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| 1 | Approaches to establish Q-markers for the quality standards of traditional Chinese medicines显示文摘Traditional Chinese medicine(TCM) has played a pivotal role in maintaining the health of Chinese people and is now gaining increasing acceptance around the global scope. However, TCM is confronting more and more concerns with respect to its quality. The intrinsic 'multicomponent and multitarget' feature of TCM necessitates the establishment of a unique quality and bioactivity evaluation system, which is different from that of the Western medicine. However, TCM is investigated essentially as'herbal medicine' or 'natural product', and the pharmacopoeia quality monographs are actually chemicalmarkers-based, which can ensure the consistency only in the assigned chemical markers, but, to some extent, have deviated from the basic TCM theory. A concept of 'quality marker'(Q-marker), following the 'property-effect-component' theory, is proposed. The establishment of Q-marker integrates multidisciplinary technologies like natural products chemistry, analytical chemistry, bionics, chemometrics,pharmacology, systems biology, and pharmacodynamics, etc. Q-marker-based fingerprint and multicomponent determination conduce to the construction of more scientific quality control system of TCM.This review delineates the background, definition, and properties of Q-marker, and the associated technologies applied for its establishment. Strategies and approaches for establishing Q-marker-based TCM quality control system are presented and highlighted with a few TCM examples. | Wenzhi Yang Yibei Zhang Wanying Wu Luqi Huang Dean Guo Changxiao Liu | 2017 | Acta Pharmaceutica Sinica B2017，7，4： | 51 |
| 2 | The Coix Genome Provides Insights into Panicoideae Evolution and Papery Hull Domestication显示文摘Coix is a grass crop domesticated as early as the Neolithic era.It is still widely cultivated for both highly nutritional food and medicinal use.However,the genetic study and breeding of this crop are hindered by the lack of a sequenced genome.Here,we report de novo sequencing and assembly of the 1619-Mb genome of Coix,and annotation of 75.39%repeats and 39629 protein-coding genes.Comparative genomics analysis showed that Coix is more closely related to sorghum than maize,but intriguingly only Coix and maize had a recent genome duplication event,which was not detected in sorghum.We further constructed a genetic map and mapped several important traits,especially the strength of hull.Selection of papery hull(thin:easy dehulling)from the stony hull(thick:difficult dehulling)in wild progenitors was a key step in Coix domestication.The papery hull makes seed easier to process and germinate.Anatomic and global transcriptome analysis revealed that the papery hull is a result of inhibition of cell division and wall biogenesis.We also successfully demonstrated that seed hull pressure resistance is controlled by two major quantitative trait loci(QTLs),which are associated with hull thickness and color,respectively.The two QTLs were further fine mapped within intervals of 250 kb and 146 kb,respectively.These resources provide a platform for evolutionary studies and will facilitate molecular breeding of this important crop. | Chao Guo Yanan Wang Aiguo Yang Jun He Chaowen Xiao Shanhua Lv Fengming Han Yibing Yuan Yuan Yuan Xiaolong Dong Juan Guo YawenYang-Hailan Liu Ningzhi Zuo Yaxi Hu Kangxu Zhao Zhengbo Jiang Xing Wang Tingting Jiang Yaou Sherf Moju Cao Yuan Wang Zhaobo Long Tingzhao Rong Luqi Huang Shufeng Zhou | 2020 | Molecular Plant2020，13，2： | 11 |
| 3 | The chromosome-level reference genome assembly for Panax notoginseng and insights into ginsenoside biosynthesis显示文摘Panax notoginseng,a perennial herb of the genus Panax in the family Araliaceae,has played an important role in clinical treatment in China for thousands of years because of its extensive pharmacological effects.Here,we report a high-quality reference genome of P.notoginseng,with a genome size up to 2.66 Gb and a contig N50 of 1.12 Mb,produced with third-generation PacBio sequencing technology.This is the first chromosome-level genome assembly for the genus Panax.Through genome evolution analysis,we explored phylogenetic and whole-genome duplication events and examined their impact on saponin biosynthesis.We performed a detailed transcriptional analysis of P.notoginseng and explored genelevel mechanisms that regulate the formation of characteristic tubercles.Next,we studied