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| 1 | First Imported Case of SARS-CoV-2 Omicron Subvariant BA.5—Shanghai Municipality,China,May 13,2022显示文摘On April 27,2022,an international flight KL857 from Amsterdam,the Netherlands arrived at Pudong International Airport,Shanghai Municipality.Passengers were transferred to the quarantine hotel for a routine 14-day medical observation in Songjiang District and regularly tested for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).One of the passengers(a 37-year-old Chinese male)was reported positive and diagnosed as a mild case on April 29.The case set out from Uganda(flight KL535)on April 25 and transferred at Amsterdam,the Netherlands on April 26 and Seoul,the Republic of Korea(KL857)on April 27.The patient has been vaccinated in four doses against coronavirus disease 2019(COVID-19)(Beijing Institute of Biological Products Co.,Ltd)in China and Uganda.After diagnosis,he was transferred to Shanghai Public Health Clinical Center for treatment.He recovered after treatment and was discharged on May 12. | Hui Jiang Changcheng Wu Wenbo Xu Hongyou Chen Fanghao Fang Min Chen Chaonan Wang Lingyue Yuan Huanyu Wu Zheng Teng Jinyuan Guo Yaxu Zheng Xihong Lyu Xuefei Qiao Guizhen Wu Wenjie Tan Xi Zhang | 2022 | China CDC weekly2022，4，30： | 10 |
| 2 | Numerical investigation of turbulent flow coherent structures in annular jet pumps using the LES method显示文摘Annular jet pumps that are used in hydraulic machinery have a very simple structure but very complex internal flow fields. Large eddy simulations were used to study the coherent structures in the turbulent flows in annular jet pumps with various area ratios,m. The distribution, movement and evolution of the coherent structure in the annular jet pumps are described based on vorticity,pressure and Q criteria. All the criteria demonstrate that the vortexes are mainly distributed in the recirculation region and in the mixing and the boundary layers, which have large velocity gradients. The various characteristics of the coherent structures are shown by the different criteria with the vorticity criterion describing the distribution, movement and evolution of the vortexes,the pressure criterion describing the movement and the Q criterion describing the vortex movement and evolution. The vorticity variation in the spanwise direction is larger than the variation in the streamwise direction; however, the streamwise vortex is the main mechanism driving the entrainment of the secondary flow and the mixing. The annular jet pump with m=3.33 had a higher vortex shedding frequency(about 1000 Hz) than that with m=1.72(313–417 Hz). The azimuthal instability is the main reason for the generation of the streamwise vortex from the spanwise vortex. The vortex structures in the recirculation region are very strong,but small and disordered with no periodic vortex rings. | XU MaoSen YANG XueLong LONG XinPing LYU Qiao JI Bin | 2018 | Science China(Technological Sciences)2018，61，1： | 8 |
| 3 | Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy显示文摘Although PD-L1/PD-1 blockade therapy has been approved to treat many types of cancers,the majority of patients with solid tumors do not respond well,but the underlying reason remains unclear.Here,we studied ovarian cancer(OvCa),a tumor type generally resistant to current immunotherapies,to investigate PD-1-independent immunosuppression.We found that PD-L1 was not highly expressed in the tumor microenvironment(TME)of human OvCa.Instead,B7-H3,another checkpoint molecule,was highly expressed by both tumor cells and tumor-infiltrating antigen-presenting cells(APCs),which correlated with T-cell exhaustion in patients.Using ID8 OvCa mouse models,we found that B7-H3 expressed on tumor cells,but not host cells,had a dominant role in suppressing antitumor immunity.Therapeutically,B7-H3 blockade,but not PD-1 blockade,prolonged the survival of ID8 tumorbearing mice.Collectively,our results demonstrate that tumor-expressed B7-H3 inhibits the function of CD8^(+)T cells and suggest that B7-H3 may be a target in patients who are not responsive to PD-L1/PD-1 inhibition,particularly OvCa patients. | Dongli Cai Jiaming Li Dingfeng Liu Shanjuan Hong Qin Qiao Qinli Sun Pingping Li Nanan Lyu Tiantian Sun Shan Xie Li Guo Ling Ni Liping Jin Chen Dong | 2020 | Cellular & Molecular Immunology2020，17，3： | 8 |
