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| 1 | A semi-spring and semi-edge combined contact model in CDEM and its application to analysis of Jiweishan landslide显示文摘Continuum-based discrete element method(CDEM)is an explicit numerical method used for simulation of progressive failure of geological body.To improve the efficiency of contact detection and simplify the calculation steps for contact forces,semi-spring and semi-edge are introduced in calculation.Semispring is derived from block vertex,and formed by indenting the block vertex into each face(24semisprings for a hexahedral element).The formation process of semi-edge is the same as that of semi-spring(24semi-edges for a hexahedral element).Based on the semi-springs and semi-edges,a new type of combined contact model is presented.According to this model,six contact types could be reduced to two,i.e.the semi-spring target face contact and semi-edge target edge contact.By the combined model,the contact force could be calculated directly(the information of contact type is not necessary),and the failure judgment could be executed in a straightforward way(each semi-spring and semi-edge own their characteristic areas).The algorithm has been successfully programmed in C++program.Some simple numerical cases are presented to show the validity and accuracy of this model.Finally,the failure mode,sliding distance and critical friction angle of Jiweishan landslide are studied with the combined model. | Chun Feng Shihai Li Xiaoyu Liu Yanan Zhang | 2014 | Journal of Rock Mechanics and Geotechnical Engineering2014，6，1： | 34 |
| 2 | A fundamental theorem for eco-environmental surface modelling and its applications显示文摘We propose a fundamental theorem for eco-environmental surface modelling(FTEEM) in order to apply it into the fields of ecology and environmental science more easily after the fundamental theorem for Earth’s surface system modeling(FTESM). The Beijing-Tianjin-Hebei(BTH) region is taken as a case area to conduct empirical studies of algorithms for spatial upscaling, spatial downscaling, spatial interpolation, data fusion and model-data assimilation, which are based on high accuracy surface modelling(HASM), corresponding with corollaries of FTEEM. The case studies demonstrate how eco-environmental surface modelling is substantially improved when both extrinsic and intrinsic information are used along with an appropriate method of HASM. Compared with classic algorithms, the HASM-based algorithm for spatial upscaling reduced the root-meansquare error of the BTH elevation surface by 9 m. The HASM-based algorithm for spatial downscaling reduced the relative error of future scenarios of annual mean temperature by 16%. The HASM-based algorithm for spatial interpolation reduced the relative error of change trend of annual mean precipitation by 0.2%. The HASM-based algorithm for data fusion reduced the relative error of change trend of annual mean temperature by 70%. The HASM-based algorithm for model-data assimilation reduced the relative error of carbon stocks by 40%. We propose five theoretical challenges and three application problems of HASM that need to be addressed to improve FTEEM. | Tianxiang YUE Na ZHAO Yu LIU Yifu WANG Bin ZHANG Zhengping DU Zemeng FAN Wenjiao SHI Chuanfa CHEN Mingwei ZHAO Dunjiang SONG Shihai WANG Yinjun SONG Changqing YAN Qiquan LI Xiaofang SUN Lili ZHANG Yongzhong TIAN Wei WANG Ying’an WANG Shengnan MA Hongsheng HUANG Yimin LU Qing WANG Chenliang WANG Yuzhu WANG Ming LU Wei ZHOU Yi LIU Xiaozhe YIN Zong WANG Zhengyi BAO Miaomiao ZHAO Yapeng ZHAO Yimeng JIAO Ufra NASEER Bin FAN Saibo LI Yang YANG John PWILSON | 2020 | Science China Earth Sciences2020，63，8： | 7 |
| 3 | Optical observations of LIGO source GW 170817 by the Antarctic Survey Telescopes at Dome A,Antarctica显示文摘The LIGO detection of gravitational waves(GW) from merging black holes in 2015 marked the beginning of a new era in observational astronomy. The detection of an electromagnetic signal from a GW source is the critical next step to explore in detail the physics involved. The Antarctic Survey Telescopes(AST3),located at Dome A, Antarctica, is uniquely situated for rapid response time-domain astronomy with its continuous night-time coverage during the austral winter. We report optical observations of the GW source(GW 170817) in the nearby galaxy NGC 4993 using AST3. The data show a rapidly fading transient at around 1 day after the GW trigger, with the i-band magnitude declining from 17:23 ± 0:13 magnitude to 17:72 ± 0:09 magnitude in ~1:8 h. The brightness and time evolution of the optical transient associated with GW 170817 are broadly consistent with the predictions of models involving merging binary neutron stars. We infer from our data that the merging process ejected about ~10^(-2) solar mass of radioactive material at a speed of up to 30% the speed of light. | lei hu xuefeng wu igor andreoni michael c.b.ashley jeff cooke xiangqun cui fujia du zigao dai bozhong gu yi hu haiping lu xiaoyan li zhengyang li ensi liang liangduan liu bin ma zhaohui shang tianrui sun n.b.suntzeff charling tao syed a.uddin lifan wang xiaofeng wang haikun wen di xiao jin xu ji yang shihai yang xiangyan yuan hongyan zhou hui zhang jilin zhou zonghong zhu | 2017 | Science Bulletin2017，62，21： | 6 |
