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| 1 | Relocation of the mainshock and aftershock sequences of M_S7.0 Sichuan Lushan earthquake显示文摘The mainshock of April 20,2013 Sichuan Lushan MS7.0 earthquake was relocated using a 3-D velocity model.Double difference algorithm was applied to relocate aftershock sequences of Lushan earthquake.The locations of 2405 aftershocks were determined.The location errors in E-W,N-S and U-D direction were 0.30,0.29 and 0.59 km on average,respectively.The location of the mainshock is 102.983°E,30.291°N and the focal depth is 17.6 km.The relocation results show that the aftershocks spread approximately 35 km in length and 16 km in width.The dominant distribution of the focal depth ranges from 10 to 20 km.A few earthquakes occurred in the shallow crust.Focal depth profiles show fault planes dip to the northwest,manifested itself as a listric thrust fault.The dip angle is steep in the shallow crust and gentle in the deep crust.Although the epicenters of aftershocks distributed mainly along both sides of the Shuangshi-Dachuan fault,the seismogenic fault may be a blind thrust fault on the eastern side of the Shuangshi-Dachuan fault.Earthquake relocation results reveal that there is a southeastward tilt aftershock belt intersecting with the seismogenic fault with y-shape.We speculate it is a back thrust fault that often appears in a thrust fault system.Lushan earthquake triggered the seismic activity of the back thrust fault. | FANG LiHua WU JianPing WANG WeiLai Lü ZuoYong WANG ChangZai YANG Ting CAI Yan | 2013 | Chinese Science Bulletin2013，58，28： | 74 |
| 2 | On the tuning of electrical and thermal transport in thermoelectrics: an integrated theory–experiment perspective显示文摘During the last two decades,we have witnessed great progress in research on thermoelectrics.There are two primary focuses.One is the fundamental understanding of electrical and thermal transport,enabled by the interplay of theory and experiment;the other is the substantial enhancement of the performance of various thermoelectric materials,through synergistic optimisation of those intercorrelated transport parameters.Here we review some of the successful strategies for tuning electrical and thermal transport.For electrical transport,we start from the classical but still very active strategy of tuning band degeneracy(or band convergence),then discuss the engineering of carrier scattering,and finally address the concept of conduction channels and conductive networks that emerge in complex thermoelectric materials.For thermal transport,we summarise the approaches for studying thermal transport based on phonon–phonon interactions valid for conventional solids,as well as some quantitative efforts for nanostructures.We also discuss the thermal transport in complex materials with chemical-bond hierarchy,in which a portion of the atoms(or subunits)are weakly bonded to the rest of the structure,leading to an intrinsic manifestation of part-crystalline part-liquid state at elevated temperatures.In this review,we provide a summary of achievements made in recent studies of thermoelectric transport properties,and demonstrate how they have led to improvements in thermoelectric performance by the integration of modern theory and experiment,and point out some challenges and possible directions. | Jiong Yang Lili Xi Wujie Qiu Lihua Wu Xun Shi Lidong Chen Jihui Yang Wenqing Zhang Ctirad Uher David J Singh | 2016 | npj Computational Materials2016，，1： | 24 |
| 3 | Rotor Strength Analysis of High-speed Permanent Magnet Synchronous Motors显示文摘为了对转子进行有效的冷却,在满足电机电磁性能的前提下,可通过减小保护套的厚度来尽可能增大定转子之间的气隙,因而必须对保护套和永磁体进行强度校核。将转子受力状况简化为平面应变问题,在此基础上推导出了两层过盈配合、三层过盈配合转子的应力场、应变场、位移场的解析公式,并利用有限元方法验证了解析公式的正确性。归纳了高速情况下热套式永磁转子强度设计准则,为转子的优化设计提供了理论依据。以一台额定转速120kr/min、10kW的高速永磁同步电机为例,给出了两种常用过盈配合高速电机转子的强度设计方法。 | CHENG Wenjie GENG Haipeng FENG Sheng YU Lie SUN Yanhua YANG Lihua | 2012 | 中国电机工程学报2012，32，27： | 21 |
