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| 1 | Associations of sense of coherence with psychological distress and quality of life in inflammatory bowel disease显示文摘AIM:To investigate the relationship between sense of coherence,psychological distress and health related quality of life in inflammatory bowel disease(IBD).METHODS:This cross-sectional study enrolled a consecutive sample of 147 IBD(aged 45.1 ± 14.1 years; 57.1% female) patients recruited from a tertiary gastroenterology service.Sixty-four participants met diagnostic criteria for Crohn's disease,while eightythree patients had ulcerative colitis.Socio-demographic data(education,age,race,gender,gross monthly income and marital status),disease-related variables(illness activity,relapse rate in past 2 years,history of surgery and time since diagnosis),sense of coherence(Antonovsky's SOC scale),psychological distress symptoms(Hospital Anxiety and Depression Scale) and health-related quality of life(HRQo L; WHOQOLBref) were assessed.Hierarchical multiple regression analyses were performed to identify factors that are independently associated with psychological distress and HRQo L in patients with IBD and to provide indications for possible moderating or mediating effects.In addition,formal moderation and mediation analyses(Sobel tests) were performed to confirm potential moderators/mediators of the relationship between SOC,psychological distress symptoms and HRQoL.RESULTS:Lower SOC scores(std beta=-0.504; P < 0.001),female gender(std beta = 0.176; P = 0.021) and White race(std beta = 0.164; P = 0.033) were independently associated with higher levels of depressive symptoms,while lower levels of SOC(std beta =-0.438; P < 0.001) and higher relapse rate(std beta = 0.161; P = 0.033) were independently associated with more severe anxiety symptoms.A significant interaction between time since diagnosis and SOC was found with regard to the severity of depressive or anxiety symptoms,as the interaction term(time since diagnosis X SOC) had beta coefficients of-0.191(P = 0.009) and-0.172(P = 0.026),respectively.Lower levels of anxiety symptoms(std beta =-0.369; P < 0.001),higher levels of SOC(std beta = 0.231; P = 0.016) and non-White race(std beta =-0.229; P = 0.006),i.e.,mixed-race,which represented the reference category,were independently associated with higher levels of overall HRQoL.Anxiety symptoms were the most potent independent correlate of most aspects of HRQoL.In addition,anxiety mediated the association between SOC and satisfaction with health,as well as its relationship with physical,mental,and social relations HRQo L.Depressive symptoms also mediated the association between SOC and mental HRQoL.CONCLUSION:Our data indicated that SOC is an important construct,as it influences psychological distress and has significant albeit indirect effects on several HRQoL domains in IBD. | Thiago H Freitas Elias Andreoulakis Gilberto S Alves Hesley LL Miranda Lúcia LBC Braga Thomas Hyphantis André F Carvalho | 2015 | World Journal of Gastroenterology2015，21，21： | 10 |
| 2 | Long-term use of cellular phones and brain tumours: increased risk associated with use for > or =10 years 显示文摘 | Hardell L Carlberg M Soderqvist F Mild KH Morgan LL | 2007 | Occup Environ Med2007，64，9： | 1 |
| 3 | Diet-inducedobesity causes innate airway hyperresponsiveness tomethacholine and enhances ozone-induced pulmonary inflammation显示文摘 | JOHNSTON R A THEMAN T A LL F L | 2008 | Journal o f Applied Physiology2008，104，6： | 1 |
| 4 | Statistical analysis of gone regulatory networks reconstructed from gene expression data of lung cancer显示文摘 | SUNA L F JIANG L LL M H | 2006 | Physica A2006，370，： | 1 |
