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| 1 | Solar activity effects of the ionosphere: A brief review显示文摘Solar radiation, which varies over multiple temporal scales, modulates remarkably the evolution of the ionosphere. The solar activity dependence of the ionosphere is a key and fundamental issue in ionospheric physics, providing information essential to understanding the variations in the ionosphere and its processes. Selected recent studies on solar activity effects of the ionosphere are briefly reviewed in this report. This report focuses on (1) observations of solar irradiance at X-ray and extreme ultraviolet wavelengths and the outstanding problems of solar proxies, in the view of ionospheric studies, (2) new findings and improved representations of the features of the solar activity dependence of ionospheric key parameters and the corresponding physical processes, (3) possible phenomena in the ionosphere under extremely high and low solar activity conditions that are unique, as indicated by historical solar datasets and the deep solar minimum of solar cycle 23/24, and (4) statistical studies and model simulations of the ionosphere response to solar flares. The above-mentioned studies provide new clues for comprehensively explaining basic processes in the ionosphere and improving the prediction capability of ionospheric models and related applications. | LIU LiBo WAN WeiXing CHEN YiDing LE HuiJun | 2011 | Chinese Science Bulletin2011，56，12： | 45 |
| 2 | Generation of arbitrary vector vortex beams on hybrid-order Poincaré sphere显示文摘We propose theoretically and verify experimentally a method of combining a q-plate and a spiral phase plate to generate arbitrary vector vortex beams on a hybrid-order Poincaré sphere. We demonstrate that a vector vortex beam can be decomposed into a vector beam and a vortex, whereby the generation can be realized by sequentially using a q-plate and a spiral phase plate. The generated vector beam, vortex, and vector vortex beam are verified and show good agreement with the prediction. Another advantage that should be pointed out is that the spiral phase plate and q-plate are both fabricated on silica substrates, suggesting the potential possibility to integrate the two structures on a single plate. Based on a compact method of transmissive-type transformation, our scheme may have potential applications in future integrated optical devices. | Zhenxing Liu Yuanyuan Liu Yougang Ke Yachao Liu Weixing Shu Hailu Luo Shuangchun Wen | 2017 | Photonics Research2017，5，1： | 18 |
| 3 | Giant photonic spin Hall effect in momentum space in a structured metamaterial with spatially varying birefringence显示文摘The photonic spin Hall effect(SHE)in the reflection and refraction at an interface is very weak because of the weak spin-orbit interaction.Here,we report the observation of a giant photonic SHE in a dielectric-based metamaterial.The metamaterial is structured to create a coordinate-dependent,geometric Pancharatnam–Berry phase that results in an SHE with a spin-dependent splitting in momentum space.It is unlike the SHE that occurs in real space in the reflection and refraction at an interface,which results from the momentum-dependent gradient of the geometric Rytov–Vladimirskii–Berry phase.We theorize a unified description of the photonic SHE based on the two types of geometric phase gradient,and we experimentally measure the giant spin-dependent shift of the beam centroid produced by the metamaterial at a visible wavelength.Our results suggest that the structured metamaterial offers a potential method of manipulating spin-polarized photons and the orbital angular momentum of light and thus enables applications in spin-controlled nanophotonics. | Xiaohui Ling Xinxing Zhou Xunong Yi Weixing Shu Yachao Liu Shizhen Chen Hailu Luo Shuangchun Wen Dianyuan Fan | 2015 | Light(Science & Applications)2015，4，1： | 15 |
| 4 | Modeling the global ionospheric total electron content with empirical orthogonal function analysis显示文摘In the present work we model the global ionospheric total electron content (TEC) with the analysis of empirical orthogonal functions (EOF). The obtained statistical eigen modes, which makeup the modeled TEC, consist of two factors: the eigen vectors mapping TEC patterns at latitude and longitude (or local time LT), and the corresponding coefficients displaying the TEC variations in different time scales, i.e., the solar cycle, the yearly (annual and semiannual) and the diurnal universal time variations. It is found that the EOF analysis can separate the TEC variations into chief processes and the first two modes illustrate the most of the ionospheric climate properties. The first mode contains both the semiannual component which shows the semiannual ionospheric anomaly and the annual component which shows the annual or non-seasonal ionospheric anomaly. The second mode contains mainly the annual component and shows the normal seasonal ionospheric variation at most latitudes and local time sectors. The annual component in the second mode also manifests seasonal anomaly of the ionosphere at higher mid-latitudes around noontime. It is concluded that the EOF analysis, as a statistical eigen mode method, is resultful in analyzing the ionospheric climatology hence can be used to construct the empirical model for the ionospheric climatology. | WAN WeiXing DING Feng REN ZhiPeng ZHANG ManLian LIU LiBo NING BaiQi | 2012 | Science China(Technological Sciences)2012，55，5： | 15 |