| 4 | Future 5G-Oriented System for Urban Rail Transit:Opportunities and Challenges显示文摘As a development direction of urban rail transit system,the train autonomous circumambulate system(TACS)can operate in a safer,more efficient,and more economical mode.However,most urban rail transit systems transmit signals through industrial,scientific,and medical(ISM)frequency bands or narrow frequency bands,which cannot meet the requirements of TACS.As a promising solution,the 5th generation(5G)mobile communication provides more services for the future urban rail transit systems,and covers the shortages of exiting communication technologies in terms of capacity and reliability.In this paper,we first briefly review the research status of current train control system and introduce its limitations.Next,we propose a novel network architecture,and present new technologies and requirements of the proposed architecture for TACS.Some potential challenges are then discussed to give insights for further research of TACS. | Junhui Zhao Jin Liu Lihua Yang Bo Ai Shanjin Ni | 2021 | China Communications2021，18，2： | 18 |
| 5 | Seasonal characters of regional vegetation activity in response to climate change in West China in recent 20 years显示文摘Using NDVI data of NOAA-AVHRR in recent 20 years and the temperature and precipitation data of West China, the vegetation activity is discussed by adopting the EOF and REOF decomposed functions. Results show that the overall increasing trend of vegetation activity in different seasons reflects an advanced and prolonged growth period of vegetation under the circumstance of climate warming, but the vegetation evolvement has much inconsistency between different regions and seasons. There are four notable regions, eight sub-areas for vegetation evolvement in spring and summer, and nine sub-areas in autumn. The vegetation activity in most sub-areas is increasing. The most notable region is represented by Lhaze station on the Tibetan Plateau. Two other marked stations are represented by Altay station in Xinjiang Uygur Autonomous Region and Pengshui station in Sichuan Province. But the time series analysis of NDVI makes clear that the trends of the other two sub-areas, Turpan station in Xinjiang and Huashan station in Shaanxi Province, are descending. It is an important reason for vegetation evolvement that temperature ascends in most of the regions and descends in the east region in some seasons. But another important reason for vegetation evolvement is that precipitation is ascending in the west and descending in the east of the region. | ZHANG Jie ZHANG Qiang YANG Lihua LI Dongliang | 2006 | Journal of Geographical Sciences2006，16，1： | 13 |
| 6 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 7 | Ecological-hydrological processes in arid environment: Past, present and future显示文摘Ecohydrology, aiming to study the interactions between terrestrial ecological systems and hydrological cycles as well as their impacts on water management, has been an emerging interdisciplinary research field since the 20 th century. It hosts both natural and human regulated processes that are potentially coupled in complex ways. Understanding the ecological-hydrological processes, the fundamental mechanisms and the connections between them is critical since these processes are not isolated but integrated to impact basin-scale hydrological and biogeochemical functioning of a larger river system, especially in arid environment where water resources are considered to be the source of life. Thus, research on ecological-hydrological processes in arid environment is not only a scientific focus area but also important to sustainable development. Research projects and initiatives involved in observation, measurement, modeling and data assimilation have been well-developed for those purposes over the past 20 years. This review summarizes the historical development of ecohydrology science in China and the state-of-the-art tools available in the research framework. Five grand scientific challenges are listed as prospects and exciting opportunities for the scientific community. To advance the current ecological-hydrological processes research, scientists from multidisciplinary backgrounds(such as geography, geology, geomorphology, hydrology, geochemistry and ecology), need to unite to tackle the many open problems in new dimensions. | SONG Changqing YUAN Lihua YANG Xiaofan FU Bojie | 2017 | Journal of Geographical Sciences2017，27，12： | 13 |
