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| 1 | Agriculture Green Development: a model for China and the world显示文摘Realizing sustainable development has become a global priority.This holds,in particular,for agriculture.Recently,the United Nations launched the Sustainable Development Goals(SDGs),and the Nineteenth National People’s Congress has delivered a national strategy for sustainable development in China—realizing green development.The overall objective of Agriculture Green Development(AGD)is to coordinate'green'with'development'to realize the transformation of current agriculture with high resource consumption and high environmental costs into a green agriculture and countryside with high productivity,high resource use efficiency and low environmental impact.This is a formidable task,requiring joint efforts of government,farmers,industry,educators and researchers.The innovative concept for AGD will focus on reconstructing the whole crop-animal production and food production-consumption system,with the emphasis on high thresholds for environmental standards and food quality as well as enhanced human well-being.This paper addresses the significance,challenges,framework,pathways and potential solutions for realizing AGD in China,and highlights the potential changes that will lead to a more sustainable agriculture in the future.Proposals include interdisciplinary innovations,whole food chain improvement and regional solutions.The implementation of AGD in China will provide important implications for the countries in developmental transition,and contribute to global sustainable development. | Jianbo SHEN Qichao ZHU Xiaoqiang JIAO Hao YING Hongliang WANG Xin WEN Wen XU Tingyu LI Wenfeng CONG Xuejun LIU Yong HOU Zhenling CUI Oene OENEMA William JDAVIES Fusuo ZHANG | 2020 | Frontiers of Agricultural Science and Engineering2020，7，1： | 18 |
| 2 | Finite-time and fixed-time consensus problems for second-order multi-agent systems with reduced state information显示文摘This paper studies the fixed-time consensus(Fix TC) and connectivity-preserving finite-time consensus(Fin TC) protocol designs for second-order multi-agent systems using output information only.Herein, a distributed Fix TC protocol based on the Lyapunov stability and bi-limit homogeneity approaches is proposed with the aid of an auxiliary system. Then, when the graph is state-dependent, i.e., the agents have limited sensing and communication ranges, a connectivity-preserving Fin TC is proposed by designing a mechanism suitable for this purpose. Theoretical analysis and several simulations are presented to verify the effectiveness of the proposed protocols. | Huifen HONG He WANG Zhenling WANG Wenwu YU | 2019 | Science China(Information Sciences)2019，62，11： | 6 |
| 3 | Detection of Variants of B.1.617 Lineage from Five Returning Chinese Nationals at a Guangxi-Vietnam Border Port——Guangxi Zhuang Autonomous Region,China,April 2021显示文摘A 47-year-old male(Patient A)passenger from Vietnam whose nucleic acid results for coronavirus disease 2019(COVID-19),also known as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),were positive at Pingxiang Customs on April 29,2021,and subsequently confirmed by Guangxi CDC laboratories on April 30. | Ning Kang Yinpin Liu Fuyin Bi Jing Wang Huafeng Chen Jing Wang Zhenli Liang Min Chen Guangwu Wei Aiming Li Yonghong Li Bao Lu Zhenling Jiang Yi Tan Ge Zhong Mei Lin Yu Ju | 2021 | China CDC weekly2021，3，30： | 3 |
| 4 | AGRICULTURAL GREEN DEVELOPMENT TO ACHIEVE FOOD SECURITY AND CARBON REDUCTION IN THE CONTEXT OF CHINA'S DUAL CARBON GOALS显示文摘The agricultural sector,a major source of greenhouse gas emissions,and emissions from agriculture must be reduced substantially to achieve carbon(C)neutrality.Based on a literature analysis and other research results,this study investigated the effects and prospects of C reduction in agricultural systems under different scenarios(i.e.,methods and approaches)in the context of China's dual C goals,as those working in the agricultural sector have yet to reach a consensus on how to move forward.Different views,standards,and countermeasures were analyzed to provide a reference for agricultural action supporting China's C neutrality goal. | Yulong YIN Kai HE Zhong CHEN Yangyang LI Fengling REN Zihan WANG Yingcheng WANG Haiqing GONG Qichao ZHU Jianbo SHEN Xuejun LIU Zhenling CUI | 2023 | Frontiers of Agricultural Science and Engineering2023，10，2： | 2 |