| 4 | Deformation Measurement of Glass Structure Using FBG Sensor显示文摘Glass has been widely used as an important component in structures such as reflection glass curtainwalls,high speed trains,and landscape glass bridges with advantages of transparent and easy to clean,which are exposed to extreme weather conditions and external loads.Over time,these factors can lead to a damage of glass.So the health status of glass structure is critical,which should be routinely monitored to improve safety and provide reliable maintenance strategy.In this paper,fiber Bragg grating(FBG)sensors are used to monitor glass damage based on the fact that the main components of both the optical fiber and the glass are silica,which hints that both optical fiber and glass have the similar mechanical properties.Furthermore,the diameter of FBG installed on the glass structure is small,which has little effect on the beauty of glass.In order to validate the feasibility of the damage monitoring method,one common glass panel model with two-side fixations is loaded impact and static loads respectively,on the upper and lower surfaces of which four FBG sensors and two resistance strain gages are installed.A comparison study among the measured strains from the FBG sensors,those from the resistance strain gages,and those calculated from finite element model(FEM)analysis is conducted and the result obtained with experiments agrees with the element result.Test results show that the FBG sensors can effectively measure the glass deformation or damage under the impact and static load. | Bin LIU Shihai ZHANG Jianping HE | 2019 | Photonic Sensors2019，9，4： | 5 |
| 5 | Quantifying 3D cell-matrix interactions during mitosis and the effect of anticancer drugs on the interactions显示文摘The mechanical force between cells and the extracellular microenvironment is crucial to many physiological processes such as cancer metastasis and stem cell differentiation. Mitosis plays an essential role in all these processes and thus an in-depth understanding of forces during mitosis gains insight into disease diagnosis and disease treatment. Here, we develop a traction force microscope method based on monolayer fluorescent beads for measuring the weak traction force (tens of Pa) of mitotic cells in three dimensions. We quantify traction forces of human ovarian granulosa (KGN) cells exerted on the extracellular matrix throughout the entire cell cycle in three dimensions. Our measurements reveal how forces vary during the cell cycle, especially during cell division. Furthermore, we study the effect of paclitaxel (PTX) and nocodazole (NDZ) on mitotic KGN cells through the measurement of traction forces. Our results show that mitotic cells with high concentrations of PTX exert a larger force than those with high concentrations of NDZ, which proved to be caused by changes in the structure and number of microtubules. These findings reveal the key functions of microtubule in generating traction forces during cell mitosis and explain how dividing cells regulate themselves in response to anti-mitosis drugs. This work provides a powerful tool for investigating cell-matrix interactions during mitosis and may offer a potential way to new therapies for cancer. | Yongman Liu Jianye Wang Yong Su Xiaohai Xu Hong Liu Kainan Mei Shihai Lan Shubo Zhang Xiaoping Wu Yunxia Cao Qingchuan Zhang Shangquan Wu | 2021 | Nano Research2021，14，11： | 3 |