| 8 | Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis显示文摘Sphingolipids 被建议了在植物房间为一连串的细胞的发信号活动充当第二个送信人,包括压力回答并且规划了房间死亡(PCD ) 。然而,这些过程不是的机制 underpinning 很好理解。这里,我们报导那 Arabidopsis 异种, fumonisin B1 抵抗 11-1 ( fbr 11-1 )没能产生反应的氧中介( ROI ),不能当异种被 fumonisin B ( 1 )( FB ( 1 ))质问时,开始 PCD , ceramide synthase 的一个特定的禁止者。显示的分子的分析 FBR11 编码一个长链的底 1 (LCB1 ) 丝氨酸 palmitoyltransferase (SPT ) 的子单元,它催化 de novo sphingolipid 的第一限制率的步合成。sphingolipid 集中的集体度谱的分析表明而 fbr 11-1 变化没影响 sphingoid 底的基础层次,异种响应 FB (1 ) 显示出 sphingoid 底的稀释形成。由一个直接的喂实验,我们证明免费 sphingoid 底 dihydrosphingosine, phytosphingosine 和鞘氨醇高效地导致产生由房间死亡跟随了的 ROI。相反地, dihydrosphingosine 导致的 ROI 产生和房间死亡被它的 phosphorylated 形式 dihydrosphingosine-1-phosphate 明确地以一种剂量依赖者方式堵住,建议在一个免费 sphingoid 底和它的 phosphorylated 衍生物之间的动态平衡的维护对决定房间命运批评。因为 sphingolipid 水平的改变发生在 ROI 生产以前,我们建议免费 sphingoid 库在 Arabidopsis 涉及 PCD 的控制,大概在收到不同发展或环境的暗示之上通过 ROI 的规定铺平。 | Lihua Shi Jacek Bielawski Jinye Mu Haili Dong Chong Teng Jian Zhang Xiaohui Yang Nario Tomishige Kentaro Hanada Yusuf A Hannun Jianru Zuo | 2007 | Cell Research2007，17，12： | 12 |
| 9 | Effect of allogeneic umbilical cord mesenchymal stem cell transplantation in a rat model of hepatic cirrhosis显示文摘OBJECTIVE: To determine the effects of human umbilical cord mesenchymal stem cell(UCMSC) transplantation, alone or in combination with tanshinone IIA(Tan IIA) on hepatic cirrhosis in rats.METHODS: A rat model of cirrhosis was established. Rats were divided into control, UCMSC, and UCSMC plus Tan IIA groups. Rats in the UCMSC group were injected via the tail vein with 0.2 m L Di I-labeled UCMSC suspension. Intraperitoneal Tan IIA injections(20 mg/kg) were started on the day ofUCMSC transplantation in the UCMSC plus Tan IIA group, and continued for 7 consecutive days thereafter. Rats were sacrificed 1 day, 3 days, 1 month,and 3 months after transplantation and the numbers of Di I-labeled UCMSCs colonizing the liver were determined. Albumin(ALB) and alanine aminotransferase(ALT) levels were measured in venous blood, and m RNA and protein expression levels of human ALB and cytokeratin(CK)-18 in liver tissues were determined by reverse transcription-polymerase chain reaction and western blotting, respectively.RESULTS: Serum ALT levels were significantly lower and serum ALB levels significantly higher in rats in the UCMSC group compared with the control group(P < 0.05). Hepatic CK-18 and ALB m RNA and protein expression levels increased after transplantation, and were significantly higher in the UCMSC plus Tan IIA group compared with the UCMSC group(P < 0.05).CONCLUSION: Human UCMSCs transplanted into rats with liver cirrhosis can grow and differentiate into hepatocyte-like cells resulting in improved liver function in vivo. Tan IIA further influenced transplantation outcomes. | Yang Lihua Wang Yun Wang Xiaohua Liu Yanqing | 2015 | Journal of Traditional Chinese Medicine2015，35，1： | 12 |
| 10 | Ecological Economic Problems and Development Patterns of the Arid Inland River Basin in Northwest China显示文摘中国西北部干旱区的内陆河流域位于欧亚大陆的中心(35°N,106°E),占全国陆地总面积的24.5%,是世界上最干旱的地区之一。该区具有较为湿润的山地和干旱的平原地带性交替特征。发源于山区的几条河流,如黑河、石羊河.疏勒河和塔里木河,在流经中游地区,孕育了一些生机盎然的绿洲后,注入一些小的湖泊或者消失在广袤的干旱荒漠盆地。山地.绿洲和沙漠相间分布的景观特征是中国西北干旱区内陆河流域典型的景观格局。尽管该区相对于其他的干旱地区来说有较多的农牧业生产活动,水资源问题仍然是限制该区经济发展的重要影响因素。我们以黑河流域作为一个案例, | Lihua Zhou Key Laboratory of Desert and Desertification,Cold and Arid Regions Environmental and Engineering Research Institute,Chinese Academy of Sciences,320 Dong Gang West Road,Lanzhou 730000,People’s Republic of China lhzhou@lzb.ac.cnGuojing Yang Laboratory of Watershed Hydrology and Ecology,Cold and Arid Regions Environmental and Engineering Research Institute,Chinese Academy of Sciences,320 Dong Gang West Road,Lanzhou 730000,People’s Republic of China ygj7518@163.com | 2006 | AMBIO-人类环境杂志2006，35，6： | 11 |