| 5 | B cell-derived anti-beta 2 glycoprotein I antibody mediates hyperhomocysteinemia-aggravated hypertensive glomerular lesions by triggering ferroptosis显示文摘Hyperhomocysteinemia(HHcy)is a risk factor for chronic kidney diseases(CKDs)that affects about 85%CKD patients.HHcy stimulates B cells to secrete pathological antibodies,although it is unknown whether this pathway mediates kidney injury.In HHcytreated 2-kidney,1-clip(2K1C)hypertensive murine model,HHcy-activated B cells secreted anti-beta 2 glycoprotein I(β2GPI)antibodies that deposited in glomerular endothelial cells(GECs),exacerbating glomerulosclerosis and reducing renal function.Mechanistically,HHcy 2K1C mice increased phosphatidylethanolamine(PE)(18:0/20:4,18:0/22:6,16:0/20:4)in kidney tissue,as determined by lipidomics.GECs oxidative lipidomics validated the increase of oxidized phospholipids upon Hcy-activated B cells culture medium(Hcy-B CM)treatment,including PE(18:0/20:4+3[O],PE(18:0a/22:4+1[O],PE(18:0/22:4+2[O]and PE(18:0/22:4+3[O]).PE synthases ethanolamine kinase 2(etnk2)and ethanolamine-phosphate cytidylyltransferase 2(pcyt2)were increased in the kidney GECs of HHcy 2K1C mice and facilitated polyunsaturated PE synthesis to act as lipid peroxidation substrates.In HHcy 2K1C mice and Hcy-B CM-treated GECs,the oxidative environment induced by iron accumulation and the insufficient clearance of lipid peroxides caused by transferrin receptor(TFR)elevation and down-regulation of SLC7A11/glutathione peroxidase 4(GPX4)contributed to GECs ferroptosis of the kidneys.In vivo,pharmacological depletion of B cells or inhibition of ferroptosis mitigated the HHcy-aggravated hypertensive renal injury.Consequently,our findings uncovered a novel mechanism by which B cell-derived pathogenic anti-β2GPI IgG generated by HHcy exacerbated hypertensive kidney damage by inducing GECs ferroptosis.Targeting B cells or ferroptosis may be viable therapeutic strategies for ameliorating lipid peroxidative renal injury in HHcy patients with hypertensive nephropathy. | Xing Du Xiaolong Ma Ying Tan Fangyu Shao Chun Li Yang Zhao Yutong Miao Lulu Han Guohui Dang Yuwei Song Dongmin Yang Zhenling Deng Yue Wang Changtao Jiang Wei Kong Juan Feng Xian Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 2 |
| 6 | ONE-STEP LEACHING OF SOME REFRACTORY GOLD CONCENTRATECONTAINING ARSENIC AND THEORY ANALYSIS显示文摘A new technology of one-step leaching of refractory gold concentrate containing arsenic and sulfur was studied and 96. 8% of gold was extracted in an hour by this technology. Themodynamic possibility of reactions of arsenopyrite. pyrite and gold with sodium hypochlorite in NaOH medium, and solution chemistry of H3AuO3 at different pH values were analyzed. The reason why the gold wrapped by FeAsS, FeS2 can be leached out rapidly by grnding of porcelain ball mill. is explained. | Mao Anzhang Qiu Guanzhou Deng Zhenling Shi Xichang Xu Jing (Department of Mineral Engineering, Central South University of Technology. Changsha 410083, China)Wang Dianzuo (Beijing General Research Institute for Nonferrous Metals, Beijing 100088) | 1997 | Journal of Central South University1997，9，2： | 2 |