| 5 | The first time observations of low-latitude ionospheric irregularities by VHF radar in Hainan显示文摘Sanya VHF radar (18.4°N, 109.6°E, dip latitude 12.8°N) at Hainan Island is the first coherent backscatter radar for sounding low-latitude ionospheric irregularities in the mainland of China. In this paper, we present the first results of low-latitude ionospheric E and F region irregularities using the radar data during the period from February 2009 to March 2010. The Doppler velocity of radar echoes from E region field aligned irregularities (FAIs) was about several tens of meters per second, while the Doppler spectral width was appreciably larger than the velocity, and could reach one hundred meters per second, indicating that the observed E region FAIs belonged to type 2 irregularities. The observations of range time intensity (RTI) maps of FAIs showed that E region irregularities most often occurred at night within the altitude range 85-115 km, and were rarely observed at afternoon hours. The percentage occurrence of E region FAIs maximized during spring months (Feb.-May) with a peak value over 80%. The heights at which the strongest echo related FAIs occurred were mainly around 100 km, lower than h'Es and the difference is mostly 10-20 km. December solstice seemed to be the minimum period of occurrence when the FAI echoes were commonly detected at a narrow altitude range 90-100 km. Moreover, simultaneous radar and GPS observations during spread F events in the pre-midnight hours of solar minimum revealed that significant GPS L band scintillations coincided with the appearance of F region plasma plume structures, which extended up to 450 km in altitude. | NING BaiQi HU LianHuan LI GuoZhu LIU LiBo WAN WeiXing | 2012 | Science China(Technological Sciences)2012，55，5： | 15 |
| 6 | Lane departure warning systems and lane line detection methods based on image processing and semantic segmentation:A review显示文摘Recently,the development and application of lane line departure warning systems have been in the market.For any of the systems,the key part of lane line tracking,lane line identification,or lane line departure warning is whether it can accurately and quickly detect lane lines.Since 1990 s,they have been studied and implemented for the situations defined by the good viewing conditions and the clear lane markings on road.After then,the accuracy for particular situations,the robustness for a wide range of scenarios,time efficiency and integration into higher-order tasks define visual lane line detection and tracking as a continuing research subject.At present,these kinds of lane marking line detection methods based on machine vision and image processing can be divided into two categories:the traditional image processing and semantic segmentation(includes deep learning)methods.The former mainly involves feature-based and model-based steps,and which can be classified into similarity-and discontinuity-based ones;and the model-based step includes different parametric straight line,curve or pattern models.The semantic segmentation includes different machine learning,neural network and deep learning methods,which is the new trend for the research and application of lane line departure warning systems.This paper describes and analyzes the lane line departure warning systems,image processing algorithms and semantic segmentation methods for lane line detection. | Weiwei Chen Weixing Wang Kevin Wang Zhaoying Li Huan Li Sheng Liu | 2020 | Journal of Traffic and Transportation Engineering(English Edition)2020，7，6： | 14 |
| 7 | Novel method of improving the alignment accuracy of SINS on revolving mounting base显示文摘In the process of initial alignment for a strapdown inertial navigation system(SINS) on a stationary base,the east gyro drift rate is an important factor affecting the alignment accuracy of the azimuth misalignment angle.When the Kalman filtering algorithm is adopted in initial alignment,it yields a constant error in the estimation of the azimuth misalignment angle because the east gyro drift rate cannot be estimated.To improve the alignment accuracy,a novel alignment method on revolving mounting base is proposed.The Kalman filtering algorithm of extending the measured values is studied.The theory of spectral condition number is utilized to analyze the degrees of observability of states.Simulation results show that the estimation accuracy of the azimuth misalignment angle is greatly improved through revolving mounting base,and the proposed method is efficient in initial alignment for a medium accurate SINS. | Qian Weixing Liu Jianye Zhao Wei Zhu Yanhua | 2009 | Journal of Systems Engineering and Electronics2009，20，5： | 11 |
