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| 1 | Oral microbiota and host innate immune response in bisphosphonate-related osteonecrosis of the jaw显示文摘Bacterial biofilms have emerged as potential critical triggers in the pathogenesis of bisphosphonate(BP)-related osteonecrosis of the jaw(ONJ) or BRONJ. BRONJ lesions have shown to be heavily colonized by oral bacteria, most of these difficult to cultivate and presents many clinical challenges. The purpose of this study was to characterize the bacterial diversity in BRONJ lesions and to determine host immune response. We examined tissue specimens from three cohorts(n530); patients with periodontal disease without a history of BP therapy(Control, n510), patients with periodontal disease having history of BP therapy but without ONJ(BP, n55) and patients with BRONJ(BRONJ, n515). Denaturing gradient gel electrophoresis of polymerase chain reaction(PCR)-amplified 16 S r RNA gene fragments revealed less bacterial diversity in BRONJ than BP and Control cohorts. Sequence analysis detected six phyla with predominant affiliation to Firmicutes in BRONJ(71.6%), BP(70.3%) and Control(59.1%). Significant differences(P,0.05) in genera were observed, between Control/BP, Control/BRONJ and BP/BRONJ cohorts. Enzyme-linked immunosorbent assay(ELISA)results indicated that the levels of myeloperoxidase were significantly lower, whereas interleukin-6 and tumor necrosis factor-alpha levels were moderately elevated in BRONJ patients as compared to Controls. PCR array showed significant changes in BRONJ patients with downregulation of host genes, such as nucleotide-binding oligomerization domain containing protein 2, and cathepsin G, the key modulators for antibacterial response and upregulation of secretory leukocyte protease inhibitor, proteinase 3 and conserved helix–loop–helix ubiquitous kinase. The results suggest that colonization of unique bacterial communities coupled with deficient innate immune response is likely to impact the pathogenesis of ONJ. | Smruti Pushalkar Xin Li Zoya Kurago Lalitha V Ramanathapuram Satoko Matsumura Kenneth E Fleisher Robert Glickman Wenbo Yan Yihong Li Deepak Saxena | 2014 | International Journal of Oral Science2014，6，4： | 4 |
| 2 | Enhancing effect of malachite green on the development of hepatic pre-neo- plastic lesions induced by N-nitrosodiethylamine in rats 显示文摘 | Fernandes C Lalitha V S Rao K V K | 1991 | Carcinogenesis1991，12，5： | 1 |
| 3 | Risk factors for treatment outcome in fungal keratitis显示文摘 | Lalitha P Prajna N V Kabra A | 2006 | Ophthalmology2006，113，4： | 1 |
| 4 | Differential gene ex-pression profile of the hepatopancreas of white spot syndrome virus infectedFenneropenaeus indicus by suppression subtractive hybridization显示文摘 | JAMES R THAMPURAN N LALITHA K V | 2010 | Fish&Shellfish Immunology2010，29，5： | 1 |
| 5 | Enhancing effects of malachite green on development of hepatic preneoplastic lesions induced by N - ni - trosodiethylamine in rats 显示文摘 | Fernandes C Lalitha V S Rao V K | 1991 | Carcinogenesis1991，12，： | 1 |
| 6 | Digoxigenin-labeled probe-based colony blotting assay for rapid quantification of Salmonella serovars in seafood and water显示文摘 | KUMAR R LALITHA K V | 2012 | Journal of AOAC International2012，95，6： | 1 |
| 7 | Xylan-Degrading Enzymes from the Therrnophilic Fungus Humicola Lanuginosa ( Griffon and Maublanc) Bunce : Action Pattern of Xylanase and β- Glucosidase on Xylans, Xylooligomers and Arabinoxylooligomers 显示文摘 | Lalitha N Paul J V | 1996 | Journal of Fermentation and Bioengineering1996，6，： | 1 |
| 8 | Enhancing effects of malachite green on development of hepatic preneoplastic lesions induced by N-nitrosodiethylamine in rats显示文摘 | Femandes C Lalitha V S Ran V K | 1991 | Carcinogenesis1991，12，： | 1 |
| 9 | Enhancing effects of malachite green on development of hepatic preneoplastic lesions induced by N - nitrosodiethylamine in rats 显示文摘 | Fernandes C Lalitha V S Rao V K | 1991 | Carcinogensis1991，12，： | 1 |
| 10 | Microbiological changes in farm reared freshwater prawn (Macrobrachium rosenbergii de Man) in ice显示文摘 | LALITHA K V SURENDRAN P K | 2006 | Food Control2006，17，： | 1 |
| 11 | Microbiological changes in farm reared freshwater prawn (Macrobrachium rosenbergii de Man) in ice显示文摘 | Lalitha K V Surendran P K | 2006 | Food Control2006，17，10： | 1 |
| 12 | Automated detection of anesthetic depth levels using chaotic features with artificial neural networks显示文摘 | Lalitha V Eswaran C | 2007 | J Med Syst2007，31，6： | 1 |
| 13 | Microbiological changes in farm reared freshwater prawn (Macrobrachium rosenbergii de Man) in ice显示文摘 | LALITHA K V SURENDRAN P K | 2006 | Food Control2006，17，10： | 1 |
| 14 | Bacteriophages for aquaculture : Are they beneficial or inimical显示文摘 | Rao B M Lalitha K V | 2015 | Aquaculture2015，437，： | 1 |
| 15 | Effect of packaging atmosphere on the microbial attributes of pearlspot( Etroplus suratensis Bloch)stored at 0 ℃ - 2℃ 显示文摘 | Ravi Sankar C N Lalitha K V Jose L | 2008 | Food Microbiology2008，25，3： | 1 |
| 16 | Higly stabilized and disperd CuO/TiO2: A promising visible senstive photocatalyst for continuous production ofhydrogden from glycerol: water mixtures 显示文摘 | Lalitha K Sadanandam G Kumari V D | 2010 | J Phys Chem C2010，114，22： | 1 |
| 17 | Effect of chitosan edible coating on the quality of double filleted Indian oil sardine (Sardinella longiceps ) during chilled storage 显示文摘 | Mohan C O Ravishankar C N Lalitha K V | 2012 | Food Hydroco112012，26，1： | 1 |
| 18 | Effects of sodium acetate dip treatment and vacuum-packaging on chemical, microbiological, textural and sensory changes of pearlspot(Etroplus suratensis ) during chill storage 显示文摘 | Manju S Jose L Gopal T K S Ravishankar C N Lalitha K V | 2007 | Food Chemistry2007，102，7： | 1 |
| 19 | Enhancing effects of malachite green on development of hepatic preneoplastic lesions induced by N-nitrosodiethyla mine in rats显示文摘 | Fernandes C Lalitha V S Rao V K | 1991 | Carcinogenesis1991，12，： | 1 |
| 20 | Crystal structure of the outer membrane actire transporter FepA from Escherichia coif显示文摘 | Susan B Barbara S Lalitha V | 1999 | Nature structural biology1999，6，： | 1 |
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