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| 1 | Effects of tetrahedral framework nucleic acid/wogonin complexes on osteoarthritis显示文摘Osteoarthritis, a disorder characterized by articular cartilage deterioration, varying degrees of inflammation, and chondrocyte apoptosis, is the most common chronic joint disease. To slow or reverse its progression, inflammation should be inhibited, and chondrocyte proliferation should be promoted. Tetrahedral framework nucleic acids can be internalized by chondrocytes(even inflammatory chondrocytes) and can enhance their proliferation and migration. Wogonin, a naturally occurring flavonoid,suppresses oxidative stress and inhibits inflammation. In this study, tetrahedral framework nucleic acids were successfully selfassembled and used to load wogonin. We confirmed the effective formation of tetrahedral framework nucleic acid/wogonin complexes by dynamic light scattering, zeta potential analysis, transmission electron microscopy, and fluorescence spectrophotometry. Tetrahedral framework nucleic acids, wogonin, and especially tetrahedral framework nucleic acid/wogonin complexes effectively alleviated inflammation in vitro and in vivo and prevented cartilage destruction. In addition, these materials remarkably downregulated the expression of inflammatory mediators and matrix metalloproteinases, upregulated chondrogenic markers, and promoted tissue inhibitor of metalloproteinase 1 and B-cell lymphoma 2 expression. In vivo, after treatment with tetrahedral framework nucleic acid/wogonin complexes, the bone mineral density in regenerated tissues was much higher than that found in the untreated groups. Histologically, the complexes enhanced new tissue regeneration, significantly suppressed chondrocyte apoptosis, and promoted chondrogenic marker expression. They also inhibited cell apoptosis, increased chondrogenic marker expression, and suppressed the expression of inflammatory mediators in osteoarthritis. Therefore, we believe that tetrahedral framework nucleic acid/wogonin complexes can be used as an injectable form of therapy for osteoarthritis. | Sirong Shi Yang Chen Taoran Tian Songhang Li Shiyu Lin Yuxin Zhang Xiaoru Shao Tao Zhang Yunfeng Lin Xiaoxiao Cai | 2020 | Bone Research2020，8，1： | 9 |
| 2 | Research on parametric design method for energy efficiency of green building in architectural scheme phase显示文摘 | Borong Lin Qiong Yu Ziwei Li Xiaoru Zhou | 2013 | Frontiers of Architectural Research2013，2，1： | 4 |
| 3 | Nucleic acids and analogs for bone regeneration显示文摘With the incidence of different bone diseases increasing, effective therapies are needed that coordinate a combination of various technologies and biological materials. Bone tissue engineering has also been considered as a promising strategy to repair various bone defects. Therefore, different biological materials that can promote stem cell proliferation, migration, and osteoblastic differentiation to accelerate bone tissue regeneration and repair have also become the focus of research in multiple fields. Stem cell therapy, biomaterial scaffolds, and biological growth factors have shown potential for bone tissue engineering; however, off-target effects and cytotoxicity have limited their clinical use. The application of nucleic acids(deoxyribonucleic acid or ribonucleic acid)and nucleic acid analogs(peptide nucleic acids or locked nucleic acids), which are designed based on foreign genes or with special structures, can be taken up by target cells to exert different effects such as modulating protein expression, replacing a missing gene, or targeting specific gens or proteins. Due to some drawbacks, nucleic acids and nucleic acid analogs are combined with various delivery systems to exert enhanced effects, but current studies of these molecules have not yet satisfied clinical requirements. In-depth studies of nucleic acid or nucleic acid analog delivery systems have been performed, with a particular focus on bone tissue regeneration and repair. In this review, we mainly introduce delivery systems for nucleic acids and nucleic acid analogs and their applications in bone repair and regeneration. At the same time, the application of conventional scaffold materials for the delivery of nucleic acids and nucleic acid analogs is also discussed. | Yuxin Zhang Wenjuan Ma Yuxi Zhan Chenchen Mao Xiaoru Shao Xueping Xie Xiawei Wei Yunfeng Lin | 2018 | Bone Research2018，6，4： | 3 |
