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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial显示文摘 | Michael P Manns John G McHutchison Stuart C Gordon Vinod K Rustgi Mitchell Shiffman Robert Reindollar Zachary D Goodman Kenneth Koury Mei-Hsiu Ling Janice K Albrecht | 2001 | The Lancet2001，，9286： | 4 |
| 3 | Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial显示文摘 | Michael P Manns John G McHutchison Stuart C Gordon Vinod K Rustgi Mitchell Shiffman Robert Reindollar Zachary D Goodman Kenneth Koury Mei-Hsiu Ling Janice K Albrecht | 2001 | The Lancet . 2001 (9286)2001，，9286： | 4 |
| 4 | Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial显示文摘 | Michael P Manns John G McHutchison Stuart C Gordon Vinod K Rustgi Mitchell Shiffman Robert Reindollar Zachary D Goodman Kenneth Koury Mei-Hsiu Ling Janice K Albrecht | 2001 | 2001 (9286)2001，，9286： | 4 |
| 5 | 云南省农村地区男男性接触者与HIV相关的风险行为显示文摘目的探讨中国农村地区男男性接触者(MSM)与艾滋病病毒(HIV)相关的风险行为的具体特点和问题。方法采用半结构化深度访谈的方式进行定性研究。通过一个当地的MSM联系网络,以滚雪球和相互转告的方式招集了24名访谈对象。主要测量指标是与HIV有关的风险行为的上升情况。结果在中国农村地区,风险行为、社会歧视、独生子女政策以及传统中医的观念,在HIV的传播中都起着重要的作用。在中国,许多MSM过着双重生活;调查显示,安全套的使用情况也是因人而异,使风险行为'合理化'的意图是决定是否使用安全套的主要因素;就泌尿生殖系统的问题主动寻求医疗帮助的现象很不普遍,而现有卫生系统以及医务人员对此问题表现出来的不敏感,也进一步加剧了这种现象。结论在资源匮乏的农村地区,MSM人群存在着HIV流行的趋势,并有向普通人群传播的危险。 | 张建波 黄志威 T S K Kong D C Y Ling | 2007 | 中国艾滋病性病2007，13，5： | 3 |
| 6 | The effects of shopping orientations, online trust and prior online pur- chase experience toward customers' online purchase inten- tion显示文摘 | Ling K C Chai L T Piew T H | 2010 | International Business Research2010，3，3： | 1 |
| 7 | Urinary protein excretion in type 2 diabetes with complications 显示文摘 | Hong C Y Chia K S Ling S L | 2000 | J Diabetes Complications2000，14，5： | 1 |
| 8 | Analysis and compensation of Rolling Shutter effect 显示文摘 | LING C K CHANG L W HOMER H C | 2008 | IEEE Transactions on Image Processing2008，17，8： | 1 |
| 9 | Hybrid particle swarm optimization with wavelet mutation and its in- dustrial applications 显示文摘 | Ling S H Iu H H C Chart K Y | 2008 | IEEE Transactions on Sys- tems Man and Cybernetics-part B : Cybernetics2008，38，3： | 1 |
| 10 | Randomised trial of safety and efficacy of immediate postoperative enteral feeding in patients undergoing gastrointestinal resection显示文摘 | Carr C S Ling K D Boulos P | 1996 | BMJ1996，312，7035： | 1 |
| 11 | Gong M Gallium Vacancy and the Residual Acceptor in Undoped GaSb Studied by Positron Lifetime Spectroscopy and Photoluminescence显示文摘 | Ling C C Mui W K Lam C H | 2002 | Appl Phys Lett2002，80，： | 1 |
| 12 | Inverse optimal adap-tive control for attitude tracking of spacecraft显示文摘 | Luo W Chu Y C Ling K V | 2005 | IEEE Trans on Auto Control2005，，50： | 1 |
| 13 | Hybrid particle swarm optimization with wavelet mutation and its industrial applica- tions显示文摘 | Ling S H lu H H C Chan K Y | 2008 | IEEE Transactions on Systems Man and Cybernet- ics Part B : Cybernetics2008，38，3： | 1 |
| 14 | Influence of Microstructure on Ultrapreeision Grinding of Cemented Carbides 显示文摘 | Yin Ling Spowage A C Ramesh K | 2004 | International Journal of Machine Tools & Manufacture2004，44，5： | 1 |
| 15 | Nature of the Acceptor Responsible for p-Type Conduction in Liquid Encapsulated Czochralski-Grown Undoped Gallium Antimonide显示文摘 | Ling C C Lui M K Ma S K | 2004 | Appl Phys Lett2004，85，： | 1 |
| 16 | Inverse optimal adaptive control for attitude tracking of spacecraft 显示文摘 | LUO W C CHU Y C LING K V | 2005 | IEEE Transaction on Automatic Control2005，50，11： | 1 |
| 17 | Hybrid particle swarm optimazation with wavelet mutation and its industri- al applications 显示文摘 | LingS H Iu H H C Chan K Y | 2008 | IEEE Transactions on Systems MAN Cybernatics part B: Cybernatics2008，38，3： | 1 |
| 18 | 查看详情显示文摘 | Ghule A Tzing S H Chang J Y Ghule K Chang H Ling Y C | | 0，，： | 1 |
| 19 | Research on visible measure- ment of dispersion spot at four quadrant photoelectric de- tector显示文摘 | Ling K H Yong G Shu C N | 2011 | Advanced Materials Research2011，，3： | 1 |
| 20 | Draft genome of the wheata-genome progenitor Triticum urartu显示文摘 | Ling HQ Zhao S Liu D Wang J Sun H Zhang C Fan H Li D Dong L Tao Y Gao C Wu H Li Y Cui Y Guo X Zheng S Wang B Yu K Liang Q Yang W Lou X Chen J Feng M Jian J Zhang X Luo G Jiang Y Liu J Wang Z Sha Y Zhang B WuH Tang D Shen Q Xue P Zou S Wang X Liu X Wang F Yang Y An X Dong Z Zhang K Zhang X Luo MC Dvorak J Tong Y Wang J Yang H Li Z Wang D Zhang A Wang J | 2013 | Nature2013，469，7443： | 1 |
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