zhu Li Odel YLi Kokouvi Kassegne Min Li Kun Yin Qin-Qin Hu Le-Shan Xiu Yong-Zhang Zhu Liang-Yu Huang Xiang-Cheng Wang Yi Zhang Han-Qing Zhao Jing-Xian Yin Tian-Ge Jiang Qin Li Si-Wei Fei Si-Yu Gu Fu-Min Chen Nan Zhou Zi-Le Cheng Yi Xie Hui-Min Li Jin Chen Zhao-Yu Guo Jia-Xin Feng Lin Ai Jing-Bo Xue Qian Ye Liz Grant Jun-Xia Song Geoff Simm Jürg Utzinger Xiao-Kui Guo Xiao-Nong Zhou | 2022 | Infectious Diseases of Poverty2022，11，3： | 3 |
| 12 | MoS2 Nanosheets Sensitized with Quantum Dots for Room-Temperature Gas Sensors显示文摘The Internet of things for environment monitoring requires high performance with low power-consumption gas sensors which could be easily integrated into large-scale sensor network.While semiconductor gas sensors have many advantages such as excellent sensitivity and low cost,their application is limited by their high operating temperature.Two-dimensional(2D)layered materials,typically molybdenum disulfide(MoS2)nanosheets,are emerging as promising gas-sensing materials candidates owing to their abundant edge sites and high in-plane carrier mobility.This work aims to overcome the sluggish and weak response as well as incomplete recovery of MoS2 gas sensors at room temperature by sensitizing MoS2 nanosheets with PbS quantum dots(QDs).The huge amount of surface dangling bonds of QDs enables them to be ideal receptors for gas molecules.The sensitized MoS2 gas sensor exhibited fast and recoverable response when operated at room temperature,and the limit of NO2 detection was estimated to be 94 ppb.The strategy of sensitizing 2D nanosheets with sensitive QD receptors may enhance receptor and transducer functions as well as the utility factor that determine the sensor performance,offering a powerful new degree of freedom to the surface and interface engineering of semiconductor gas sensors. | Jingyao Liu Zhixiang Hu Yuzhu Zhang HuaYao Li Naibo Gao Zhilai Tian Licheng Zhou Baohui Zhang Jiang Tang Jianbing Zhang Fei Yi Huan Liu | 2020 | Nano-Micro Letters2020，12，5： | 3 |
| 13 | Establishment and validation of a model for brain injury state evaluation and prognosis prediction显示文摘Purpose:Traumatic brain injury(TBI)is one of the leading causes of disability and death in modern times,whose evaluation and prognosis prediction have been one of the most critical issues in TBI management.However,the existed models for the abovementioned purposes were defective to varying degrees.This study aims to establish an ideal brain injury state clinical prediction model(BISCPM).Methods:This study was a retrospective design.The six-month outcomes of patients were selected as the end point event.BISCPM was established by using the split-sample technology,and externally validated via different tests of comparison between the observed and predicted six-month mortality in validating group.TBI patients admitted from July 2006 to June 2012 were recruited and randomly divided into establishing model group and validating model group.Twenty-one scoring indicators were included in BISCPM and divided into three parts,A,B,and C.Part A included movement,pupillary reflex and diameter,CT parameters,and secondary brain insult factors,etc.Part B was age and part C was medical history of the patients.The total score of part A,B and C was final score of BISCPM.Results:Altogether 1156 TBI patients were included with 578 cases in each group.The score of BISCPM from validating group ranged from 2.75 to 31.94,averaging 13.64±5.59.There was not statistical difference between observed and predicted mortality for validating group.The discrimination validation showed that the BISCPM is superior to international mission for prognosis and analysis of clinical trials(IMPACT)lab model.Conclusion:BISCPM is an effective model for state evaluation and prognosis prediction of TBI patients.The use of BISCPM could be of great significance for decision-making in management of TBI. | Xia Li Chao Lü Jun Wang Yi Wan Shu-Hui Dai Lei Zhang Xue-An Hu Xiao-Fan Jiang Zhou Fei | 2020 | Chinese Journal of Traumatology2020，23，5： | 3 |
