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| 1 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 2 | Hepatocellular carcinoma xenograft supports HCV replication:A mouse model for evaluating antivirals显示文摘AIM: To develop a hepatocellular carcinoma (HCC) xenograft model for studying hepatitis C virus (HCV) replication in a mice, and antiviral treatment.METHODS: We developed a stable S3-green fluorescence protein (GFP) cell line that replicated the GFP-tagged HCV sub-genomic RNA derived from a highly efficient JFH1 virus. S3-GFP replicon cell line was injected subcutaneously into γ-irradiated SCID mice. We showed that the S3-GFP replicon cell line formed human HCC xenografts in SCID mice. Cells were isolated from subcutaneous tumors and then serially passaged multiple times in SCID mice by culturing in growth medium supplemented with G-418. The mouse-adapted S3-GFP replicon cells were implanted subcutaneously and also into the liver of SCID mice via intrasplenic infusion to study the replication of HCV in the HCC xenografts. The tumor model was validated for antiviral testing after intraperitoneal injection of interferon-α (IFN-α). RESULTS: A highly tumorigenic S3-GFP replicon cell line was developed that formed subcutaneous tumors within 2 wk and diffuse liver metastasis within 4 wk in SCID mice. Replication of HCV in the subcutaneous and liver tumors was confirmed by cell colony assay, detection of the viral RNA by ribonuclease protection assay and real-time quantitative reverse transcription polymerase chain reaction. High-level replication of HCV sub-genomic RNA in the tumor could be visualized by GFP expression using fluorescence microscopy. IFN-α cleared HCV RNA replication in the subcutaneous tumors within 2 wk and 4 wk in the liver tumor model. CONCLUSION: A non-infectious mouse model allows us to study replication of HCV in subcutaneous and metastatic liver tumors. Clearance of HCV by IFN-α supports use of this model to test other anti-HCV drugs. | Sidhartha Hazari Henry J Hefler Partha K Chandra Bret Poat Feyza Gunduz Tara Ooms Tong Wu Luis A Balart Srikanta Dash | 2011 | World Journal of Gastroenterology2011，17，3： | 2 |
| 3 | Estrogen receptor alpha genotype is associated with a reduced prevalence of radiographic hip osteoarthritis in elderly Caucasian women1显示文摘 | LIAN K LUI L ZMUDA J M | 2007 | Osteoarthrtis Cartilage2007，15，8： | 1 |
| 4 | AACVPR/ACC/AHA2007 performance measures on cardiac rehabilitation for referral to and delivery of cardiac rehabilitation/secondary prevention services 显示文摘 | Thomas R J King M Lui K | 2007 | Circulation2007，116，14： | 1 |
| 5 | The Complex Trial Protocol (CTP) : A new, countermeasure-resistant, accurate P300-based method for detection of concealed informa- tion 显示文摘 | Rosenfeld J P Labkovsky E Lui M A Winograd M Van- denboom C & Chedid K | 2008 | Psychophysiology2008，45，： | 1 |
| 6 | Oxygen reduction reaction (ORR) catalyzed by carbon-supported cobalt polypyrrole (Co-PPy/C) electrocatalysts 显示文摘 | LEE K ZHANG L LUI H HUI R SHI Z ZHANG J | 2009 | Electrochim Acta2009，54，20： | 1 |
| 7 | Sex hormones and cognitive function in older men显示文摘 | Yaffe K Lui LY Zmuda J | 2009 | J Am Geriatr Soc2009，50，： | 1 |
| 8 | The deferrable server algorithm for enhanced aperiodic responsiveness in hard real-time environments 显示文摘 | STROSNIDER J K LEHOCZKY J P LUI Sha | 1987 | In Proceedings of the Real-Time Systems Symposium1987，1，3： | 1 |
| 9 | Effect of conjugated linoleic acid on body composition in mice显示文摘 | Park Y Albright K J Lui W | 1997 | Lipids1997，32，： | 1 |
| 10 | Point Estimation on Relative Risk under Inverse Sampling显示文摘 | LUI K J | 1996 | Biometfical Journal1996，38，： | 1 |
| 11 | Sample Size for the Exact Conditional Test Under Inverse Sampling显示文摘 | LUI K J | 1995 | Statistics in Medicine1995，15，： | 1 |
| 12 | Development and characterization of biodegradable/edible wheat protein films 显示文摘 | Luis M R Ruben J H Perry K W N | 1997 | Journal of Food Science1997，62，1： | 1 |
| 13 | Seasonal dynamics of wood formation in Pinus halepensis from dry and semi-arid ecosystems in Spain显示文摘 | LUIS M D GRICAR J CUFAR K | 2007 | IAWA Journal2007，28，： | 1 |
| 14 | AACVPR/ACCF/AHA 2010 update: performance measures on cardiac rehabilitation for referral to cardiac rehabilitation/secondary prevention services: a report of the American Association of Cardiovascular and Pulmonary Rehabilitation and the American College of Cardiology Foundation/American Heart Association task force on performance measures (writing committee to develop clinical performance measures for cardiac rehabilitation)显示文摘 | THOMAS R J KING M LUI K | 2010 | Circulation2010，30，5： | 1 |
| 15 | Clinical significance of microscopic tumor venous invasion in patients with resectable hepatocellular carcinoma显示文摘 | Tsai T J Chau G Y Lui W Y Tsay S H King K L Loong C C | 2000 | Surgery2000，127，： | 1 |
| 16 | Estrogen receptor alpha genotype is associated with a reduced prevalence of radiographic hip osteoarthritis in elderly Caucasian women显示文摘 | Lian K Lui L Zmuda J M | 2007 | Osteoarthritis Cartilage2007，15，8： | 1 |
| 17 | Small-world overylay P2P networks:construction,management and handling of dynamic flash crowds显示文摘 | Hui K Y K Lui J C S Yau D K Y | 2006 | Computer Networks2006，50，15： | 1 |
| 18 | Sex hormones and cognitive function in older men显示文摘 | YAFFE K LUI LY ZMUDA J CAULEY J | 2002 | J Am Geriatr Soc2002，50，4： | 1 |
| 19 | Shellfish and fish biodiversity of mangrove ecosystems in Leizhou Penisula, China显示文摘 | Han W D Lui J K He X L | 2003 | Journal of Coastal Development2003，7，1： | 1 |
| 20 | Adaptability and leaf anatomical features in oil palm seedlings produced by embryo rescue and pre-germinated seeds 显示文摘 | Luis Z G Bezerra K M G Scherwinski-Pereira J E | 2010 | Brazilian Journal of Plant Physiology2010，22，3： | 1 |
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