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46篇 您的检索式:作者名="Lander P A"
    题名 作者 年代 出处 被引量
1胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 2017中华高血压杂志2017,25,9:2
2Retesting after initial failure, coaching rumors, and warnings against faking in online personality measures for selection显示文摘Landers R N Sackett P R Tuzinski K A 2011Journal of Applied Psychology2011,96,1:1
3MAPMAKER: an interactive computer package for constructing primary genetic maps of experimental and natural populations显示文摘Lander E S Green P Abrahamson J Barlow A Day M J Lincoln S E Newbury L 1987Genetics1987,1,:1
4Imaging of pyogenic infectious spondylodiskitis显示文摘Varma R Lander P Assaf A 2001Radiol Clin North Am2001,39,2:1
5MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations显示文摘Lander E S Green P Abrahamson J Barlow A Daley M 1987Genomics1987,,1:1
6Self- paced exercise is less physically challenging than enforced con- stant pace exercise of the same intensity: influence of com- plex central metabolic eontro显示文摘Lander P J Butterly R J Edwards A M 2009Br J Sports Med2009,43,10:1
7MAPMAKER:an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations 显示文摘Lander E S Green P Abrahamson J Barlow A Daly M J Lincoln S E Newburg L 1987Genomics1987,1174,181:1
8Asymmetric synthesis of α-amino acids by copper catalyzed conjugate addition of Grignard reagents to optically active carbamatoacrylates显示文摘Lander P A Hegedus L S 1994J Am Chem Soc1994,116,:1
9Genomic surveillance elucidates Ebola virus origin and transmission during the 2014outbreak显示文摘Gire S K Goba A Andersen K G Sealfon R S Park D J Kanneh L Jalloh S Momoh M Fullah M Dudas G Wohl S Moses L M Yozwiak N L Winnicki S Matranga C B Malboeuf C M Qu J Gladden A D Schaffner S F Yang X Jiang P P Nekoui M Colubri A Coomber M R Fonnie M Moigboi A Gbakie M Kamara F K Tucker V Konuwa E Saffa S Sellu J Jalloh A A Kovoma A Koninga J Mustapha I Kargbo K Foday M Yillah M Kanneh F Robert W Massally J L Chapman S B Bochicchio J Murphy C Nusbaum C Young S Birren B W Grant D S Scheiffelin J S Lander E S Happi C Gevao S M Gnirke A Rambaut A Garry R F Khan S H Sabeti P C 2014Science2014,345,6202:1
10Studies on the mechanism of hydroxymethylbilane synthase concerning the role of arginine residues in substrate binding显示文摘LANDER M PITT A R ALEFOUNDER P R 1991The Biochemical Journal1991,275,:1
11MAPMAKER: an interactive computer package for constructing primary genetic maps of experimental and natural populations 显示文摘Lander E S Green P Abrahamson J Barlow A Daly M J Lincoln S E Newburg L 1987Genomics1987,1,:1
12Imaging of pyogenic infectious spondylodiskitis显示文摘Varma R Lander P Assaf A 2001Radiol Clin North Am2001,39,2:1
13Evaluation of silica resins for direct and efficient extraction of DNA from cimplex biological Matrices in aminiaturized format显示文摘TIAN H HUHMER A F LANDERS J P 2000Anal Biothem2000,283,2:1
14Molecular classification of cancer:class discovery and class prediction by gene expression monitoring显示文摘Golub T R Slonim D K Tamayo P Huard C Gaasenbeek M Mesirov J P Coller H Loh M L Downing J R Caligiuri M A Bloomfield C D Lander E S 1999Science1999,286,5439:1
15based ST-T indexes in recor-dings from human subjects with induced myocardial ischemia显示文摘García J lander P Sommo L Comparative study of local and Karhunen-Loève 1998Comput Biomed Res1998,31,4:1
16Two decades of global tsunamis 1982-2002: Science of tsunami hazards显示文摘Lander J F Whiteside L S Lockridge P A 2003The International Journal of the Tsunami Society2003,21,1:1
17MAPMAKER: an interac- tive computer package for constructing primary genetic linkage maps of experimental and natural populations 显示文摘Lander E S Green P Barlow A 1987Genomics1987,1,2:1
18lmage of pyogenic infectious spondy-lodiskitis显示文摘Varma R Lander P’Assaf A 2001RadiolClin North Am2001,39,2:1
19Evaluation of silica resins for direct and efficient extracton of DNA from complex biological matrices in a miniaturized format 显示文摘 Huhmer A F Landers J P 2000Anal Biochem2000,283,2:1
20MAPMAKER:an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations显示文摘Lander E S Green P Abrahamson J Barlow A Daly M J Lincoln S E Newberg L A 0,,:1
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