| 7 | Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells显示文摘Neutrophil extracellular traps(NETs)can capture and kill viruses,such as influenza viruses,human immunodeficiency virus(HIV),and respiratory syncytial virus(RSV),thus contributing to host defense.Contrary to our expectation,we show here that the histones released by NETosis enhance the infectivity of SARS-CoV-2,as found by using live SARS-CoV-2 and two pseudovirus systems as well as a mouse model.The histone H3 or H4 selectively binds to subunit 2 of the spike(S)protein,as shown by a biochemical binding assay,surface plasmon resonance and binding energy calculation as well as the construction of a mutant S protein by replacing four acidic amino acids.Sialic acid on the host cell surface is the key molecule to which histones bridge subunit 2 of the S protein.Moreover,histones enhance cell-cell fusion.Finally,treatment with an inhibitor of NETosis,histone H3 or H4,or sialic acid notably affected the levels of sgRNA copies and the number of apoptotic cells in a mouse model.These findings suggest that SARS-CoV-2 could hijack histones from neutrophil NETosis to promote its host cell attachment and entry process and may be important in exploring pathogenesis and possible strategies to develop new effective therapies for COVID-19. | Weiqi Hong Jingyun Yang Jun Zou Zhenfei Bi Cai He Hong Lei Xuemei He Xue Li Aqu Alu Wenyan Ren Zeng Wang Xiaohua Jiang Kunhong Zhong Guowen Jia Yun Yang Wenhai Yu Qing Huang Mengli Yang Yanan Zhou Yuan Zhao Dexuan Kuang Junbin Wang Haixuan Wang Siyuan Chen Min Luo Ziqi Zhang Tiangi Lu Li Chen Haiying Que Zhiyao He Qiu Sun Wei Wang Guobo Shen Guangwen Lu Zhiwei Zhao Li Yang Jinliang Yang Zhenling Wang Jiong Li Xiangrong Song Lunzhi Dai Chong Chen Jia Geng Maling Gou Lu Chen Haohao Dong Yong Peng Canhua Huang Zhiyong Qian Wei Cheng Changfa Fan Yuquan Wei Zhaoming Su Aiping Tong Shuaiyao Lu Xiaozhong Peng Xiawei Wei | 2022 | Cellular & Molecular Immunology2022，19，5： | 2 |
| 8 | Long-term exposure to imatinib reduced cancer stem cell ability through induction of cell differentiation via activation of MAPK signaling in glioblastoma cells显示文摘 | Yucui Dong Qinglian Han Yan Zou Zhenling Deng Xinliang Lu Xiaohua Wang Weihua Zhang Hua Jin Jun Su Tao Jiang Huan Ren | 2012 | Molecular and Cellular Biochemistry2012，，1： | 2 |
| 9 | Non-equilibrium microstructure and the metastable phase of Al-9.6wt%Mg Alloy solidification under high pressure显示文摘The non-equilibrium microstructure and a new metastable phase of Al-9.6wt%Mg alloy solidified at 6 GPa were studied by optical microscope,differential scanning calorimetry,X-ray diffraction and transmission electron microscope.The results showed that dendrite microstructure was refined,and the solid solubility of Mg in α-Al phase increased greatly.Correspondingly,the lattice parameter of α-Al phase increased.Al3Mg2 phases disappeared under high pressure solidification.In particular,a metastable phase with small size(20 nm or so) was produced in the alloy,its melting temperature range was 464~518.2 ℃,which was higher than that of Al3Mg2 phase(453~465 ℃) under normal pressure.These metastable phases located in the interdendritic position.It was the first time that the metastable phase was found in Al-Mg alloy at a high pressure of 6 GPa.The formation mechanism of the metastable phases was discussed. | WEI Zunjie,WANG Zhenling,WANG Hongwei,ZHU Zhaojun,CAO Lei,and LI Zhiwei School of Materials Science and Engineering,Harbin Institute of Technology,Harbin 150001,China | 2007 | Rare Metals2007，26，S1： | 2 |
| 10 | Low levels of neutralizing antibodies against XBB Omicron subvariants after BA.5 infection显示文摘The COVID-19 response strategies in Chinese mainland were recently adjusted due to the reduced pathogenicity and enhanced infectivity of Omicron subvariants.In Chengdu,China,an infection wave was predominantly induced by the BA.5 subvariant.It is crucial to determine whether the hybrid anti-SARS-CoV-2 immunity following BA.5 infection. | Jingyun Yang Weiqi Hong Hong Lei Cai He Wenwen Lei Yanan Zhou Tingmei Zhao Aqu Alu Xuelei Ma Jiong Li Li Yang Zhenling Wang Wei Wang Guangwen Lu Guobo Shen Shuaiyao Lu Guizhen Wu Huashan Shi Xiawei Wei | 2023 | Signal Transduction and Targeted Therapy2023，8，7： | 1 |
| 11 | Preparation of TiO2 nsnocrystaltites by hydrolyzing with gaseous water and their photocatalytic activity显示文摘 | Mao Liqun Lin Jun | 2006 | Journal of Photochemistry and Photobiology:A Chemistry2006，177，23： | 1 |
