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| 1 | Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility显示文摘Premature ovarian failure(POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study,umbilical cord mesenchymal stem cells on a collagen scaffold(collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3 a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF. | Lijun Ding Guijun Yan Bin Wang Lu Xu Yan Gu Tong Ru Xiaoying Cui Lei Lei Jingyu Liu Xiaoqiang Sheng Bin Wang Chunxue Zhang Yanjun Yang Ruiwei Jiang Jianjun Zhou Na Kong Feifei Lu Huaijun Zhou Yannan Zhao Bing Chen Yali Hu Jianwu Dai Haixiang Sun | 2018 | Science China(Life Sciences)2018，61，12： | 43 |
| 2 | Transplantation of collagen scaffold with autologous bone marrow mononuclear cells promotes functional endometrium reconstruction via downregulating ΔNp63 expression in Asherman's syndrome显示文摘Asherman's syndrome(AS) is a common disease that presents endometrial regeneration disorder. However, little is known about its molecular features of this aregenerative endometrium in AS and how to reconstruct the functioning endometrium for the patients with AS. Here, we report that ΔNp63 is significantly upregulated in residual epithelial cells of the impaired endometrium in AS; the upregulated-ΔNp63 induces endometrial quiescence and alteration of stemness. Importantly, we demonstrate that engrafting high density of autologous bone marrow mononuclear cells(BMNCs) loaded in collagen scaffold onto the uterine lining of patients with AS downregulates ΔNp63 expression, reverses ΔNp63-induced pathological changes, normalizes the stemness alterations and restores endometrial regeneration. Finally, five patients achieved successful pregnancies and live births. Therefore, we conclude that ΔNp63 is a crucial therapeutic target for AS. This novel treatment significantly improves the outcome for the patients with severe AS. | Guangfeng Zhao Yun Cao Xianghong Zhu Xiaoqiu Tang Lijun Ding Haixiang Sun Juan Li Xinan Li Chenyan Dai Tong Ru Hui Zhu Jingjie Lu Caimei Lin Jingmei Wang Guijun Yan Huiyan Wang Lei Wang Yimin Dai Bin Wang Ruotian Li Jianwu Dai Yan Zhou Yali Hu | 2017 | Science China(Life Sciences)2017，60，4： | 39 |
| 3 | PIKA as an Adjuvant Enhances Specific Humoral and Cellular Immune Responses Following the Vaccination of Mice with HBsAg plus PIKA显示文摘An adjuvant is usually used to enhance the immune response induced by vaccines. The choice of adjuvant or immune enhancer determines the effectiveness of the immune response. Currently, aluminium (Alum, a generic term for salts of aluminium) is the only FDA-approved adjuvant. Alum predominantly induces the differentiation of Th2 cells and thus mediates an antibody immune response. Therefore, there is an urgent need for new adjuvants that enhance not only humoral but also cellular immune responses. In the present study, we demonstrates that PIKA (a stabilized dsRNA) as an adjuvant directly induces the activation and the proliferation of both B and NK cells in vitro. Injection of PIKA into mice results in the production of cytokines in vivo. In addition, the study demonstrates that PIKA promotes the maturation of bone marrow-derived dendritic cells (BMDCs) including up-regulation of the co-stimulatory molecules CD80, CD86 and CD40, and the induction of cytokines such as IL-12p70, IL-12p40 and IL-6. Importantly, after immunization of mice with HBsAg plus PIKA, the presence of PIKA enhances the titers of HBsAg-specific IgG and HBsAg-specific IFN-γ production. These results demonstrate that PIKA as an adjuvant can promote both humoral and cellular immune responses. These might have an implication in applying PIKA as an adjuvant to be used in the design and development of both therapeutic and preventive vaccines, and used in the clinical study. | Erxia Shen Li Li Lietao Li Lianqiang Feng Lin Lu Ziliang Yao Haixiang Lin Changyou Wu | 2007 | Cellular & Molecular Immunology2007，4，2： | 13 |
| 4 | Experimental Wave Attenuation Study over Flexible Plants on a Submerged Slope显示文摘Using plants is a kind of environmentally-friendly coastal protection to attenuate wave energy. In this paper, a set of experiments were conducted to investigate the wave attenuation performance using flexible grasses on a submerged slope, and the wave attenuation coefficient for these experiments was calculated for different still water depths, slope and grass configurations. It was found that the slope plays a significant role in wave attenuation. The wave attenuation coefficient increases with increasing relative row number and relative density. For a small relative row number, the two configurations from the slope