| 4 | Non‑Magnetic Bimetallic MOF‑Derived Porous Carbon‑Wrapped TiO2/ ZrTiO4 Composites for Efficient Electromagnetic Wave Absorption显示文摘Modern communication technologies put forward higher requirements for electromagnetic wave(EMW)absorption materials.Metal-organic framework(MOF)derivatives have been widely concerned with its diverse advantages.To break the mindset of magneticderivative design,and make up the shortage of monometallic non-magnetic derivatives,we first try non-magnetic bimetallic MOFs derivatives to achieve efficient EMW absorption.The porous carbon-wrapped TiO2/ZrTiO4 composites derived from PCN-415(TiZr-MOFs)are qualified with a minimum reflection loss of−67.8 dB(2.16 mm,13.0 GHz),and a maximum effective absorption bandwidth of 5.9 GHz(2.70 mm).Through in-depth discussions,the synergy of enhanced interfacial polarization and other attenuation mechanisms in the composites is revealed.Therefore,this work confirms the huge potentials of nonmagnetic bimetallic MOFs derivatives in EMW absorption applications. | Jing Qiao Xue Zhang Chang Liu Longfei Lyu Yunfei Yang Zhou Wang Lili Wu Wei Liu Fenglong Wang Jiurong Liu | 2021 | Nano-Micro Letters2021，13，5： | 7 |
| 5 | Porous Pt nanoframes decorated with Bi(OH)3 as highly efficient and stable electrocatalyst for ethanol oxidation reaction显示文摘High-quality Pt-based catalysts are highly desirable for ethanol oxidation reaction(EOR),which is of critical importance for the commercial applications of direct ethanol fuel cells(DEFCs).However,most of the Pt-based catalysts have suffered from high cost and low operation durability.Herein a two-step method has been developed to synthesize porous Pt nanoframes decorated with Bi(OH)3,which show excellent catalytic activity and operation durability in both alkaline and acidic media.For example,the nanoframes show a mass activity of 6.87 A·mgPt−1 in alkaline media,which is 13.5-fold higher than that of commercial Pt/C.More importantly,the catalyst can be reactivated simply,which shows negligible activity loss after running for 180,000 s.Further in situ attenuated total reflection-infrared(ATR-IR)absorption spectroscopy and CO-stripping experiments indicate that surface Bi(OH)3 species can greatly facilitate the formation of adsorbed OH species and subsequently remove carbonaceous poison,resulting in a significantly enhanced stability towards EOR.This work may favor the tailoring of desired electrocatalysts with high activity and durability for future commercial application of DEFCs. | Xiaolei Yuan Bei Jiang Muhan Cao Congyang Zhang Xiaozhi Liu Qinghua Zhang Fenglei Lyu Lin Gu Qiao Zhang | 2020 | Nano Research2020，13，1： | 3 |
| 6 | Facile one-step synthesis of PdPb nanochains for high-performance electrocatalytic ethanol oxidation显示文摘The widespread application of direct ethanol fuel cells is hampered due to the low activity,high cost and poor operation durability of electrocatalysts for ethanol oxidation reaction(EOR).Herein,we report a one-pot synthetic method to synthesize PdPb3 nanochains with well-defined shape,size and composition via a solution-phase reduction method.The morphology,composition distribution and structure characteristics of PdPb3 nanochains were investigated by transmission electron microscopy,X-ray photoelectron spectroscopy and X-ray diffraction.Thanks to the unique structure,the as-obtained PdPb3 nanochains can manifest much higher mass activity(2523 mA·mg-1)and higher operation durability than commercial Pd/C(1272 mA·mg-1)during the EOR measurements.More importantly,further CO-stripping measurements indicate that the incorporation of Pb species could favor the oxidative removal of CO intermediates on the Pd electrode at the negative potential and enhance the EOR activity and stability,making it possible to develop highly active and durable electrocatalysts. | Yong Zhang Xiao-Lei Yuan Feng-Lei Lyu Xu-Chun Wang Xiao-Jing Jiang Mu-Han Cao Qiao Zhang | 2020 | Rare Metals2020，39，7： | 3 |
| 7 | Consensus on clinical management of tumor-induced osteomalacia显示文摘Tumor-induced osteomalacia(TIO)is a rare paraneoplastic syndrome caused by excessive fibroblast growth factor 23(FGF23)production by a tumor,which often arises from a mesenchymal origin.[1-3]Most clinical symptoms of TIO are the consequences of prolonged FGF23-mediated hypophosphatemia as muscle weakness,bone pain,impaired mobility,and fractures.[4]Clinical diagnosis and management of TIO are challenging because knowledge about this condition is still restricted to a few specialized centers,leading to delay in diagnosis and appropriate treatment.The scope of the present consensus is to provide up-to-date guidance on the assessment and treatment of TIO. | Yan Jiang Xiang Li Li Huo Yong Liu Wei Lyu Lian Zhou Wei Yu Huan-Wen Wu Xiao-Ping Xing Mei Li Ou Wang Yue Chi Rui-Zhi Jiajue Yu Pei Jian-Min Liu Jian-Ming Ba Qiao Zhang Zhi-Feng Sheng Zhen-Lin Zhang Jia-Jun Zhao Salvatore Minisola Wei-Bo Xia on behalf of Chinese Society of Osteoporosis and Bone Mineral Research and Chinese Society of Endocrinology | 2021 | Chinese Medical Journal2021，，11： | 3 |