| 12 | Growth of highlycrystalline CaMoO4:Tb3+phosphor layers on spherical SiO2 particlesvia sol–gel process:structural characterization and luminescent proper-ties显示文摘 | LI Guangzhi WANG Zhenling QUAN Zewei | 2007 | Cryst Growth Des2007，7，17： | 1 |
| 13 | Depletion of phosphatidyl-glycerol head-group induces changes in oxygen evolution and protein secondary structures of photosystem Ⅱ显示文摘The techniques of oxygen electrode polarogra-phy and Fourier transform infrared (FT-IR) spectroscopy were employed to explore the roles of polar head-group of phosphatidylglycerol (PG) molecules in the functional and structural aspects of photosystem Ⅱ (PS Ⅱ) through enzymatic approach. It was shown that the depletion of PG by treatment of phospholipase C (PLC) on PS Ⅱ particles caused the inhibition of oxygen evolving activity in PS Ⅱ. This effect also gave rise to changes in the protein secondary structures of PS Ⅱ, that is, an increase in a-helical conformation which is compensated by the loss of p-strand structures. It revealed that the head-group of PG molecules plays an important structural role in the maintenance of normal structure of PS Ⅱ proteins, which is required to maintain the appropriate physiological activity of the PS Ⅱ complex such as the oxygen evolving activity. It is suggested that there most probably exist hydrogen-bonding interactions between PG molecules and PS Ⅱ proteins. | YANG Zhenle, WANG Zeneng, JIANG Guizhen, XU Yinong, LI Liangbi & KUANG TingyunPhotosynthesis Research Center, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China | 2002 | Chinese Science Bulletin2002，47，10： | 1 |
| 14 | Urea method for the synthesis of hydrotalcites显示文摘 | Piaoping Yang Jianfeng Yu Zhenlü Wang Qingsheng Liu Tonghao Wu | 2004 | Reaction Kinetics and Catalysis Letters2004，，2： | 1 |
| 15 | Controllable synthesis of Eu3+ ions doped Zn(OH)F and ZnO micro-structures:Phase,morphology and luminescence property显示文摘Eu3+ions doped Zn(OH)F and ZnO micro-structures with specific morphologies were synthesized by a simple hydrothermal method only through altering the addition amount of NH4F and hexamethylenetetramine(HMT).The phase structure,morphology and luminescence properties of the as-prepared samples were characterized by X-ray powder diffraction(XRD),scanning electron microscopy(SEM),transmission electron microscopy(TEM),photoluminescence(PL)spectra and lifetime.The results indicate that the obtained Zn(OH)F:Eu^3+samples possess net-like and dandelion-like morphologies,which have an identical orthorhombic phase structure.It is found that the addition amount of raw materials such as NH4F and HMT plays a critical role for the formation of Zn(OH)F:Eu^3+.If the addition amounts of NH4F or HMT are reduced by half,the hexagonal ZnO:Eu^3+sample with peanut-like morphology can be obtained.Under the excitation of UV light,both the as-prepared Zn(OH)F:Eu^3+and ZnO:Eu^3+samples exhibit the characteristic emission of the doped Eu^3+. | Zhiyuan Chen Jingbin Huang Yanyan Wang Dan Yue Zhenling Wang Jingyang Niu | 2019 | Journal of Rare Earths2019，37，9： | 1 |
| 16 | Cell deaths:Involvement in the pathogenesis and intervention therapy of COVID-19显示文摘The current pandemic of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARSCoV-2)infection has dramatically influenced various aspects of the world.It is urgent to thoroughly study pathology and underlying mechanisms for developing effective strategies to prevent and treat this threatening disease.It is universally acknowledged that cell death and cell autophagy are essential and crucial to maintaining host homeostasis and participating in disease pathogenesis.At present,more than twenty different types of cell death have been discovered,some parts of which have been fully understood,whereas some of which need more investigation.Increasing studies have indicated that cell death and cell autophagy caused by coronavirus might play an important role in virus infection and pathogenicity.However,the knowledge of the interactions and related