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| 1 | Approaches to establish Q-markers for the quality standards of traditional Chinese medicines显示文摘Traditional Chinese medicine(TCM) has played a pivotal role in maintaining the health of Chinese people and is now gaining increasing acceptance around the global scope. However, TCM is confronting more and more concerns with respect to its quality. The intrinsic 'multicomponent and multitarget' feature of TCM necessitates the establishment of a unique quality and bioactivity evaluation system, which is different from that of the Western medicine. However, TCM is investigated essentially as'herbal medicine' or 'natural product', and the pharmacopoeia quality monographs are actually chemicalmarkers-based, which can ensure the consistency only in the assigned chemical markers, but, to some extent, have deviated from the basic TCM theory. A concept of 'quality marker'(Q-marker), following the 'property-effect-component' theory, is proposed. The establishment of Q-marker integrates multidisciplinary technologies like natural products chemistry, analytical chemistry, bionics, chemometrics,pharmacology, systems biology, and pharmacodynamics, etc. Q-marker-based fingerprint and multicomponent determination conduce to the construction of more scientific quality control system of TCM.This review delineates the background, definition, and properties of Q-marker, and the associated technologies applied for its establishment. Strategies and approaches for establishing Q-marker-based TCM quality control system are presented and highlighted with a few TCM examples. | Wenzhi Yang Yibei Zhang Wanying Wu Luqi Huang Dean Guo Changxiao Liu | 2017 | Acta Pharmaceutica Sinica B2017，7，4： | 51 |
| 2 | Offline two-dimensional liquid chromatography coupled with ion mobility-quadrupole time-of-flight mass spectrometry enabling fourdimensional separation and characterization of the multicomponents from white ginseng and red ginseng显示文摘Inherent complexity of plant metabolites necessitates the use of multi-dimensional information to accomplish comprehensive profiling and confirmative identification.A dimension-enhanced strategy,by offline two-dimensional liquid chromatography/ion mobility-quadrupole time-of-flight mass spectrometry(2 D-LC/IM-QTOF-MS)enabling four-dimensional separations(2 D-LC,IM,and MS),is proposed.In combination with in-house database-driven automated peak annotation,this strategy was utilized to characterize ginsenosides simultaneously from white ginseng(WG)and red ginseng(RG).An offline 2 DLC system configuring an Xbridge Amide column and an HSS T3 column showed orthogonality 0.76 in the resolution of ginsenosides.Ginsenoside analysis was performed by data-independent high-definition MSE(HDMSE)in the negative ESI mode on a Vion?IMS-QTOF hybrid high-resolution mass spectrometer,which could better resolve ginsenosides than MSEand directly give the CCS information.An in-house ginsenoside database recording 504 known ginsenosides and 58 reference compounds,was established to assist the identification of ginsenosides.Streamlined workflows,by applying UNIFI?to automatedly annotate the HDMSEdata,were proposed.We could separate and characterize 323 ginsenosides(including 286 from WG and 306 from RG),and 125 thereof may have not been isolated from the Panax genus.The established 2 D-LC/IM-QTOF-HDMSEapproach could also act as a magnifier to probe differentiated components between WG and RG.Compared with conventional approaches,this dimensionenhanced strategy could better resolve coeluting herbal components and more efficiently,more reliably identify the multicomponents,which,we believe,offers more possibilities for the systematic exposure and confirmative identification of plant metabolites. | Tiantian Zuo Chunxia Zhang Weiwei Li Hongda Wang Ying Hu Wenzhi Yang Li Jia Xiaoyan Wang Xiumei Gao Dean Guo | 2020 | Journal of Pharmaceutical Analysis2020，10，6： | 9 |
