|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Characterization of drug responses of mini patient-derived xenografts in mice for predicting cancer patient clinical therapeutic response显示文摘Background:Patient-derived organoids and xenografts(PDXs)have emerged as powerful models in functional diag-nostics with high predictive power for anticancer drug response.However,limitations such as engraftment failure and time-consuming for establishing and expanding PDX models followed by testing drug efficacy,and inability to subject to systemic drug administration for ex vivo organoid culture hinder realistic and fast decision-making in selecting the right therapeutics in the clinic.The present study aimed to develop an advanced PDX model,namely MiniPDX,for rapidly testing drug efficacy to strengthen its value in personalized cancer treatment.Methods:We developed a rapid in vivo drug sensitivity assay,OncoVee®MiniPDX,for screening clinically relevant regimens for cancer.In this model,patient-derived tumor cells were arrayed within hollow fiber capsules,implanted subcutaneously into mice and cultured for 7 days.The cellular activity morphology and pharmacokinetics were systematically evaluated.MiniPDX performance(sensitivity,specificity,positive and negative predictive values)was examined using PDX as the reference.Drug responses were examined by tumor cell growth inhibition rate and tumor growth inhibition rate in PDX models and MiniPDX assays respectively.The results from MiniPDX were also used to evaluate its predictive power for clinical outcomes.Results:Morphological and histopathological features of tumor cells within the MiniPDX capsules matched those both in PDX models and in original tumors.Drug responses in the PDX tumor graft assays correlated well with those in the corresponding MiniPDX assays using 26 PDX models generated from patients,including 14 gastric cancer,10 lung cancer and 2 pancreatic cancer.The positive predictive value of MiniPDX was 92%,and the negative predictive value was 81%with a sensitivity of 80%and a specificity of 93%.Through expanding to clinical tumor samples,Min-iPDX assay showed potential of wide clinical application.Conclusions:Fast in vivo MiniPDX assay based on capsule implantation was developed-to assess drug responses of both PDX tumor grafts and clinical cancer specimens.The high correlation between drug responses of paired MiniPDX and PDX tumor graft assay,as well as translational data suggest that MiniPDX assay is an advanced tool for personalized cancer treatment. | Feifei Zhang Wenjie Wang Yuan Long Hui Liu Jijun Cheng Lin Guo Rongyu Li Chao Meng Shan Yu Qingchuan Zhao Shun Lu Lili Wang Haitao Wang Danyi Wen | 2018 | Cancer Communications2018，38，1： | 20 |
| 2 | MCP-1-induced ERK/GSK-3β/Snail signaling facilitates the epithelial-mesenchymal transition and promotes the migration of MCF-7 human breast carcinoma cells显示文摘Monocyte chemoattractant protein-1(MCP-1)is a chemotactic cytokine that can bind to its receptor cysteine-cysteine chemokine receptor 2(CCR2)and plays an important role in breast cancer cell metastasis.However,the molecular mechanisms underlying MCP-1-induced alterations in cellular functions during tumor progression are poorly understood.Here,we showed that MCP-1 stimulated the epithelial-mesenchymal transition(EMT)and induced the tumorigenesis of breast cancer cells by downregulating