| 11 | Spatio-temporal variation of net anthropogenic nitrogen inputs in the upper Yangtze River basin from 1990 to 2012显示文摘The net anthropogenic nitrogen input(NANI) is an important nutrient source that causes eutrophication in water bodies. Understanding the spatio-temporal variation of NANI is important for regional environment assessment and management.This paper calculated NANI in the upper Yangtze River basin(YRB), upstream of the Three Gorges Dam(TGD), from1990 to 2012, and analyzed its spatio-temporal characteristics. Over the past 23 years of the study, the average annual NANI increased from 3200 kg N km^(-2) to 4931 kg N km^(-2). The major components were fertilizer N application, atmospheric N deposition,and net food and feed N import. In the northwest high mountainous region with a sparse population, the main component was atmospheric N deposition. Fertilizer N application and net food and feed N import were concentrated in the Chengdu Plain because of the high population density and large areas of farmland. This research found that NANI increased with rapid urbanization and increasing population. The Pearson correlation results illustrated that the spatial distributions of NANI and its major components were affected by land cover/use, agricultural GDP and total population. Increasing NANI has been the major cause of the degrading stream water quality over the past 20 years and is becoming a major threat to the water quality of the TGD reservoir. | WANG Ai TANG LiHua YANG DaWen LEI HuiMin | 2016 | Science China Earth Sciences2016，59，11： | 11 |
| 12 | Yolk-shell structured Co-C/Void/Co9S8 composites with a tunable cavity for ultrabroadband and efficient low- frequency microwave absorption显示文摘 | Xiaofang Liu Chengcheng Hao Lihua He Cheng Yang Yubin Chen Chengbao Jiang Ronghai Yu | 2018 | Nano Research2018，11，8： | 10 |
| 13 | Characteristics of fecal microbiota in non-alcoholic fatty liver disease patients显示文摘This study was designed to investigate the gut microbiota of patients with non-alcoholic fatty liver disease. The inclusive and exclusive criteria for NAFLD patients and healthy subjects were formulated, and detailed clinical data were collected. The genomic DNA of stool samples were extracted for 16 S r DNA sequencing, and the amplified V4-region was sequenced on the Illumina Miseq platform. Metastats analysis was performed to identify the differential taxa between the groups. Redundancy analysis was used to evaluate the association between gut microbial structure and clinical variables. Thirty NAFLD patients and37 healthy controls were involved. The 16 S r DNA sequencing showed that there was a dramatic variability of the fecal microbiota among all the individuals. Metastats analysis identified eight families and 12 genera with significant differences between the two groups. When some clinical parameters, such as waist-to-hip ratio(WHR) and homeostasis model assessment of insulin resistance(HOMA-IR), were enrolled in Redundancy analysis, the distribution of the two group of samples was obviously changed. The compositional shifts in fecal bacterial communities of NAFLD patients from the healthy controls were mainly at family or genus levels. According to our Redundancy analysis, insulin resistance and obesity might be closely related to both NAFLD phenotype and intestinal microecology. | Fan Li Gang Sun Zikai Wang Wenming Wu He Guo Lihua Peng Lili Wu Xu Guo Yunsheng Yang | 2018 | Science China(Life Sciences)2018，61，7： | 9 |
| 14 | Efficient elimination of multidrug-resistant bacteria using copper sulfide nanozymes anchored to graphene oxide nanosheets显示文摘Antibacterial nanomaterials have attracted growing interest for bacterial infection therapy.However,most nanomaterials eliminate bacteria either physically or chemically,which hampers their efficacy when dealing with multidrug-resistant bacteria.To overcome this,we integrated copper sulfide(CuS)nanoparticles with active graphene oxide nanosheets(GO NSs)to synthesize a superior nanocomposite(CuS/GO NC)that acts both physically and chemically on the bacteria.CuS/GO NC was produced using a facile hydrothermal method,whereby the CuS nanoparticles grew and were uniformly dispersed on the GO NSs in situ.We found that the CuS/GO NC possesses a unique needle-like morphology that physically damages the bacterial cell membrane.CuS/GO NC also exhibits high oxidase-and peroxidase-like activity,ensuring efficient generation of the reactive