| 3 | Novel C-17 spirost protostane-type triterpenoids from Alisma plantago-aquatica with antiinflammatory activity in Caco-2 cells显示文摘Twenty-one protostane-type triterpenoids with diverse structures, including nine new compounds(1 e9), were isolated from the of Alisma plantago-aquatica Linn. Structurally, alisolides A-F(1 e6), composed of an oxole group coupled to a five-membered ring, represent unusual C-17 spirost protostane-type triterpenoids. Alisolide H(8) is a novel triterpenoid with an unreported endoperoxide bridge. Alisolide I(9) represents the first example of 23,24-acetal triterpenoid. Their structures were elucidated based on spectroscopic analysis, wherein the absolute configurations of 4-6, 8 were further confirmed by the Mo2(OAc)4-induced ECD method. Furthermore, all isolates were evaluated for their inhibitory effects on LPS-induced NO production in Caco-2 cells, and all the compounds showed remarkable inhibitory activities, with IC50 values in the range of 0.76 e38.20 mmol/L. | Qinghao Jin Jianqing Zhang Jinjun Hou Min Lei Chen Liu Xia Wang Yong Huang Shuai Yao Bang Yeon Hwang Wanying Wu Dean Guo | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 3 |
| 4 | Efficacy and Safety of Cinitapride in the Treatment of Mild to Moderate Postprandial Distress Syndrome–predominant Functional Dyspepsia显示文摘 | Yiqi Du Tun Su Xinmiao Song Jun Gao Duowu Zou Changjing Zuo Weifen Xie Bangmao Wang Zhiguang Zhang Jianming Xu Dean Tian Hesheng Luo Zhenyu Zhang Shaofeng Wang Jianping Chen Jizhong Guo Lei Gong Yanbing Ding Zhaoshen Li | 2014 | Journal of Clinical Gastroenterology2014，，4： | 1 |
| 5 | New cytotoxic bufadienolides from the biotransformation ofresibufenin by Mucor polymorphosprus 显示文摘 | Min Ye Dean Guo | 2005 | Tetrahedron2005，61，37： | 1 |
| 6 | Steroidal saponins from Smilax china and their anti-inflammatory activities显示文摘 | Bo Shao Hongzhu Guo Yajun Cui Min Ye Jian Han Dean Guo | 2006 | Phytochemistry2006，，5： | 1 |
| 7 | Global health 2035: a world converging within a generation显示文摘 | Dean T Jamison Lawrence H Summers George Alleyne Kenneth J Arrow Seth Berkley Agnes Binagwaho Flavia Bustreo David Evans Richard G A Feachem Julio Frenk Gargee Ghosh Sue J Goldie Yan Guo Sanjeev Gupta Richard Horton Margaret E Kruk Adel Mahmoud Linah K Mo | 2013 | 2013 (9908)2013，，9908： | 1 |
| 8 | A new transclerodane diterpene lactone from Conyza blinii 显示文摘 | Liping Xu Dean Guo Jiansheng Liu | 1999 | Haterocycles1999，51，3： | 1 |
| 9 | Neuroprotective Effects of Hydroxysafflor Yellow A: In Vivo and in Vitro Studies显示文摘 | Haibo Zhu Zhenhua Wang Chengjun Ma Jingwei Tian Fenghua Fu Changling Li Dean Guo E. Roeder Ke Liu | 2003 | Planta Med2003，，05： | 1 |
| 10 | Phytochemical and Bioactive Studies on Conyza blinii显示文摘 | For Ph. D. Degree: Su Yanfang Supervisors: Prof: Zheng Junhua, Prof: Guo Dean, and Prof: Ma Junjiang Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100083 | 2001 | Journal of Chinese Pharmaceutical Sciences2001，10，2： | 1 |
| 11 | Gaultherins A and B,two lignans from Gaultheria yunnanensis显示文摘 | Zhang Zhizhen Guo Dean Li Chang ling | 1999 | Phytochemistry1999，51，： | 1 |
| 12 | A stereological study of the renal glomerular vasculature in the db/db mouse model of diabetic nephropathy显示文摘 | Guo M Ricardo SD Deane JA | 2005 | J Anat2005，207，： | 1 |
| 13 | A stereological study of the renal glomerular vasculature in the db/db mouse model of diabetic nephropathy显示文摘 | Guo M Ricardo SD Deane JA | 2005 | J Anat2005，207，6： | 1 |
| 14 | A stereological study of the renal glomerular vasculature in the db/db mouse model of diabetic nephropathy显示文摘 | GUO M RICARDO SD DEANE JA | 2005 | J Anat2005，207，6： | 1 |
| 15 | Global health 2035: a world converging within a generation显示文摘 | Dean T Jamison Lawrence H Summers George Alleyne Kenneth J Arrow Seth Berkley Agnes Binagwaho Flavia Bustreo David Evans Richard G A Feachem Julio Frenk Gargee Ghosh Sue J Goldie Yan Guo Sanjeev Gupta Richard Horton Margaret E Kruk Adel Mahmoud Linah K Mo | 2013 | The Lancet . 2013 (9908)2013，，： | 1 |
| 16 | A stereological study of the renal glomerular vasculature in the db/db mouse model of dia- betic nephropathy显示文摘 | Guo M Ricardo SD Deane JA | 2005 | J Anat2005，207，6： | 1 |
| 17 | Analysisi of phenolic com- pounds in rhubarbs using liquid chromatography coupled with electrospray ionization mass spectrometry 显示文摘 | Min Ye Jian Jan Dean Guo | 2007 | J Amer Soc Mass Spectrom2007，18，： | 1 |
| 18 | Mitochondrial thioredoxin-2/peroxiredoxin-3 system functions in parallel with mitochondrial GSH system in protection against oxidative stress显示文摘 | Zhang H Guo YM Dean PJ | 2007 | Archives of Biochemistry and Biophysics2007，，465： | 1 |
| 19 | A stereological study of the renal glomerular vasculature in the db/db mouse model of diabetic nephropathy 显示文摘 | Guo M Ricardo S D Deane J A | 2005 | J Anat2005，207，： | 1 |
| 20 | A stereological study of the renal glomerular vasculature in the db/db mouse model of diabetic nephropathy显示文摘 | Guo M Ricardo SD Deane JA | | 0，，： | 1 |
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