| 8 | Metal sulfides based composites as promising efficient microwave absorption materials:A review显示文摘The increasingly severe electromagnetic microwave pollution raises higher requirements for the development of efficient microwave absorption(MA)materials.Metal sulfides are regarded as potential robust MA materials because of their unique optical,thermal,electrical,and magnetic properties,as well as the controllable microstructures.However,due to the limited MA performances of unary metal sulfides,morphology regulations and foreign materials hybridizations are adopted as effective strategies to improve their MA performances.Recent years witnessed the fast research progresses on the metal sulfides based MA materials and thus,a systematic literature survey on the materials design,fabrication,characterizations,MA behaviors,and the mechanisms behind is,highly desirable to summarize the rapid progress of this hot research area so as to provide guidance for the future development trend.This review firstly reviewed the research background,research progress,and basic principles of MA materials.Subsequently,the present synthetic methods and performance improvement strategies of metal sulfides based MA materials are systematically introduced.Then,by comparing the MA properties of one-dimensional,two-dimensional,and three-dimensional metal sulfides based composites,the influence of dimensionality and morphology on the MA properties are analyzed.By summarizing the research process of metal sulfides/dielectrics composites,metal sulfides/magnets composites,and metal sulfides/dielectrics/magnets composites MA materials,the influence of foreign materials hybridizations on the loss mechanisms and impedance matching conditions of metal sulfides based composites are revealed.Finally,the challenges and development prospects of metal sulfides based MA materials are presented.This review would provide a comprehensive understanding and insightful guidance for the exploration and development of efficient MA materials with thin thickness,light weight,wide absorption bandwidth,and strong absorption intensity. | Bin Li Fenglong Wang Kejun Wang Jing Qiao Dongmei Xu Yunfei Yang Xue Zhang Longfei Lyu Wei Liu Jiurong Liu | 2022 | Journal of Materials Science & Technology2022，，9： | 3 |
| 9 | Self-templated formation of cobalt-embedded hollow N-doped carbon spheres for efficient oxygen reduction显示文摘The slow kinetics at the cathode of oxygen reduction reaction(ORR)seriously limits the efficiencies of fuel cells and metal-air batteries.Pt,the state-of-the-art ORR electrocatalyst,suffers from high cost,low earth abundance,and poor stability.Here a self-templated strategy based on metal-organic frameworks(MOFs)is proposed for the fabrication of hollow nitrogen-doped carbon spheres that are embedded with cobalt nanoparticles(Co/HNC).The Co/HNC manifests better ORR activities,methanol tolerance,and stability than commercial Pt/C.The high ORR performance of Co/NHC can be attributed to the hollow structure which provides enlarged electrochemically active surface area,the formation of more Co-N species,and the introduction of defects.This work highlights the significance of rational engineering of MOFs for enhanced ORR activity and stability and offers new routes to the design and synthesis of high-performance electrocatalysts. | Ayaz Mahsud Jianian Chen Xiaolei Yuan Fenglei Lyu Qixuan Zhong Jinxing Chen Yadong Yin Qiao Zhang | 2021 | Nano Research2021，14，8： | 2 |