| 8 | Quantifying the effects of short-term heat stress at booting stage on nonstructural carbohydrates remobilization in rice显示文摘Extreme heat stress events are becoming more frequent under anticipated climate change,which can have devastating impacts on rice growth and yield.To quantify the effects of short-term heat stress at booting stage on nonstructural carbohydrates(NSC)remobilization in rice,two varieties(Nanjing 41 and Wuyunjing 24)were subjected to 32/22/27°C(maximum/minimum/mean),36/26/31°C,40/30/35°C,and 44/34/39°C for 2,4 and 6 days in phytotrons at booting stage during 2014 and 2015.Yield and yield components,dry matter partitioning index(DMPI),NSC accumulation and translocation were measured and calculated.The results showed that the increase of high-temperature level and duration significantly reduced grain yield by suppressing spikelet number per panicle,seed-setting rate,and grain weight.Heat stress at booting decreased DMPI in panicles,increased DMPI in stems,but had no significant effect on photosynthetic rate.Stem NSC concentration increased whereas panicles NSC concentration,stem NSC translocation efficiency,and contribution of stem NSC to grain yield decreased.Severe heat stress even transformed the stem into a carbohydrate sink during grain filling.The heat-tolerant Wuyunjing 24 showed a higher NSC transport capacity under heat stress than the heat-sensitive Nanjing 41.Heat degree-days(HDD),which combines the effects of the intensity and duration of heat stress,used for quantifying the impacts of heat stress indicates the threshold HDD for the termination of NSC translocation is 9.82°C day.Grain yield was negatively correlated with stem NSC concentration and accumulation at maturity,and yield reduction was tightly related to NSC translocation reduction.The results suggest that heat stress at booting inhibits NSC translocation due to sink size reduction.Therefore,genotypes with higher NSC transport capacity under heat stress could be beneficial for rice yield formation. | Fengxian Zhen Junjie Zhou Aqib Mahmood Wei Wang Xini Chang Bing Liu Leilei Liu Weixing Cao Yan Zhu Liang Tang | 2020 | The Crop Journal2020，8，2： | 9 |
| 9 | Olivine-norite rock detected by the lunar rover Yutu-2 likely crystallized from the SPA-impact melt pool显示文摘Chang’E-4 landed in the South Pole-Aitken(SPA)basin,providing a unique chance to probe the composition of the lunar interior.Its landing site is located on ejecta strips in Von Karm´an crater that´possibly originate from the neighboring Finsen crater.A surface rock and the lunar regolith at 10 sites along the rover Yutu-2 track were measured by the onboard Visible and Near-Infrared Imaging Spectrometer in the first three lunar days of mission operations.In situ spectra of the regolith have peak band positions at 1 and 2μm,similar to the spectral data of Finsen ejecta from the Moon Mineralogy Mapper,which confirms that the regolith’s composition of the landing area is mostly similar to that of Finsen ejecta.The rock spectrum shows similar band peak positions,but stronger absorptions,suggesting relatively fresh exposure.The rock may consist of 38.1±5.4%low-Ca pyroxene,13.9±5.1%olivine and 48.0±3.1%plagioclase,referred to as olivine-norite.The plagioclase-abundant and olivine-poor modal composition of the rock is inconsistent with the origin of the mantle,but representative of the lunar lower crust.Alternatively,the rock crystallized from the impact-derived melt pool formed by the SPA-impact event via mixing the lunar crust and mantle materials.This scenario is consistent with fast-cooling thermal conditions of a shallow melt pool,indicated by the fine to medium-sized texture(<3 mm)of the rock and the SPA-impact melting model[Icarus 2012;220:730–43]. | Honglei Lin Zhiping He Wei Yang Yangting Lin Rui Xu Chi Zhang Meng-Hua Zhu Rui Chang Jinhai Zhang Chunlai Li Hongyu Lin Yang Liu Sheng Gou Yong Wei Sen Hu Changbin Xue Jianfeng Yang Jie Zhong Xiaohui Fu Weixing Wan Yongliao Zou | 2020 | National Science Review2020，7，5： | 9 |
| 10 | Effects of afforestation on soil carbon turnover in China's subtropical region显示文摘Afforestation in China's subtropics plays an important role in sequestering CO2 from the atmosphere and in storage of soil carbon (C). Compared with natural forests,plantation forests have lower soil organic carbon (SOC) content and great potential to store more C. To better evaluate the effects of afforestation on soil C turnover,we investigated SOC and its stable C isotope (δ13C) composition in three planted forests at Qianyanzhou Ecological Experimental Station in southern China. Litter and soil samples were collected and analyzed for total organic C,δ13C and total nitrogen. Similarly to the vertical distribution of SOC in natural forests,SOC concentrations decrease exponentially with depth. The land