| 5 | Evaluation of antimicrobial activities of Satureja hortensis L.显示文摘 | F ?ahin ? Karaman M Güllüce H ??üt?ü M ?engül A Ad?güzel S ?ztürk R Kotan | 2003 | Journal of Ethnopharmacology2003，，1： | 1 |
| 6 | Increased cardiac troponin I on admission predicts in-hospital mortality in acute pulmonary embolism 显示文摘 | Vecchia LL Ottani F Favero L | 2004 | Heart2004，90，6： | 1 |
| 7 | Prediction of recovery after abstinence in alcoholic cardiomyopathy: role of hemodynamic and morphometric parameters显示文摘 | Vecchia LL Bedogni F Bozzola L | 1996 | Clin Cardiol1996，19，1： | 1 |
| 8 | Improved interfacial and electrical properties of vanadyl-phthalocyanine metal-insulator-semiconductor devices with silicon nitride as gate insulator 显示文摘 | WANG L J Ll Y P SONG X F et ?i | 2013 | Applied Physics Letters2013，103，24： | 1 |
| 9 | Peritoneal carcinomatosis from ovarian cancer: the role of CT and FDG-PET/CT显示文摘 | Funicelli L Travaini LL Landoni F | 2010 | Abdom Imaging2010，35，6： | 1 |
| 10 | Role of lipids in oste- oporosis 显示文摘 | Parhemi F Garfinkel A Demer LL eta l | | Arterioscler Thromb Vasc Biol0，2，11： | 1 |
| 11 | Association of 1704G/T and G82S polymorphisms in the receptor for advanced glycarion end products gene with diabetic retinopathy in Chinese population显示文摘 | Zhang HM Chen LL Wang L Liao YF Wu ZH Ye F | | 0，，03： | 1 |
| 12 | Increased cardiac troponin Ⅰ on admission predicts in-hospital mortality in acute pulmonary embolism显示文摘 | Vecchia LL Ottani F Favero L | 2004 | Heart2004，90，6： | 1 |
| 13 | Increased cardiac troponin I on admission predicts in-hospital mortality in acute pulmonary embolism显示文摘 | Ottani F Favero L | 2004 | Heart2004，90，6： | 1 |
| 14 | Omega-6fatty acids and risk for cardiovascular disease,a science advisory from the American Heart Association Nutrition Subcommittee of the Council on Nutrition,Physical Activity,and Metabolism,Council on Cardiovascular Nursing,and Council on Epidemiology显示文摘 | Harris WS Mozaffarian D Rimm E Kris-Etherton P Rudel LL Appel L J Engler MM Engler MB Sacks F | | 0，，06： | 1 |
| 15 | A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants 显示文摘 | Scott L J Mohlke KL Bonnycastle LL Wilier CJ Li Y Duren WL Erdos MR Stringham HM Chines PS Jackson AU Prokunina-Olsson L Dingl CJ Swift AJ Narisu N Hu T Pruim R Xiao R Li XY Conneely KN Riebow NL Sprau AG Tong M White PP Hetrick KN Barnhart MW Bark CW Goldstein JL Watkins J Xiang F Saramies J Buchanan TA Watanabe RM Valle TT Kinnunen L Abecasis GR Pugh EW Doheny KF Bergman RN Tuomilehto J Collins FS Boehnke M 2007 | 2007 | Science2007，3161，5829： | 1 |
| 16 | Peritoneal carcinomatosis from ovarian cancer:the role of CT and[18F]FDG-PET/CT显示文摘 | Funicelli L Travaini LL Landoni F | | 0，，： | 1 |
| 17 | Decreased cerebrospinal fluid concentrations of substance P in treatment - resistant depression and lack of alteralion after acute adjunct vagus nerve stimulation therapy显示文摘 | Carpenter LL Bavat L Moteno F | 2008 | Psychiatry Res2008，157，13： | 1 |
| 18 | TGF-β1 suppression of microRNA-450b-5p expression: A novel mechanism for blocking myogenic differentiation of rhabdomyosarcoma显示文摘 | Sun MM Li JF Guo LL JCiao HT Dong L Wang F | 2013 | Oneogene2013，32，10： | 1 |
| 19 | Heterosubtypic neutralizing monoclonal antibodies cross-protective against HSN1 and H1N1 recovered from human IgM memory B cells 显示文摘 | Throsby M van den Brink E Jongeneelen M Poon LL Alard P Cornelissen L Bakker A Cox F van Deventer E Guan Y Cinatl J ter Meulen J Lasters I Carsetti R Peiris M de Kruif J Goudsmit J | 2008 | PLoS One2008，3，12： | 1 |
| 20 | Simulect (Basiliximab) reduces acute cellular rejection in renal allografts from cadaveric and living donors显示文摘 | Mulloy LL Wright F Hall M L | 1999 | Transplantation Proceedings1999，31，： | 1 |
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