E-cadherin,upregulating vimentin and fibronectin,activating matrix metallopeptidase-2(MMP-2),and promoting migration and invasion.Moreover,MCP-1 treatment reduced glycogen synthase kinase-3β(GSK-3β)activity via the MEK/ERK-mediated phosphorylation of serine-9 in MCF-7 cells.The inhibition of MEK/ERK by U0126 attenuated the MCP-1-induced phosphorylation of GSK-3βand decreased the expression of Snail,an EMT-related transcription factor,leading to the inhibition of MCF-7 cell migration and invasion.Inactivation of GSK-3βby LiCl(lithium chloride)treatment notably increased MMP-2 activity,vascular endothelial growth factor expression and EMT of MCF-7 cells.These findings revealed that MCP-1-induced EMT and migration are mediated by the ERK/GSK-3β/Snail pathway,and identified a potential novel target for therapeutic intervention in breast cancer. | Shun Li Juan Lu Yu Chen Niya Xiong Li Li Jing Zhang Hong Yang Chunhui Wu Hongjuan Zeng Yiyao Liu | 2017 | Cellular & Molecular Immunology2017，14，7： | 14 |
| 3 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 4 | Clinical value of serum CA19-9 levels in evaluating resectability of pancreatic carcinoma显示文摘AIM:To evaluate the clinical value of serum CA19-9 levels in predicting the respectability of pancreatic carcinoma according to receiver operating characteristic(ROC) curve analysis. METHODS:Serum CA19-9 levels were measured in 104 patients with pancreatic cancer which were possible to be resected according to the imaging. ROC curve was plotted for the CA19-9 levels. The point closest to the upper left-hand corner of the graph were chosen as the cut-off point. The sensitivity,specificity,positive and negative predictive values of CA19-9 at this cut-off point were calculated. RESULTS:Resectable pancreatic cancer was detected in 58(55.77%) patients and unresectable pancreatic cancer was detected in 46(44.23%) patients. The area under the ROC curve was 0.918 and 95% CI was 0.843-0.992. The CA19-9 level was 353.15 U/mL,and the sensitivity and specificity of CA19-9 at this cut-off point were 93.1% and 78.3%,respectively. The positive and negative predictive value was 84.38% and 90%,respectively. CONCLUSION:Preoperative serum CA19-9 level is a useful marker for further evaluating the resectability of pancreatic cancer. Obviously increased serum levels of CA19-9(> 353.15 U/mL) can be regarded as an ancillary parameter for unresectable pancreatic cancer. | Shun Zhang Yi-Ming Wang Chuan-Dong Sun Yun Lu Li-Qun Wu | 2008 | World Journal of Gastroenterology2008，14，23： | 13 |
| 5 | Facile,Noncovalent Decoration of Graphene Oxide Sheets with Nanocrystals显示文摘Facile dry decoration of graphene oxide sheets with aerosol Ag nanocrystals synthesized from an arc plasma source has been demonstrated using an electrostatic force directed assembly technique at room temperature.The Ag nanocrystal-graphene oxide hybrid structure was characterized by transmission electron microscopy(TEM)and selected area diffraction.The ripening of Ag nanocrystals on a graphene oxide sheet was studied by consecutive TEM imaging of the same region on a sample after heating in Ar at elevated temperatures of 100°C,200°C,and 300°C.The average size of Ag nanocrystals increased and the number density decreased after the annealing process.In particular,migration and coalescence of Ag nanocrystals were observed at a temperature as low as 100°C,suggesting a van der Waals interaction between the Ag nanocrystal and the graphene oxide sheet.The availability of affordable graphene-nanocrystal structures and their fundamental properties will open up new opportunities for nanoscience and nanotechnology and accelerate their applications. | Ganhua Lu Shun Mao Sungjin Park Rodney S.Ruoff Junhong Chen | 2009 | Nano Research2009，2，3： | 13 |