cover type (grassland) before plantation had a significant influence on the vertical distribution of SOC. The SOC ?13C composition of the upper soil layer of two plantation forests has been mainly affected by the grass biomass 13C composition. Soil profiles with a change in photosynthetic pathway had a more complex 13C isotope composition distribution. During the 20 years after plantation establishment,the soil organic matter sources influenced both the δ13C distribution with depth,and C replacement. The upper soil layer SOC turnover in masson pine (a mean 34% of replacement in the 10 cm after 20 years) was more than twice as fast as that of slash pine (16% of replacement) under subtropical conditions. The results demonstrate that masson pine and slash pine plantations cannot rapidly sequester SOC into long-term storage pools in subtropical China. | WANG Shaoqiang LIU Jiyuan ZHANG Cheng YI Chuixiang WU Weixing | 2011 | Journal of Geographical Sciences2011，21，1： | 8 |
| 11 | A theoretical model for mid-and low-latitude ionospheric electric fields in realistic geomagnetic fields显示文摘The geomagnetic fields,which play important roles in the ionospheric dynamo,can greatly affect the global distribution of ionospheric electric fields,currents and other ionospheric electrodynamics phenomena.In the study of ionospheric electrodynamics phenomena,such as the longitudinal variations of ionospheric electric fields,the non-dipolar component of the geomagnetic fields must be taken into account.In this paper,we deduce a theoretical electric field model for ionospheric dynamo at mid-and low-latitude which adopt a modified magnetic apex coordinates system.In the new electric field model,the geomagnetic fields can be calculated from either the IGRF model or the dipole field model,and the neutral winds and conductivities are calculated based on empirical models.Then the dynamo equation for the electric potential is finally solved in terms of the line-by-line iteration method,and the ionospheric electric fields and currents are derived from the calculated potential.Our model can reproduce the main features of the ionospheric electrodynamics processes,so it will be a useful tool for the investigation of the upper atmosphere and ionosphere. | REN ZhiPeng WAN WeiXing WEI Yong LIU LiBo YU Tao | 2008 | Chinese Science Bulletin2008，53，24： | 7 |
| 12 | Development of a middle and low latitude theoretical ionospheric model and an observation system data assimilation experiment显示文摘On the basis of previous work, we develop a middle and low latitude theoretical ionospheric model in this paper, named Theoretical Ionospheric Model of the Earth in the Institute of Geology and Geophysics, Chinese Academy of Sciences (TIME-IGGCAS). TIME-IGGCAS solves the equations of mass continuity, motion and energy of electron and ions self-consistently and uses an eccentric dipole field approxima-tion to the Earth’s magnetic field. We combine the Eulerian and Lagrangian approaches in the model and take account of the plasma E×B drift velocity. Calculation results reveal that the model is steady and credible and can reproduce most large-scale features of ionosphere. By using TIME-IGGCAS, we carried out an observation system data assimilation experiment. Assimilation results show that the E×B drift velocity can be accurately estimated by ingesting the observed foF2 and hmF2 into the model ap-plying nonlinear least-square fit method. We suggest that this work is of great significance in the de-velopment of ionospheric data assimilation model to give better nowcast and forecast of ionosphere. | YUE XinAn WAN WeiXing LIU LiBo LE HuiJun CHEN YiDing YU Tao | 2008 | Chinese Science Bulletin2008，53，1： | 7 |
| 13 | Enhanced anti-sunward flow near local noon during a period of horizontal IMF and high solar wind velocity V_Y显示文摘It is believed that a southward interplanetary magnetic field (IMF) is mainly responsible for the energy input from solar wind into the magnetosphere.This paper presents an unusual case of strong anti-sunward plasma flow (up to 2 km/s) in the polar cap ionosphere and large cross-polar cap potential (CPCP) during a period of horizontal IMF (|BZ| < 2 nT) observed by both ACE (at the L1 point) and Geotail (on the dusk flank of the magnetosheath).The CPCP is even higher than that under preceding BZ ≈-23 nT.Furthermore,GOES8 observed that the magnetosheath field turns northward as the anti-sunward plasma flow and CPCP start to increase,which implies that the magnetosheath field interacting with the Earth's magnetopause has significantly rotated and differs from the IMF observed by ACE and Geotail.In accordance with previous theoretical work,we suggest that the magnetic field line draping produces a southward magnetosheath field and enhances anti-sunward plasma flow and the CPCP. | WEI Yong ZONG QiuGang PU ZuYin WAN WeiXing LIU JianJun FU SuiYan SHI QuanQi | 2011 | Chinese Science Bulletin2011，56，11： | 7 |