| 6 | Model-based robustness testing for avionics-embedded software显示文摘Robustness testing for safety-critical embedded software is still a challenge in its nascent stages. In this paper, we propose a practical methodology and implement an environment by employing model-based robustness testing for embedded software systems. It is a system-level black-box testing approach in which the fault behaviors of embedded software is triggered with the aid of modelbased fault injection by the support of an executable model-driven hardware-in-loop (HIL) testing environment. The prototype implementation of the robustness testing environment based on the proposed approach is experimentally discussed and illustrated by industrial case studies based on several avionics-embedded software systems. The results show that our proposed and implemented robustness testing method and environment are effective to find more bugs, and reduce burdens of testing engineers to enhance efficiency of testing tasks, especially for testing complex embedded systems. | Yang Shunkun Liu Bin Wang Shihai Lu Minyan | 2013 | Chinese Journal of Aeronautics2013，26，3： | 3 |
| 7 | Energy-and spectral-efficiency of zero-forcing beamforming in massive MIMO systems with imperfect reciprocity calibration: bound and optimization显示文摘In a time-division duplex(TDD) system with massive multiple input multiple output(MIMO),channel reciprocity calibration(RC) is generally required in order to cope with the reciprocity mismatch between the uplink and downlink channel state information. Currently, evaluating the achievable spectral efficiency(SE) and energy efficiency(EE) of TDD massive MIMO systems with imperfect RC(IRC) mainly relies on exhausting Monte Carlo simulations and it is infeasible to precisely and concisely quantify the achievable SE and EE with IRC. In this study, a novel method is presented for tightly bounding the achievable SE of massive MIMO systems with zero-forcing beamforming under IRC. On the basis of the analytical results, we demonstrate key insights for practical system design with IRC in three aspects: the scaling rule for interference power, saturation region of the SE, and the bound on the SE loss. Finally, the trade-off between spectral and energy efficiencies in the presence of IRC is determined with algorithms developed to optimize SE(EE) under a constrained EE(SE) value. The loss of optimal total SE and EE due to IRC is also quantified, which shows that the loss of optimal EE is more sensitive to IRC in a typical range of transmit power values. | Donglin LIU Fei WU Xin QUAN Wanzhi MA Ying LIU Shihai SHAO | 2018 | Science China(Information Sciences)2018，61，12： | 2 |
| 8 | A hazard analysis via an improved timed colored petri net with time–space coupling safety constraint显示文摘Petri nets are graphical and mathematical tools that are applicable to many systems for modeling, simulation, and analysis. With the emergence of the concept of partitioning in time and space domains proposed in avionics application standard software interface(ARINC 653), it has become difficult to analyze time–space coupling hazards resulting from resource partitioning using classical or advanced Petri nets. In this paper, we propose a time–space coupling safety constraint and an improved timed colored Petri net with imposed time–space coupling safety constraints(TCCP-NET) to fill this requirement gap. Time–space coupling hazard analysis is conducted in three steps: specification modeling, simulation execution, and results analysis. A TCCP-NET is employed to model and analyze integrated modular avionics(IMA), a real-time, safety-critical system. The analysis results are used to verify whether there exist time–space coupling hazards at runtime. The method we propose demonstrates superior modeling of safety-critical real-time systems as it can specify resource allocations in both time and space domains. TCCP-NETs can effectively detect underlying time–space coupling hazards. | Li Zelin Wang Shihai Zhao Tingdi Liu Bin | 2016 | Chinese Journal of Aeronautics2016，29，4： | 2 |
| 9 | Establishing Gene Delivery Systems Based on Small-Sized Chitosan Nanoparticles显示文摘Chitosan is a natural cationic polysaccharide,which is often used for preparing biomedical materials because of its high biocompatibility.In this study,chitosan with a molecular weight of 160 k Da was chosen to prepare chitosan nanoparticles(CSNPs) as gene vectors by ionic cross-linking with tripolyphosphate(TPP).CSNPs were characterized in terms of particle size,zeta potential,and polydispersity index(PDI) using a Zetasizer,and morphology was evaluated by transmission electron microscopy(TEM).Furthermore,the cytotoxicity and biocompatibility of CSNPs were correspondingly examined by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay and histological examination.Agarose gel electrophoresis and UV spectrophotometric methods were performed to measure the loading capacity.The cell transfection efficiency of CSNPs loaded with plasmids or si RNA was analyzed by fluorescence microscopy or laser scanning confocal microscopy.The results showed that CSNPs were prepared successfully by the ionic gelation method,which had a smaller particle size(100 nm-200 nm),stable dispersibility,low cytotoxicity,good tissue-biocompatibility,and high gene-loading efficiency.These CSNPs could transfer the plasmids or si RNA to cells.However,CSNPs might have a much higher transfection efficiency for si RNAs than for plasmids,which implies that CSNPs might be a safer and more efficient vector for delivering si RNAs rather than plasmids. | WANG Liping ZHANG Wenhua ZHOU Quan LIU Shihai XU Wenhua SUN Teng LIANG Ye | 2018 | Journal of Ocean University of China2018，17，5： | 2 |