mechanisms of SARS-CoV-2 between cell death and cell autophagy lacks systematic elucidation.Therefore,in this review,we comprehensively delineate how SARS-CoV-2 manipulates diverse cell death(including apoptosis,necroptosis,pyroptosis,ferroptosis,and NETosis)and cell autophagy for itself benefits,which is simultaneously involved in the occurrence and progression of COVID-19,aiming to provide a reasonable basis for the existing interventions and further development of novel therapies. | Xue Li Ziqi Zhang Zhenling Wang Pedro Gutiérrez-Castrellón Huashan Shi | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 1 |
| 17 | Polyol-Mediated Synthesis and Photoluminescent Properties of LaPO_4∶Eu ^( 3+) Nanoparticles显示文摘Eu 3+-doped LaPO4 nanoparticles were prepared by polyol method and characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), thermogravimetry-differential thermal analysis (TG-DTA), Uv-vis diffuse reflectance spectra (DRS), photoluminescence (PL) spectra and lifetime measurement. The results of XRD indicate that the as-prepared nanoparticles are crystallized well at 160 ℃ and assigned to the monoclinic monazite-structure of LaPO4 phase. The obtained LaPO4∶Eu 3+ nanoparticles are spherical with narrow size distribution and the average size of 25 nm. Upon excitation into the Eu 3+ at 258 nm, the emission spectrum of LaPO4∶Eu 3+ nanoparticles is composed of 5D0-7FJ (J=1, 2, 3, 4) emission lines of Eu 3+, with the magnetic-dipole transition 5D0-7F1 (592 nm) being the most prominent group. This is characterized by orange-red emission. The optimum doping concentration of Eu 3+ is 5%(molar fraction) of the La 3+ concentration in the LaPO4∶Eu 3+ nanoparticles. The luminescence decay curve of LaPO4∶Eu 3+ nanoparticles shows single-exponential behavior, and the lifetime (τ) of Eu 3+ is about 3.9 ms. | Wang Zhenling Qiao Ziwen Quan Zewei Lin Jun | 2006 | Journal of Rare Earths2006，24，3： | 1 |
| 18 | HnRNP A2/ B1 promotes stem cell differentiation into smooth muscle cell in vitro and embryonic artery angiogenesis显示文摘 | Gang Wang Qingzhong Xiao Zhenling Luo | 2012 | J Biol Chem2012，287，4： | 1 |
| 19 | Intranasal administration of a recombinant RBD vaccine induces long-term immunity against Omicron-included SARS-CoV-2 variants显示文摘The outbreak of coronavirus disease 2019(COVID-19)has posed great threats to global health and economy.Several effective vaccines are available now,but additional booster immunization is required to retain or increase the immune responses owing to waning immunity and the emergency of new variant strains.The deficiency of intramuscularly delivered vaccines to induce mucosal immunity urged the development of mucosal vaccines.Here,we developed an adjuvanted intranasal RBD vaccine and monitored its long-term immunogenicity against both wild-type and mutant strains of severe acute respiratory syndrome coronavirus-2(SARSCoV-2),including Omicron variants,in mice.Three-dose intranasal immunization with this vaccine induced and maintained high levels of neutralizing IgG antibodies in the sera for at least 1 year.Strong mucosal immunity was also provoked,including mucosal secretory IgA and lung-resident memory T cells(TRM).We also demonstrated that the long-term persistence of lung TRM cells is a consequence of local T-cell proliferation,rather than T-cell migration from lymph nodes.Our data suggested that the adjuvanted intranasal RBD vaccine is a promising vaccine candidate to establish robust,long-lasting,and broad protective immunity against SARS-CoV-2 both systemically and locally. | Hong Lei Aqu Alu Jingyun Yang Wenyan Ren Cai He Tianxia Lan Xuemei He Li Yang Jiong Li Zhenling Wang Xiangrong Song Wei Wang Guangwen Lu Xiawei Wei | 2022 | Signal Transduction and Targeted Therapy2022，7，6： | 1 |
| 20 | Fabrication and optical properties of core-shell structured spherical SiO2 @GdVO4:Eu3+ phosphors via sol-gel process显示文摘 | Li Guangzhi Wang Zhenling Yu Min | 2006 | J Solid State Chem2006，179，8： | 1 |
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