| 6 | Pemetrexed monotherapy versus pemetrexed plus platinum combination as second-line treatment for advanced non-small cell lung cancer显示文摘背景 Pemetrexed 是有多重目标的一个新奇 folic 酸对手,它广泛地在非小的房间肺癌症(NSCLC ) 的治疗被使用了。这研究的目的是在加一个铂联合代理人与 pemetrexed monotherapy 对 pemetrexed 对待的 NSCLC 病人比较效果和毒性,以便为标准第二线的化疗提供一个基础。从 2006 年 8 月进入上海胸医院到 2008 年 10 月的有 NSCLC 的 52 个病人的临床的数据回顾地被分析的方法。52 个病人中的十个收到了 pemetrexed monotherapy,并且另外的 42 个病人加铂政体收到了 pemetrexed。主要结束点是全面幸存(OS ) 。没有前进的幸存时间(PFS ) 被分析,效果和毒性被估计。幸存分析被 Kaplan-Meier 方法评估。单个因素分析和 COX 回归模型被做分析在有影响的因素和疾病的预后之间的关系。老病人(> 60 岁) 作为亚群独立被分析。结果 OS 的没有统计上重要的增加(X^2=0.09, P=0.76 ) , PFS (X^2=0.15, P=0.70 ) ,疾病控制率(DCR )(X^2=0.06, P=-0.81 ) 或 1 年的幸存率(X^2=0.33, P=-0.57 ) 在二政体之间被发现。单个因素分析证明包括外科历史,在治疗前的 PS 分数,临床的阶段,和对第二线的治疗的反应的因素影响了 NSCLC 的预后(所有 P < 0.05 ) 。在治疗(P=0.043 ) 可以与幸存被联系以前,艇长回归分析表明了那外科历史(P=0.041 ) 和表演地位(PS ) 分数。二政体的毒性是类似的。在老病人的亚群,在 OS 0 的没有重要差别(2=0.01, P=0.94 ) , PFS (X^2=0.14, P=0.70 ) , DCR (X^2=0.004, P=-0.95 ) ,或 1 年的幸存率(X^2=0.03, P=0.87 ) 在二政体之间被发现。联合治疗的毒性以 hematologic 是显著地更高的(X^2=9.95, P=-0.01 ) 并且胃肠的不利事件(X^2=7.66, P=0.03 ) 在那里的 .Conclusiona 不是在在这二政体之间的幸存或副作用的重要差别。为老病人(60 ) , pemetrexed monotherapy 看类似的功效和更好的安全侧面是否与 pemetrexed 相比联合治疗。 | ZHANG Yi-fei CHEN Zhi-wei LU Shun | 2009 | Chinese Medical Journal2009，，20： | 12 |
| 7 | Predominant expression of Th1-type cytokines in primary hepatic cancer and adjacent liver tissues显示文摘BACKGROUND: Research has revealed a shift towards Th2 in many types of malignant tumor, but the state of Th1/Th2 is not clear in patients with primary hepatic cancer (PHC). This study was designed to determine the expression of Th1- versus Th2-type cytokines in primary hepatic cancer and the adjacent liver tissue in order to provide evidence for treatment of the Th1/Th2 shift. METHODS: Samples were collected from 11 patients with PHC. The gene expression of Th1/Th2 cytokines was detected by reverse transcriptase polymerase chain reaction (RT-PCR) using IFN-γ and IL-2 as Th1-type cytokine genes, and IL-4 and IL-10 as Th2-type cytokine genes. RESULTS: Th1-type cytokines were expressed in 7/11 PHCs and 9/11 adjacent liver tissues, while Th0 type cytokines occurred in 4/11 PHCs and 2/11 adjacent liver tissues. CONCLUSION: Th1-type cytokines are expressed predominantly in primary hepatic cancer and the adjacent liver tissue. | Qiu, Fa-Bo Wu, Li-Qun Lu, Yun Zhang, Shun Zhang, Bing-Yuan | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，1： | 10 |
| 8 | Erlotinib as a salvage treatment for patients with advanced non-small cell lung cancer after failure of gefitinib treatment显示文摘背景几临床的试用证明 erlotinib 在在先进非小的房间肺癌症(NSCLC ) 的 gefitinib 的失败以后是有效的。这研究的目的是从我们的医院基于数据在 gefitinib 的失败以后评估 erlotinib 治疗的可行性。从 2007 年 8 月进入上海胸医院到 2008 年 12 月的有先进 NSCLC 的 20 个病人的临床的数据回顾地被分析的方法。所有在 gefitinib 的失败以后病人被给 erlotinib 治疗。幸存分析被 Kaplan-Meier 方法做。艇长回归模型被执行分析在有影响的因素和 erlotinib 之间的关系没有前进的幸存(PFS ) 。结果五个病人有部分回答(PR ) ,九个病人有稳定的疾病(SD ) ,六个病人与 gefitinib 治疗有进步疾病(PD ) 。中部的 PFS 是 277 天(95% C/0-566 ) 。没有病人与 erlotinib 治疗有 PR,七有的 SD 和十四 PD。中部的 PFS 是 31 天(95% Cl 9.1-52.9 ) 。反应率(RR ) 是 0,并且疾病控制率(DCR ) 是 35%(7/20 ) 。考克斯回归分析表明了那性(P=0.96 ) ,年龄(P=0.89 ) ,吸烟历史(P=0.78 ) ,表演地位(PS )(P=0.98 ) , gefitinib 功效(P=0.90 ) 并且化疗是否用二药(P=0.45 ) 被使用在之间,没与 erlotinib PFS 有重要关联。十五个病人有因素受体(EGFR ) 变化地位决定了的表皮的生长。有五个盒子有在十个变化的 erlotinib 治疗的得到的 SD 否定(野类型) 病人。没有 SD 在五个变化被记录积极病人。在 gefitinib 失败以后的 erlotinib 治疗的功效被限制的结论。然而,是 EGFR 变化的病人否定罐头可能在 gefitinib 以后得益于 erlotinib 治疗失败。 | SONG Zheng-bo YU Yong-feng CHEN Zhi-wei LU Shun | 2011 | Chinese Medical Journal2011，，15： | 8 |
