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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Partial recording protocols for periodontal disease assessment in epidemiological surveys显示文摘 | Vettore MV Lamarca G de A Leao AT | 2007 | Cad Saude Publica2007，23，1： | 1 |
| 3 | Clomiphene citrate increases insulin-like growth factor binding protein - 1 and reduces insulin-like growth factor - 1 without correcting insulin resistance associated with polycystic ovarian syndrome显示文摘 | DeLeo V LaMarca A Margate G | 2000 | Hum Reprod2000，15，11： | 1 |
| 4 | Perioperative chemotherapy for resectable gastroesophageal cancer:a single-center experience显示文摘 | Molina R Lamarca A Martínez-Amores B | | 0，，： | 1 |
| 5 | Murine xenograft model for human uterine fibroids: an in vivo imaging approach 显示文摘 | Suo G Sadarangani A Lamarca B | 2009 | ReproduetiveSci2009，16，9： | 1 |
| 6 | Optimizing static calendar queues 显示文摘 | ERICKSON K B LADNER R E LAMARCA A | 2000 | ACM Trans on Modeling and Computer Simulation2000，10，3： | 1 |
| 7 | N-cadherin expression is regulated by UTP in schwannoma cells显示文摘 | Martianez T Lamarca A Casals N | | 0，，： | 1 |
| 8 | Health - related quality of life and mortality in male patients with chronic obstructive pulmonary disease 显示文摘 | Domingo- Salvany A Lamarca R Ferret M | 2002 | Am J Respir Crit Care Med2002，166，5： | 1 |
| 9 | Impact of biliary stent-related events in patients diagnosed with advanced pancreatobiliary tumours receiving palliative chemotherapy显示文摘AIM: To determine the impact(morbidity/mortality) of biliary stent-related events(SRE)(cholangitis or stent obstruction) in chemotherapy-treated pancreaticobiliary patients.METHODS: All consecutive patients with advanced pancreatobiliary cancer and a biliary stent in-situ prior to starting palliative chemotherapy were identified retrospectively from local electronic case-note records(Jan 13 to Jan 15). The primary end-point was SRE rate and the time-to-SRE(defined as time from first stenting before chemotherapy to date of SRE). Progressionfree survival and overall survival were measured from the time of starting chemotherapy. Kaplan-Meier, Cox and Fine-Gray regression(univariate and multivariable) analyses were employed, as appropriate. For the analysis of time-to-SRE, death was considered as a competing event.RESULTS: Ninety-six out of 693 screened patients were eligible; 89% had a metal stent(the remainder were plastic). The median time of follow-up was 9.6 mo(range 2.2 to 26.4). Forty-one patients(43%)developed a SRE during follow-up [cholangitis(39%), stent obstruction(29%), both(32%)]. There were no significant differences in baseline characteristics between the SRE group and no-SRE groups. Recorded SRE-consequences were: none(37%), chemotherapy delay(24%), discontinuation(17%) and death(22%). The median time-to-SRE was 4.4 mo(95%CI: 3.6-5.5). Patients with severe comorbidities(P < 0.001) and patients with ≥ 2 baseline stents/biliary procedures [HR = 2.3(95%CI: 1.2-4.44), P = 0.010] had a shorter time-to-SRE on multivariable analysis. Stage was an independent prognostic factor for overall survival(P = 0.029) in the multivariable analysis adjusted for primary tumour site, performance status and development of SRE(SRE group vs no-SRE group).CONCLUSION: SREs are common and impact on patient's morbidity. Our results highlight the need for prospective studies exploring the role of prophylactic strategies to prevent/delay SREs. | Angela Lamarca Christina Rigby Mairéad G Mc Namara Richard A Hubner Juan W Valle | 2016 | World Journal of Gastroenterology2016，22，26： | 1 |
| 10 | partial recording protocols for periodontal disease assessment in epidemiological surveys显示文摘 | Vettore MV Lamarca Gde A Leao AT | 2007 | Cad Saude Publica2007，23，1： | 1 |
| 11 | Health - related quality of life and mortality in male patients with chronic obstructive pul- monary disease 显示文摘 | Domingo - Salvany A Lamarca R Ferrer M | 2002 | Am J Respir Crit Care Med2002，166，： | 1 |
| 12 | Health relatedquality of life and mortality in male patients with chronic obstructivepulmonary disease显示文摘 | Domingo-Salvany A Lamarca R Ferrer M | 2002 | AmJ Respir Critic Med2002，166，： | 1 |
| 13 | Health related quality of life and mortality in male patients with chronic obstructive pulmonary disease显示文摘 | Dorningo-Salvany A Lamarca R Ferrer M | 2002 | Am J Respir Crit Care Med2002，166，： | 1 |
| 14 | Effection of Metformin on Insulin-like Growth Fator (IGF) and IGF-binding Protein 1 In polycystic Ovary Syndrom 显示文摘 | De Leo V Lamarca A Qrvieto R | 2000 | J Clin Endocrinol Metab2000，85，4： | 1 |
| 15 | Safety and efficacy of short-duration oral terbinafine for the treatment of tinea corporis or tinea cruris in subjects with HIV infection or diabetes显示文摘 | Rich P Houpt KR LaMarca A | 2001 | Cutis2001，68，1： | 1 |
| 16 | Partial recording protocols for periodontal disease assessment in epidemiological surveys显示文摘 | Vettore MV Lamarca Gde A Leoo AT | 2007 | Cad Saude Publica2007，23，1： | 1 |
| 17 | Efficacy and safety of once daily elvitegravir versus twice daily raltegravir in treat- ment-experienced patients with HIV-1 receiving a ritonavir-boosted protease inhibitor: randomised, double-blind, phase 3, non-inferiority study显示文摘 | Molina JM Lamarca A Andrade-Villanueva J | 2012 | Lancet Infect Dis2012，12，1： | 1 |
| 18 | Health re- lated quality of life and mortality in male patients with chronic obstructive pulmonary disease 显示文摘 | I)omingo-Salvany A Lamarca R Ferret M | 2002 | Am J Respir Crit Care Med2002，166，5： | 1 |
| 19 | Semi-Empirical Rate Law for Rice-Herzfeld Pyrolysis of Mixture: Capturing Chemistry With Reasonable Computational Burden显示文摘 | NIGAM A LAMARCA C FAKE D | 1992 | Energy Fuels1992，，06： | 1 |
| 20 | Health- related quality of life and mortality in male patients with chronic obstruc- tive pulmonary disease显示文摘 | Domingo- Salvany A Lamarca R Ferrer M | 2002 | Am J Respir Crit Care Med2002，166，5： | 1 |
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