| 14 | Stratospheric Ozone-induced Cloud Radiative Effects on Antarctic Sea Ice显示文摘Recent studies demonstrate that the Antarctic Ozone Hole has important influences on Antarctic sea ice.While most of these works have focused on effects associated with atmospheric and oceanic dynamic processes caused by stratospheric ozone changes,here we show that stratospheric ozone-induced cloud radiative effects also play important roles in causing changes in Antarctic sea ice.Our simulations demonstrate that the recovery of the Antarctic Ozone Hole causes decreases in clouds over Southern Hemisphere(SH)high latitudes and increases in clouds over the SH extratropics.The decrease in clouds leads to a reduction in downward infrared radiation,especially in austral autumn.This results in cooling of the Southern Ocean surface and increasing Antarctic sea ice.Surface cooling also involves ice-albedo feedback.Increasing sea ice reflects solar radiation and causes further cooling and more increases in Antarctic sea ice. | Yan XIA Yongyun HU Jiping LIU Yi HUANG Fei XIE Jintai LIN | 2020 | Advances in Atmospheric Sciences2020，37，5： | 3 |
| 15 | Evaluating the Quality of Case-control Studies involving the Association between Tobacco Exposure and Diseases in a Chinese Population based on the Newcastle-Ottawa Scale and Post-hoc Power显示文摘According to the 2017 Global Burden of Disease Study,smoking is among the four leading risk factors contributing to deaths and disability-adjusted life years(DALYs)in China.In the past 20 years,there has been a substantial increase in the number of studies focusing on the association between tobacco exposure and disease. | SHI Yu Lin ZHAO Jian AI Fei Ling WANG Yu Tong HU Kui Ru WANG Xue Wei YANG Wen Yi WANG Jing Xin AI Li Mei WAN Xia | 2022 | Biomedical and Environmental Sciences2022，35，9： | 2 |
| 16 | Effects of Antiretroviral Therapy and HIV Exposure in Utero on Adverse Pregnancy and Infant Outcomes:A Prospective Cohort Study in Guangzhou, China显示文摘Objective This study aimed to evaluate the effects of in-utero exposure to HIV and ART on pregnancy outcome and early growth of children.Methods This cohort study enrolled 802 HIV-infected pregnant women between October 2009 and May 2018 in Guangzhou, China. The women were assigned to receive combination ART(c ART) or mono/dual ART or no treatment. The primary outcomes were the combined endpoints of any adverse pregnancy outcome [including ectopic pregnancy, spontaneous abortion, stillbirth, preterm birth, small for gestational age(SGA)] and adverse early growth outcome(including infant death, HIV infection of mother-to-child transmission, and underweight, wasting and stunting of infants at 4 weeks of age).Results Adverse pregnancy outcomes occurred in 202(35.1%) of all enrolled HIV-infected women, and121(31.3%) of all infants exhibited adverse effects on early growth at 4 weeks of age. The rates of adverse pregnancy outcomes, spontaneous abortion, ectopic pregnancy, stillbirth, infant death and perinatal HIV infection were higher among women not receiving ART, compared to those treated with c ART or mono/dual ART(P < 0.05). However, women treated with c ART had a higher rate of SGA,compared to untreated women(P < 0.05). No differences in early infant growth were observed among the different treatment regimens.Conclusion Our findings underscore the essentiality of prioritizing HIV-positive pregnant women for ART, as even mono/dual ART available in resource-limited countries could improve pregnancy outcomes and infant survival. | HU Fang LIANG Jing Jing LU Jian Jun HU Yi Fei HU Yan YU Jia ZOU Xing Wen MA Ying Hua LIN Sui Fang | 2019 | Biomedical and Environmental Sciences2019，32，10： | 2 |