the biosynthesis and regulation of saponins at temporal and spatial levels.We combined multi-omics data to identify genes that encode key enzymes in the P.notoginseng terpenoid biosynthetic pathway.Finally,we identified five glycosyltransferase genes whose products catalyzed the formation of different ginsenosides in P.notoginseng.The genetic information obtained in this study provides a resource for further exploration of the growth characteristics,cultivation,breeding,and saponin biosynthesis of P.notoginseng. | Zhouqian Jiang Lichan Tu Weifei Yang Yifeng Zhang Tianyuan Hu Baowei Ma Yun Lu Xiuming Cui Jie Gao Xiaoyi Wu Yuru Tong Jiawei Zhou Yadi Song Yuan Liu Nan Liu Luqi Huang Wei Gao | 2021 | Plant Communications2021，2，1： | 11 |
| 4 | EVenn:Easy to create repeatable and editable Venn diagrams and Venn networks online显示文摘Effective visualization of features generated in next-generation sequencing or other experimental assays is of great interest.These features include operational taxonomy units(OTUs)in microbiome analysis(Zhang et al.,2019),genes,single nucleotide variants,and gene ontology information in transcriptome,genome,and epigenome analysis(Liu et al.,2018),ingredients in traditional Chinese formulas(Li et al.,2020). | Tong Chen Haiyan Zhang Yu Liu Yong-Xin Liu Luqi Huang | 2021 | Journal of Genetics and Genomics2021，48，9： | 8 |
| 5 | Filtration of fine particles in atmospheric aerosol with electrospinning nanofibers and its size distribution显示文摘In this study,the size distribution of atmospheric aerosol in Beijing was monitored by the scanning mobility particle sizer spectrometer and the optical particle sizer.The size of particles in atmospheric aerosol was primarily distributed in the range of less than 1 m.It showed different changes with the mass concentrations of particulate matters with an aerodynamic diameter of 2.5 m(PM2.5)for different sizes of fine particles.The amount of ultrafine particles(less than about 60 nm)decreased while the larger ones(>60 nm)increased along with the mass concentration of PM2.5 in atmospheric aerosol.This was because of the formation of the secondary atmospheric aerosol.The polylactic acid(PLA)nanofibers were prepared for filtering the aerosol by electrospinning.PLA nanofiber mats were used as the middle layer to design the composite filter membranes.Atmospheric aerosol was used as dust source in the filtration test.The results showed that the filtration efficiency of the composite filter media increased along with the thickness of nanofiber mats,which was controlled by the collection time during electrospinning.Filtration efficiency can be improved obviously by compositing with a thin layer of nanofibers. | LI Juan SHI XiaoFei GAO Feng LIU LuQi CHEN Rui CHEN ChunYing ZHANG Zhong | 2014 | Science China(Technological Sciences)2014，57，2： | 7 |
| 6 | Application of Raman spectroscopy in carbon nanotube-based polymer composites显示文摘Raman spectroscopy has been widely used to identify the physical properties of carbon nanotubes(CNTs),and to assess their functionalization as well as orientation.Recently,Raman spectroscopy has become a powerful tool to characterize the interfacial properties between CNTs and polymer matrices.This review provides an overview of micro-Raman spectroscopy of CNTs and its application in studying CNT reinforced polymer composites.Based on the specific Raman band shifts relating to the mechanical deformation of CNTs,Raman scattering can be used to evaluate the interactions between the CNTs and the surrounding polymer in the composites,and to detect the phase transitions of the polymer,and investigate the local stress state as well as the Young's modulus of the CNTs.Moreover,we also review the current progress of Raman spectroscopy in various CNT macroarchitectures(such as films,fibers as well as composite fibers).The microscale structural deformation of CNT macroarchitectures and strain transfer factors from macroscale architectures to microscale structures are inferred.Based on an in situ Raman-tensile test,we further predict the Young's modulus of the CNT macroarchitectures and reveal the dominating factors affecting the mechanical performances of the CNT macroarchitectures. | GAO Yun LI LingYun TAN PingHeng LIU LuQi ZHANG Zhong | 2010 | Chinese Science Bulletin2010，55，35： | 5 |