| 10 | 3D bioprinting of integral ADSCs-NO hydrogel scaffolds to promote severe burn wound healing显示文摘Severe burns are challenging to heal and result in significant death throughout the world.Adiposederived mesenchymal stem cells(ADSCs)have emerged as a promising treatment for fullthickness burn healing but are impeded by their low viability and efficiency after grafting in vivo.Nitric oxide(NO)is beneficial in promoting stem cell bioactivity,but whether it can function effectively in vivo is still largely unknown.In this study,we bioprinted an efficient biological scaffold loaded with ADSCs and NO(3D-ADSCs/NO)to evaluate its biological efficacy in promoting severe burn wound healing.The integral 3D-ADSCs/NO hydrogel scaffolds were constructed via 3D bioprinting.Our results shown that 3D-ADSCs/NO can enhance the migration and angiogenesis of Human Umbilical Vein Endothelial Cells(HUVECs).Burn wound healing experiments in mice revealed that 3D-ADSCs/NO accelerated the wound healing by promoting faster epithelialization and collagen deposition.Notably,immunohistochemistry of CD31 suggested an increase in neovascularization,supported by the upregulation of vascular endothelial growth factor(VEGF)mRNA in ADSCs in the 3D biosystem.These findings indicated that 3D-ADSC/NO hydrogel scaffold can promote severe burn wound healing through increased neovascularization via the VEGF signalling pathway.This scaffold may be considered a promising strategy for healing severe burns. | Yu Wu Tangzhao Liang Ying Hu Shihai Jiang Yuansen Luo Chang Liu Guo Wang Jing Zhang Tao Xu Lei Zhu | 2021 | Regenerative Biomaterials2021，8，3： | 2 |
| 11 | Comparisons on Mineralogy and Lithology between Paleozoic Marine and Lacustrine Dolostones, Northern China显示文摘1 Introduction Dolomite[Ca Mg(CO3)2],a common mineral in carbonate rocks,can be found in various geological settings from Precambrian to modern age,and is widely reported in almost all sedimentary and | LI Hong LIU Yiqun NIU Yuanzhe FENG Shihai LEI Yun LIU Yongjie | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 2 |
| 12 | CRM1 is a novel independent prognostic factor for the poor prognosis of gastric carcinomas显示文摘 | Fang Zhou Wensheng Qiu Ruyong Yao Jinyu Xiang Xiaoxiao Sun Shihai Liu Jing Lv Lu Yue | 2013 | Medical Oncology2013，，4： | 1 |
| 13 | Comprehensive evaluation on the heating capacities of four typical whole body hyperthermia strategies via compartmental model显示文摘 | Xiang Shihai Liu Jing | 2008 | International Journal of Heat and Mass Transfer2008，51，2324： | 1 |
| 14 | The Ecological Vulnerability Evaluation in Southwestern Mountain Region of China Based on GIS and AHP Method显示文摘 | Guoba. Song Yu Chen Meirong Tian Shihai Lv Shushen Zhang Suling Liu | 2010 | Procedia Environmental Sciences2010，，： | 1 |
| 15 | Effects of non-flooding mulching cultivation on crop yield, nutrient uptake and nutrient balance in rice-wheat cropping systems 显示文摘 | Liu Xinjie Wang Jinchun Lu Shihai | 2003 | Field Crops Research2003，83，3： | 1 |
| 16 | Holographic QSAR of environmental estrogens显示文摘Experimental and epidemiological studies suggest that some man-made and natu- rally occurring chemicals related to the environment have the potential to interrupt normal func- tioning of the endocrine systems of humans and wildlife. These chemicals, termed EDCs (Endo- crine disrupting Chemicals), pose serious threats to the reproductive capability of humans and wildlife. Because of the structural diversity and various types, development of structure-based rapid screening methodologies is important and necessary for the assessment of the environ- mental pollutants. In this paper molecular hologram based QSAR models were developed with the combinatory application of partial least square (PLS) regression for a large diverse set of 105 environmental estrogens. Quantitatively predictive models were developed based on only mo- lecular structures, which can be used for the accurate prediction of estrogenicity to rapidly screen potential environmental endocrine disrupting chemicals. | WANG Xiaodong XIAO Qianfen CUI Shihai LIU Shushen YIN Daqiang WANG Liansheng | 2005 | Science China Chemistry2005，48，2： | 1 |