| 9 | Effectiveness of PD-1/PD-L1 inhibitors in the treatment of lung cancer:Brightness and challenge显示文摘Immune checkpoint inhibitors(ICIs),especially inhibitors of the PD-1/PD-L1 axis,have significantly affected the outcomes of patients with lung cancer.Nivolumab and pembrolizumab have been approved as PD-1 blocking antibodies,whereas atezolizumab,avelumab,and durvalumab are approved as PD-L1 blocking antibodies by the United States Food and Drug Administration.However,which patient may benefit the most and how to identify patients at risk of primary or acquired resistance has not been completely defined.Meanwhile,close attention has been paid to the ongoing international and domestic clinical trials in Chinese patients with lung cancer.This review aimed to provide deep insight into the effectiveness of PD-1/PD-L1 inhibitors in patients with lung cancer,including the current settings for varied disease status,the predictive biomarkers,the resistance to ICIs,and the ongoing clinical trials in Chinese patients. | Ying Yang Yongfeng Yu Shun Lu | 2020 | Science China(Life Sciences)2020，63，10： | 8 |
| 10 | Surgical resection for hepatoportal bile duct cancer显示文摘METHODSAretrospectiveanalysiswasmadefor52casesofhepatoportalbileductcancertreatedfromJanuary1991toDecember1996.Althecaseswere... | HE Xiao Shun, HUANG Jie Fu, LIANG Li Jian, LU Ming De and CAO Xiu Hu | 1999 | World Journal of Gastroenterology1999，5，2： | 7 |
| 11 | Xenograft tumors derived from malignant pleural effusion of the patients with non-small-cell lung cancer as models to explore drug resistance显示文摘Background:Non-small cell lung cancer(NSCLC)patients with epidermal growth factor receptor(EGFR)mutations or anaplastic lymphoma kinase(ALK)fusions show dramatic responses to specific tyrosine kinase inhibitors(TKIs);however,after 10-12 months,secondary mutations arise that confer resistance.We generated a murine xenograft model using patient-derived NSCLC cells isolated from the pleural fluid of two patients with NSCLC to investigate the mechanisms of resistance against the ALK-and EGFR-targeted TKIs crizotinib and osimertinib,respectively.Methods:Genotypes of patient biopsies and xenograft tumors were determined by whole exome sequencing(WES),and patients and xenograft-bearing mice received targeted treatment(crizotinib or osimertinib)accordingly.Xenograft mice were also treated for prolonged periods to identify whether the development of drug resistance and/or treatment responses were associated with tumor size.Finally,the pathology of patients biopsies and xenograft tumors were compared histologically.Results:The histological characteristics and chemotherapy responses of xenograft tumors were similar to the actual patients.WES showed that the genotypes of the xenograft and patient tumors were similar(an echinoderm microtu-bule-associated protein-like 4-ALK(EML4-ALK)gene fusion(patient/xenograft:CTC15035EML4-ALK)and EGFR L858R