| 7 | Molecular cloning and functional identification of sterol C24-methyltransferase gene from Tripterygium wilfordii显示文摘Sterol C24-methyltransferase(SMT) plays multiple important roles in plant growth and development. SMT1, which belongs to the family of transferases and transforms cycloartenol into 24-methylene cycloartenol, is involved in the biosynthesis of 24-methyl sterols. Here, we report the cloning and characterization of a cDNA encoding a sterol C24-methyltransferase from Tripterygium wilfordii(Tw SMT1). Tw SMT1(Gen Bank access number KU885950) is a 1530 bp cDNA with a 1041 bp open reading frame predicted to encode a 346-amino acid, 38.62 k Da protein. The polypeptide encoded by the SMT1 cDNA was expressed and purified as a recombinant protein from Escherichia coli(E. coli) and showed SMT activity. The expression of Tw SMT1 was highly up-regulated in T. wilfordii cell suspension cultures treated with methyl jasmonate(Me JA). Tissue expression pattern analysis showed higher expression in the phellem layer compared to the other four organs(leaf, stem, xylem and phloem), which is about ten times that of the lowest expression in leaf. The results are meaningful for the study of sterolbiosynthesis of T. wilfordii and will further lay the foundations for the research in regulating both the content of other main compounds and growth and development of T. wilfordii. | Hongyu Guan Yujun Zhao Ping Su Yuru Tong Yujia Liu Tianyuan Hu Yifeng Zhang Xianan Zhang Jia Li Xiaoyi Wu Luqi Huang Wei Gao | 2017 | Acta Pharmaceutica Sinica B2017，7，5： | 4 |
| 8 | Engineering electrochemical actuators with large bending strain based on 3D-structure titanium carbide MXene composites显示文摘Electrically responsive electrochemical actuators that contain a polymer electrolyte membrane laminated between two electrodes have attracted great attention due to their potential applications in smart electronics,wearable devices,and soft robotics.However,some challenges such as the achievement of large bending strain under low applied voltage and fast ion diffusion and accumulation still exist to be resolved.The key to the solution lies in the choice of electrode materials and the design of electrode structures.In this study,an engineering electrochemical actuator that presents large bending strain under low applied voltage based on MXene/polystyrene-MXene hybrid electrodes is developed.The developed electrochemical actuator based on the MXene/polystyrene-MXene 3D-structure is found to exhibit large bending strain(ca.1.18%),broad frequency bandwidth,good durability(90%retention after 10,000 cycles)and considerable Young’s modulus(ca.246 MPa).The high-performance actuation mainly stems from the excellent properties of MXene and 3D-structure of the electrode.The MXene provides excellent mechanical strength and high electrical conductivity which facilitate strong interaction and rapid electron transfer in electrodes.The 3D architectures formed by polystyrene microspheres generate unimpeded ion pathways for ionic short diffusion and fast injection.This study reveals that the 3D-structure hybrid electrodes play a crucial role in promoting the performance of such electrochemical actuators. | Tong Wang Tianjiao Wang Chuanxin Weng Luqi Liu Jun Zhao Zhong Zhang | 2021 | Nano Research2021，14，7： | 4 |
| 9 | Engineering of triterpene metabolism and overexpression of the lignin biosynthesis gene PAL promotes ginsenoside Rg3 accumulation in ginseng plant chassis显示文摘The ginsenoside Rgfound in Panax species has extensive pharmacological properties,in particular anti-cancer effects.However,its natural yield in Panax plants is limited.Here,we report a multimodular strategy to improve yields of Rgin a Panax ginseng chassis,combining engineering of triterpene metabolism and overexpression of a lignin biosynthesis gene,phenylalanine ammonia lyase(PAL).We first performed semi-rational design and site mutagenesis to improve the enzymatic efficiency of Pq3-O-UGT2,a glycosyltransferase that directly catalyzes the biosynthesis of Rgfrom Rh.Next,we used clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)gene editing to knock down the branch pathway of protopanaxatriol-type ginsenoside biosynthesis to enhance the metabolic flux of the protopanaxadiol-type ginsenoside Rg.Overexpression of PAL accelerated the formation of the xylem structure,significantly improving ginsenoside Rgaccumulation(to 6.19-fold higher than in thecontrol).Wecombinedoverexpression of the ginsenoside aglycon synthetic genes squalene epoxidase,Pq3-O-UGT2,and PAL with CRISPR/Cas9-based knockdown of CYP716A53v2 to improve ginsenoside Rgaccumulation.Finally,we produced ginsenoside Rgat a yield of 83.6 mg/L in a shake flask(7.0 mg/g dry weight,21.12-fold higher than with wild-type cultures).The highproduction system established in this study could be a potential platform to produce the ginsenoside Rgcommercially for pharmaceutical use. | Lu Yao Huanyu Zhang Yirong Liu Qiushuang Ji Jing Xie Ru Zhang Luqi Huang Kunrong Mei Juan Wang Wenyuan Gao | 2022 | Journal of Integrative Plant Biology2022，64，9： | 3 |
