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| 1 | Near infrared electrochromism of lutetium phthalocyanine显示文摘 | Zhang Jidong Lu Fanli Huang Haichao | 2005 | Synthetic Met-als2005，148，： | 1 |
| 2 | Crystal structure of SARS-CoV-2 nsp10/nsp162′-O-methylase and its implication on antiviral drug design显示文摘Dear Editor,The unexpected outbreak of a novel human coronavirus infection has imposed great threat to public health.Thus far,this newly-identified virus has spread to 215 countries and territories,infected more than 3.5 million people,and caused over 240,000 deaths worldwide.1 Although intensified countermeasures have been implemented globally to control the virus infection,the pandemic is still surging with a daily increase in infection case of over 65,000 ever since April 1st 2020.1 No prophylactic vaccines or clinical drugs are currently available to prevent or treat the disease,namely coronavirus disease 2019(COVID-19). | Sheng Lin Hua Chen Fei Ye Zimin Chen Fanli Yang Yue Zheng Yu Cao Jingxin Qiao Shengyong Yang Guangwen Lu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 3 | Near infrared electrochromism of lutetium phthalocyanine显示文摘 | Zhang Jidong Lu Fanli Huang Haichao | 2005 | Synthetic Metals2005，148，： | 1 |
| 4 | Columnar Liquid Crystalline Corannulenes: Synthesis, Assembly and Charge-Carrier Transport Properties显示文摘Two discotic liquid crystalline(LC)molecules consisting of a bowl-shaped corannulene core and five-fold photoactive azobenzene branches with differe nt pa raff i nk side chai ns were developed.Their self-assembly,photo-resp on sive behavior and charge-carrier tran sport properties were investigated in detail.A wider mesophase temperature range was achieved when utilizi ng Ion ger and furcal flexible side chai n substituti on.2D XRD measureme nts revealed the n-packed cora nnulen e-ce ntered lb(i.e.,with furcal side alkoxy I chains)exhibited helical columnar LC phase.This packing structure also led to a higher hole charge carrier mobility of 7.07 ×1O^(-2) cm^(2)-V^(-1)s^(-1) compared to that of the counterpart la with linear side chain substitutions. | Yang Li Zunzhi Wang Mengwei Li Feiyi Chen Yang Zhao Qi Wang Fanli Lu Yi Liu Xiang-Kui Ren Long Chen | 2021 | Chinese Journal of Chemistry2021，39，9： | 0 |
| 5 | Ultrathin 2D Covalent Organic Framework Film Fabricated via Langmuir-Blodgett Method with a“Two-in-One”Type Monomer显示文摘In recent years, covalent organic frameworks(COFs) are evolving as a novel kind of porous materials for catalysis and molecular separation, gas adsorption, etc. Various functional building blocks have been explored to tune the pore channels, including the pore size and structures. In this article, a new terphenyl(TP) based COF(TP-COF) was developed via a “two-in-one” strategy by using a symmetric A2B2monomer, i.e., 4,4''-diamino-2',5'-diformyl-1,1':4',1''-terphenyl(DADFTP). The pore size of TP-COF was only 0.99 nm by shortening the arm length of the DADFTP monomer. Freestanding, continuous and ultrathin COF films could be facilely prepared at the air-liquid interface through the modified Langmuir-Blodgett(LB) method. TP-COF films exhibited high rejection of over 90% for dyes removal. | MENG Weijia LI Yang ZHAO Ziqiang SONG Xiaoyu LU Fanli CHEN Long | 2022 | Chemical Research in Chinese Universities2022，38，2： | 0 |
| 6 | S19W,T27W,and N33OY mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis显示文摘SARS-CoV-2 recognizes,via its spike receptor-binding domain(S-RBD),human angiotensin-converting enzyme 2(ACE2)to initiate infection.Ecto-domain protein of ACE2 can therefore function as a decoy.Here we show that mutations of S19W,T27W,and N330Y in ACE2 could individually enhance SARS-CoV-2 S-RBD binding.Y330 could be synergistically combined with either W19 or W27,whereas W19 and W27 are mutually unbeneficial.The structures of SARS-CoV-2S-RBD bound to the ACE2 mutants reveal that the enhan ced binding is mainly con tributed by the van der Waals interactio ns mediated by the aromatic side-chai ns from W19,W27,and Y330.While Y330 and W19/W27 are distantly located and devoid of any steric interference,W19 and W27 are shown to orient their side-chains toward each other and to cause steric conflicts,explai ning their in compatibility.Finally,using pseudotyped SARS-CoV-2 viruses,we dem on strate that these residue substitutions are associated with dramatically improved entry-inhibition efficacy toward both wild-type and antibody-resistant viruses.Taken together,our biochemical and structural data have delineated the basis for the elevated S-RBD binding associated with S19W,T27W,and N330Y mutations in ACE2,paving the way for potential application of these mutants in dinical treatment of COVID-19. | Fei Ye Xi Lin Zimin Che Fanli Yang Sheng Lin Jing Yang Hua Chen Honglu Sun Lingling Wang Ao Wen Xindan Zhang Yushan Dai Yu Cao Jingyun Yang Guobo Shen Li Yang Jiong Li Zhenling Wang Wei Wang Xiawei Wei Guangwen Lu | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 0 |
| 7 | Palmitoleic acid on top of HFD ameliorates insulin resistance independent of diacylglycerols and alters gut microbiota in C57BL/6J mice显示文摘With the prevalence of obesity and obesity-related metabolic syndrome,such as insulin resistance in recent years,it is urgent to explore effective interventions to prevent the progression of obesity-related metabolic syndrome.Palmitoleic acid is a monounsaturated fatty acid that is available from dietary sources,mainly derived from marine products.P almitoleic acid plays a positive role in maintaining glucose homeostasis and reducing inflammation.However,it is still unknow the mechanism of palmitoleic acid in ameliorating insulin resistance.Here,we investigated the effects of palmitoleic acid on chow diet(CD)-fed and high-fat diet(HFD)-fed mice,which were fed CD or HFD for 12 weeks before administration.We administrated mice with BSA(control),oleic acid,or palmitoleic acid for 6 weeks on top of CD or HFD feeding.We found that palmitoleic acid only improved glucose homeostasis in HFD-fed obese mice by increasing glucose clearance and reducing HOMA-IR.Further study explored that palmitoleic acid changed the composition of gut microbiota by decreasing Firmicutes population and increasing Bacteroidetes population.In colon,palmitoleic acid increased intestinal tight junction integrity and reduced inflammation.Moreover,palmitoleic acid decreased macrophage infiltration in liver and adipose tissue and increase glucose uptake in adipose tissue.Diacylglycerol(DAG)in tissue(for example,liver)is found to positively correlated with HOMA-IR.HFD enhanced the levels of DAGs in liver but not in adipose tissue in this study.Palmitoleic acid did not reverse the high DAG levels induced by HFD in liver.Therefore,in HFD-fed mice,palmitoleic acid reduced insulin resistance by an independent-manner of DAGs.It might be associated with the beneficial effects of palmitoleic acid on altering the gut microbiota composition,improving of intestinal barrier function,and downregulating the inflammation in colon,liver,and adipose tissue. | Qijian Liang Yan Zheng Fanli Meng Xiaofan Jiang Qingcai Zhen Zhongting Lu Shixiu Zhang Lei Du Hao Wu Xin Guo | 2024 | Food Science and Human Wellness2024，13，2： | 0 |
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