and T790M mutations(patient/xenograft:CTC15063EGFR L858R,T790M)).After continuous crizotinib or osimertinib treatment,WES data suggested that acquired ALK E1210K mutation conferred crizotinib resistance in the CTC15035EML4-ALK xenograft,while decreased frequencies of EGFR L858R and T790M mutations plus the appearance of v-RAF murine sarcoma viral oncogene homolog B(BRAF)G7V mutations and phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha(PIK3C2A)A86fs frame shift mutations led to osimertinib resistance in the CTC15063EGFR L858R,T790M xenografts.Conclusions:We successfully developed a new method of generating drug resistance xenograft models from liquid biopsies using microfluidic technology,which might be a useful tool to investigate the mechanisms of drug resist-ance in NSCLC. | Yunhua Xu Feifei Zhang Xiaoqing Pan Guan Wang Lei Zhu Jie Zhang Danyi Wen Shun Lu | 2018 | Cancer Communications2018，38，1： | 7 |
| 12 | Peripheral CD4^(+) T cell signatures in predicting the responses to anti-PD-1/PD-L1 monotherapy for Chinese advanced non-small cell lung cancer显示文摘Limited benefit population of immune checkpoint inhibitors makes it urgent to screen predictive biomarkers for stratifying the patients.Herein,we have investigated peripheral CD4^(+) T cell signatures in advanced non-small cell lung cancer(NSCLC)patients receiving anti-PD-1/PD-L1 treatments.It was found that the percentages of IFN-γand IL-17A secreting naïve CD4^(+) T cells(Tn),and memory CD4^(+) T cells(Tm)expressing PD-1,PD-L1 and CTLA-4 were significantly higher in responder(R)than non-responder(NonR)NSCLC patients associated with a longer progression free survival(PFS).Logistic regression analysis revealed that the baseline IFN-γ-producing CD4^(+) Tn cells and PD-1^(+)CD4^(+) Tm cells were the most significant signatures with the area under curve(AUC)value reaching 0.849.This was further validated in another anti-PD-1 monotherapy cohort.Conversely,high percentage of CTLA-4^(+)CD4^(+) Tm cells was associated with a shorter PFS in patients receiving anti-PD-L1 monotherapy.Our study therefore elucidates the significance of functional CD4^(+) Tn and Tm subpopulations before the treatment in predicting the responses to anti-PD-1 treatment in Chinese NSCLC patients.The fact that there display distinct CD4^(+) T cell signatures in the prediction to anti-PD-1 and anti-PD-L1 monotherapy from our study provides preliminary evidence on the feasibility of anti-PD-1 and anti-PD-L1 combination therapy for advanced NSCLC patients. | Liliang Xia Hui Wang Mingjiao Sun Yi Yang Chengcheng Yao Sheng He Huangqi Duan Weimin Xia Ruiming Sun Yaxian Yao Zhiwei Chen Qiong Zhao Hong Li Shun Lu Ying Wang | 2021 | Science China(Life Sciences)2021，64，10： | 7 |
| 13 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 7 |
| 14 | Highly Sensitive Protein Sensor Based on Thermally-Reduced Graphene Oxide Field-Effect Transistor显示文摘我们报导一只高度敏感的地效果晶体管(联邦货物税) 的制造用减少 thermally 的 graphene 氧化物(TRGO ) 的生物传感器有抗体结合的金 nanoparticle (NP ) 的表 functionalized。探查抗体通过 Au NP 在 TRGO 表的表面上被标记,蛋白质绑定(免疫球蛋白 G/IgG 和反免疫球蛋白 G/anti-IgG ) 的电的察觉被联邦货物税和直接电流(dc ) 完成大小。蛋白质绑定事件在 TRGO 表的电阻导致了重要变化,它被叫作传感器反应。在 TRGO 表上的传感器和抗体 areal 密度中的 TRGO 基础电阻上的传感器反应的依赖系统地被学习,从哪个有传感器参数的传感器反应的关联被发现:传感器反应与更大的 TRGO 基础电阻和更高的抗体 areal 密度是更重要的。新奇生物传感器的察觉限制在 0.2 ng/mL 水平附近,它在报导的碳的最好之中基于 nanomaterial 的蛋白质传感器和罐头被调节传感器结构进一步优化。 | Shun Mao Kehan Yu Ganhua Lu Junhong Chen | 2011 | Nano Research2011，4，10： | 6 |