| 10 | Variations in Optical Scattering and Backscattering by Organic and Inorganic Particulates in Chinese Lakes of Taihu, Chaohu and Dianchi显示文摘This study presents an investigation of the scattering and backscattering properties of the particulates in three Chinese inland lakes(the Taihu Lake, the Chaohu Lake and the Dianchi Lake) based on in situ measurements taken at 119 sites. We modeled the particulate scattering spectra using a wavelength-dependent power-law function, finding that the power-law exponents in the Taihu Lake and the Chaohu Lake differ from those in the Dianchi Lake but are similar to the values in the U.S. coastal waters. In contrast to the open ocean, the backscattering properties in the three lakes can not be determined only from chlorophyll-a concentration. The backscattering ratio spectra exhibit a wavelength dependence feature in all three lakes, generally decreasing with the increasing wavelength. Analysis results of the correlations between the backscattering ratio and the individual water quality parameters clearly show that there are distinctive relations among the three lakes, attributed primarily to different compositions of optically active materials in the three lakes. Analysis of the mass-specific scattering and backscattering coefficients shows that the coefficients at wavelength 532 nm in the Taihu Lake and Chaohu Lake are similar, but they are apparently different from those in the Dianchi Lake. Lastly, Model I multiple linear regressions were adopted to partition the mass-specific cross-sections for scattering and backscattering into organic and inorganic cross-sections to further interpret the scattering and backscattering properties. The relative contribution of organic and inorganic particulates to scattering and backscattering is clearly different among the three lakes. The scattering and backscattering properties of the particulates in the three inland lakes vary significantly based on our collected data. The results indicated that the existing semi-analytical water quality retrieval models of the Taihu Lake can not be applied perfectly to the Chaohu Lake and the Dianchi Lake. | LYU Heng WANG Qiao WU Chuanqing ZHU Li LI Yunmei HUANG Jiazhu | 2015 | Chinese Geographical Science2015，25，1： | 2 |
| 11 | Confined-solution process for high-quality CH3NH3PbBr3 single crystals with controllable morphologies显示文摘 | Yitan Li Lu Han Qiao Liu Wei Wang Yuguang Chen Min Lyu Xuemei Li Hao Sun Hao Wang Shufeng Wang Yan Li | 2018 | Nano Research2018，11，6： | 2 |
| 12 | Hybrid Energy Sharing Mechanism for Integrated Energy Systems Based on the Stackelberg Game显示文摘Integrating the sharing economy and the power industry is of positive significance for the development of the energy market.With the energy market transforming from a traditional vertical structure to an interactive and competitive structure,users'roles need to change,along with supply and demand interacting more frequently.Thus,the traditional centralized optimization method for a single energy source can hardly reveal the complex multi-entity behavior of multi-energy coupling.Therefore,this paper establishes a distributed electrical-gas-thermal energy sharing mechanism centered on an energy hub that can converse energy,and build a more applicable integrated energy system body.First,the supply-demand interaction and the energy conversion process is constructed with reference to the operationa丨mode of’a sharing economy and the dual role of prosumers.A Stackelberg model is established with the integrated energy system operator as the leader and prosumers as the followers,to simultaneously optimize the profit of the leader in the upper level and the comfort of the fo!lowers,energy use and utility in the lower level.Furthermore,for protecting the participants’privacy,a distributed algorithm is used to find the optimal solution to equilibrate the model,and the existence and uniqueness of the solution is proved.Finally,a case study validates the effectiveness of the hybrid energy sharing mechanism and provides a reference for the integration of the energy sharing economy with the integrated energy system. | Qiao Peng Xiuli Wang Yi Kuang Yifei Wang Hongyang Zhao Zhicheng Wang Jianhu Lyu | 2021 | CSEE Journal of Power and Energy Systems2021，7，5： | 2 |