oxygen species•OH from H2O2,which kills bacteria chemically.These features endow the CuS/GO NC with excellent antibacterial capabilities to kill multidrug-resistant bacteria such as methicillin-resistant Staphylococcus aureus(MRSA)with only a single dose.Additionally,it was found that the CuS/GO NC accelerated the healing of infected wounds in vivo owing to its good biocompatibility as well as facilitation of cell migration and collagen secretion.This study provides a new strategy to combine the physical and chemical antibacterial modes of nanomaterials to develop more effective therapies to combat multidrug-resistant bacterial infections. | Wanshun Wang Binglin Li Huili Yang Zefeng Lin Lingling Chen Zhan Li Jiayuan Ge Tao Zhang Hong Xia Lihua Li Yao Lu | 2020 | Nano Research2020，13，8： | 8 |
| 15 | Relocation of the 2012 M_s6.6 Xinjiang Xinyuan earthquake sequence显示文摘At 05:07 AM on June 30,2012(Beijing time),an Ms6.6earthquake(hereafter referred to as Xinyuan earthquake)occurred at the junction of Xinyuan County,Ili Kazak Autonomous Prefecture and Hejing County,Bayinguoleng Mongol Autonomous Prefecture in Xinjiang Uygur Autonomous Region.The location of the main shock determined by China Earthquake Network Center is 43.4°N,84.8°E and focal depth is 7 km.By the end of 08:00 AM | FANG LiHua WU JianPing WANG ChangZai WANG WeiLai YANG Ting | 2014 | Science China Earth Sciences2014，57，2： | 8 |
| 16 | The structure of instantaneous frequencies of periodic analytic signals显示文摘In this paper, the structure of analytic signals is investigated by means of the relation between analytic signals and functions in the Hardy space. It is shown that an analytic signal is made up of two parts, one depending on the amplitude of the signal and another on the boundary value of an inner function. Based on this result, properties of the instantaneous frequencies of these two parts are studied, and it is found that negative instantaneous frequencies are caused by the amplitude of a signal. Finally, such conditions that an analytic signal is of positive instantaneous frequency are presented. | Tan LiHui Yang LiHua Huang DaRen | 2010 | Science China Mathematics2010，53，2： | 7 |
| 17 | Cytotoxic Effect on Osteosarcoma MG-63 Cells by Degradation of Magnesium显示文摘Biocompatible and biodegradable magnesium(Mg)based metals have attracted great interest for use in orthopedic implants and devices.Based on our previous study that Mg with and without micro-arc oxidation(MAO)coating showed obvious cytotoxic effect on tumor cells due to the increase of pH value during the degradation of Mg,this study further evaluated the cytotoxic effect of Mg and MAO coated Mg on osteosarcoma(MG-63)cells by analyzing the cell adhesion,morphology and number through observation of scanning electron microscope,as well as live/dead staining,lactate dehydrogenase(LDH)activity and 4,6-diamidino-2-phenylindole(DAPI)assay.The results indicated that,compared to titanium,Mg could strongly inhibit the cell adherence,morphology and number of MG-63 on the surface of the naked Mg,whereas the MAO coated Mg showed relative weak cytotoxic effect on MG-63 cells,expecting that magnesium based metals with suitable coating can be designed to be applied as tumor prosthesis in the clinical practice. | Mei Li Ling Ren LiHua Li Peng He GuoBo Lan Yu Zhang Ke Yang | 2014 | Journal of Materials Science & Technology2014，30，9： | 7 |
| 18 | Estimation of coal particle size distribution by image segmentation显示文摘Several industrial coal processes are largely determined by the distribution of particle sizes in their feed.Currently these parameters are measured by manual sampling,which is time consuming and cannot provide real time feedback for automatic control purposes.In this paper,an approach using image segmentation on images of overlapped coal particles is described.The estimation of the particle size distribution by number is also described.The particle overlap problem was solved using image enhancement algorithms that converted those image parts representing material in lower layers to black.Exponential high-pass filter(EHPF) algorithms were used to remove the texture from particles on the surface.Finally,the edges of the surface particles were identified by morphological edge detection.These algorithms are described in detail as is the method of extracting the coal particle size.Tests indicate that using more coal images gives a higher accuracy estimate.The positive absolute error of 50 random tests was consistently less than 2.5% and the errors were reduced as the size of the fraction increased. | Zhang Zelin Yang Jianguo Ding Lihua Zhao Yuemin | 2012 | International Journal of Mining Science and Technology2012，22，5： | 7 |