| 4 | Multi?targeted Antisense Oligonucleotide Delivery by a Framework Nucleic Acid for Inhibiting Biofilm Formation and Virulence显示文摘Biofilm formation is responsible for numerous chronic infections and represents a serious health challenge.Bacteria and the extracellular polysaccharides(EPS)cause biofilms to become adherent,toxic,resistant to antibiotics,and ultimately difficult to remove.Inhibition of EPS synthesis can prevent the formation of bacterial biofilms,reduce their robustness,and promote removal.Here,we have developed a framework nucleic acid delivery system with a tetrahedral configuration.It can easily access bacterial cells and functions by delivering antisense oligonucleotides that target specific genes.We designed antisense oligonucleotide sequences with multiple targets based on conserved regions of the VicK protein-binding site.Once delivered to bacterial cells,they significantly decreased EPS synthesis and biofilm thickness.Compared to existing approaches,this system is highly efficacious because it simultaneously reduces the expression of all targeted genes(gtfBCD,gbpB,ftf).We demonstrate a novel nucleic acid-based nanomaterial with multi-targeted inhibition that has great potential for the treatment of chronic infections caused by biofilms. | Yuxin Zhang Xueping Xie Wenjuan Ma Yuxi Zhan Chenchen Mao Xiaoru Shao Yunfeng Lin | 2020 | Nano-Micro Letters2020，12，6： | 3 |
| 5 | Imitated Ecological Cultivation Technology of Dendrobium offcinale: A Case Study of Longshitou Village,Longmen County显示文摘In order to optimize the planting structure of Longshitou Village in Longmen County and promote the efficient cultivation of Dendrobium offcinale industry,the imitate ecological cultivation technology of D.offcinale is studied from the aspects of site selection,seedling domestication,seedling colonization,and disease and pest control after colonization according to the natural environmental conditions of Longshitou Village. | Xiulian Lin Yingjun Zhou Junhong Zhong Jinhe Zhu Xiaoru Chen Yonggeng Lin Minchun Huang Lihua Yang Zhi Zhang | 2021 | Plant Diseases and Pests2021，12，2： | 1 |
| 6 | Innovative Mode and Application of Flipped Classroom in City Design Course显示文摘The city planning quick topic design is a part of the city design course in many urban planning colleges.It can help stimulate the students’off-handed creativity and image expression ability.So it is necessary to explore the teaching mode which can adapt to it and stimulate students’learning enthusiasm and creative ability.In the context of promoting the'classroom revolution'of higher education in China,the flipped classroom has received widespread attention in the higher education community.Based on this,after three years of teaching practice,the author adaptively adjusted and innovatively modified the basic model of flip classroom in the quick topic design teaching of the city design course,and has found a variant model applicable to this course,namely OCTIAS(objective-case exploration-trial and error-instructional video-activities-summary and promotion).Firstly,insert two sections before the video learning,including'case travel exploration'and'trial and error(in order to accumulate beneficial failures)'.Secondly,in the classroom activities,sort out the problems reflected by the students,and organize the students to make self-evaluation,mutual evaluation and revise the trial and error plan before the class.Finally,think about the problems that may occur in the cities in the future and their spatial organization responses.The practice showed that compared with the traditional teaching mode,the OCTIAS model could make the city design course more interesting,and help the students to improve in the solidity of theoretical knowledge learning,the flexibility of practical operation,the initiative to think about realistic problems,and the ability of critical thinking and expression. | LIN Xiaoru YANG Zhe WANG Anlin LI Haidong | 2020 | Journal of Landscape Research2020，12，3： | 1 |