| 14 | Polarization evolution of vector beams generated by q-plates显示文摘The polarization evolution of vector beams(VBs) generated by q-plates is investigated theoretically and experimentally.An analytical model is developed for the VB created by a general quarter-wave q-plate based on vector diffraction theory.It is found that the polarization distribution of VBs varies with position and the value q.In particular,for the incidence of circular polarization,the exit vector vortex beam has polarization states that cover the whole surface of the Poincarésphere,thereby constituting a full Poincarébeam.For the incidence of linear polarization,the VB is not cylindrical but specularly symmetric,and exhibits an azimuthal spin splitting.These results are in sharp contrast with those derived by the commonly used model,i.e.,regarding the incident light as a plane wave.By implementing q-plates with dielectric metasurfaces,further experiments validate the theoretical results. | WEIXING SHU XIAOHUI LING XIQUAN FU YACHAO LIU YOUGANG KE HAILU LUO | 2017 | Photonics Research2017，5，2： | 7 |
| 15 | Algorithm for complex network diameter based on distance matrix显示文摘The network diameter is an important characteristic parameter of a complex network. Calculation for a large-scale complex network's diameter has been an important subject in the study of complex networks. If the network diameter is calculated directly, the problem mainly exists in efficiency for searching and counting the shortest paths. If the network diameter is calculated indirectly by studying the statistical function about the relationship between the network diameter and parameters affecting the diameter, the problems not only exist in the efficiency of statistic, but also exist in the function which may be not applicable to all kinds of networks. An algorithm for the complex network diameter based on the k order distance matrix is proposed with a matrix multiplication approach, and a mathematical proof for the algorithm correctness is given as well. Furthermore, some relevant propositions and deductions for reducing the complexity of this algorithm are put forward. With a good theoretical basis and a simple calculation process, this algorithm can be used to calculate the diameter of a large-scale complex network with small-world effect more accurately and efficiently. Two cases about the advanced research projects agency(ARPA) network model and the Chinese airline network model are adopted to verify the effect of this algorithm. | CHEN Bin ZHU Weixing LIU Ying | 2018 | Journal of Systems Engineering and Electronics2018，29，2： | 4 |
| 16 | Empirical modeling of ionospheric F2 layer critical frequency over Wakkanai under geomagnetic quiet and disturbed conditions显示文摘The hourly values of the ionospheric F2 layer critical frequency, foF2, recorded at Wakkanai ionosonde station (45.4°N, 141.7°E) have been collected to construct a middle-latitude single-station model for forecasting foF2 under geomagnetic quiet and disturbed conditions. The module for the geomagnetic quiet conditions incorporates local time, seasonal, and solar variability of climatological foF2 and its upper and lower quartiles. It is the first attempt to predict the upper and lower quartiles of foF2 to account for the notable day-to-day variability in ionospheric foF2. The validation statistically verifies that the model captures the climatological variations of foF2 with higher accuracy than IRI does. The storm-time module is built to capture the geomagnetic storm induced relative deviations of foF2 from the quiet time references. In the geomagnetically disturbed module, the storm-induced deviations are described by diurnal and semidiurnal waves, which are modulated by a modified magnetic activity index, the Kf index, reflecting the delayed responses of foF2 to geomagnetic activity forcing. The coefficients of the model in each month are determined by fitting the model formula to the observation in a least-squares way. We provide two options for the geomagnetic disturbed module, including or not including Kalman filter algorithm. The Kalman filter algorithm is introduced to optimize these coefficients in real time. Our results demonstrate that the introduction of the Kalman filter algorithm in the storm time module is promising for improving the accuracy of predication. In addition, comparisons indicate that the IRI model prediction of the F2 layer can be improved to provide better performances over this region. | LIU Jing LIU LiBo ZHAO BiQiang WAN WeiXing CHEN YiDing | 2012 | Science China(Technological Sciences)2012，55，5： | 4 |