| 19 | Promoting Bone Mesenchymal Stem Cells and Inhibiting Bacterial Adhesion of Acid-Etched Nanostructured Titanium by Ultraviolet Functionalization显示文摘Titanium(Ti) and its alloys are used extensively in orthopedic implants because of their excellent biocompatibility,mechanical properties and corrosion resistance. However,titanium-based implant materials face many severe complications,such as implant loosening due to poor osseointegration and bacterial infections,which may lead to implant failure. Hence,preparing a biomaterial surface,which enhances the interactions with host cells and inhibits bacterial adhesion,may be an optimal strategy to reduce the incidence of implant failure. This study aims to improve osseointegration and confer antibacterial properties on Ti through a combination of two surface modifications including nanostructuring generated by acid etching and ultraviolet(UV) light treatment.Our results showed that without UV treatment,the acid etching treatment of Ti surface was effective at both improving the adhesion of bone mesenchymal stem cells(BMSCs) and increasing bacterial adhesion. A further UV treatment of the acid-etched surface however,not only significantly improved the cell adhesion but also inhibited bacterial adhesion. The acid-etched nanostructured titanium with UV treatment also showed a significant enhancement on cell proliferation,alkaline phosphatase(ALP) activity and mineralization. These results suggest that such nanostructured materials with UV treatment can be expected to have a good potential in orthopedic applications. | Guobo Lan Mei Li Ying Tan Lihua Li Xiaoming Yang Limin Ma Qingshui Yin Hong Xia Yu Zhang Guoxin Tan Chengyun Ning | 2015 | Journal of Materials Science & Technology2015，31，2： | 7 |
| 20 | Multi-functional bismuth-doped bioglasses: combining bioactivity and photothermal response for bone tumor treatment and tissue repair显示文摘Treatment of large bone defects derived from bone tumor surgery is typically performed in multiple separate operations,such as hyperthermia to extinguish residual malignant cells or implanting bioactive materials to initiate apatite remineralization for tissue repair;it is very challenging to combine these functions into a material.Herein,we report the first photothermal(PT)effect in bismuth(Bi)-doped glasses.On the basis of this discovery,we have developed a new type of Bi-doped bioactive glass that integrates both functions,thus reducing the number of treatment cycles.We demonstrate that Bi-doped bioglasses(BGs)provide high PT efficiency,potentially facilitating photoinduced hyperthermia and bioactivity to allow bone tissue remineralization.The PT effect of Bi-doped BGs can be effectively controlled by managing radiative and non-radiative processes of the active Bi species by quenching photoluminescence(PL)or depolymerizing glass networks.In vitro studies demonstrate that such glasses are biocompatible to tumor and normal cells and that they can promote osteogenic cell proliferation,differentiation,and mineralization.Upon illumination with near-infrared(NIR)light,the bioglass(BG)can efficiently kill bone tumor cells,as demonstrated via in vitro and in vivo experiments.This indicates excellent potential for the integration of multiple functions within the new materials,which will aid in the development and application of novel biomaterials. | Liping Wang Nicholas J.Long Lihua Li Yao Lu Mei Li Jiangkun Cao Yu Zhang Qinyuan Zhang Shanhui Xu Zhongmin Yang Chuanbin Mao Mingying Peng | 2018 | Light(Science & Applications)2018，7，1： | 6 |
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