| 7 | Distribution and Migration Patterns of Lead in Atmosphere-tea System by Isotopic Tracing Method显示文摘With low concentration of stable lead isotope as the tracer,using inductively coupled plasma mass spectrometry( ICP-MS),the lead absorption of tea plants as well as the distribution and migration pattern of lead in plants under different p H environments and spraying introduction of lead sources were studied through pot trial. The results showed that tea plants were very sensitive to atmospheric lead source pollution; atmospheric lead source pollution had a tendency of moving up to the top( bud); low p H conditions enhanced lead absorption of plants and promoted upward migration of lead in plants. The experimental method is closer to the actual situation that plants are exposed to low concentration pollution,and could distinguish experimentally introduced lead source from environmentally introduced lead source. | Huang Huabin Yang Miaofeng Lin Ying Ke Nafen Xiao Yueming Zhuang Zhixia Wang Xiaoru | 2017 | Plant Diseases and Pests2017，8，4： | 0 |
| 8 | MXene Lubricated Tribovoltaic Nanogenerator with High Current Output and Long Lifetime显示文摘Tribovoltaic nanogenerators(TVNGs)have the characteristics of high current density,low matched impedance and continuous output,which is expected to solve the problem of power supply for small electronic devices.However,wear occurrence in friction interface will seriously reduce the performance of TVNGs as well as lifetime.Here,we employ MXene solution as lubricate to improve output current density and lifetime of TVNG simultaneously,where a high value of 754 mA m^(-2)accompanied with a record durability of 90,000 cycles were achieved.By comparing multiple liquid lubricates with different polarity,we show that conductive polar liquid with MXene as additive plays a crucial role in enhancing the electrical output performance and durability of TVNG.Moreover,the universality of MXene solution is well demonstrated in various TVNGs with Cu and P-type Si,and Cu and N-GaAs as material pairs.This work may guide and accelerates the practical application of TVNG in future. | Wenyan Qiao Linglin Zhou Zhihao Zhao Peiyuan Yang Di Liu Xiaoru Liu Jiaqi Liu Dongyang Liu Zhong Lin Wang Jie Wang | 2023 | Nano-Micro Letters2023，15，12： | 0 |
| 9 | Enhancement and recovery of photoluminescence and stability by multifunctional etching ligands treatment for perovskite nanocrystals显示文摘Perovskite nanocrystals(PNCs)have recently become promising optoelectronic materials due to their excellent photophysical properties.However,the highly dynamic binding state between ligands and the surface of PNCs has severely restricted their luminescent properties and stabilities.In this work,1,3-bisbenzyl-2-oxoimidazolidine-4,5-dicarboxylic acid(cycle acid,CA)is introduced as both an etchant and a ligand upon post-synthetic surface treatment of PNCs.By removing the imperfect octahedrons[Pb X_(6)]^(4-)and passivating the surface defects synergistically,this treatment improves photoluminescence quantum yields from 76%to 95%and enhances the stability of PNCs against polar solvent,moisture,heat,and illumination.Meanwhile,CA can effectively and instantly recover the luminescence emission for aged PNCs.As a result,the CA-Cs Pb Br_(3)PNCs and CA-Cs Pb IxBr_(3-x)PNCs are applied as color-converting layers on a blue LED chip for warm white light-emitting diodes(WLEDs)with a color coordinate of(0.41,0.40).Importantly,the CA-based WLED device exhibits superior stability in operational conditions. | Yang Zhao Haipeng Zeng Xueqing Cai Yingshan Zhou Yangming Jiang Xin Zheng Lin Li Shujing Zhang Long Luo Weixi Li Xiaoru Zhang Ranran Liu Wenxi Liang Rui Guo Xiong Li | 2023 | Journal of Energy Chemistry2023，，1： | 0 |
| 10 | Exploring Urbanization Patterns for Counties in Underdeveloped Mountainous Areas: A Case Study of Hubei, China显示文摘In the present work, features of urbanization of 24 underdeveloped mountainous counties(UMCs) in Hubei Province are analyzed and summarized, which includes low rates of urbanization, signifi cant nonlocal urbanization, undeveloped three industries, and a homogeneous spatial layout of underdeveloped towns. Moreover, our analysis reveals that driving forces originating from favorable macro policies, medium economy, and micro elements are needed to speed up the urbanization in such areas. Based on the case study, we proposes a new path pattern for urbanization of these UMCs in western & central China. In principle, this pattern mainly consists of two important strategies which are driven by a simultaneous development of industry and trade and the exploitation of local characteristics in both economics and culture. In addition, the practice of such a new urbanization path should be carried out through incremental development together with the construction of node-centralizing towns. | Lin Xiaoru | 2015 | China City Planning Review2015，24，1： | 0 |
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