| 15 | Everolimus and zoledronic acid——a potential synergistic treatment for lung adenocarcinoma bone metastasis显示文摘Non-small-cell 肺癌症(NSCLC ) 经常转移到骨头。zoledronic 酸是到肿瘤,和 everolimus 的 cytostatic,这被知道,为 rapamycin 的哺乳动物的目标的禁止者,能禁止癌症的许多类型。此处,我们在在 vitro 并且在 vivo 对待肺腺癌骨头转移上与 everolimus 独自并且在联合评估了 zoledronic 酸的效果。与 everolimus 在联合与 zoledronic 酸对待的老鼠有更多的 apoptotic 肺癌症房间,更多的房间在 G1/G0 阶段被逮捕。p70S6K 的 phosphorylation 在联合治疗组被禁止。肺癌症房间侵略显著地也在 vitro 与联合治疗在这个组被禁止。骨头原子扫描在联合治疗组与那些相比在控制揭示了更变形的损害。骨头扫描和 X 光线照相术的图象显示那联合治疗显著地减少了骨头转移。中等幸存率建议药联合是 synergistic,它能推迟 NSCLC 骨头转移并且在 vivo 延长幸存。 | Yongfeng Yu Zhengbo Song Shunfang Yang Xiaohua Yang Jie Zhang Shun Lu | 2014 | Acta Biochimica et Biophysica Sinica2014，46，9： | 5 |
| 16 | A Modified Certainty Coefficient Method(M-CF) for Debris Flow Susceptibility Assessment:A Case Study for the Wenchuan Earthquake Meizoseismal Areas显示文摘In the meizoseismal areas hit by the China Wenchuan earthquake on May 12, 2008, the disasterprone environment has changed dramatically, making the susceptibility assessment of debris flow more complex and uncertain. After the earthquake, debris flow hazards occurred frequently and effective susceptibility assessment of debris flow has become extremely important. Shenxi gully in Du Jiangyan city, located in the meizoseismal areas, was selected as the study area. Based on the research of disaster-prone environment and the main factors controlling debris flow, the susceptibility zonations of debris flow were mapped using factor weight method(FW), certainty coefficient method(CF) and geomorphic information entropy method(GI). Through comparative analysis, the study showed that these three methods underestimated susceptible degree of debris flow when used in the meizoseismal areas of Wenchuan earthquake. In order to solve this problem, this paper developed a modified certainty coefficient method(M-CF) to reflect the impact of rich loose materials on the susceptible degree of debris flow. In the modified method, the distribution and area of loose materials were obtained by field investigations and postearthquake remote sensing image, and four data sets, namely, lithology, elevation, slop and aspect, wereused to calculate the CF values. The result of M-CF method is in agreement with field investigations and the accuracy of the method is satisfied. The method has a wide application to the susceptibility assessment of debris flow in the earthquake stricken areas. | WANG Jun YU Yan YANG Shun LU Gui-hong OU Guo-qiang | 2014 | Journal of Mountain Science2014，11，5： | 4 |
| 17 | Microstructure and composition engineering Yb single-filled CoSb_(3) for high thermoelectric and mechanical performances显示文摘A broad tunability of the thermoelectric and mechanical properties of CoSb_(3) has been demonstrated by adjusting the composition with the addition of an increasing number of elements.However,such a strategy may negatively impact processing repeatability and composition control.In this work,singleelement-filled skutterudite is engineered to have high thermoelectric and mechanical performances.Increased Yb filling fraction is found to increase phonon scattering,whereas cryogenic grinding contributes additional microstructural scattering.A peak zT of 1.55 and an average zT of about 1.09,which is comparable to the reported results of multiple-filled SKDs,are realized by the combination