| 13 | RECQL4 regulates DNA damage response and redox homeostasis in esophageal cancer显示文摘Objective:RECQL4(a member of the RECQ helicase family)upregulation has been reported to be associated with tumor progression in several malignancies.However,whether RECQL4 sustains esophageal squamous cell carcinoma(ESCC)has not been elucidated.In this study,we determined the functional role for RECQL4 in ESCC progression.Methods:RECQL4 expression in clinical samples of ESCC was examined by immunohistochemistry.Cell proliferation,cellular senescence,the epithelial-mesenchymal transition(EMT),DNA damage,and reactive oxygen species in ESCC cell lines with RECQL4 depletion or overexpression were analyzed.The levels of proteins involved in the DNA damage response(DDR),cell cycle progression,survival,and the EMT were determined by Western blot analyses.Results:RECQL4 was highly expressed in tumor tissues when compared to adjacent non-tumor tissues in ESCC(P<0.001)and positively correlated with poor differentiation(P=0.011),enhanced invasion(P=0.033),and metastasis(P=0.048).RECQL4 was positively associated with proliferation and migration in ESCC cells.Depletion of RECQL4 also inhibited growth of tumor xenografts in vivo.RECQL4 depletion induced G0/G1 phase arrest and cellular senescence.Importantly,the levels of DNA damage and reactive oxygen species were increased when RECQL4 was depleted.DDR,as measured by the activation of ATM,ATR,CHK1,and CHK2,was impaired.RECQL4 was also shown to promote the activation of AKT,ERK,and NF-k B in ESCC cells.Conclusions:The results indicated that RECQL4 was highly expressed in ESCC and played critical roles in the regulation of DDR,redox homeostasis,and cell survival. | Guosheng Lyu Peng Su Xiaohe Hao Shiming Chen Shuai Ren Zixiao Zhao Yaoqin Gong Qiao Liu Changshun Shao | 2021 | Cancer Biology & Medicine2021，18，1： | 2 |
| 14 | An improved genetic algorithm for integrated process planning and scheduling显示文摘 | QIAO L H LYU S P | 2012 | International Journal of Advanced Manufacturing Technology2012，58，5678： | 1 |
| 15 | A scoring system for prediction of early recurrence after liver resection for Barcelona Clinic Liver Cancer stage B hepatocellular carcinoma显示文摘 | Qian Honggang Wei Meng Qiu Hu Wu Jianhui Liu Bonan Lyu Ang Liu Qiao Li Chengpeng Leng Jiahua | 2014 | Chinese Medical Journal2014，，24： | 1 |
| 16 | Exponential isothermal amplification coupled MALDI-TOF MS for microRNAs detection显示文摘Micro RNAs(mi RNAs) have attracted significant attention in biomedical research and clinical diagnosis.However, due to their inherent characteristics of low abundance and the high complexity of corresponding biological matrices, simultaneous detection of multiple mi RNAs at low abundance is still a challenge.In this work, a method coupling exponential amplification reaction(EXPAR) with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF MS) is developed for label-free and simultaneous detection of multiple mi RNAs. The assay can be performed under isothermal conditions in a single reaction tube, and finished in less than 30 min. It exhibits good quantification ability and with attomolar-level sensitivity for mi RNAs detection. It also shows high specificity to distinguish mi RNAs at single-nucleotide resolution. We used the method to detect the mi RNA-21, let-7a, mi RNA-100, and mi RNA-125b in samples of spiked human serum and breast cancer cells(i.e., MCF-7, MDA-MB-231 and SK-BR-3). The quantification results were well consistent with the standard real-time fluorescence EXPAR.Consequently, the label-free mass-spectrometric platform could be a potential tool for mi RNAs analysis in complex biological samples, and may be used for clinical diagnosis. | Guobin Han Dandan Li Qiuyuan Lin Jia Yi Qian Lyu Qingwei Ma Liang Qiao | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
| 17 | Hardware-in-loop adaptive neural control for a tiltable V-tail morphing aircraft显示文摘This paper proposes an adaptive neural control(ANC)method for the coupled nonlinear model of a novel type of embedded surface morphing aircraft which has a tiltable V-tail.A nonlinear model with sixdegrees-of-freedom is established.The first-order sliding mode differentiator(FSMD)is applied to the control scheme to avoid the problem of“differential explosion”.Radial basis function neural networks are introduced to estimate the uncertainty and external disturbance of the model,and an ANC controller is proposed based on this design idea.The stability of the proposed ANC controller is proved using Lyapunov theory,and the tracking error of the closed-loop system is semi-globally uniformly bounded.The effectiveness and robustness of the proposed method are verified by numerical simulations and hardware-in-the-loop(HIL)simulations. | Fu-xiang Qiao Jing-ping Shi Xiao-bo Qu Yong-xi Lyu | 2023 | Defence Technology(防务技术)2023，22，4： | 0 |