| 10 | Chemical study and medical application of saponins as anti-cancer agents显示文摘 | Shuli Man Wenyuan Gao Yanjun Zhang Luqi Huang Changxiao Liu | 2010 | Fitoterapia2010，，7： | 2 |
| 11 | Organic modification of carbon nanotubes显示文摘The organic modification of carbon nanotubes is a novel research field being developed recently. In this article, the history and newest progress of organic modification of carbon nanotubes are reviewed from two aspects: organic covalent modification and organic noncovalent modification of carbon nanotubes. The preparation and properties of organic modified carbon nanotubes are discussed in detail. In addition, the prospective development of organic modification of carbon nanotubes is suggested. | Luqi Liu Zhixin Guo Liming Dai Daoben Zhu | 2002 | Chinese Science Bulletin2002，47，6： | 2 |
| 12 | Classic mechanisms and experimental models for the anti-inflammatory effect of traditional Chinese medicine显示文摘Inflammation is a common disease involved in the pathogenesis,complications,and sequelae of a large number of related diseases,and therefore considerable research has been directed toward developing anti-inflammatory drugs for the prevention and treatment of these diseases.Traditional Chinese medicine(TCM)has been used to treat inflammatory and related diseases since ancient times.According to the re-view of abundant modern scientific researches,it is suggested that TCM exhibit anti-inflammatory effects at different levels,and via multiple pathways with various targets,and recently a series of in vitro and in vivo anti-inflammatory models have been developed for anti-inflammation research in TCM.Currently,the reported classic mechanisms of TCM and experimental models of its anti-inflammatory effects pro-vide reference points and guidance for further research and development of TCM.Importantly,the research clearly confirms that TCM is now and will continue to be an effective form of treatment for many types of inflammation and inflammation-related diseases. | Du Hongzhi Hou Xiaoying Guo Yujie Chen Le Miao Yuhuan Liu Dahui Huang Luqi | 2022 | Animal Models and Experimental Medicine2022，5，2： | 2 |
| 13 | MECHANICAL PERFORMANCE OF NANO-CaCO_3 FILLED POLYSTYRENE COMPOSITES显示文摘Nano-CaCO3 incorporated polystyrene composites are compounded by twin-screw extrusion.Tensile and compact tensile tests show that the strength and toughness of polystyrene are decreased after the addition of nano-CaCO3 particles.Fracture surface analysis suggests that the defects induced by interfacial debonding and nano-filler agglomerations would be the key factors responsible for the declined strength and toughness.Nevertheless,it has to be stated,if the applied stress is lower than the ultimate strength,the rigid nanoparticles would still stiffen the polymer molecules,and resist polymer chain mobility.Hence,the improved tensile modulus and creep resistance can be obtained with the increasing contents of nanoparticles. | Yun Gao Luqi Liu Zhong Zhang | 2009 | Acta Mechanica Solida Sinica2009，22，6： | 2 |
| 14 | The photoconductivity of PVK-carbon nanotube blends显示文摘 | Wei Wu Junxin Li Luqi Liu | 2002 | Chem Phys Lett2002，364，： | 1 |
| 15 | A novel polishing technology for epoxy resin based on 355 nm UV laser显示文摘The electromagnetic shielding film has drawn much attention due to its wide applications in the integrated circuit package,which demands a high surface quality of epoxy resin.However,gaseous Cu will splash and adhere to epoxy resin surface when the Cu layer in PCB receives enough energy in the process of laser cutting,which has a negative effect on the quality of the shielding film.Laser polishing technology can solve this problem and it can effectively improve the quality of epoxy resin surface.The paper studies the mechanism of Cu powder spraying on the compound surface by 355 nm ultraviolet(UV) laser,including the parameters of laser polishing process and the remains of Cu content on compound surface.The results show that minimal Cu content can be realized with a scanning speed of 700 mm/s,a laser frequency of 50 kHz and the distance between laser focus and product top surface of-1.3 mm.This result is important to obtain an epoxy resin surface with high quality. | Xinling Meng | 2017 | Journal of Semiconductors2017，38，5： | 1 |