| 17 | Extracorporeal Membrane Oxygenation Therapy for Critically Ill Coronavirus Disease 2019 Patients in Wuhan,China:A Retrospective Multicenter Cohort Study显示文摘Currently,little in-depth evidence is known about the application of extracorporeal membrane oxygenation(ECMO)therapy in coronavirus disease 2019(COVID-19)patients.This retrospective multicenter cohort study included patients with COVID-19 at 7 designated hospitals in Wuhan,China.The patients were followed up until June 30,2020.Univariate and multivariate logistic regression analyses were performed to identify the risk factors associated with unsuccessful ECMO weaning.Propensity score matching was used to match patients who received veno-venous ECMO with those who received invasive mechanical ventilation(IMV)-only therapy.Of 88 patients receiving ECMO therapy,27 and 61 patients were and were not successfully weaned from ECMO,respectively.Additionally,15,15,and 65 patients were further weaned from IMV,discharged from hospital,or died during hospitalization,respectively.In the multivariate logistic regression analysis,a lymphocyte count≤0.5×10^(9)/L and D-dimer concentration>4×the upper limit of normal level at ICU admission,a peak PaCO_(2)>60 mmHg at 24 h before ECMO initiation,and no tracheotomy performed during the ICU stay were independently associated with lower odds of ECMO weaning.In the propensity scorematched analysis,a mixed-effect Cox model detected a lower hazard ratio for 120-day all-cause mortality after ICU admission during hospitalization in the ECMO group.The presence of lymphocytopenia,higher D-dimer concentrations at ICU admission and hypercapnia before ECMO initiation could help to identify patients with a poor prognosis.Tracheotomy could facilitate weaning from ECMO.ECMO relative to IMV-only therapy was associated with improved outcomes in critically ill COVID-19 patients. | Jing FANG Rui LI Yue CHEN Juan-juan QIN Ming HU Chao-lin HUANG Lin CHENG Yi HE Yi LI Qiang ZHOU Dai-xing ZHOU Fei HUANG Fang LEI Bo YANG Jun CHEN Hong-ping DENG Yu-feng YUAN Jia-hong XIA Song WAN Hong-liang LI Xiang WEI | 2021 | Current Medical Science2021，41，1： | 2 |
| 18 | Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population:Findings from the China Cardiometabolic Disease and Cancer Cohort(4C)Study显示文摘Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains inconclusive.We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population.Methods The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid assessment.The nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive models.Results A total of 30,941 men and 62,361 women were eligible for the current analysis.Generalized additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and women.The thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women. | ZHU Yuan Yue ZHENG Rui Zhi WANG Gui Xia CHEN Li SHI Li Xin SU Qing XU Min XU Yu CHEN Yu Hong YU Xue Feng YAN Li WANG Tian Ge ZHAO Zhi Yun QIN Gui Jun WAN Qin CHEN Gang GAO Zheng Nan SHEN Fei Xia LUO Zuo Jie QIN Ying Fen HUO Ya Nan LI Qiang YE Zhen ZHANG Yin Fei LIU Chao WANG You Min WU Sheng Li YANG Tao DENG Hua Cong ZHAO Jia Jun CHEN Lu Lu MU Yi Ming TANG Xu Lei HU Ru Ying WANG Wei Qing NING Guang LI Mian LU Jie Li BI Yu Fang | 2021 | Biomedical and Environmental Sciences2021，34，1： | 2 |
| 19 | Study on the interaction mechanism between laser and rock during perforation显示文摘 | Fei Yan Yafei Gu Yajun Wang Chunming Wang Xiyuan Hu Hanxiu Peng Zhiliang Yao Zheng Wang Yi Shen | 2013 | Optics and Laser Technology2013，，： | 1 |
| 20 | The draft genome of watermelon (Citrullus lanatus ) and reseqnencing of 20 diverse accessions显示文摘 | Guo S G Zhang J G Sun H H Salse J Lucas W J Zhang H Y Zheng Y Mao L Y Ren Y WangZ W Min J M Guo X S Murat F Ham B K Zhang Z L Gao S Huang M Xu Y M Zhong S L Bombarely A Mueller L Zhao H He H Q Zhang Y Zhang Z H Huang S W Tan T Pang E Lin K Hu Q Kuang H H Ni P X Wang B Liu J G Kou Q H Hou W J Zou X H Jiang J Gong G Y Klee K Schoof H Huang Y Hu X S Dong S S Liang D Q Wang J Wu K Xia Y Zhao X Zheng Z Q Xing M Liang X M Huang B Q Lv T Wang J Y Yin Y Yi H P Li R Q Wu M Z Levi A Zhang X P Giovannoni J Wang J Li YF Fei Z J Xu Y | 2013 | Nature genetics2013，45，1： | 1 |
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