top to its toe and from the slope toe to its top performed equally to a large extent. For a medium relative row number, the configuration from the slope toe to its top performed more poorly than that from the slope top to its toe; however, it performed better than that from the slope top to its toe for a high relative row number. With a single row of grasses close to the slope top from the slope toe, the wave attenuation coefficient shows double peaks. With increasing grass rows or still water depth, the grass location corresponding to the maximum wave attenuation coefficient is close to the slope top. The dimensional analysis and the least square method were used to derive an empirical equation of the wave attenuation coefficient considering the effect of relative density, the slope, the relative row number and the relative location of the middle row, and the equation was validated to experimental data. | YIN Zegao YANG Xiaoyu XU Yuanzhao DING Meiling LU Haixiang | 2017 | Journal of Ocean University of China2017，16，6： | 1 |
| 5 | One-pot synthesis of carbonaceous monolith with surface sulfonic groups and its carbonization/activation显示文摘 | Weili Zhang Haixiang Tao Baohua Zhang Jiawen Ren Guanzhong Lu Yanqin Wang | 2010 | Carbon2010，，6： | 1 |
| 6 | Magnetic retrieval of ionic liquids: Fast dispersive liquid–liquid microextraction for the determination of benzoylurea insecticides in environmental water samples显示文摘 | Jiaheng Zhang Min Li Miyi Yang Bing Peng Yubo Li Wenfeng Zhou Haixiang Gao Runhua Lu | 2012 | Journal of Chromatography A2012，，： | 1 |
| 7 | USE OF IONIC LIQUID-BASED DISPERSIVE LIQUID–LIQUID MICROEXTRACTION AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY TO DETECT FORMALDEHYDE IN AIR, WATER, AND SOIL SAMPLES显示文摘 | Bing Peng Jiaheng Zhang Chenghao Wu Songqing Li Yubo Li Haixiang Gao Runhua Lu Wenfeng Zhou | 2014 | Journal of Liquid Chromatography & Related Technologies2014，，6： | 1 |
| 8 | Umbilical cord artery-derived perivascular stem cells for treatment of ovarian failure through CD146 signaling显示文摘Dear Editor,Chemotherapy-induced ovarian failure significantly diminishes ovarian blood flow,ovarian size,and follicular development.Angiogenesis plays a vital role in repairing ovarian damage.1 Perivascular stem cells(PSCs),known as mural cells covering the vasculature,are essential for blood vessel formation and postulated as progenitors of mesenchymal stem cells(MSCs).2,3 We previously established umbilical cord artery-derived PSCs(UCA-PSCs)and Wharton’s jelly-derived MSCs(WJ-MSCs)and UCAPSCs display optimal angiogenic capacity in vitro.4 Therefore,we explored the angiogenesis and pro-angiogenesis mechanisms of UCA-PSCs and provided them as an efficient treatment strategy for ovarian failure. | Lu Xu Yanjun Yang Lingling Zhang Guijun Yan Shiyuan Li Yifan Li Yali Hu Lijun Ding Bruno Péault Haixiang Sun | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 0 |
| 9 | In-situ-reduced synthesis of cyano group modified g-C_(3)N_(4)/CaCO_(3) composite with highly enhanced photocatalytic activity for nicotine elimination显示文摘Graphite carbon nitride has many excellent properties as a two-dimensional semiconductor material so that it has a wide application prospect in the field of photocatalysis.However,the traditional problems such as high recombination rate of photogenerated carriers limit its application.In this work,we introduce nitrogen deficiency into g-C_(3)N_(4)to solve this problem a simple and safe in-situ reduction method.g-C_(3)N_(4)/CaCO_(3)was obtained by a simple and safe one-step calcination method with industrial-grade micron particles CaCO_(3).Cyano group modification was in-situ reduced during the thermal polymerization process,which would change the internal electronic structure of g-C_(3)N_(4).The successful combination of g-C_(3)N_(4)and CaCO_(3)and the introduction of cyanide have been proved by Fourier transform infrared spectroscopy and X-ray photoelectron spectrometer.The formation of the cyano group,an electron-absorbing group,promotes the effective separation of photogenic electron hole pairs and inhibits the recombination of photogenic carriers.These advantages result in the generation of more·O_(2)-and1O_(2)in the catalytic system,which increases the photocatalytic efficiency of nicotine degradation by ten times.Furthermore,the degradation process of nicotine has been studied in this work to provide a basis for the degradation of nicotine organic pollutants in the air. | Chenxiao Qi Haixiang Chen Xiufang Chen Chengyu Chu Xueting Mei Wangyang Lu Nan Li | 2023 | Journal of Environmental Sciences2023，，4： | 0 |
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