| 16 | A physics-informed data-driven model for landslide susceptibility assessment in the Three Gorges Reservoir area显示文摘Landslide susceptibility mapping is a crucial tool for analyzing geohazards in a region.Recent publications have popularized data-driven models,particularly machine learning-based methods,owing to their strong capability in dealing with complex nonlinear problems.However,a significant proportion of these models have neglected qualitative aspects during analysis,resulting in a lack of interpretability throughout the process and causing inaccuracies in the negative sample extraction.In this study,Scoops 3D was employed as a physics-informed tool to qualitatively assess slope stability in the study area(the Hubei Province section of the Three Gorges Reservoir Area).The non-landslide samples were extracted based on the calculated factor of safety(FS).Subsequently,the random forest algorithm was employed for data-driven landslide susceptibility analysis,with the area under the receiver operating characteristic curve(AUC)serving as the model evaluation index.Compared to the benchmark model(i.e.,the standard method of utilizing the pure random forest algorithm),the proposed method’s AUC value improved by 20.1%,validating the effectiveness of the dual-driven method(physics-informed data-driven). | Songlin Liu Luqi Wang Wengang Zhang Weixin Sun Jie Fu Ting Xiao Zhenwei Dai | 2023 | Geoscience Frontiers2023，14，5： | 1 |
| 17 | Diabetic vascular diseases:molecular mechanisms and therapeutic strategies显示文摘Vascular complications of diabetes pose a severe threat to human health.Prevention and treatment protocols based on a single vascular complication are no longer suitable for the long-term management of patients with diabetes.Diabetic panvascular disease(DPD)is a clinical syndrome in which vessels of various sizes,including macrovessels and microvessels in the cardiac,cerebral,renal,ophthalmic,and peripheral systems of patients with diabetes,develop atherosclerosis as a common pathology.Pathological manifestations of DPDs usually manifest macrovascular atherosclerosis,as well as microvascular endothelial function impairment,basement membrane thickening,and microthrombosis.Cardiac,cerebral,and peripheral microangiopathy coexist with microangiopathy,while renal and retinal are predominantly microangiopathic.The following associations exist between DPDs:numerous similar molecular mechanisms,and risk-predictive relationships between diseases.Aggressive glycemic control combined with early comprehensive vascular intervention is the key to prevention and treatment.In addition to the widely recommended metformin,glucagon-like peptide-1 agonist,and sodium-glucose cotransporter-2 inhibitors,for the latest molecular mechanisms,aldose reductase inhibitors,peroxisome proliferator-activated receptor-γagonizts,glucokinases agonizts,mitochondrial energy modulators,etc.are under active development.DPDs are proposed for patients to obtain more systematic clinical care requires a comprehensive diabetes care center focusing on panvascular diseases.This would leverage the advantages of a cross-disciplinary approach to achieve better integration of the pathogenesis and therapeutic evidence.Such a strategy would confer more clinical benefits to patients and promote the comprehensive development of DPD as a discipline. | Yiwen Li Yanfei Liu Shiwei Liu Mengqi Gao Wenting Wang Keji Chen Luqi Huang Yue Liu | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 1 |
| 18 | Reduction of solubilized multi -walled carbon nanotubes 显示文摘 | LIU LUQI QIN YUJUN GUO ZHI -XIN | 2003 | Carbon2003，41，： | 1 |
| 19 | Comparison of two types of persistent heavy rainfall events during sixteen warm seasons in the Sichuan Basin显示文摘本文筛选出四川盆地西部(盆西型)和盆地东部(盆东型)持续性暴雨个例,深入对比两类持续性暴雨的大气环流特征和直接造成持续性暴雨的西南低涡维持的机理.四川盆地的短波槽和西太平洋副热带高压的配置有利于持续性暴雨的维持,盆东型的降水强度较盆西型个例强,高空急流位置偏南,南亚高压的强度更强,高层辐散更强,对流层中层副热带高压偏东偏南.盆西型的水汽输送主要来自南海,而盆东型的水汽输送主要来自南海和孟加拉湾.合成涡度收支的结果表明散度项是两类持续暴雨中西南涡维持的主要原因,但盆西型中,垂直平流的作用更强. | Yuanchun Zhang Jianhua Sun Luqi Zhu Huan Tang Shuanglong Jin Xiaolin Liu | 2021 | Atmospheric and Oceanic Science Letters2021，14，6： | 1 |
| 20 | Rubbery and glassy epoxy resins reinforced with carbon nanotubes composites显示文摘 | Liu Luqi H Daniel Wagner | 2005 | Science and Technology2005，，65： | 1 |
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