|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Tumor budding as a potential histopathological biomarker in colorectal cancer:Hype or hope?显示文摘Colorectal cancer(CRC),the third most commonly diagnosed type of cancer in men and women worldwide is recognized as a complex multi-pathway disease,an observation sustained by the fact that histologically identical tumors may have different outcome,including various response to therapy.Therefore,particularly in early and intermediate stage(stages Ⅱ and Ⅲ,respectively) CRC,there is a compelling need for biomarkers helpful of selecting patients with aggressive disease that might benefit from adjuvant and targeted therapy.Histopathological examination shows that likely other solid tumors the development and progression of human CRC is not only determined by genetically abnormal cells,but also by intricate interactions between malignant cells and the surrounding microenvironment.This has led to reconsider the features of tumor microenvironment as potential predictive and prognostic biomarkers.Among the histopathological biomarkers,tumor budding(i.e.,the presence of individual cells and small clusters of tumor cells at the tumor invasive front) has received much recent attention,particularly in the setting of CRC.Although its acceptance as a reportable factor has been held back by a lack of uniformity with respect to qualitative and quantitative aspects,tumor budding is now considered as an independent adverse prognostic factor in CRC that may allow for stratification of patients into risk categories more meaningful than those defined by tumor-node-metastasis staging alone,and also potentially guide treatment decisions,especially in T2-T3 N0(stage Ⅱ) CRCs. | Fabio Grizzi Giuseppe Celesti Gianluca Basso Luigi Laghi | 2012 | World Journal of Gastroenterology2012，18，45： | 8 |
| 2 | Computed tomography colonography in 2014:An update on technique and indications显示文摘Twenty years after its introduction,computed tomographic colonography(CTC)has reached its maturity,and it can reasonably be considered the best radiological diagnostic test for imaging colorectal cancer(CRC)and polyps.This examination technique is less invasive than colonoscopy(CS),easy to perform,and standardized.Reduced bowel preparation and colonic distention using carbon dioxide favor patient compliance.Widespread implementation of a new image reconstruction algorithm has minimized radiation exposure,and the use of dedicated software with enhanced views has enabled easier image interpretation.Integration in the routine workflow of a computer-aided detection algorithm reduces perceptual errors,particularly for small polyps.Consolidated evidence from the literature shows that the diagnostic performances for the detection of CRC and large polyps in symptomatic and asymptomatic individuals are similar to CS and are largely superior to barium enema,the latter of which should be strongly discouraged.Favorable data regarding CTC performance open the possibility for many different indications,some of which are already supported by evidence-based data:incomplete,failed,or unfeasible CS;symptomatic,elderly,and frail patients;and investigation of diverticular disease.Other indications are still being debated and,thus,are recommended only if CS is unfeasible:the use of CTC in CRC screening and in surveillance after surgery for CRC or polypectomy.In order for CTC to be used appropriately,contraindications such as acute abdominal conditions(diverticulitis or the acute phase of inflammatory bowel diseases)and surveillance in patients with a long-standing history of ulcerative colitis or Crohn’s disease and in those with hereditary colonic syndromes should not be overlooked.This will maximize the benefits of the technique and minimize potential sources of frustration or disappointment for both referring clinicians and patients. | Andrea Laghi | 2014 | World Journal of Gastroenterology2014，20，45： | 6 |
| 3 | Colorectal cancer screening:The role of CT colonography显示文摘Computed tomography colonography(CTC) in colorectal cancer(CRC) screening has two roles:one present and the other potential.The present role is,without any further discussion,the integration into established screening programs as a replacement for barium enema in the case of incomplete colonoscopy.The potential role is the use of CTC as a first-line screening method together with Fecal Occult Blood Test,sigmoidoscopy and colonoscopy.However,despite the fact that CTC has been officially endorsed for CRC screening of average-risk individuals by different scientif ic societies including the American Cancer Society,the American College of Radiology,and the US Multisociety Task Force on Colorectal Cancer,other entities,such as the US Preventive Services Task Force,have considered the evidence insuff icient to justify its use as a mass screening method.Medicare has also recently denied reimbursement for CTC as a screening test.Nevertheless,multiple advantages exist for using CTC as a CRC screening test:high accuracy,full evaluation of the colon in virtually all patients,non-invasiveness,safety,patient comfort,detection of extracolonic findings and cost-effectiveness.The main potential drawback of a CTC screening is the exposure to ionizing radiation.However,this is not a major issue,since low-dose protocols are now routinely implemented,delivering a dose comparable or slightly superior to the annual radiation exposure of any individual.Indirect evidence exists that such a radiation exposure does not induce additional cancers. | Andrea Laghi Franco Iafrate Marco Rengo Cesare Hassan | 2010 | World Journal of Gastroenterology2010，16，32： | 6 |