| 17 | Effect of low dose fractionated radiation on reversing cisplatin resistance in ovarian carcinoma via VEGF and mTOR显示文摘Objective To investigate the mechanism of low-dose fractionated radiation on reversing cisplatin resistance in ovarian carcinoma via vascular endothelial growth factor(VEGF) and mammalian target of rapamycin(mTOR) in vivo.Methods Human cisplatin-resistant ovarian carcinoma cells(SKOV3/DDP) were injected into nude mice to establish ovarian cancer xenografts. The mice were randomly divided into three groups: a control group, a low-dose fractionated radiation(LDRFT) group, and a conventional-dose radiation group. Each group was exposed to 0 cGy, 50 cGy, and 200 cGy radiation, respectively, for 4 weeks, up to a total of 8.0 Gy. Mice in the LDFRT group were irradiated twice daily with 6 hour intermissions on day 1 and 2 of every week for a total of 4 weeks. Conventional-dose group mice were given a single 200 cGy radiation dose on the first day each week for a total of 4 weeks. Maximum horizontal and vertical diameters of the tumors were measured every other day and used to create a tumor growth curve. After 4 weeks of irradiation, we dissected the tumor tissue and calculated the tumor inhibition rate. RT-PCR detected the expression of VEGF and m TOR, and Western blots detected the expression of corresponding proteins.Results Both LDRFT and conventional-dose radiation inhibited the growth of tumor cells, and growth of tumors in the two radiation groups compared with growth in the control group were significantly different(P < 0.05). The rate of tumor inhibition in the LDFRT group(37.5603%) was lower than in the conventionaldose group(47.4446%), but there was no significant difference(P 0.05). Compared with the other two groups, the m RNA expression of VEGF was significantly lower in the LDFRT group(P < 0.05), but there was no obvious difference between the conventional-dose and control groups. There was no obvious difference in the m RNA expression of m TOR among the three groups, but the expression of the protein p-m TOR was lower in the LDFRT group(P < 0.05), as confirmed by Western blotting.Conclusion LDFRT is as effective at inhibiting the growth of tumor cells as conventional-dose radiation. In addition, LDFRT could deregulate the expression of VEGF and p-m TOR, and may therefore play a vital role in reversing cisplatin resistance in ovarian cancer. | Xingyan Ju Shihai liu Donghai Liang Tao Jiang Ronghui Yuan Wei Zhao Hongsheng Yu | 2017 | Oncology and Translational Medicine2017，3，4： | 1 |
| 18 | Domainspecific monoclonal antibodies produced aganist human PGRN显示文摘 | Chai Lihong Mao Qinwen Liu Shihai | 2011 | Hybrodoma2011，30，： | 1 |
| 19 | Identification of potential immune-related prognostic biomarkers of lung cancer using gene co-expression network analysis显示文摘Objective The objective of this study was to identify new carcinogenetic hub genes and develop the integration of differentially expressed genes to predict the prognosis of lung cancer.Methods GSE139032 microarray data packages were downloaded from the Gene Expression Omnibus for planning,testing,and review of data.We identified KRT6C,LAMC2,LAMB3,KRT6A,and MYEOV from a key module for validation.Results We found that the five genes were related to a poor prognosis,and the expression levels of these genes were associated with tumor stage.Furthermore,Kaplan-Meier plotter showed that the five hub genes had better prognostic values.The mean levels of methylation in lung adenocarcinoma(LUAD)were significantly lower than those in healthy lung tissues for the hub genes.However,gene set enrichment analysis(GSEA)for single hub genes showed that all of them were immune-related.Conclusion Our findings demonstrated that KRT6C,LAMC2,LAMB3,KRT6A,and MYEOV are all candidate diagnostic and prognostic biomarkers for LUAD.They may have clinical implications in LUAD patients not only for the improvement of risk stratification but also for therapeutic decisions and prognosis prediction. | Aixia Chen Shengnan Zhao Fei Zhou Hongying Lv Donghai Liang Tao Jiang Rui Liu Lijin Zhu Jingyu Cao Shihai Liu Hongsheng Yu | 2020 | Oncology and Translational Medicine2020，6，6： | 1 |
| 20 | CBR,KDD and Smart Algorisms Based Design Methods for High-rise Structure Form-selection显示文摘 | Zhang shihai Liu Xiaoyan Ou Jinping Wang Guangyuan | 2002 | Pacific Science Review2002，，4： | 1 |
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