| 17 | Seasonal variations of night mesopause temperature in Beijing observed by SATI4显示文摘The data observed by a spectral airglow temperature imager (SATI) at Beijing National Observatory of Space Environment from July 23, 2008 to July 31, 2009 are used to study night mesopause temperature in Beijing. From variations of temperature at 87 and 94 km obtained from OH (6-2) and O2 (0-1) airglow spectra, temperature at night is shown lowest in the summer and highest in the winter. In summer, average temperature at 87 km is 173.9 K, lower than average temperature 180.1 K at 94 km. But in winter, average temperature at 87 km is 201.2 K, higher than average temperature 194.8 K at 94 km. The altitude of mesopause in Beijing is below 87 km in summer and above 94 km in winter. There are about 120-150 days when the mesopause locates below 87 km, which is in agreement with the results of SABER/TIMED. Variations of temperatures at 87 and 94 km are analyzed by harmonic method. Our results show that amplitudes of annual oscillation of temperature at 87 and 94 km are 17.5 and 7.8 K respectively. Amplitudes of semi-annual oscillation at 87 and 94 km are 1.6 and 5.3 K, which are smaller than those of annual oscil- lation. Although there are differences among different observations because of different locations and different instruments, our results are in general agreement with observation at similar latitude as Beijing. | XIONG JianGang WAN WeiXing NING BaiQi LIU LiBo WU BaoYuan HU LianHuan XU Tao | 2012 | Science China(Technological Sciences)2012，55，5： | 3 |
| 18 | The payloads of planetary physics research onboard China’s First Mars Mission (Tianwen-1)显示文摘Mars is not only our nearby but also the most Earth-like planetary neighbor.Scientific exploration of Mars is thus of crucial value to our understanding of the solar system.The existence of abundant evidence for the former presence of water on Mars demands further exploration for signs of life on our sister planet,and investigations that could shed light on conditions favorable to the origin of life.For nearly 60 years,humans have conducted orbitally-based remote sensing and in-situ surface exploration of Mars,leading to many significant scientific discoveries.But much remains to be done before we can be sure that we truly and fully understand Mars.Key research topics include the history of water on Mars and how that history relates to the planet’s habitable environment-past,present,and future;the distribution and evolution of waterbearing and evaporative salt minerals on the planet’s surface;the history of volcanic activity on Mars;the Martian magnetic field and its effect on the escape of water and atmosphere from the planet;interactions between the solar wind and the Martian atmosphere and ionosphere;atmospheric characteristics and climate change on Mars;and so on(Li CL et al.,2018;Liu JJ et al.,2018).Based on the above scientific questions about life,climate,and geology on Mars,the international planetary science community has formulated ambitious Mars exploration programs. | WeiXing Wan Chi Wang ChunLai Li Yong Wei JianJun Liu | 2020 | Earth and Planetary Physics2020，4，4： | 3 |
| 19 | Recent ionospheric investigations in China(2018–2019)显示文摘Since the release of the 2018 National Report of China on ionospheric research(Liu LB and Wan WX,2018)to the Committee on Space Research(COSPAR),scientists from China's Mainland have made many new fruitful investigations of various ionospheric-related issues.In this update report,we briefly introduce more than 130 recent reports(2018–2019).The current report covers the following topics:ionospheric space weather,ionospheric structures and climatology,ionospheric dynamics and couplings,ionospheric irregularity and scintillation,modeling and data assimilation,and radio wave propagation in the ionosphere and sounding techniques. | LiBo Liu WeiXing Wan | 2020 | Earth and Planetary Physics2020，4，3： | 3 |
| 20 | Trifolirhizin induces autophagy-dependent apoptosis in colon cancer via AMPK/mTOR signaling显示文摘Dear Editor,Colorectal cancer(CRC)is one of the most frequent diseases with high mortality around the world.Conventional treatments of CRC remain unsatisfactory due to the increasing recurrence rate and adverse reactions including neutropenia,drug resistance,etc.Recently,autophagy has been shown to be involved in regulating cancer development and progression by regulating apoptosis through pro-apoptosis proteins including caspases,in addition to being a potential target for cancer therapeutic intervention.1 Trifolirhizin(Supplementary Fig.S1a)is a natural flavonoid glycosides isolated from Sophora flavescens as well as a bioactive constituent of Xian-Lian-Ke-Li,a commercial traditional Chinese medicine for the cancer prevention.Numerous evidence manifested that trifolirhizin inhibited proliferative activity in melanoma B16 cell,lung cancer H23 cell,human ovarian A2780 cell,and human gastric cancer cell MKN45.2 However,its pharmacological effect and mechanism on CRC remain elusive.Herein,we evaluated the effect of trifolirhizin on autophagy and apoptosis on CRC as well as its related mechanisms,in order to provide evidence to develop a potential agent with less adverse effect in treating CRC. | Dongdong Sun Weiwei Tao Feng Zhang Weixing Shen Jiani Tan Liu Li Qinghai Meng Yugen Chen Ye Yang Haibo Cheng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
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