of simple composition and microstructure engineering.Furthermore,the mechanical properties of Yb single-filled CoSb_(3) skutterudite are improved by manipulation of the microstructure through cryogenic grinding.These findings highlight the realistic prospect of producing high-performance thermoelectric materials with reduced compositional complexity. | Zhenxing Zhou Matthias T.Agne Qihao Zhang Shun Wan Qingfeng Song Qing Xu Xiaofang Lu Shijia Gu Yuchi Fan Wan Jiang Gerald Jeffrey Snyder Lianjun Wang | 2019 | Journal of Materiomics2019，5，4： | 4 |
| 18 | Toeplitz Operators on Dirichlet Spaces | Yu Feng LU Shun Hua SUN Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, P. R. China Department of Mathematics, Sichuan University, Chengdu 610064, P. R. China Department of Mathematics, Sichuan University, Chengdu 610064, P. R. China | 2001 | Acta Mathematica Sinica,English Series2001，17，4： | 4 |
| 19 | Low-dose dopamine reduces inflammatory factors of acute pancreatitis in rats显示文摘BACKGROUND: Acute pancreatitis, especially acute necrotizing pancreatitis (ANP), is a serious disease with a high morbidity because of multiorgan dysfunction. Recent studies have indicated that during the pathogenesis of ANP, changes of the microcirculation play an important role in the worsening of the disease. This study based on a model of acute pancreatitis in Wistar rats was to determine the effect of treatment with low-dose dopamine on acute pancreatitis by the dynamic measurement of serum levels of inflammatory factors IL-6 and TNF-α. METHODS: Fifty Wistar rats were randomly divided into two groups, and a model of ANP was set up by injecting sodium taurocholate into the pancreatic duct. Rats in the dopamine group (treatment group) were given dopamine by vein and those in the acute pancreatitis group (control group) were given normal saline. To assess the effect of low-dose dopamine (5 μg·kg-1·min-1) on induced acute pancreatitis, the antibody sandwich ELISA method was used to measure the serum levels of IL-6 and TNF-α at different times before and after the induction of ANP. RESULTS: The serum levels of IL-6 and TNF-α in the treatment and control groups before and after ANP induction were significantly different. There was a markedly significant difference in the comparison of the two groups after ANP induction (P<0.01), but no significant difference in the comparison before the induction (P>0.05). Postoperative pancreatic histopathologic changes in the treatment group were more marked than those in the control group. CONCLUSIONS: Low-dose dopamine is effective in treating ANP by alleviating inflammatory reactions. This effect may be related to the fact that low-dose dopamine not only can increase the blood flow of the pancreatic microcirculation but also reduce its permeability. | Zhang, Shun Peng, Xin-Gang Liu, Chang-Chang Liu, Hong Lu, Yun | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，6： | 3 |
| 20 | Peginterferon Alfa-2a Plus Ribavirin for the Treatment of Dual Chronic Infection With Hepatitis B and C Viruses显示文摘 | Chun–Jen Liu Wan–Long Chuang Chuan–Mo Lee Ming–Lung Yu Sheng–Nan Lu Shun–Sheng Wu Li–Ying Liao Chi–Ling Chen Hsing–Tao Kuo You–Chen Chao Shui–Yi Tung Sien–Sing Yang Jia–Horng Kao Chen–Hua Liu Wei–Wen Su Chih–Lin Lin Yung–Ming Jeng Pei–Jer Chen Ding–Shinn | 2009 | Gastroenterology2009，，2： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员