| 4 | Prognostic value of innate and adaptive immunity in colorectal cancer显示文摘Colorectal cancer(CRC) remains one of the major public health problems throughout the world.Originally depicted as a multi-step dynamical disease,CRC develops slowly over several years and progresses through cytologically distinct benign and malignant states,from single crypt lesions through adenoma,to malignant carcinoma with the potential for invasion and metastasis.Moving from histological observations since a long time,it has been recognized that inflammation and immunity actively participate in the pathogenesis,surveillance and progression of CRC.The advent of immunohistochemical techniques and of animal models has improved our understanding of the immune dynamical system in CRC.It is well known that immune cells have variable behavior controlled by complex interactions in the tumor microenvironment.Advances in immunology and molecular biology have shown that CRC is immunogenic and that host immune responses influence survival.Several lines of evidence support the concept that tumor stromal cells,are not merely a scaffold,but rather they influence growth,survival,and invasiveness of cancer cells,dynamically contributing to the tumor microenvironment,together with immune cells.Different types of immune cells infiltrate CRC,comprising cells of both the innate and adaptive immune system.A relevant issue is to unravel the discrepancy between the inhibitory effects on cancer growth exerted by the local immune response and the promoting effects on cancer proliferation,invasion,and dissemination induced by some types of inflammatory cells.Here,we sought to discuss the role played by innate and adaptive immune system in the local progression and metastasis of CRC,and the prognostic information that we can currently understand and exploit. | Fabio Grizzi Paolo Bianchi Alberto Malesci Luigi Laghi | 2013 | World Journal of Gastroenterology2013，19，2： | 4 |
| 5 | New frontiers of MRI in Crohn’s disease: motility imaging, diffusion-weighted imaging, perfusion MRI, MR spectroscopy, molecular imaging, and hybrid imaging (PET/MRI)显示文摘 | Francesca Maccioni Michael A. Patak Alberto Signore Andrea Laghi | 2012 | Abdominal Imaging2012，，6： | 3 |
| 6 | The second ESGAR consensus statement on CT colonography显示文摘 | Emanuele Neri Steve Halligan Mikael Hellstr?m Philippe Lefere Thomas Mang Daniele Regge Jaap Stoker Stuart Taylor Andrea Laghi | 2013 | European Radiology2013，，3： | 2 |
| 7 | Perforation rate in CT colonography: a systematic review of the literature and meta-analysis显示文摘 | Davide Bellini Marco Rengo Carlo Nicola Cecco Franco Iafrate Cesare Hassan Andrea Laghi | 2014 | European Radiology2014，，7： | 2 |
| 8 | Experimental colonic phantom for the evaluatlon of the optimal scanning technique for CT colonography using a multidetector spiral CT equipntent显示文摘 | Laghi A lan naccone R Man giapane F | 2003 | Eur Radiol2003，13，3： | 1 |
| 9 | Can diaphragmatic contractility be assessed by airway twitch pressure in mechanically ventilated patients? 显示文摘 | Cattapan SE Laghi F Tobin MJ | 2003 | Thorax2003，58，1： | 1 |
| 10 | Blood pressure lowering effect of lactotripeptides assumed as functional foods: a meta - analysis of current available clinical trials 显示文摘 | Cicero AF Gerocarni B Laghi L | 2011 | Journal of Human Hypertension2011，25，7： | 1 |
| 11 | Influence of ventilator settings in determining respiratory frequency during mechanical ventilation显示文摘 | Laghi F Karamchandani K Tobin M J | 1999 | Am J Respir Crit Care Med1999，160，5： | 1 |
| 12 | Magnetic resonance angiography with contrast media in the study of carotid arteries显示文摘 | Catalano C Laghi A Pediconi F | 2001 | Radiol Mid(Torino)2001，10，： | 1 |
| 13 | Responses of different UV-visible detectors in high performance liquid chromatographic measurements when the absolute number of moles of an analyte is measured 显示文摘 | TORSI G CHIAVARI G LAGHI C | 1990 | J Chromatogr A1990，518，1： | 1 |
| 14 | Role of the respiratory muscles in a- cute respiratory failure of COPD :lessons from weaning failure显示文摘 | Tobin M J Laghi F Brochard L | 2009 | J Appl Physio2009，107，： | 1 |
| 15 | High-resolution multidetec-tor CT in the preoperative evaluation of patients with renal cellcarcinoma显示文摘 | Catalano C Fraioli F Laghi A | 2003 | AJR2003，180，5： | 1 |
| 16 | Hight- resolution CT angiography of the abdomen 显示文摘 | Catalano C Laghi A Fraioli F | 2002 | Abdomen Imaging2002，27，5： | 1 |
| 17 | Colorectal carcinoma: detection and staging with multislice CT (MSCT) colonography显示文摘 | R. Iannaccone A. Laghi R. Passariello | 2004 | Abdominal Imaging2004，，： | 1 |
| 18 | Virtual colonoscopy: clinical application显示文摘 | Andrea Laghi | 2005 | European Radiology Supplements2005，，： | 1 |
| 19 | Multislice spiral CT angiography in the evaluation of the anatomy of splanchnic vessels: preliminary experience显示文摘 | Laghi A Catalano C Iannaccone R | 2001 | Radiol Med(Torino)2001，102，3： | 1 |
| 20 | Prediction of colloidalstability in white wines using infrared spectroscopy显示文摘 | VERSARI A LAGHI L THORNGATE H | 2011 | Journal of FoodEngineering2011，104，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员