| 18 | In situ surface-confined fabrication of single atomic Fe-N_(4) on N-doped carbon nanoleaves for oxygen reduction reaction显示文摘Controllable fabrication of Fe-N-C based single-atom catalysts(SACs)for enhanced electrocatalytic performance is highly desirable but still challenging.Here,an in situ surface-confined strategy was demonstrated for the synthesis of single atomic Fe-N_(4))on N-doped carbon nanoleaves(L-FeNC).The in situ generated Zn3[Fe(CN)6]2 could not only serve as a protection layer against collapse of nanoleaves but also provide abundant Fe source for the formation of Fe-N moieties during pyrolysis,leading to high surface area and high graphitization degree of L-FeNC simultaneously.Benefiting from abundant Fe-N_(4))active sites,enhanced mass and charge transfer,the as-prepared L-FeNC manifested a half-wave potential of 0.89 V for oxygen reduction reaction(ORR)in 0.1 M KOH.A maximum power density of 140 m W cm^(-2)and stable discharge voltage even after operation for 50,000 s have been demonstrated when the L-FeNC was used as air cathode for Zn-air battery.This work not only provided a unique surfaceconfined strategy for the synthesis of two-dimensional nanocarbons,but also demonstrated the significant benefit from rational design and engineering of Fe-N-C SACs,thus offering great opportunities for fabrication of efficient energy conversion and storage devices. | Xiaojing Jiang Jianian Chen Fenglei Lyu Chen Cheng Qixuan Zhong Xuchun Wang Ayaz Mahsud Liang Zhang Qiao Zhang | 2021 | Journal of Energy Chemistry2021，30，8： | 0 |
| 19 | FOLR1-induced folate deficiency reduces viral replication via modulating APOBEC3 family expression显示文摘Folate receptor alpha(FOLR1)is vital for cells ingesting folate(FA).FA plays an indispensable role in cell pro-liferation and survival.However,it is not clear whether the axis of FOLR1/FA has a similar function in viral replication.In this study,we used vesicular stomatitis virus(VSV)to investigate the relationship between FOLR1-mediated FA deficiency and viral replication,as well as the underlying mechanisms.We discovered that FOLR1 upregulation led to the deficiency of FA in HeLa cells and mice.Meanwhile,VSV replication was notably sup-pressed by FOLR1 overexpression,and this antiviral activity was related to FA deficiency.Mechanistically,FA deficiency mainly upregulated apolipoprotein B mRNA editing enzyme catalytic subunit 3B(APOBEC3B)expression,which suppressed VSV replication in vitro and in vivo.In addition,methotrexate(MTX),an FA metabolism inhibitor,effectively inhibited VSV replication by enhancing the expression of APOBEC3B in vitro and in vivo.Overall,our present study provided a new perspective for the role of FA metabolism in viral infections and highlights the potential of MTX as a broad-spectrum antiviral agent against RNA viruses. | Jing Wu Yajing Han Ruining Lyu Fang Zhang Na Jiang Hongji Tao Qiao You Rui Zhang Meng Yuan Waqas Nawaz Deyan Chen Zhiwei Wu | 2023 | Virologica Sinica2023，38，3： | 0 |
| 20 | Folate-conjugated polyspermine for lung cancer–targeted gene therapy显示文摘Biodegradable polyamines have long been studied as potential recombinant viral gene vectors.Spermine(SPE) is an endogenous tetra-amine with excellent biocompatibility yet poor gene condensation capacity. We have previously synthesized a polyspermine based on SPE and poly(ethylene glycol)(PEG)diacrylate(SPE-alt-PEG) for enhanced transfection performance, but the synthesized SPE-alt-PEG still lacked specificity towards cancer cells. In this study, folic acid(FA) was incorporated into SPE-alt-PEG to fabricate a targeted gene delivery vector(FA-SPE-PEG) via an acylation reaction. FA-SPE-PEG exhibited mild cytotoxicity in both cancer cells and normal cells. FA-SPE-PEG possessed higher transfection efficiency than PEI 25 K and Lipofectamines2000 in two tested cancer cell lines at functional weight ratios, and its superiority over untargeted SPE-alt-PEG was prominent in cells with overexpressed folate receptors(FRs). Moreover, in vivo delivery of green fluorescent protein(GFP) with FA-SPE-PEG resulted in highest fluorescent signal intensity of all investigated groups. FA-SPE-PEG showed remarkably enhanced specificity towards cancer cells both in vivo and in vitro due to the interaction between FA and FRs. Taken together, FA-SPE-PEG was demonstrated to be a prospective targeted gene delivery vector with high transfection capacity and excellent biocompatibility. | Mei Zhang You-Kyoung Kim Pengfei Cui Jialiang Zhang Jianbin Qiao Yujing He Jinyuan Lyu Chengqiong Luo Lei Xing Hulin Jiang | 2016 | Acta Pharmaceutica Sinica B2016，6，4： | 0 |
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